公开(公告)号：US06896873B2

公开(公告)日：2005-05-24

申请号：US10096368

申请日：2002-03-12

Applicant: Richard Frayne ,  Charles M. Strother ,  Orhan Unal ,  Zhihao Yang ,  Abukar Wehelie ,  Hyuk Yu

Inventor： Richard Frayne ,  Charles M. Strother ,  Orhan Unal ,  Zhihao Yang ,  Abukar Wehelie ,  Hyuk Yu

IPC: A61B5/055 ,  A61K49/08 ,  A61L29/18 ,  A61L31/18

CPC classification number: A61K49/12 ,  A61K49/085 ,  A61K49/18 ,  A61L29/18 ,  A61L31/18

Abstract: The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer complex that facilitates diagnostic and therapeutic techniques by readily visualizing medical devices coated with the complex.

Abstract translation: 本发明提供了发射磁共振信号的涂层和用于涂覆医疗装置的方法。 该涂层包括含顺磁金属离子的聚合物复合物，其通过容易地观察涂覆有复合物的医疗装置来促进诊断和治疗技术。

公开(公告)号：US06797393B2

公开(公告)日：2004-09-28

申请号：US10020747

申请日：2001-11-30

Applicant: Tiecheng A. Qiao ,  Krishnan Chari ,  Thomas L. Penner ,  Zhihao Yang

Inventor： Tiecheng A. Qiao ,  Krishnan Chari ,  Thomas L. Penner ,  Zhihao Yang

IPC: B32B902

CPC classification number: B82Y30/00 ,  B01J2219/00274 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00725 ,  C40B40/10 ,  G01N33/54353 ,  Y10T428/31504 ,  Y10T428/31768

Abstract: A gelatin-based substrate for fabricating protein arrays, the substrate containing: gelatin and a trifunctional compound A—L—B; wherein A is a functional group capable of interacting with the gelatin; L is a linking group capable of interacting with A and with B; and B is a functional group capable of interacting with a protein capture agent. A may be the same or different from B.

Abstract translation: 用于制造蛋白质阵列的明胶基底物，所述基质含有：明胶和三官能化合物A-L-B; 其中A是能够与明胶相互作用的官能团; L是能够与A和B相互作用的连接基团; 并且B是能够与蛋白质捕获剂相互作用的官能团。 A可能与B相同或不同。

公开(公告)号：US06568799B1

公开(公告)日：2003-05-27

申请号：US10055295

申请日：2002-01-23

Applicant: Zhihao Yang ,  Ravi Sharma ,  Christopher N. Delametter ,  Milton S. Sales

Inventor： Zhihao Yang ,  Ravi Sharma ,  Christopher N. Delametter ,  Milton S. Sales

IPC: B41J275

CPC classification number: B41J2/14 ,  B41J2202/12

Abstract: A drop on demand microfluidic ink jet printing system includes an ink flow chamber having a nozzle opening in a wall of the flow chamber through which ink droplets are ejected when ink in the flow chamber is at or above a predetermined positive pressure. An inlet channel opens into the flow chamber to supply thermally-responsive ink to the flow chamber at or above the predetermined pressure. A microfluidic outlet channel communicates the flow chamber with a low pressure ink reservoir such that thermally-responsive ink is normally transported from the flow chamber at a flow velocity sufficient to maintain ink in the flow chamber at a pressure less than the predetermined positive pressure. A valve selectively restricts the flow of the thermally-responsive ink through the microfluidic outlet channel sufficiently to cause an increase in ink pressure in the flow chamber to at least the predetermined positive pressure, the valve including a heater in contact with at least a portion of the associated microfluidic outlet channel, whereby the viscosity of the thermally-responsive ink can selectively be increased by heat from the heater to restrict the flow of the thermally-responsive ink from the flow chamber such that an ink droplet is ejected through the nozzle opening.

Abstract translation: 按需微型喷墨打印系统包括墨水流动室，其具有在流动室的壁中的喷嘴开口，当流动室中的墨水处于或高于预定的正压时，通过该喷嘴开口喷射墨滴。 入口通道通向流动室，以在预定压力或高于预定压力的情况下向流动室供应热响应性油墨。 微流出口通道将流动室与低压储墨器连通，使得热响应性油墨通常以足以将流动室中的墨维持在小于预定正压力的压力的流速从流动室输送。 阀选择性地限制热响应性油墨通过微流体出口通道的流动，足以使流动室中的油墨压力增加到至少预定的正压，该阀包括与至少一部分 相关联的微流体出口通道，由此热响应性油墨的粘度可以通过来自加热器的热量而选择性地增加，以限制来自流动室的热响应性油墨的流动，使得墨滴通过喷嘴开口喷射。

公开(公告)号：US20070077349A1

公开(公告)日：2007-04-05

申请号：US11241370

申请日：2005-09-30

Applicant: David Newman ,  Timothy Tredwell ,  Ronald Cok ,  Zhihao Yang

Inventor： David Newman ,  Timothy Tredwell ,  Ronald Cok ,  Zhihao Yang

IPC: B05D5/12 ,  B29C71/02

CPC classification number: H01L51/5228 ,  B82Y20/00 ,  B82Y30/00 ,  H01L27/3213 ,  H01L27/322 ,  H01L27/3244 ,  H01L51/5212 ,  H01L51/5234 ,  H01L51/5268 ,  H01L51/5275 ,  H01L51/5284 ,  H01L2251/5315 ,  H01L2251/5369

Abstract: A method of making an OLED display having a plurality of OLED devices includes providing a plurality of OLED devices on a substrate, such OLED devices sharing a common light-transmissive electrode; forming a patterned conductive layer structure over the common light-transmissive electrode to define wells in alignment with emissive areas of one or more OLED devices; and providing optical material into one or more wells

Abstract translation: 制造具有多个OLED器件的OLED显示器的方法包括在衬底上提供多个OLED器件，所述OLED器件共享公共透光电极; 在所述公共透光电极上形成图案化导电层结构，以限定与一个或多个OLED器件的发射区域对齐的阱; 并将光学材料提供到一个或多个孔中

公开(公告)号：US06815078B2

公开(公告)日：2004-11-09

申请号：US10091644

申请日：2002-03-06

Applicant: Tiecheng A. Qiao ,  Jeffrey W. Leon ,  Thomas L. Penner ,  Zhihao Yang

Inventor： Tiecheng A. Qiao ,  Jeffrey W. Leon ,  Thomas L. Penner ,  Zhihao Yang

IPC: B32B904

CPC classification number: C07K1/042 ,  C07B2200/11 ,  C07K1/047 ,  C40B40/00 ,  Y10S435/96 ,  Y10S436/809 ,  Y10T428/31768

Abstract: A gelatin-based substrate for fabricating protein arrays, the substrate comprising: gelatin having at least one surface; a polymer scaffold affixed to the gelatin surface; wherein the polymer in the scaffold is rich in reactive units capable of immobilizing proteins.

Abstract translation: 一种用于制造蛋白质阵列的基于明胶的底物，所述底物包括：具有至少一个表面的明胶;固定到所述明胶表面的聚合物支架;其中所述支架中的聚合物富含能够固定蛋白质的反应单元。

公开(公告)号：US06638693B2

公开(公告)日：2003-10-28

申请号：US10046024

申请日：2001-10-29

Applicant: Constantine N. Anagnostopoulos ,  Emmanuel K. Dokyi ,  Ravi Sharma ,  Mridula Nair ,  Zhihao Yang

Inventor： Constantine N. Anagnostopoulos ,  Emmanuel K. Dokyi ,  Ravi Sharma ,  Mridula Nair ,  Zhihao Yang

IPC: G03C500

CPC classification number: B41M5/52 ,  B32B27/10 ,  B41M5/506 ,  B41M5/5227 ,  B41M5/5254 ,  B41M5/5272 ,  B41M5/5281 ,  Y10T428/24802

Abstract: Disclosed is media for receiving jetted ink comprising a support bearing a predetermined array of three dimensional cells composed of hydrophobic walls and having a hydrophilic base, the cross-section of the cells parallel to the support being of a size sufficiently small so as to increase the range of color density gradations attainable.

Abstract translation: 公开了一种用于接收喷射墨的介质，其包括支撑由疏水壁组成并具有亲水基底的预定阵列的三维单元的支撑体，平行于支撑件的单元的横截面尺寸足够小以增加 颜色浓度范围可达到。

公开(公告)号：US06364456B1

公开(公告)日：2002-04-02

申请号：US09470809

申请日：1999-12-22

Applicant: Zhihao Yang ,  Ravi Sharma ,  Thomas L. Penner

Inventor： Zhihao Yang ,  Ravi Sharma ,  Thomas L. Penner

IPC: B41J241

CPC classification number: B82Y30/00 ,  B41J2/1433 ,  B41J2/16552

Abstract: A nozzle plate for an ink jet printhead, the nozzle plate having the following layers in the order recited: a) a first monomolecular layer of an organic material having first and second functional groups, the first functional group of the first monomolecular layer being bound to the surface of the nozzle plate, and the second functional group of the first monomolecular layer being bound to a second monomolecular layer, and b) the second monomolecular layer of an organic material having first and second functional groups, the first functional group of the second monomolecular layer being bound to the second functional group of the first monomolecular layer, and the second functional group of the second monomolecular layer is an anti-wetting group.

Abstract translation: 一种用于喷墨打印头的喷嘴板，喷嘴板具有以下顺序的层：a）具有第一和第二官能团的有机材料的第一单分子层，第一单分子层的第一官能团与 喷嘴板的表面和第一单分子层的第二官能团与第二单分子层结合，以及b）具有第一和第二官能团的有机材料的第二单分子层，第二官能团的第二官能团 单分子层与第一单分子层的第二官能团结合，第二单分子层的第二官能团为抗潮湿基团。

公开(公告)号：US06361759B1

公开(公告)日：2002-03-26

申请号：US09105033

申请日：1998-06-25

Applicant: Richard Frayne ,  Charles M. Strother ,  Orhan Unal ,  Zhihao Yang ,  Abukar Wehelie ,  Hyuk Yu

Inventor： Richard Frayne ,  Charles M. Strother ,  Orhan Unal ,  Zhihao Yang ,  Abukar Wehelie ,  Hyuk Yu

IPC: A61B5055

CPC classification number: A61K49/12 ,  A61K49/085 ,  A61K49/18 ,  A61L29/18 ,  A61L31/18

Abstract: The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer complex that facilitates diagnostic and therapeutic techniques by readily visualizing medical devices coated with the complex.

公开(公告)号：US20210290828A1

公开(公告)日：2021-09-23

申请号：US12298287

申请日：2007-05-08

Applicant: Zhihao Yang ,  Richard Cornelius ,  Paige Hastings ,  Bodo Quint ,  Gerd Seibold ,  Ib Erling Joergensen ,  Stevan Nielsen

Inventor： Zhihao Yang ,  Richard Cornelius ,  Paige Hastings ,  Bodo Quint ,  Gerd Seibold ,  Ib Erling Joergensen ,  Stevan Nielsen

IPC: A61L31/10 ,  A61L27/30 ,  A61L31/08 ,  A61L31/14 ,  A61L27/54 ,  A61L27/44 ,  A61L27/58

Abstract: The present invention generally relates to the use of small particles, such as micro particles or nanoparticles, to produce a therapeutic scar such as “trans-mural” scarring or other desired “deep tissue” scarring. In one preferred embodiment, these particles can be delivered to a target location by an implant. More specifically, these particles can be incorporated into the structure of implants or into the coatings on implants. In another preferred embodiment, these small particles can be delivered directly with a catheter by electrophoresis or hydraulic pressure.

公开(公告)号：US06622746B2

公开(公告)日：2003-09-23

申请号：US10021457

申请日：2001-12-12

Applicant: Zhihao Yang ,  Gilbert A. Hawkins

Inventor： Zhihao Yang ,  Gilbert A. Hawkins

IPC: F15C104

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K99/0036 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084 ,  Y10T137/0335 ,  Y10T137/2082 ,  Y10T137/2196 ,  Y10T137/6606 ,  Y10T137/7736

Abstract: A microfluidic system is provided for controlling delivery and mixing of thermally-responsive fluids. A plurality of microfluidic inlet channels open into a mixing chamber. A valve is associated with each of the inlet channels for controlling the flow of the thermally-responsive fluids through the inlet channels. The valves include a heater in thermal contact with at least a portion of the associated inlet channel, whereby the viscosity of the thermally-responsive fluids can selectively be controlled by heat to cause a change in flow of the thermally-responsive fluids through the inlet channels. A plurality of microfluidic outlet channels may be provided for transporting mixed fluids from the mixing chamber. A valve associated with each of the outlet channels controls the flow of the mixed thermally-responsive fluids through the outlet channels. These valves also include a heater in contact with at least a portion of the associated outlet channel, whereby said mixed thermally-responsive fluids can be directed from the mixing chamber selectively through each outlet channel.

Abstract translation: 提供微流体系统用于控制热响应流体的输送和混合。 多个微流体入口通道进入混合室。 阀与每个入口通道相关联，用于控制通过入口通道的热响应流体的流动。 阀包括与相关入口通道的至少一部分热接触的加热器，由此热响应流体的粘度可以选择性地通过加热来控制，以引起热响应流体通过入口通道的流动变化 。 可以提供多个微流体出口通道用于从混合室输送混合流体。 与每个出口通道相关联的阀控制混合的热响应流体通过出口通道的流动。 这些阀还包括与相关联的出口通道的至少一部分接触的加热器，由此所述混合的热响应流体可以选择性地通过每个出口通道从混合室引导。