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公开(公告)号：US20080275343A1
公开(公告)日：2008-11-06
申请号：US12218054
申请日：2008-07-11
Applicant: Andrew Kenneth Hoffmann
Inventor： Andrew Kenneth Hoffmann
CPC classification number: A61B8/08 , A61B8/0883 , A61B8/0891 , A61B8/4455 , A61B8/483 , A61N7/00
Abstract: The present invention relates to a new non-invasive method for inducing angiogenesis and more particularly coronary angiogenesis wherein an operator applies localized percussion upon the upper torso proximate an ischemic myocardial region, whereby the percussive forces penetrate to cause sheer stresses to the endothelium of the coronaries which lie thereupon, and thereby cause new coronary growth by virtue of endogenous liberation of beneficial angiogenic mediators. A pair of vibratory contacts are advantageously applied to rib-spaces to either side of the sternum (or alternatively to the upper back), where-after percussion is applied at the resonance frequency of the heart/epimyocardium at a displacement amplitude of 0.1 mm-15 mm (preferably greater than 1 mm), such as to maximize an internal oscillatory effect. The system is also adaptable for cerebral and peripheral vasculature applications. Ultrasonic imaging may optionally be utilized to direct percussive therapy.
Abstract translation: 本发明涉及用于诱导血管发生的新的非侵入性方法，更具体地说是冠状动脉血管发生，其中操作者将局部敲击对临近缺血心肌区域的上部躯体施加，由此冲击力穿透以对冠状动脉内皮产生纯粹的应力 因此，由于有益血管生成介质的内源性释放，从而引起新的冠状动脉增长。 一对振动触点有利地应用于胸骨（或可选地到上背）的任一侧上的肋空间，其中以心脏/外膜心肌的共振频率以0.1mm- 15mm（优选大于1mm），以使内部振荡效应最大化。 该系统还适用于脑和外周血管系统应用。 可以可选地使用超声成像来引导冲击疗法。
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2.发明申请Non-invasive reperfusion system by deformation of remote, superficial arteries at a frequency much greater than the pulse rate 审中-公开非侵入性再灌注系统通过远端，浅表动脉变形的频率远大于脉率公开(公告)号：US20130281897A1
公开(公告)日：2013-10-24
申请号：US13986252
申请日：2013-04-17
Applicant: Andrew Kenneth Hoffmann , Harjit Kaur Gill-Hoffmann
Inventor： Andrew Kenneth Hoffmann , Harjit Kaur Gill-Hoffmann
IPC: A61H23/00
CPC classification number: A61M37/0092 , A61B8/08 , A61B8/0816 , A61B8/0883 , A61B8/4455 , A61B8/483 , A61B17/22004 , A61B2017/22001 , A61H19/32 , A61H19/34 , A61H19/50 , A61H23/00 , A61H23/0236 , A61H23/0263 , A61H2201/0103 , A61H2201/123 , A61H2201/1418 , A61H2201/1619 , A61H2201/1635 , A61H2201/165 , A61H2201/1664 , A61H2201/5038 , A61H2201/5048 , A61H2201/5084 , A61H2205/06 , A61H2205/084 , A61H2205/087 , A61H2230/255 , A61H2230/505 , A61N7/00
Abstract: Preferred systems for assisting clearance of an acutely thrombosed artery substantially surrounded by boney external body surfaces which are resistant to deformative displacement relative to the thrombosed artery by the application of external percussive force are described. The method consists of applying targeted, localized, non-invasive, high infrasonic to low sonic frequency vibratory percussion with a serial impact frequency much greater than the pulse rate of a patient being treated, the percussion directed towards a remote, preferably superficial “target vessel” residing palpably close to the skin surface. Marked vessel deformations with resultant blood pressure and flow fluctuations are thereby induced by the percussion within the target vessel which propagate to the acutely thrombosed artery to provide localized agitation and turbulence to assist thrombolytic and/or IV microbubble delivery and effectiveness in facilitating reperfusion. Preferred apparatus for treatment of ST elevation myocardial infarction, acute ischemic stroke and acute pulmonary embolus are presented.
Abstract translation: 描述了通过施加外部冲击力来帮助抵抗相对于血栓形成的动脉变形位移的体外外表面的基本上包围的急性血栓形成的动脉的优选系统。 该方法包括将目标，局部，非侵入性，高次声波应用于低声波振动敲击，其串联冲击频率远大于被治疗患者的脉搏频率，打击指向远程的，优选表面的“靶血管 “居然可以接近皮肤表面。 因此，通过靶向血管中的冲击引起标记的血管变形，其传播到急性血栓形成的动脉以提供局部的搅动和湍流以辅助溶栓和/或IV微泡输送和促进再灌注的有效性。 提出了治疗ST段抬高型心肌梗死，急性缺血性中风和急性肺栓塞的优选装置。
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3.发明申请公开(公告)号：US20100222723A1
公开(公告)日：2010-09-02
申请号：US12798437
申请日：2010-04-05
Applicant: Andrew Kenneth Hoffmann
Inventor： Andrew Kenneth Hoffmann
IPC: A61H23/00
CPC classification number: A61B8/08 , A61B8/0883 , A61B8/4455 , A61B8/483 , A61B17/22004 , A61N7/00
Abstract: An emergency method of using localized mechanical percussion for enhancing clearance of potentially life threatening acute thrombotic arterial obstructions blocking blood flow to vital internal organs such as the heart or brain of a patient, comprising the step of applying non-invasive localized low frequency mechanical percussion at a frequency between 1 Hz-1000 Hz and a stroke or displacement amplitude in the range of 0.1-10 mm upon a targeted external body surface deemed generally proximate such acute thrombotic arterial obstruction, whereby said percussion accelerates the emergency clearance of the acute thrombotic arterial obstruction in restoration of blood flow to the vital internal organ. Preferred methods for percussion delivery to the chest wall/upper back or head/neck of a patient are described for use in treatment of heart attack or acute ischemic stroke respectively.
Abstract translation: 使用局部机械打击器来增强清除可能危及生命的急性血栓形成动脉障碍物的紧急方法，其阻止血液流向患者的心脏或脑部的重要内部器官，包括以下步骤：将非侵入性局部低频机械敲击应用于 频率在1Hz-1000Hz之间，并且在目标外部身体表面上的0.1-10mm范围内的行程或位移振幅通常被认为接近于这种急性血栓形成动脉阻塞，由此所述敲击加速急性血栓动脉阻塞的紧急清除 恢复血液流向重要的内脏器官。 描述了用于打击输送到患者的胸壁/上背部或头/颈部的优选方法用于治疗心脏病发作或急性缺血性中风。
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公开(公告)号：US20090270773A1
公开(公告)日：2009-10-29
申请号：US12378321
申请日：2009-02-17
Applicant: Andrew Kenneth Hoffmann
Inventor： Andrew Kenneth Hoffmann
IPC: A61H1/00
CPC classification number: A61H23/02 , A61H7/005 , A61H31/006 , A61H2201/1647
Abstract: A vibratory attachment interface enabling transmission of oscillations generated by an oscillation source upon an external human body surface. The interface comprises a first contact node and a second contact node slideably mounted alongside the first contact node, wherein the contact nodes are each sized and shaped to enable seating within a human rib-space, and whereby upon forced engagement of the first contact node within a first rib-space, the second contact node automatically slides and conforms to the contour of a second differing rib-space thereby optimally nestling within the second rib-space. The attachment interface is for use in contoured application to preferably the anatomic left sternal border, third and fourth intercostal space, such as to enable and ensure an optimized vibratory transmission pathway from the chest wall to the base of the heart and coronary arteries thereupon.
Abstract translation: 振动附接界面，其能够将振荡源产生的振荡传递到外部人体表面。 接口包括第一接触节点和可滑动地安装在第一接触节点旁边的第二接触节点，其中接触节点各自的尺寸和形状被设计成使得能够在人体肋空间内就位，并且由此在第一接触节点被强制接合时 第一肋状空间，第二接触节点自动滑动并符合第二不同肋间空间的轮廓，从而最佳地嵌套在第二肋空间内。 附件接口用于轮廓应用以优选解剖左胸骨边缘，第三和第四肋间隙，以便能够并确保从胸壁到心脏的基部和冠状动脉的优化的振动传递路径。
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Patent Agency Ranking
公开(公告)号：US07517328B2
公开(公告)日：2009-04-14
申请号：US10902122
申请日：2004-07-30
Applicant: Andrew Kenneth Hoffmann
Inventor： Andrew Kenneth Hoffmann
IPC: A61H1/00
CPC classification number: A61H31/005 , A61B17/225 , A61H1/00 , A61H31/00 , A61H31/006 , A61H2023/0209 , A61H2201/5043 , A61H2201/5061
Abstract: An emergency system for treatment of a patient (20) experiencing an acute vascular obstruction, employing a non-invasive vibrator (10), optimally in conjunction with drugs, for disrupting and lysing thromboses, relieving spasm (if associated), and thereby restoring blood perfusion. Vibrator (10) is operable in the sonic to infrasonic range, with a source output of up to 15 mm. For acute myocardial infarction cases, a pair of contacts (12), are advantageously placed to bridge the sternum at the fourth intercostal space. Vibration is initiated at 50 Hz (or any frequency, preferably within the 20-120 Hz range), and is ideally adjusted to a maximal amplitude (or force) deemed tolerable and safe to the patient (20), preferably with the administration of thrombolytic agents or other form of drug therapy. A synergistic effect is achieved between vibration and drugs to facilitate the disruption of thromboses, relieve spasm, and restore blood perfusion. In a variation, ultrasonic imaging may be used to direct vibration therapy.
Abstract translation: 用于治疗经历急性血管阻塞的患者（20）的紧急系统，使用非侵入式振动器（10），最佳地与药物结合，用于破坏和溶解血栓形成，缓解痉挛（如果相关联），从而恢复血液 灌注。 振动器（10）可在声速到声速范围内操作，源输出高达15 mm。 对于急性心肌梗死病例，有利地放置一对触点（12）以在第四肋间隙处桥接胸骨。 振动以50Hz（或任何频率，优选在20-120Hz范围内）开始，并且理想地被调整为对患者（20）被认为是可容忍和安全的最大幅度（或力），优选地通过施用溶栓剂 药剂或其他形式的药物治疗。 在振动和药物之间实现协同效应，以促进血栓形成的破坏，缓解痉挛和恢复血液灌注。 在一个变型中，可以使用超声成像来引导振动治疗。
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6.发明申请公开(公告)号：US20060025683A1
公开(公告)日：2006-02-02
申请号：US11036386
申请日：2005-01-18
Applicant: Andrew Hoffmann
Inventor： Andrew Hoffmann
IPC: A61B8/12
CPC classification number: A61B8/08 , A61B8/0883 , A61B8/0891 , A61B8/4455 , A61B8/483 , A61N7/00
Abstract: A non-invasive hand-held treatment imaging probe for treatment of acute blood flow disturbances and states of low blood perfusion. The treatment imaging probe is operable to emit high intensity therapeutic mechanical acoustic waves while under ultrasonic imaging guidance. The probe has a substantially rigid application surface, sized to enable seating within a rib space of a patient (i.e. for cardiac applications), comprising the combination of an engagement face of an ultrasonic imaging transducer and an application end of a high powered therapeutic actuator operable in about the 1-500 kHz (and preferably 1-150 kHz) range. Treatment imaging probe can be used as an adjunct to thrombolytic therapy in the treatment of acute thrombotic vascular obstructions, such as in acute myocardial infarction, or alternatively to enhance localized delivery of angiogenic agents or other useful medications to targeted vascular regions.
Abstract translation: 一种用于治疗急性血流紊乱和低血液灌注状态的非侵入式手持治疗成像探针。 治疗成像探针可操作以在超声成像引导下发射高强度治疗机械声波。 该探针具有基本上刚性的施加表面，其大小使得能够在患者的肋部空间（即，用于心脏应用）中安置，包括超声波成像换能器的接合面和高功率治疗致动器的施加端的组合，其可操作 在约1-500kHz（优选地1-150kHz）范围内。 治疗成像探针可用作治疗急性血栓形成血管阻塞物（例如急性心肌梗塞）中血栓溶解治疗的辅助剂，或者用于增强血管生成剂或其它有用的药物到靶向血管区域的局部递送。
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7.发明授权公开(公告)号：US08870796B2
公开(公告)日：2014-10-28
申请号：US12798437
申请日：2010-04-05
Applicant: Andrew Kenneth Hoffmann
Inventor： Andrew Kenneth Hoffmann
CPC classification number: A61B8/08 , A61B8/0883 , A61B8/4455 , A61B8/483 , A61B17/22004 , A61N7/00
Abstract: An emergency method of using localized mechanical percussion for enhancing clearance of potentially life threatening acute thrombotic arterial obstructions blocking blood flow to vital internal organs such as the heart or brain of a patient, employing the application of non-invasive localized low frequency mechanical percussion at a frequency between 1 Hz-1000 Hz and a stroke or displacement amplitude in the range of 0.1-10 mm upon a targeted external body surface deemed generally proximate such acute thrombotic arterial obstruction, whereby the percussion accelerates the emergency clearance of the acute thrombotic arterial obstruction in restoration of blood flow to the vital internal organ. Preferred methods for percussion delivery to the chest wall/upper back or head/neck of a patient are described for use in treatment of heart attack or acute ischemic stroke respectively.
Abstract translation: 使用局部机械打击器的紧急方法，用于增强潜在危及生命的急性血栓形成动脉障碍物的清除，阻止血液流向患者心脏或脑部的重要内部器官，采用非侵入式局部低频机械打击 频率在1Hz-1000Hz之间，并且在目标外部身体表面上的0.1-10mm范围内的行程或位移振幅通常被认为是接近这种急性血栓动脉阻塞，由此敲击加速急性血栓动脉阻塞的紧急清除 恢复血液流向重要的内脏器官。 描述了用于打击输送到患者的胸壁/上背部或头/颈部的优选方法用于治疗心脏病发作或急性缺血性中风。
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8.发明授权Vibrator with a plurality of contact nodes for treatment of myocardial ischemia 有权振动器具有多个接触节点用于治疗心肌缺血公开(公告)号：US08079968B2
公开(公告)日：2011-12-20
申请号：US12154508
申请日：2008-05-23
Applicant: Andrew Kenneth Hoffmann
Inventor： Andrew Kenneth Hoffmann
IPC: A61H1/00
CPC classification number: A61H31/005 , A61B17/225 , A61H1/00 , A61H31/00 , A61H31/006 , A61H2023/0209 , A61H2201/5043 , A61H2201/5061
Abstract: A vibrator for use in enhancement of pre-hospital coronary thrombolysis comprising a vibration source operable to generate vibration at a frequency in the range of 1-1000 Hz with at least a pair of oscillatory contacts spaced to enable simultaneous seating to the anatomic left and right of the sternum (such as to match the geometry of the right and left coronary arteries) of a patient in need of coronary thrombolysis. The preferred vibrator is operable to emit vibration in the low frequency sonic range (at least 20 Hz) with an amplitude of about 1 mm-15 mm (and more preferably greater than 2 mm), such as to provide an effective transthoracic tool for acute coronary thrombolysis applications. In a variation, greater than a pair of contacts are utilized to provide oscillatory contact at differing intercostal space levels (in order to maximize vibratory penetration to the heart which is variably situated depending on the patient's anatomy).
Abstract translation: 用于增强住院前冠状动脉溶栓治疗的振动器，包括振动源，其可操作以产生在1-1000Hz范围内的频率的振动，并且至少一对振荡接触件间隔开，使得能够同时对解剖左和右 的胸骨（例如匹配右冠状动脉和左冠状动脉的几何形状）需要冠状动脉溶栓治疗的患者。 优选的振动器可操作以在具有约1mm-15mm（更优选大于2mm）的振幅的低频声波范围（至少20Hz）中发射振动，以提供用于急性的有效的经胸手术 冠状动脉溶栓治疗应用。 在一个变型中，大于一对触点用于在不同的肋间空间水平提供振荡接触（以便使根据患者的解剖结构可变地位于心脏的振动穿透最大化）。
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9.发明申请Vibrator with a plurality of contact nodes for treatment of myocardial ischemia 有权振动器具有多个接触节点用于治疗心肌缺血公开(公告)号：US20080275371A1
公开(公告)日：2008-11-06
申请号：US12154508
申请日：2008-05-23
Applicant: Andrew Kenneth Hoffmann
Inventor： Andrew Kenneth Hoffmann
IPC: A61N7/00
CPC classification number: A61H31/005 , A61B17/225 , A61H1/00 , A61H31/00 , A61H31/006 , A61H2023/0209 , A61H2201/5043 , A61H2201/5061
Abstract: A vibrator for use in enhancement of pre-hospital coronary thrombolysis comprising a vibration source operable to generate vibration at a frequency in the range of 1-1000 Hz with at least a pair of oscillatory contacts spaced to enable simultaneous seating to the anatomic left and right of the sternum (such as to match the geometry of the right and left coronary arteries) of a patient in need of coronary thrombolysis. The preferred vibrator is operable to emit vibration in the low frequency sonic range (at least 20 Hz) with an amplitude of about 1 mm-15 mm (and more preferably greater than 2 mm), such as to provide an effective transthoracic tool for acute coronary thrombolysis applications. In a variation, greater than a pair of contacts are utilized to provide oscillatory contact at differing intercostal space levels (in order to maximize vibratory penetration to the heart which is variably situated depending on the patient's anatomy).
Abstract translation: 用于增强住院前冠状动脉溶栓治疗的振动器，包括振动源，其可操作以产生在1-1000Hz范围内的频率的振动，并且至少一对振荡接触件间隔开，使得能够同时对解剖左和右 的胸骨（例如匹配右冠状动脉和左冠状动脉的几何形状）需要冠状动脉溶栓治疗的患者。 优选的振动器可操作以在具有约1mm-15mm（更优选大于2mm）的振幅的低频声波范围（至少20Hz）中发射振动，以提供用于急性的有效的经胸手术 冠状动脉溶栓治疗应用。 在一个变型中，大于一对触点用于在不同的肋间空间水平提供振荡接触（以便使根据患者的解剖结构可变地位于心脏的振动穿透最大化）。
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