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公开(公告)号：US20230201257A1
公开(公告)日：2023-06-29
申请号：US17986080
申请日：2022-11-14
Applicant: Yeda Research and Development Co. Ltd. , The Walter and Eliza Hall Institute of Medical Research
Inventor： Sarel FLEISHMAN , Assaf ELAZAR , Jonathan Y. WEINSTEIN , Melissa J. CALL , Matthew E. CALL , Nicholas J. CHANDLER
IPC: A61K35/17 , C07K14/725 , C07K14/705 , C07K16/32 , A61P35/00
CPC classification number: A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K16/32 , C07K2317/622 , C07K2319/03 , C07K2319/41
Abstract: Provided herein is a family of programmable de novo designed transmembranal protein domain polypeptides, and uses thereof in the production of engineered chimeric antigen receptor T (CAR T) cells, which are used, for example, to fight cancer.
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公开(公告)号：US20170206308A1
公开(公告)日：2017-07-20
申请号：US15323994
申请日：2015-07-06
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Sarel FLEISHMAN , Gideon LAPIDOTH , Maria Gabriele PSZOLLA , Christoffer NORN
Abstract: A method for constructing a library of amino-acid sequences having a common structural fold, and a method for designing and selecting an amino-acid sequence having a desired affinity to a molecular surface of interest of a molecular entity, using the library, are provided herein. The methods are based on a stochastic sampling of backbone conformations and amino acid conservation patterns observed in experimentally available protein structures having the common structural fold.
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公开(公告)号：US20170032079A1
公开(公告)日：2017-02-02
申请号：US15259311
申请日：2016-09-08
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Sarel FLEISHMAN , Adi Goldenzweig , Dan S. Tawfik
CPC classification number: G16B15/00 , C12N9/1007 , C12N9/16 , C12N9/18 , C12Y201/01037 , C12Y301/01007 , C12Y301/08001 , G16B15/20 , G16B30/00 , G16B35/00 , G16C20/10 , G16C20/60
Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.
Abstract translation: 与相应的野生型蛋白质相比，设计和选择具有稳定结构的蛋白质的方法，以及相对于相应野生型蛋白质具有至少6个氨基酸取代的蛋白质，其设计用于改善热稳定性，改善的比活性和/或 改善的表达水平。
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公开(公告)号：US20250092158A1
公开(公告)日：2025-03-20
申请号：US18832710
申请日：2022-08-04
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Deborah FASS , Sarel FLEISHMAN , Lev KHMELNITSKY , Ariel TENNENHOUSE
IPC: C07K16/40 , A61K39/00 , A61K47/68 , G01N33/573
Abstract: The present invention provides humanized monoclonal antibodies that specifically recognize human QSOX1 and inhibit its activity. The humanized antibodies of the present invention were designed following in-silico selection of specific variable region segments, based on their energy scores, and were produced and confirmed to function properly in binding and inhibiting human QSOX1. The present invention further provides pharmaceutical compositions comprising the humanized antibodies and methods for their use in cancer therapy and diagnosis.
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Patent Agency Ranking
公开(公告)号：US20240301368A1
公开(公告)日：2024-09-12
申请号：US18672113
申请日：2024-05-23
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Sarel FLEISHMAN , Shiran BARBER-ZUCKER
CPC classification number: C12N9/0065 , C12N15/81 , C12P7/10 , C12Y111/01007
Abstract: Recombinant peroxidase enzymes are disclosed having mutations that increase yield when expressed in yeast cells as compared to their corresponding wild-type peroxidase enzyme. Methods of generating are also disclosed as well as uses thereof.
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公开(公告)号：US20210292437A1
公开(公告)日：2021-09-23
申请号：US17267049
申请日：2019-08-14
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Deborah FASS , Sarel FLEISHMAN , Shira WARSZAWSKI , Iris GROSSMAN , Lev KHMELNITSKY
IPC: C07K16/40
Abstract: Antibodies for binding QSOX1 are provided. Also provided are use of these antibodies.
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公开(公告)号：US20230132790A1
公开(公告)日：2023-05-04
申请号：US17915500
申请日：2021-03-29
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Anthony H. FUTERMAN , Israel SILMAN , Joel L. SUSSMAN , Sarel FLEISHMAN , Adi GOLDENZWEIG , Sarka POKORNA , Yaacov ASHANI , Olga KHERSONSKY
IPC: C12N9/24
Abstract: A genetically modified human beta-glucocerebrosidase (GCase) is disclosed. The genetically modified GCase comprising an amino acid sequence at least 85% identical to SEQ ID NO: 2; and comprising mutations at coordinates L34P, K224N/G, T369E and N370D, where the coordinates correspond to said SEQ ID NO: 2; and capable of catalyzing hydrolysis of a glycolipid glucosylceramide (GlcCer). Pharmaceutical compositions comprising the genetically modified GCase and therapeutic methods of using same are also disclosed.
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公开(公告)号：US20210178207A1
公开(公告)日：2021-06-17
申请号：US17267816
申请日：2019-08-14
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Sarel FLEISHMAN , Dan S. TAWFIK , Olga KHERSONSKY
IPC: A62D3/02
Abstract: Provided herein is a library of designed phosphotriesterase (PTE) enzymes, exhibiting an improved catalytic hydrolysis activity of various substrates, including nerve agents, and a general method of generating and using the same.
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公开(公告)号：US20200058367A1
公开(公告)日：2020-02-20
申请号：US16672601
申请日：2019-11-04
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Sarel FLEISHMAN , Adi GOLDENZWEIG , Dan S. TAWFIK
IPC: G16B15/00 , G16B15/20 , G16C20/60 , G16C20/10 , G16B35/00 , G16B30/00 , C12N9/10 , C12N9/16 , C12N9/18
Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.
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