摘要:
Provided herein are aminoquinolones of formula I and compositions containing the compounds, wherein formula I is The compounds and compositions provided herein are useful in the amelioration or treatment of GSK-3 inhibitors mediated diseases.
摘要:
Provided herein are aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases.
摘要:
To provide a novel mutilin derivative having a substitution at the 14-position, which is a novel mutilin analogue exhibiting a potent and broad antimicrobial action against Gram-positive bacteria and Gram-negative bacteria including various drug-resistant bacteria, and which is expected to be useful as an agent for treating infectious diseases. A mutilin derivative represented by the following general formula (1): or a pharmaceutically acceptable addition salt thereof.
摘要:
Provided is a method of controlling operation of a tandem rolling mill which enables large reduction rolling in the latter-stage stand of the tandem rolling mill necessary for manufacturing fine-grained steel, and so on. The method comprises: a step of determining a first exit-side sheet thickness in rolling a constant portion of a material to be rolled; and a step of determining a second exit-side sheet thickness in rolling a front end portion of the material, such that a pre-tightening load becomes a set value or less; the material is rolled into the second exit-side sheet thickness, until the front end portion is fed into the stands; the constant portion is rolled by the stand given a pre-tightening load into the first exit-side sheet thickness; and the second exit-side sheet thicknesses of the stands given the pre-tightening load are made larger than the first exit-side sheet thickness.
摘要:
Provided is a method of controlling operation of a tandem rolling mill which enables large reduction rolling in the latter-stage stand of the tandem rolling mill necessary for manufacturing fine-grained steel, and so on. The method comprises: a step of determining a first exit-side sheet thickness in rolling a constant portion of a material to be rolled; and a step of determining a second exit-side sheet thickness in rolling a front end portion of the material, such that a pre-tightening load becomes a set value or less; the material is rolled into the second exit-side sheet thickness, until the front end portion is fed into the stands; the constant portion is rolled by the stand given a pre-tightening load into the first exit-side sheet thickness; and the second exit-side sheet thicknesses of the stands given the pre-tightening load are made larger than the first exit-side sheet thickness.
摘要:
To provide a novel mutilin derivative having a substitution at the 14-position, which is a novel mutilin analogue exhibiting a potent and broad antimicrobial action against Gram-positive bacteria and Gram-negative bacteria including various drug-resistant bacteria, and which is expected to be useful as an agent for treating infectious diseases. A mutilin derivative represented by the following general formula (1): or a pharmaceutically acceptable addition salt thereof.
摘要:
A position 12-substituted mutilin derivative, a novel mutilin analogue, is provided that exhibits strong antimicrobial activity against abroad spectrum of Gram-positive or Gram-negative bacteria, including various drug-resistant bacteria, as well as intermediates for the production of such mutilin derivatives.Specifically, a mutilin derivative or an acid-addition salt thereof is provided that is represented by the following chemical formula (1): (wherein R1 is a hydrogen atom, a formyl group, a substituted or unsubstituted lower alkyl group, an aralkyl group whose aromatic ring may be optionally substituted, a heteroaralkyl group whose aromatic ring may be optionally substituted or a lower alkyloxycarbonyl group; and R2 is a hydrogen atom, a lower alkyl group or an aralkyl group whose aromatic ring may be optionally substituted) (R1 is neither an ethyl group nor a vinyl group).
摘要翻译:提供了一种位置12-取代的mutilin衍生物,一种新的mutilin类似物,其显示出对革兰氏阳性或革兰氏阴性细菌(包括各种耐药性细菌)的国外光谱的强抗微生物活性,以及用于生产这种mutilin的中间体 衍生品 具体而言,提供由以下化学式(1)表示的脯氨酸衍生物或其酸加成盐:(其中R 1是氢原子,甲酰基,取代或未取代的 芳基可以任选被取代的芳烷基,芳香环可以被任选取代的杂芳烷基或低级烷氧基羰基; R 2是氢原子,低级烷基 或其芳环可以任选被取代的芳烷基)(R 1 O 2既不是乙基也不是乙烯基)。