公开(公告)号：US20020058798A1

公开(公告)日：2002-05-16

申请号：US09933814

申请日：2001-08-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Mark Boldin ,  Eugene Varfolomeev ,  Igor Mett

IPC: C12Q001/68 ,  C07H021/04 ,  A61K048/00

CPC classification number: C07K14/70578 ,  A61K38/00 ,  C07K14/715 ,  C07K16/2866 ,  C07K2319/00 ,  C12N9/641 ,  C12N9/6475

Abstract: Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.

Abstract translation: 提供了能够调节FAS / APO1功能的蛋白质。 可以通过在合适的条件下培养用含有编码这种蛋白质的DNA的载体转化的宿主细胞并分离蛋白质来制备蛋白质。

公开(公告)号：US20040013646A1

公开(公告)日：2004-01-22

申请号：US10349977

申请日：2003-01-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Mark Boldin ,  Igor Mett ,  Eugene Varfolomeev

IPC: A61K048/00 ,  A61K039/395 ,  C07K016/30 ,  C07H021/04

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K14/7151 ,  C07K16/2878 ,  C07K2317/82 ,  C07K2319/00

Abstract: The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.

Abstract translation: 本发明通常涉及能够调节p55和p75 TNF-R和FAS-R功能的p55和p75 TNF-R和FAS-R的细胞内结构域的新型蛋白质，以及 编码它们的DNA序列。 本发明还涉及具有TNF-R和FAS-R的混合物的新的可溶性寡聚TNF-R，寡聚FAS-Rs和寡聚受体。 此外，本发明涉及上述所有方法的制备和用途。

公开(公告)号：US20030219411A1

公开(公告)日：2003-11-27

申请号：US10368438

申请日：2003-02-20

Applicant: Yeda Research and Development Co., LTD

Inventor： David Wallach ,  Mark Boldin ,  Tanya Goncharov ,  Yury V. Golstev

IPC: A61K038/00 ,  A61K048/00 ,  A61K038/17 ,  C07K014/705

CPC classification number: C12N9/641 ,  A61K38/00 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/715 ,  C07K14/7151 ,  C07K16/2866 ,  C07K2319/00 ,  C12N9/6475

Abstract: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors that interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided, as well as a method of designing them.

Abstract translation: 本发明提供能够通过与MORT-1蛋白结合或相互作用而与携带FAS受体或p55受体的细胞调节或介导FAS受体配体或TNF作用的蛋白，其又结合FAS受体的细胞内结构域或另一种 结合p55受体的蛋白质TRADD。 另外，提供干扰具有蛋白水解活性的MORT-1结合蛋白质的蛋白水解活性的肽抑制剂，以及设计它们的方法。