公开(公告)号：US20230295070A1

公开(公告)日：2023-09-21

申请号：US18200431

申请日：2023-05-22

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

CPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/091 ,  C07F9/572 ,  C07C2602/22

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US11691939B2

公开(公告)日：2023-07-04

申请号：US17071382

申请日：2020-10-15

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

CPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/091 ,  C07F9/572 ,  C07C2602/22

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US20230100818A1

公开(公告)日：2023-03-30

申请号：US17785821

申请日：2020-12-18

申请人： NICHIAS CORPORATION ,  KYOTO INSTITUTE OF TECHNOLOGY

发明人： Tomoya SHIMIZU ,  Ayumi TOH ,  Tsutomu KONNO

IPC分类号： C08K5/06 ,  C07C35/50 ,  C07C43/196 ,  C07C43/192 ,  C08L27/12 ,  C08K5/053

摘要： The present invention provides a crosslinking agent which can improve crosslinked fluoroelastomer high-temperature vapor resistance and a crosslinked fluoroelastomer having improved high-temperature vapor resistance. The present invention provides a compound having a structure represented by the following formula (1) (in the formula, R1 to R6 are each a hydrogen atom, a substituent, or a leaving group, and two or more of R1 to R6 are leaving groups; Ra to Rc are each a hydrogen atom or a substituent; and n is an integer from 2 to 5).

公开(公告)号：US5352708A

公开(公告)日：1994-10-04

申请号：US948056

申请日：1992-09-21

申请人： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

发明人： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

IPC分类号： A61K31/045 ,  A61K31/075 ,  A61K31/13 ,  A61K31/16 ,  A61K31/275 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/655 ,  A61P1/00 ,  A61P1/16 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P27/02 ,  A61P27/06 ,  A61P27/14 ,  A61P37/08 ,  A61P43/00 ,  C07C35/21 ,  C07C35/50 ,  C07C69/732 ,  C07C69/734 ,  C07C205/17 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C405/00

CPC分类号： A61K31/559 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C35/21 ,  C07C405/00 ,  C07C2101/08

摘要： The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, either or thioether groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) derivatives of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.

摘要翻译： 本发明提供在1-位被卤素，甲基，羟基，硝基，氨基，酰氨基，叠氮基，肟，氰基，硫醇，或硫醚基取代的环戊烷庚酸，2-环烷基或芳基烷基衍生物，例如 1-OH环戊烷庚酸，2-（环烷基或芳基烷基）衍生物。 本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是有效的眼睛低血压剂，特别适用于治疗青光眼。 此外，本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 平滑肌松弛剂适用于胃肠道疾病，繁殖，生育，失禁，休克等。

公开(公告)号：US4508822A

公开(公告)日：1985-04-02

申请号：US433093

申请日：1982-10-06

申请人： Stephen C. Taylor

发明人： Stephen C. Taylor

IPC分类号： C12P7/18 ,  C07C35/14 ,  C07C35/50 ,  C07C255/45 ,  C07C255/47 ,  C08F8/00 ,  C08F32/06 ,  C08L45/00 ,  C12N1/20 ,  C12N1/26 ,  C12P7/02 ,  C12P13/00 ,  C12R1/40 ,  C12N15/00

CPC分类号： C07C255/00 ,  C07C35/14 ,  C07C35/50 ,  C08F32/06 ,  C08F8/00 ,  C08L45/00 ,  C12P7/02 ,  C12R1/40 ,  Y10S435/877

摘要： Preparation of 1,2-dihydroxy-cyclohexadienes by a biochemical process using strains of Pseudomonas putida. The dihydroxy compounds can be converted into novel 1,2-disubstituted-cyclohexadienes. Certain of the novel compounds are useful as intermediates for the production of polymers.

摘要翻译： 通过使用恶臭假单胞菌的生化过程制备1,2-二羟基 - 环己二烯。 二羟基化合物可以转化成新的1,2-二取代环己二烯。 某些新化合物可用作生产聚合物的中间体。

公开(公告)号：US20220002552A1

公开(公告)日：2022-01-06

申请号：US17469792

申请日：2021-09-08

申请人： BIOLEGEND, INC.

发明人： Xinshe Xu ,  Jing Wang

IPC分类号： C09B69/10 ,  C08G81/00 ,  C07C25/22 ,  C07C237/04 ,  C07D235/02 ,  C07D311/96 ,  C07D211/18 ,  C09B57/00 ,  C07C35/50 ,  C07C211/60 ,  G01N21/64

摘要： The present invention provides fluorescent polyfluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.

公开(公告)号：US20210047258A1

公开(公告)日：2021-02-18

申请号：US17071382

申请日：2020-10-15

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US20200017433A1

公开(公告)日：2020-01-16

申请号：US16495092

申请日：2018-03-16

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07F9/09 ,  C07F9/572 ,  C07C35/50 ,  C07C39/23 ,  C07C215/70 ,  C07C43/23 ,  C07C49/83 ,  C07C49/683 ,  C07C307/02 ,  C07C271/34 ,  C07C309/66 ,  C07C255/47 ,  C07D249/04

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US5607978A

公开(公告)日：1997-03-04

申请号：US371339

申请日：1995-01-11

申请人： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

发明人： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

IPC分类号： A61K31/045 ,  A61K31/075 ,  A61K31/13 ,  A61K31/16 ,  A61K31/275 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/655 ,  A61P1/00 ,  A61P1/16 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P27/02 ,  A61P27/06 ,  A61P27/14 ,  A61P37/08 ,  A61P43/00 ,  C07C35/21 ,  C07C35/50 ,  C07C69/732 ,  C07C69/734 ,  C07C205/17 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C405/00 ,  A61K31/135 ,  A61K31/34 ,  A61K31/38 ,  A61K31/44

CPC分类号： A61K31/559 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C35/21 ,  C07C405/00 ,  C07C2101/08

摘要： The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, either or thioether groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) derivatives of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.

摘要翻译： 本发明提供在1-位被卤素，甲基，羟基，硝基，氨基，酰氨基，叠氮基，肟，氰基，硫醇，或硫醚基取代的环戊烷庚酸，2-环烷基或芳基烷基衍生物，例如 1-OH环戊烷庚酸，2-（环烷基或芳基烷基）衍生物。 本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是有效的眼睛低血压剂，特别适用于治疗青光眼。 此外，本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 平滑肌松弛剂适用于胃肠道疾病，繁殖，生育，失禁，休克等。

公开(公告)号：US5180741A

公开(公告)日：1993-01-19

申请号：US713697

申请日：1991-06-11

申请人： Didier Babin ,  Jean-Pierre Demoute ,  Jean Tessier

发明人： Didier Babin ,  Jean-Pierre Demoute ,  Jean Tessier

IPC分类号： A61K31/215 ,  A01N53/00 ,  A01N53/02 ,  A01N53/10 ,  A61P33/00 ,  A61P33/10 ,  C07C35/50 ,  C07C69/67 ,  C07C69/73 ,  C07C69/734 ,  C07C253/30 ,  C07C255/53 ,  C07C255/55 ,  C07C255/58 ,  C07C327/32 ,  C07D309/12 ,  C07F7/18 ,  C07F7/22

CPC分类号： C07C35/50 ,  A01N53/00 ,  C07C255/53 ,  C07C2102/08

摘要： Pyrenthrinoid esters with an indenyl nucleus having the following structural formula ##STR1## wherein the substituents are herein defined, have been shown to be useful as pesticides and in pesticidal compositions.

摘要翻译： 具有以下结构式（IMAGE）的具有茚基核的嘧啶衍生物酯，其中本文定义的取代基已被证明可用作杀虫剂和农药组合物。