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公开(公告)号:US08071591B2
公开(公告)日:2011-12-06
申请号:US12721454
申请日:2010-03-10
申请人: Masahiro Nomura , Kyoko Okada , Taro Sato , Yasushi Kohno
发明人: Masahiro Nomura , Kyoko Okada , Taro Sato , Yasushi Kohno
IPC分类号: C07D498/06 , A61K31/5383
CPC分类号: C07D498/06
摘要: Provided herein are aminoquinolones of formula I and compositions containing the compounds, wherein formula I is The compounds and compositions provided herein are useful in the amelioration or treatment of GSK-3 inhibitors mediated diseases.
摘要翻译: 本文提供了式I的氨基喹诺酮和含有化合物的组合物,其中式I是本文提供的化合物和组合物可用于改善或治疗GSK-3抑制剂介导的疾病。
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公开(公告)号:US20100234367A1
公开(公告)日:2010-09-16
申请号:US12721454
申请日:2010-03-10
申请人: MASAHIRO NOMURA , Kyoko Okada , Taro Sato , Yasushi Kohno
发明人: MASAHIRO NOMURA , Kyoko Okada , Taro Sato , Yasushi Kohno
IPC分类号: A61K31/5383 , C07D265/34 , A61P3/10 , A61P25/16 , A61P25/28 , A61P25/00 , A61P19/02 , A61P19/10 , A61P1/04 , A61P1/06 , A61P31/04 , A61P35/00
CPC分类号: C07D498/06
摘要: Provided herein are aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases.
摘要翻译: 本文提供了式I的氨基喹诺酮和含有该化合物的组合物。 本文提供的化合物和组合物可用于预防,改善或治疗GSK-3抑制剂介导的疾病。
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公开(公告)号:US08476261B2
公开(公告)日:2013-07-02
申请号:US12678120
申请日:2008-09-12
申请人: Oana Cociorva , Yasumichi Fukuda , Yasushi Kohno , Bei Li , Kyoko Okada , Ayako Nakamura , Masahiro Nomura , Shigeki Seto , Anna Katrin Szardenings , Kazuhiro Yumoto
发明人: Oana Cociorva , Yasumichi Fukuda , Yasushi Kohno , Bei Li , Kyoko Okada , Ayako Nakamura , Masahiro Nomura , Shigeki Seto , Anna Katrin Szardenings , Kazuhiro Yumoto
IPC分类号: A61K31/5386
CPC分类号: C07D498/06 , A61J1/00 , C07D498/10 , C07D498/20
摘要: Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases. In Formula (I): X1 is O or NR8; A is bond or substituted or unsubstituted C1-C2 alkylene, wherein the substituents when present are selected from one to four Q2 groups; where Q2 is alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2.
摘要翻译: 本文提供式I的螺环氨基喹诺酮和含有该化合物的组合物。 本文提供的化合物和组合物可用于预防,改善或治疗GSK-3抑制剂介导的疾病。 式(I)中,X 1为O或NR 8; A是键或取代或未取代的C 1 -C 2亚烷基,其中当存在时的取代基选自1至4个Q 2基团; 其中Q2是烷基或卤代烷基; p为0或1; q为0〜2的整数。
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公开(公告)号:US20110034436A1
公开(公告)日:2011-02-10
申请号:US12678120
申请日:2008-09-12
申请人: Oana Cociorva , Yasumichi Fukuda , Yasushi Kohno , Bei Li , Kyoko Okada , Ayako Nakamura , Masahiro Nomura , Shigeki Seto , Anna Katrin Szardenings , Yumoto Kazuhiro
发明人: Oana Cociorva , Yasumichi Fukuda , Yasushi Kohno , Bei Li , Kyoko Okada , Ayako Nakamura , Masahiro Nomura , Shigeki Seto , Anna Katrin Szardenings , Yumoto Kazuhiro
IPC分类号: A61K31/553 , C07D265/28 , C07D487/10 , A61K31/5386 , A61P25/00 , A61P25/28 , A61P1/00 , A61P25/18 , A61P35/00 , A61P3/10
CPC分类号: C07D498/06 , A61J1/00 , C07D498/10 , C07D498/20
摘要: Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases. In Formula (I): X1 is O or NR8; A is bond or substituted or unsubstituted C1-C2 alkylene, wherein the substituents when present are selected from one to four Q2 groups; where Q2 is alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2.
摘要翻译: 本文提供式I的螺环氨基喹诺酮和含有该化合物的组合物。 本文提供的化合物和组合物可用于预防,改善或治疗GSK-3抑制剂介导的疾病。 式(I)中,X 1为O或NR 8; A是键或取代或未取代的C 1 -C 2亚烷基,其中当存在时的取代基选自1至4个Q 2基团; 其中Q2是烷基或卤代烷基; p为0或1; q为0〜2的整数。
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公开(公告)号:US20070254866A1
公开(公告)日:2007-11-01
申请号:US11718000
申请日:2007-03-13
申请人: Oana Cociorva , Bei Li , Katrin Szardenings , Yasumichi Fukuda , Masahiro Nomura , Shigeki Seto , Kazuhiro Yumoto , Kyoko Okada , Ayako Nakamura
发明人: Oana Cociorva , Bei Li , Katrin Szardenings , Yasumichi Fukuda , Masahiro Nomura , Shigeki Seto , Kazuhiro Yumoto , Kyoko Okada , Ayako Nakamura
IPC分类号: A61K31/47 , A61K31/535 , A61K31/553 , A61P19/02 , A61P19/10 , A61P25/16 , A61P25/24 , A61P25/28 , A61P3/10 , A61P31/12 , A61P35/00 , C07D215/02 , C07D265/34 , C07D267/08 , C12N9/99
CPC分类号: C12N9/99 , C07D498/06
摘要: Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases.
摘要翻译: 本文提供氨基喹诺酮及其药学上可接受的衍生物。 在某些实施方案中,本文提供了用于治疗,预防或改善GSK-3介导的疾病的化合物,组合物和方法。
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公开(公告)号:US08063221B2
公开(公告)日:2011-11-22
申请号:US11718000
申请日:2007-03-13
申请人: Oana Cociorva , Bei Li , Anna Katrin Szardenings , Yasumichi Fukuda , Masahiro Nomura , Shigeki Seto , Kazuhiro Yumoto , Kyoko Okada , Ayako Nakamura
发明人: Oana Cociorva , Bei Li , Anna Katrin Szardenings , Yasumichi Fukuda , Masahiro Nomura , Shigeki Seto , Kazuhiro Yumoto , Kyoko Okada , Ayako Nakamura
IPC分类号: C07D215/00 , A01N43/42 , A61K31/47
CPC分类号: C12N9/99 , C07D498/06
摘要: Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases.
摘要翻译: 本文提供氨基喹诺酮及其药学上可接受的衍生物。 在某些实施方案中,本文提供了用于治疗,预防或改善GSK-3介导的疾病的化合物,组合物和方法。
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公开(公告)号:US20090036489A1
公开(公告)日:2009-02-05
申请号:US11886909
申请日:2006-03-22
申请人: Masahiro Nomura , Yasuo Takano , Kazuhiro Yumoto , Kyoko Okada , Takehiro Shinozaki , Shigeki Isogai
发明人: Masahiro Nomura , Yasuo Takano , Kazuhiro Yumoto , Kyoko Okada , Takehiro Shinozaki , Shigeki Isogai
IPC分类号: A61K31/4535 , C07D401/12 , A61P3/04 , A61P3/10
CPC分类号: C07D417/12 , C07D409/12
摘要: The present invention provides cyclic aminophenylalkanoic acid derivatives that act as agonists for human peroxisome proliferator-activated receptors (PPARs), in particular human PPARα isoform, and are effective in the treatment of abnormal lipid metabolism, diabetes and other disorders. The present invention also provides addition salts of such cyclic aminophenylalkanoic acid derivatives and pharmaceutical compositions containing these compounds.Specifically, the present invention provides cyclic aminophenylalkanoic acid derivatives represented by the following general formula (1): , or pharmaceutically acceptable salts thereof.
摘要翻译: 本发明提供了作为人类过氧化物酶体增殖物激活受体(PPAR),特别是人PPARα同种型的激动剂的环状氨基苯基链烷酸衍生物,并且有效治疗脂质代谢异常,糖尿病等疾病。 本发明还提供了这种环状氨基苯基链烷酸衍生物的加成盐和含有这些化合物的药物组合物。 具体地说,本发明提供由以下通式(1)表示的环状氨基苯基链烷酸衍生物或其药学上可接受的盐。
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公开(公告)号:US20070238271A1
公开(公告)日:2007-10-11
申请号:US11806862
申请日:2007-06-05
申请人: Shoichi Yamauchi , Yoshiyuki Hattori , Kyoko Okada
发明人: Shoichi Yamauchi , Yoshiyuki Hattori , Kyoko Okada
IPC分类号: H01L21/20
CPC分类号: H01L29/7811 , H01L29/0615 , H01L29/0634 , H01L29/0696 , H01L29/1095 , H01L29/402 , H01L29/41741 , H01L29/66734 , H01L29/7813
摘要: A semiconductor device having SJ structure has a peripheral region having a higher withstand voltage than the withstand voltage of the cell region. A semiconductor upper layer including second conductivity-type impurities and a semiconductor lower layer including first conductivity-type impurities whose concentration is lower than the first portion region constituting the combination of the cell region are formed in the semiconductor layer of the peripheral region. A field oxide layer is formed on a surface of the semiconductor upper layer.
摘要翻译: 具有SJ结构的半导体器件具有比电池区域的耐电压更高的耐受电压的周边区域。 在周边区域的半导体层中形成有包含第二导电型杂质的半导体上层和包含第一导电型杂质的半导体下层,该第一导电型杂质的浓度低于构成该单元区域组合的第一部分区域。 在半导体上层的表面上形成场氧化物层。
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公开(公告)号:US08519748B2
公开(公告)日:2013-08-27
申请号:US13433624
申请日:2012-03-29
申请人: Takaaki Aoki , Shoji Mizuno , Shigeki Takahashi , Takashi Nakano , Nozomu Akagi , Yoshiyuki Hattori , Makoto Kuwahara , Kyoko Okada
发明人: Takaaki Aoki , Shoji Mizuno , Shigeki Takahashi , Takashi Nakano , Nozomu Akagi , Yoshiyuki Hattori , Makoto Kuwahara , Kyoko Okada
IPC分类号: H03K3/00
CPC分类号: H01L27/0629 , H01L27/0255 , H03K17/063 , H03K17/165 , H03K17/168 , H03K17/567 , H03K17/687 , H03K2217/0036
摘要: A switching circuit includes: a transistor having a first electrode, a second electrode and a control electrode; a zener diode; and a capacitor. A connection between the first electrode and the second electrode is capable of temporally switching between a conduction state and a non-conduction state by switching a control voltage of the transistor. The zener diode and the capacitor are coupled in series between the first electrode and the control electrode of the transistor. The first electrode is a drain or a collector.
摘要翻译: 开关电路包括:具有第一电极,第二电极和控制电极的晶体管; 齐纳二极管; 和电容器。 通过切换晶体管的控制电压,第一电极和第二电极之间的连接能够在导通状态和非导通状态之间暂时切换。 齐纳二极管和电容器串联耦合在晶体管的第一电极和控制电极之间。 第一电极是漏极或集电极。
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公开(公告)号:US08179169B2
公开(公告)日:2012-05-15
申请号:US13105021
申请日:2011-05-11
申请人: Takaaki Aoki , Shoji Mizuno , Shigeki Takahashi , Takashi Nakano , Nozomu Akagi , Yoshiyuki Hattori , Makoto Kuwahara , Kyoko Okada
发明人: Takaaki Aoki , Shoji Mizuno , Shigeki Takahashi , Takashi Nakano , Nozomu Akagi , Yoshiyuki Hattori , Makoto Kuwahara , Kyoko Okada
IPC分类号: H03K3/00
CPC分类号: H01L27/0629 , H01L27/0255 , H03K17/063 , H03K17/165 , H03K17/168 , H03K17/567 , H03K17/687 , H03K2217/0036
摘要: A switching circuit includes: a transistor having a first electrode, a second electrode and a control electrode; a zener diode; and a capacitor. A connection between the first electrode and the second electrode is capable of temporally switching between a conduction state and a non-conduction state by switching a control voltage of the transistor. The zener diode and the capacitor are coupled in series between the first electrode and the control electrode of the transistor. The first electrode is a drain or a collector.
摘要翻译: 开关电路包括:具有第一电极,第二电极和控制电极的晶体管; 齐纳二极管; 和电容器。 通过切换晶体管的控制电压,第一电极和第二电极之间的连接能够在导通状态和非导通状态之间暂时切换。 齐纳二极管和电容器串联耦合在晶体管的第一电极和控制电极之间。 第一电极是漏极或集电极。
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