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公开(公告)号：US20140155479A1
公开(公告)日：2014-06-05
申请号：US14084949
申请日：2013-11-20
申请人： QBiotics Limited
IPC分类号： A61K31/336 , A01N53/00 , C07D303/44
CPC分类号： A61K31/336 , A01N43/20 , A01N43/90 , A01N45/00 , A01N53/00 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K47/10 , C07D301/32 , C07D303/14 , C07D303/17 , C07D303/32 , C07D303/44 , C07D493/04
摘要： The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders. The tiglien-3-one compounds are also used in methods of controlling pests in humans, animals, plants and the environment.
摘要翻译： 本发明涉及tiglien-3-one化合物及其在治疗或预防原生动物感染，细菌感染，寄生虫感染和细胞增殖性疾病的方法中的用途。 噻咯-3-酮化合物也用于控制人类，动物，植物和环境中的害虫的方法。
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公开(公告)号：US20190161462A1
公开(公告)日：2019-05-30
申请号：US16197785
申请日：2018-11-21
申请人： QBiotics Limited
发明人： Paul Warren Reddell , Victoria Anne Gordon , Ryan Moseley , Robert Steadman , Rachael Louise Moses , Glen Mathew Boyle , Peter Gordon Parsons
IPC分类号： C07D303/40 , A61Q19/00 , A61K31/122 , A61K31/336 , A61K47/10 , A61K9/00 , A61K9/06 , C07D303/32 , A61K8/49 , A61K36/47
摘要： The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds Sand compositions for use in wound healing are also described.
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公开(公告)号：US10183922B2
公开(公告)日：2019-01-22
申请号：US15425739
申请日：2017-02-06
申请人： QBiotics Limited
发明人： Paul Warren Reddell , Victoria Anne Gordon , Ryan Moseley , Robert Steadman , Rachael Louise Moses , Glen Mathew Boyle , Peter Gordon Parsons
IPC分类号： A61K31/122 , A61K31/336 , A61K47/10 , C07D303/40 , C07D303/32 , A61K36/47 , A61K8/49 , A61Q19/00 , A61K9/00 , A61K9/06
摘要： The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds and compositions for use in wound healing are also described.
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公开(公告)号：US20160068499A1
公开(公告)日：2016-03-10
申请号：US14785127
申请日：2014-04-17
申请人： QBiotics Limited
发明人： Paul Warren Reddell , Victoria Anne Gordon , Ryan Moseley , Robert Steadman , Rachael Louise Moses , Glen Mathew Boyle , Peter Gordon Parsons
IPC分类号： C07D303/40 , A61Q19/00 , A61K8/49
CPC分类号： C07D303/40 , A61K8/4973 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K31/122 , A61K31/336 , A61K36/47 , A61K47/10 , A61K2236/15 , A61K2236/33 , A61K2800/74 , A61Q19/00 , C07D303/32
摘要： The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds and compositions for use in wound healing are also described.
摘要翻译： 本发明涉及环氧 - 噻吩类化合物及其在促进伤口愈合中的用途。 在具体实施方案中，环氧 - 噻吩化合物是环氧 - 三叠氮-3-酮化合物。 描述诱导或促进伤口愈合的方法以及减少瘢痕形成和改善伤口愈合时的美容效果的方法。 还描述了用于伤口愈合的化合物和组合物。
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公开(公告)号：US10822317B2
公开(公告)日：2020-11-03
申请号：US16197785
申请日：2018-11-21
申请人： QBiotics Limited
发明人： Paul Warren Reddell , Victoria Anne Gordon , Ryan Moseley , Robert Steadman , Rachael Louise Moses , Glen Mathew Boyle , Peter Gordon Parsons
IPC分类号： C07D303/40 , A61K31/122 , A61K31/336 , C07D303/32 , A61K8/49 , A61Q19/00 , A61K9/00 , A61K9/06 , A61K47/10 , A61P17/02 , A61K36/47
摘要： The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds and compositions for use in wound healing are also described.
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公开(公告)号：US20190099397A1
公开(公告)日：2019-04-04
申请号：US16149977
申请日：2018-10-02
申请人： QBiotics Limited
IPC分类号： A61K31/336 , C07D303/17 , A61K9/00 , A01N53/00 , C07D493/04 , C07D303/32 , C07D303/14 , C07D301/32 , A01N45/00 , A01N43/90 , A01N43/20 , A61K47/10 , A61K9/06 , C07D303/44
摘要： The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders. The tiglien-3-one compounds are also used in methods of controlling pests in humans, animals, plants and the environment.
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公开(公告)号：US20170144981A1
公开(公告)日：2017-05-25
申请号：US15425739
申请日：2017-02-06
申请人： QBiotics Limited
发明人： Paul Warren Reddell , Victoria Anne Gordon , Ryan Moseley , Robert Steadman , Rachael Louise Moses , Glen Mathew Boyle , Peter Gordon Parsons
IPC分类号： C07D303/40 , A61K31/336 , A61K36/47 , A61K9/06 , A61K9/00 , A61K47/10
CPC分类号： C07D303/40 , A61K8/4973 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K31/122 , A61K31/336 , A61K36/47 , A61K47/10 , A61K2236/15 , A61K2236/33 , A61K2800/74 , A61Q19/00 , C07D303/32
摘要： The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds and compositions for use in wound healing are also described.
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公开(公告)号：US10183921B2
公开(公告)日：2019-01-22
申请号：US14785127
申请日：2014-04-17
申请人： QBiotics Limited
发明人： Paul Warren Reddell , Victoria Anne Gordon , Ryan Moseley , Robert Steadman , Rachael Louise Moses , Glen Mathew Boyle , Peter Gordon Parsons
IPC分类号： A61K31/12 , A61K31/336 , C07D303/40 , C07D303/32 , A61K31/122 , A61K36/47 , A61K8/49 , A61Q19/00 , A61K9/00 , A61K9/06 , A61K47/10
摘要： The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds and compositions for use in wound healing are also described.
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公开(公告)号：US09770431B2
公开(公告)日：2017-09-26
申请号：US15041960
申请日：2016-02-11
申请人： QBiotics Limited
IPC分类号： A61K31/352 , A61K31/336 , A01N43/20 , A01N43/90 , A01N45/00 , C07D301/32 , C07D303/14 , C07D303/32 , C07D493/04 , A01N53/00 , C07D303/44 , C07D303/17
CPC分类号： A61K31/336 , A01N43/20 , A01N43/90 , A01N45/00 , A01N53/00 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K47/10 , C07D301/32 , C07D303/14 , C07D303/17 , C07D303/32 , C07D303/44 , C07D493/04
摘要： The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections, parasitic infections and cell proliferative disorders. The tiglien-3-one compounds are also used in methods of controlling pests in humans, animals, plants and the environment.
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公开(公告)号：US20190160035A1
公开(公告)日：2019-05-30
申请号：US16320762
申请日：2017-07-28
申请人： QBIOTICS LIMITED
发明人： Peter Gordon PARSONS , Peter Frederick SCHMIDT , Charles Stewart LOWDEN , Justine Emma CAMPBELL , Victoria GORDON
IPC分类号： A61K31/336 , A61K31/495 , A61K31/44 , A61K31/4439 , A61K31/5415 , A61K31/137 , A61K31/426 , A61K31/573 , A61K9/06 , A61K9/00 , A61K47/34 , A61P35/00
摘要： The present invention relates to methods of treating mast cell tumors and soft tissue sarcomas using 6,7-epoxy-4,5,9,12,13,20-hexahydroxy-1-tigliaen-3-one derivatives in combination with at least one other pharmaceutically active agent. In particular embodiments, the tigliaen-3-one derivatives are 12, 13-acyl or ether derivatives and the derivative compound is delivered in a localised manner to the tumor or sarcoma. In particular embodiments, the at least one other pharmaceutically active agent is selected from an antihistamine, an anti-inflammatory agent and mixtures thereof.
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