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    Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
    1.
    发明授权
    Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved 有权
    针对骨膜素的抗体，以及包含其用于预防或治疗涉及骨膜素的疾病的药物组合物

    公开(公告)号：US08372957B2

    公开(公告)日：2013-02-12

    申请号：US13198618

    申请日：2011-08-04

    申请人： Yoshiaki Taniyama ,  Ryuichi Morishita ,  Naruto Katsuragi

    发明人： Yoshiaki Taniyama ,  Ryuichi Morishita ,  Naruto Katsuragi

    IPC分类号： C07K16/00

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/73

    摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.

    摘要翻译： 本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂 。 本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。

    ANTIBODY AGAINST PERIOSTIN, AND A PHARMACEUTICAL COMPOSITION COMPRISING IT FOR PREVENTING OR TREATING A DISEASE IN WHICH PERIOSTIN IS INVOLVED
    2.
    发明申请
    ANTIBODY AGAINST PERIOSTIN, AND A PHARMACEUTICAL COMPOSITION COMPRISING IT FOR PREVENTING OR TREATING A DISEASE IN WHICH PERIOSTIN IS INVOLVED 有权
    抗周期抗体，以及包含其用于预防或治疗周围疾病的疾病的药物组合物

    公开(公告)号：US20120058572A1

    公开(公告)日：2012-03-08

    申请号：US13198618

    申请日：2011-08-04

    申请人： Yoshiaki TANIYAMA ,  Ryuichi Morishita ,  Naruto Katsuragi

    发明人： Yoshiaki TANIYAMA ,  Ryuichi Morishita ,  Naruto Katsuragi

    IPC分类号： G01N33/53 ,  C12N5/16 ,  C12P21/08 ,  C07K16/18

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/73

    摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.

    摘要翻译： 本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂 。 本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。

    Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
    4.
    发明授权
    Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved 有权
    针对骨膜素的抗体，以及包含其用于预防或治疗涉及骨膜素的疾病的药物组合物

    公开(公告)号：US08017119B2

    公开(公告)日：2011-09-13

    申请号：US12147331

    申请日：2008-06-26

    申请人： Yoshiaki Taniyama ,  Ryuichi Morishita ,  Naruto Katsuragi

    发明人： Yoshiaki Taniyama ,  Ryuichi Morishita ,  Naruto Katsuragi

    IPC分类号： A61K39/395

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/73

    摘要： The present invention provides an antibody against a periostin isoform having anti-cell adhesive activity, especially an anti-periostin antibody having the ability to neutralize anti-cell adhesive properties, as well as a prophylactic or therapeutic agent for periostin-related diseases comprising the antibody. The present invention also provides methods for detecting and quantifying the periostin isoform in a sample by using the antibody, as well as a method for diagnosing periostin-related diseases comprising measuring the amount of the periostin isoform by the detection or quantification method.

    摘要翻译： 本发明提供具有抗细胞粘附活性的抗骨膜素同种型抗体，特别是具有中和抗细胞粘附性能的抗骨膜素抗体，以及包含抗体的骨膜素相关疾病的预防或治疗剂 。 本发明还提供了通过使用抗体检测和定量样品中骨膜素异构体的方法，以及用于诊断骨膜素相关疾病的方法，包括通过检测或定量方法测量骨膜素同种型的量。

    Remedies for heart failure
    5.
    发明授权
    Remedies for heart failure 失效
    心力衰竭的补救措施

    公开(公告)号：US07816511B2

    公开(公告)日：2010-10-19

    申请号：US10383241

    申请日：2003-07-16

    申请人： Kayoko Kawashima ,  Naruto Katsuragi ,  Keijiro Sugimura ,  Mayumi Furuya ,  Ryuichi Morishita

    发明人： Kayoko Kawashima ,  Naruto Katsuragi ,  Keijiro Sugimura ,  Mayumi Furuya ,  Ryuichi Morishita

    IPC分类号： C07H21/04 ,  A01N43/04 ,  A61K31/70

    CPC分类号： C07K14/475 ,  A01K2217/05 ,  A61K39/00 ,  C07K14/47

    摘要： The present invention provides methods for screening drugs inhibiting the expression of OSF-2 gene or the production or function of the protein encoded thereby and therapeutic agents for heart failure having such effects. Useful methods for diagnosing heart failure can be provided by monitoring the expression or variation of said gene or the production of the protein encoded thereby. The present invention also provides transgenic animals with forced expression of OSF-2 gene and methods for studying changes in gene expression or protein production or the functions of various genes or proteins with the progress of the pathology of heart failure using them and novel therapeutic agents for heart failure.

    摘要翻译： 本发明提供了筛选抑制OSF-2基因表达的药物的方法或由其编码的蛋白质的产生或功能以及具有这种作用的心力衰竭治疗剂。 可以通过监测所述基因的表达或变异或由其编码的蛋白质的产生来提供用于诊断心力衰竭的有用方法。 本发明还提供了强力表达OSF-2基因的转基因动物以及用于研究基因表达或蛋白质生产的变化的方法，或者使用它们的心力衰竭病理进展的各种基因或蛋白质的功能和新的治疗剂 心脏衰竭。

    Gene Therapy for Skin Disorders Using Needleless Syringes
    7.
    发明申请
    Gene Therapy for Skin Disorders Using Needleless Syringes 审中-公开
    使用无针注射器进行皮肤疾病的基因治疗

    公开(公告)号：US20070293447A1

    公开(公告)日：2007-12-20

    申请号：US10570052

    申请日：2004-08-27

    申请人： Yasuo Kunugiza ,  Naruya Tomita ,  Hideki Yoshikawa ,  Yoshiaki Taniyama ,  Katsuto Tamai ,  Ryuichi Morishita

    发明人： Yasuo Kunugiza ,  Naruya Tomita ,  Hideki Yoshikawa ,  Yoshiaki Taniyama ,  Katsuto Tamai ,  Ryuichi Morishita

    IPC分类号： A61K31/70 ,  A61P17/02

    CPC分类号： A61K9/0024 ,  A61K31/7088 ,  A61K48/0075

    摘要： The present invention provides highly useful clinical methods for treating skin disorders, particularly intractable skin disorders. Specifically, the methods comprise injecting/subcutaneously introducing a 10 μg to 10 mg dose of a polynucleotide, such as a DNA, oligonucleotide, RNA, siRNA, and antisense, around a lesion associated with a skin disorder, such as a wound, cutaneous ulcer, or psoriasis, using a needleless syringe that injects a pharmaceutical liquid by using gas pressure or the elastic force of an elastic member to drive a piston.

    摘要翻译： 本发明提供用于治疗皮肤病症，特别是顽固性皮肤病症的非常有用的临床方法。 具体地说，所述方法包括将注射/皮下注射10μg至10mg剂量的多核苷酸，例如DNA，寡核苷酸，RNA，siRNA和反义，在与皮肤病症如伤口，皮肤溃疡相关的病变周围 或牛皮癣，使用无针注射器，其通过使用气体压力或弹性构件的弹力来驱动活塞而喷射药液。

    Method and Apparatus for Ultrasonic Drug Delivery and Medical Diagnostic Imaging Apparatus
    8.
    发明申请
    Method and Apparatus for Ultrasonic Drug Delivery and Medical Diagnostic Imaging Apparatus 审中-公开
    超声波药物输送和医学诊断成像仪的方法和装置

    公开(公告)号：US20090069678A1

    公开(公告)日：2009-03-12

    申请号：US12087407

    申请日：2007-01-05

    申请人： Yoshiaki Taniyama ,  Ryuichi Morishita ,  Takashi Miyake ,  Katsuhiko Fujimoto

    发明人： Yoshiaki Taniyama ,  Ryuichi Morishita ,  Takashi Miyake ,  Katsuhiko Fujimoto

    IPC分类号： A61N7/00 ,  A61B8/00

    CPC分类号： A61M37/0092 ,  A61B5/413 ,  A61B5/4839 ,  A61B6/508 ,  A61B8/00

    摘要： According to the present invention, there are provided an ultrasonic drug delivery method and an ultrasonic drug delivery apparatus each capable of performing more localized and efficient drug-delivery with the aid of ultrasonic irradiation under static pressure, which increases the effect of drug delivery to deep tissue parts in treatment by ultrasonic irradiation to a living body for delivery of drugs such as nucleic acids (such as DNA, RNA, decoys, and RNAi), proteins and pharmaceutical compounds, and there is also provided a medical diagnostic imaging apparatus.

    摘要翻译： 根据本发明，提供了一种超声药物输送方法和超声药物输送装置，其能够在静压下借助超声波照射进行更局部有效的药物输送，这增加了药物输送到深度的作用 通过超声波照射到用于输送诸如核酸（例如DNA，RNA，诱饵和RNAi）的药物的生物体的组织部件，蛋白质和药物化合物，并且还提供了医疗诊断成像装置。

    Needleless syringe having medical agent accomodated therein
    9.
    发明申请
    Needleless syringe having medical agent accomodated therein 审中-公开
    无针注射器，其中含有药剂

    公开(公告)号：US20070066935A1

    公开(公告)日：2007-03-22

    申请号：US10555925

    申请日：2004-04-30

    申请人： Ryuichi Morishita ,  Naruya Tomita ,  Yasuo Kunugiza ,  Yoshiaki Taniyama ,  Hiromi Koike ,  Haruhide Udagawa ,  Tatsuo Kimura

    发明人： Ryuichi Morishita ,  Naruya Tomita ,  Yasuo Kunugiza ,  Yoshiaki Taniyama ,  Hiromi Koike ,  Haruhide Udagawa ,  Tatsuo Kimura

    IPC分类号： A61M5/30

    CPC分类号： A61M5/30 ,  A61K38/1833 ,  A61K48/00

    摘要： The present invention provides a needleless syringe having, accommodated therein, a pharmaceutical preparation containing genes and/or analogues thereof. A needleless syringe comprising: a medical agent chamber 22 having one or multiple nozzle bore(s) 25 and accommodated with a medical agent L, and a syringe main body 12 being provided with pressure application means 32 to apply pressure on the medical agent L toward a direction of the nozzle bore(s) 25 and effect emission of the medical agent L through the nozzle bore(s) 25, wherein the medical agent L is a pharmaceutical preparation containing genes and/or analogues thereof. Examples of the medical agent L include pharmaceutical preparation containing HGF gene and pharmaceutical preparation containing NF-κB decoy oligonucleotide.

    摘要翻译： 本发明提供一种无针注射器，其中容纳有含有其基因和/或类似物的药物制剂。 一种无针注射器，包括：药剂腔室22，其具有一个或多个喷嘴孔25并且容纳有药剂L;以及注射器主体12，其设有施加压力的压力施加装置32，以对药剂L施加压力 喷嘴孔25的方向并且通过喷嘴孔25发射药剂L，其中药剂L是含有其基因和/或类似物的药物制剂。 药剂L的实例包括含有HGF基因的药物制剂和含有NF-κB诱饵寡核苷酸的药物制剂。