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1.发明授权
公开(公告)号：US3885002A
公开(公告)日：1975-05-20
申请号：US35561473
申请日：1973-04-30
发明人： BARBER F TAYLOR
摘要： The manufacture of trialkyltrithiophosphites by reacting an excess of an alkyl mercaptan with phosphorous trihalide and scrubbing of noncondensible reactor off-gases with strong caustic solution, continuing the scrubbing until the strong caustic solution becomes spent though still mildly alkaline when the alkyl mercaptan separates into a separate phase. The mercaptans are separated to recycle. The trialkyltrithiophosphite can be oxidized to trialkyltriphosphorothioate with further stripping and recovery of remaining mercaptans.
摘要翻译： 通过使过量的烷基硫醇与三卤化磷反应并用强碱性溶液洗涤不可冷凝的反应器废气来制造三烷基三硫代亚磷酸酯，当烷基硫醇分离成单独的时，继续进行洗涤，直到强碱性溶液消耗，但仍然是弱碱性的 相。 硫醇分离回收。 三烷基三亚磷酸酯可以被氧化成三烷基三硫代磷酸酯，进一步剥离和回收剩余的硫醇。
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2.发明授权Process for the preparation and recovery of trimethyl phosphite and derivatives thereof 失效亚磷酸三甲酯及其衍生物的制备和回收方法
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公开(公告)号：US3136807A
公开(公告)日：1964-06-09
申请号：US16028461
申请日：1961-12-18
发明人： WARNER PAUL F , SLAGLE JAMES R
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公开(公告)号：US20230212200A1
公开(公告)日：2023-07-06
申请号：US18147172
申请日：2022-12-28
摘要： Disclosed herein are acyclic thiol prodrugs, and pharmaceutical compositions thereof. The prodrugs and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example cystinosis, cystinuria, cancer neurodegenerative disease, Parkinson's disease, Huntington's disease, malaria, nonalcoholic fatty liver disease, radiation poisoning, arsenic poisoning, radioprotection, Wilson's disease or rheumatoid arthritis.
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公开(公告)号：US3095439A
公开(公告)日：1963-06-25
申请号：US17079562
申请日：1962-02-02
发明人： MASON MELTON THOMAS
IPC分类号： C07F9/202
CPC分类号： C07F9/202
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公开(公告)号：US09708352B2
公开(公告)日：2017-07-18
申请号：US15108790
申请日：2015-01-01
CPC分类号： C07F9/202 , C07B2200/13 , C07F9/17
摘要： The present invention relates to a process for preparation of Echothiophate Iodide (I). Echothiophate Iodide (I) obtained by the process of the present invention is obtained as new crystalline form designated as Form-SET. The process for preparation of Echothiophate Iodide (I) according to present invention is an ecofriendly process that avoids the use of hazardous solvent systems and provides Echothiophate Iodide (I) of high purity. Pharmaceutical composition of the said crystalline Form-SET of Echothiophate Iodide (I) of high purity is useful in the treatment of ocular disorders like Glaucoma.
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公开(公告)号：US3922325A
公开(公告)日：1975-11-25
申请号：US37224173
申请日：1973-06-21
发明人： ANDERSON JOHN E
IPC分类号： C07F9/202
CPC分类号： C07F9/202
摘要： In the preparation of trialkyl trithiophosphites by the reaction of phosphorus trihalide with alkyl mercaptan, the addition of a few parts per million of water increases the reaction rate and ultimate yield of desired trialkyl trithiophosphite.
摘要翻译： 在通过三卤化磷与烷基硫醇的反应制备三烷基三硫代亚磷酸酯时，每百万分之一份水中的添加增加了所需三烷基三硫代亚磷酸酯的反应速率和最终产率。
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9.发明授权Process for the preparation of dimethyl-thiophosphite or of organothiophosphonous acid o-monomethyl ester 失效制备二甲基 - 硫代磷酸酯或有机酸性磷酸二甲酯的方法
公开(公告)号：US3655835A
公开(公告)日：1972-04-11
申请号：US3655835D
申请日：1969-05-05
申请人： BAYER AG
发明人： SCHLIEBS REINHARD
摘要： REACTING TRIMETHYLPOSPHITE OR ORGANO-PHOSPHONOUS ACID O,O-DIMETHYL ESTER WITH HYDROGEN SULFIDE IN THE PRESENCE OF A WEAK ORGANIC BASE (THE PKA OF WHICH IN AQUEOUS SOLUTION IS ABOT 0.5-8) AT A TEMPERATURE OF SUBSTANTIALLY BETWEEN ABOUT 0-70*C. AND A STARTING PRESSURE OF SUBSTANTIALLY BETWEEN ABOUT 1-65 ATMOSPHERES ABSOLUTE, TO FORM IN HIGH YIELD AND PURITY THE CORRESPONDING KNOWN DIMETHYL-THIOPHOSPHITE OR ORGANO-THIOPHOSPHONOUS ACIDO-MONO METHYL ESTER, WHICH ARE KNOWN INTERMEDIATES USEABLE FOR THE SYNTHESIS OF KNOWN BIOCIDAL, ESPECIALLY INSECTICIDAL, PHOSPHORIC ACID ESTERS.
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