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公开(公告)号：US20230301960A1
公开(公告)日：2023-09-28
申请号：US18055778
申请日：2022-11-15
申请人： QBIOTICS PTY LTD
IPC分类号： A61K31/336 , A01N43/20 , A01N43/90 , A01N45/00 , C07D301/32 , C07D303/14 , C07D303/32 , C07D493/04 , A01N53/00 , C07D303/44 , C07D303/17 , A61K9/00 , A61K9/06 , A61K47/10
CPC分类号： A61K31/336 , A01N43/20 , A01N43/90 , A01N45/00 , A01N53/00 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K47/10 , C07D301/32 , C07D303/14 , C07D303/17 , C07D303/32 , C07D303/44 , C07D493/04
摘要： The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders. The tiglien-3-one compounds are also used in methods of controlling pests in humans, animals, plants and the environment
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公开(公告)号：US10980769B2
公开(公告)日：2021-04-20
申请号：US16702296
申请日：2019-12-03
申请人： QBIOTICS PTY LTD
IPC分类号： A61K31/336 , A01N43/20 , A01N43/90 , A01N45/00 , C07D301/32 , C07D303/14 , C07D303/32 , C07D493/04 , A01N53/00 , C07D303/44 , C07D303/17 , A61K9/00 , A61K9/06 , A61K47/10
摘要： The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders. The tiglien-3-one compounds are also used in methods of controlling pests in humans, animals, plants and the environment
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公开(公告)号：US10822317B2
公开(公告)日：2020-11-03
申请号：US16197785
申请日：2018-11-21
申请人： QBiotics Limited
发明人： Paul Warren Reddell , Victoria Anne Gordon , Ryan Moseley , Robert Steadman , Rachael Louise Moses , Glen Mathew Boyle , Peter Gordon Parsons
IPC分类号： C07D303/40 , A61K31/122 , A61K31/336 , C07D303/32 , A61K8/49 , A61Q19/00 , A61K9/00 , A61K9/06 , A61K47/10 , A61P17/02 , A61K36/47
摘要： The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds and compositions for use in wound healing are also described.
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公开(公告)号：US10543188B2
公开(公告)日：2020-01-28
申请号：US16149977
申请日：2018-10-02
申请人： QBIOTICS PTY LTD
IPC分类号： A61K31/336 , A01N43/20 , A01N43/90 , A01N45/00 , C07D301/32 , C07D303/14 , C07D303/32 , C07D493/04 , A01N53/00 , C07D303/44 , C07D303/17 , A61K9/00 , A61K9/06 , A61K47/10
摘要： The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders. The tiglien-3-one compounds are also used in methods of controlling pests in humans, animals, plants and the environment.
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公开(公告)号：US11213506B2
公开(公告)日：2022-01-04
申请号：US16496333
申请日：2018-03-23
申请人： QBIOTICS PTY LTD
发明人： Paul Warren Reddell , Jason Kingsley Cullen , Glen Mathew Boyle , Peter Gordon Parsons , Victoria Anne Gordon
IPC分类号： A61K31/336 , A61K39/395 , A61K9/00 , A61P35/00
摘要： The present invention relates to a combination therapy for tumours comprising the administration of an epoxytigliane compound and an immune checkpoint inhibitor. In particular embodiments, there is a method of treating a tumour and/or treating or preventing one or more bystander tumours with the therapy. Pharmaceutical compositions and kits containing epoxytigliane compounds and immune checkpoint inhibitors are also described.
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公开(公告)号：US20210196668A1
公开(公告)日：2021-07-01
申请号：US17204747
申请日：2021-03-17
申请人： QBIOTICS PTY LTD
IPC分类号： A61K31/336 , A01N43/20 , A01N43/90 , A01N45/00 , C07D301/32 , C07D303/14 , C07D303/32 , C07D493/04 , A01N53/00 , C07D303/44 , C07D303/17 , A61K9/00 , A61K9/06 , A61K47/10
摘要： The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders. The tiglien-3-one compounds are also used in methods of controlling pests in humans, animals, plants and the environment
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公开(公告)号：US20220193023A1
公开(公告)日：2022-06-23
申请号：US17602909
申请日：2020-04-09
申请人： QBIOTICS PTY LTD
发明人： Victoria Anne GORDON , Paul Warren REDDELL , Glen Mathew BOYLE , Jason Kingsley CULLEN , Peter Gordon PARSONS
IPC分类号： A61K31/336 , A61P35/00 , A61K9/00
摘要： The present invention relates to methods of treating tumours comprising the localised administration, for example, intratumourally or topically, of an epoxytiglienone compound (as a monotherapy) to cancerous tumours to generate a systemic anticancer C abscopal (anenestic) and/or bystander effect.
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公开(公告)号：US20220313648A1
公开(公告)日：2022-10-06
申请号：US17620517
申请日：2020-06-19
申请人： QBIOTICS PTY LTD
发明人： David William THOMAS , Paul Warren REDDELL , Glen Mathew BOYLE , Jason Kingsley CULLEN , Victoria Anne GORDON , Katja Etel HILL , Lydia Charlotte POWELL , Manon F. PRITCHARD , Peter G. PARSONS
IPC分类号： A61K31/336 , A61P31/04 , A61K45/06
摘要： The present invention relates to methods of dispersing biofilms comprising Gram-negative bacteria, the methods comprising exposing the biofilm to an epoxytiglienone compound or a salt thereof. Methods of treating infections comprising the localised administration, for example, topically or by injection, of an epoxytiglienone compound into or onto an established biofilm comprising Gram-negative bacteria to disrupt the structure of that biofilm and methods of preventing biofilms comprising Gram-negative bacteria forming or dispersing biofilms comprising Gram-negative biofilms that have formed on medical devices are also described.
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