公开(公告)号：US20060117859A1

公开(公告)日：2006-06-08

申请号：US11002409

申请日：2004-12-02

Applicant: James Liu ,  James Cook ,  Peter Dierauer

Inventor： James Liu ,  James Cook ,  Peter Dierauer

IPC: G01L9/00

CPC classification number: A61B5/02152 ,  A61B5/031 ,  G01L9/007 ,  G01L9/0072 ,  G01L9/10 ,  G01L9/12

Abstract: Disposable pressure sensor methods and systems are disclosed. A substrate can be provided, along with a capacitor and an inductor fixed to the substrate to form a pressure sensor thereof. In a variable L configuration, the inductor can be configured to comprise an inductor surface and a diaphragm, such that when the diaphragm is exposed to a pressure, the diaphragm moves close to the inductor surface, thereby resulting in an increase in the inductance and a decrease in the resonant frequency associated with the capacitor and the inductor and any associated circuitry. In a variable C configuration, the capacitor can be configured to comprise one electrode on the surface and one on the diaphragm, such that when the diaphragm is exposed to a pressure, the diaphragm moves close to the capacitor surface, thereby resulting in an increase in the capacitance and a decrease in the resonant frequency associated with the capacitor and the inductor and any associated circuitry. Such increase and/or decrease data are detectable by external interrogation.

Abstract translation: 公开了一次性压力传感器方法和系统。 可以提供衬底以及固定到衬底的电容器和电感器，以形成其压力传感器。 在可变L配置中，电感器可以被配置为包括电感器表面和膜片，使得当膜片暴露于压力时，膜片移动靠近电感器表面，从而导致电感增加，并且a 降低与电容器和电感器以及任何相关电路相关联的谐振频率。 在可变C构造中，电容器可以被配置为包括表面上的一个电极和隔膜上的一个电极，使得当隔膜暴露于压力时，隔膜移动到电容器表面附近，从而导致增加 电容和与电容器和电感器以及任何相关电路相关联的谐振频率的降低。 这种增加和/或减少的数据可以通过外部询问来检测。

公开(公告)号：US20060055531A1

公开(公告)日：2006-03-16

申请号：US10940239

申请日：2004-09-14

Applicant: James Cook ,  Richard Dale

Inventor： James Cook ,  Richard Dale

IPC: G08B1/08

CPC classification number: B60C23/0408 ,  G01D21/00 ,  G06K19/0672 ,  G06K19/07749

Abstract: Sensors and transponders combined on a single semiconductor substrate package. The invention includes an RFID tag and a sensor commonly assembled onto a common substrate. The substrates can be provided in the form of a flex circuit or printed circuit board. The flex circuit would be fabricated using standard flex circuit fabrication methods. It is a polymer/metal laminate film structure and incorporates the antenna pattern for the sensor and RFID tag system on the circuit. The flex circuit can also combine antennas for the sensor and the RFID tag onto a single flex circuit substrate, thus eliminating the need for separate antennas.

Abstract translation: 传感器和转发器组合在单个半导体衬底封装上。 本发明包括RFID标签和通常组装在公共基板上的传感器。 基板可以以柔性电路或印刷电路板的形式提供。 柔性电路将使用标准柔性电路制造方法制造。 它是聚合物/金属层压膜结构，并且在电路上并入传感器的天线图案和RFID标签系统。 柔性电路还可以将用于传感器和RFID标签的天线组合到单个柔性电路基板上，从而消除对单独天线的需要。

公开(公告)号：US20060003995A1

公开(公告)日：2006-01-05

申请号：US11173981

申请日：2005-06-30

Applicant: James Cook ,  Hao Zhou ,  Shengming Huang ,  P.V.V.S Sarma ,  Chunchun Zhang

Inventor： James Cook ,  Hao Zhou ,  Shengming Huang ,  P.V.V.S Sarma ,  Chunchun Zhang

IPC: A61K31/5513 ,  C07D487/04

CPC classification number: C07D243/24 ,  C07D243/16 ,  C07D471/06 ,  C07D487/04 ,  C07D487/06

Abstract: The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.

公开(公告)号：US20050260280A1

公开(公告)日：2005-11-24

申请号：US11193540

申请日：2005-07-28

Applicant: James Cook ,  Stanley Huth

Inventor： James Cook ,  Stanley Huth

IPC: A61K9/00 ,  A61K31/728 ,  A61K33/00 ,  A61K45/06 ,  A61P27/00 ,  A61P27/02 ,  A61K33/14

CPC classification number: A61K9/0048 ,  A61K31/728 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

Abstract: Stable ophthalmic formulations comprising hyaluronic acid (sodium hyaluronate) as the primary active demulcent ingredient, stabilized oxy-chloro complex (available commercially as OcuPure(tm) from Advanced Medical Optics, Purite® from Allergan, and Purogene from Biocide) for preservative efficacy, balanced salts mimicking the tear film, and sodium borate as a buffer are disclosed. In one embodiment, preferred stable formulations may be used in the human eye with or without contact lenses. In another embodiment preferred formulations may also be used as a storage and conditioning solution for contact lenses following disinfection.

Abstract translation: 包含透明质酸（透明质酸钠）作为主要的活性缓和成分的稳定的眼用制剂，稳定的氧 - 氯络合物（可从Advanced Medical Optics，Allergan的Purite和来自杀生物剂的Purogene以商品名OcuPure（tm获得）），用于防腐​​功效 公开了模仿泪膜的平衡盐和作为缓冲剂的硼酸钠。 在一个实施方案中，优选的稳定制剂可以在具有或不具有隐形眼镜的人眼中使用。 在另一个实施方案中，优选的制剂也可以用作消毒后的隐形眼镜的储存和调理溶液。

公开(公告)号：US20050145851A1

公开(公告)日：2005-07-07

申请号：US10879695

申请日：2004-06-28

Applicant: Jerry Johnson ,  Ricardo Borges ,  Jeffrey Brown ,  James Cook ,  Allen Hanson ,  Edwin Piner ,  Pradeep Rajagopal ,  John Roberts ,  Sameer Singhal ,  Robert Therrien ,  Andrei Vescan

Inventor： Jerry Johnson ,  Ricardo Borges ,  Jeffrey Brown ,  James Cook ,  Allen Hanson ,  Edwin Piner ,  Pradeep Rajagopal ,  John Roberts ,  Sameer Singhal ,  Robert Therrien ,  Andrei Vescan

IPC: H01L21/285 ,  H01L21/329 ,  H01L21/335 ,  H01L29/20 ,  H01L29/872 ,  H01L29/15

CPC classification number: H01L29/7787 ,  H01L21/28587 ,  H01L21/7605 ,  H01L29/2003 ,  H01L29/66212 ,  H01L29/66462 ,  H01L29/872

Abstract: Gallium nitride material structures, including devices, and methods associated with the same are provided. In some embodiments, the structures include one or more isolation regions which electrically isolate adjacent devices. One aspect of the invention is the discovery that the isolation regions also can significantly reduce the leakage current of devices (e.g., transistors) made from the structures, particularly devices that also include a passivating layer formed on a surface of the gallium nitride material. Lower leakage currents can result in increased power densities and operating voltages, amongst other advantages.

Abstract translation: 提供了氮化镓材料结构，包括器件和与其相关的方法。 在一些实施例中，结构包括一个或多个隔离相邻器件的隔离区域。 本发明的一个方面是发现隔离区域还可以显着地减少由结构制成的器件（例如，晶体管）的泄漏电流，特别是还包括形成在氮化镓材料表面上的钝化层的器件。 较低的漏电流可以导致增加的功率密度和工作电压以及其它优点。

公开(公告)号：US06713190B2

公开(公告)日：2004-03-30

申请号：US10098005

申请日：2002-03-13

Applicant: Gordon James Cook ,  Andrew Hughes ,  Arthur Robert Bailey ,  George Charles Hartnup ,  Dugald Stewart

Inventor： Gordon James Cook ,  Andrew Hughes ,  Arthur Robert Bailey ,  George Charles Hartnup ,  Dugald Stewart

IPC: B32B522

CPC classification number: B07B1/4618 ,  B01D29/012 ,  B01D29/05 ,  B01D29/445 ,  B07B1/46 ,  B07B1/4627 ,  B07B1/4645 ,  B07B1/4663 ,  B07B1/4672 ,  B07B1/48 ,  B29C45/14336 ,  B29C70/56 ,  B29C70/82 ,  B29C70/885 ,  B29C2045/14442 ,  B29L2031/14 ,  B29L2031/737 ,  Y10T29/49616 ,  Y10T29/4962 ,  Y10T29/49895 ,  Y10T428/12347 ,  Y10T428/12361 ,  Y10T428/12444 ,  Y10T428/12965 ,  Y10T428/249923 ,  Y10T428/298

Abstract: A method is described for making a reinforcing wire frame for embedding in a moulded polymer support frame over which woven wire cloth is to be stretched and secured to form a sifting screen. The method involves locating lengths of cut wire substantially equally spaced apart in a jig to form a first array. A second array of lengths of cut wire is located over the first array with the lengths of wire in the second array being substantially at right angles to those of the first array. The lengths of wire in the first and second arrays are resistance welded at points of mutual intersection so as to form a first substantially rectilinear matrix. Lengths of cut wire are located in a jig to form a third array, in which the lengths are also substantially equally spaced apart, and a fourth array of lengths of cut wire is arranged over the third array with the lengths of the fourth array substantially at right angles to the lengths of wire of the third array, and the wires of the third and fourth arrays are also resistance welded at points of mutual intersection to form a second substantially rectilinear matrix.

Abstract translation: 描述了一种用于制造用于嵌入到模制的聚合物支撑框架中的增强线框架的方法，在该模制聚合物支撑框架上，编织线布将被拉伸和固定以形成筛网。 该方法包括将切割线的长度定位在夹具中基本等间隔开以形成第一阵列。 切割线的长度的第二阵列位于第一阵列上方，第二阵列中的线的长度基本上与第一阵列的长度成直角。 第一和第二阵列中的线的长度在相互交叉的点处被电阻焊接，以便形成第一基本上直线的矩阵。 切割线的长度位于夹具中以形成第三阵列，其中长度也基本等间隔开，并且第四阵列的长度的第四阵列的切割线布置在第三阵列上，其中第四阵列的长度基本上在 与第三阵列的线的长度成直角，并且第三和第四阵列的线也在相互交叉的点处被电阻焊接以形成第二基本上直线的矩阵。

公开(公告)号：US06692599B2

公开(公告)日：2004-02-17

申请号：US10097920

申请日：2002-03-13

Applicant: Gordon James Cook ,  Andrew Hughes ,  Arthur Robert Bailey ,  George Charles Hartnup ,  Dugald Stewart

Inventor： Gordon James Cook ,  Andrew Hughes ,  Arthur Robert Bailey ,  George Charles Hartnup ,  Dugald Stewart

IPC: B32B3500

CPC classification number: B07B1/4618 ,  B01D29/012 ,  B01D29/05 ,  B01D29/445 ,  B07B1/46 ,  B07B1/4627 ,  B07B1/4645 ,  B07B1/4663 ,  B07B1/4672 ,  B07B1/48 ,  B29C45/14336 ,  B29C70/56 ,  B29C70/82 ,  B29C70/885 ,  B29C2045/14442 ,  B29L2031/14 ,  B29L2031/737 ,  Y10T29/49616 ,  Y10T29/4962 ,  Y10T29/49895 ,  Y10T428/12347 ,  Y10T428/12361 ,  Y10T428/12444 ,  Y10T428/12965 ,  Y10T428/249923 ,  Y10T428/298

Abstract: A method of repairing or refurbishing a filter screen is described. The type of screen is defined in the specification. The repair or refurbishment is effected by stripping worn or damaged wirecloth from the surface of the frame and placing fresh cloth over the frame and tensioning it as appropriate. Heat is then applied so as to soften surfaces of the frame over which wirecloth is stretched, so that the latter can penetrate softened plastics material in the surfaces and become embedded therein. The frame and its associated fresh cloth is allowed to cool, after which the applied tensioning is removed. Exposed edges of the wirecloth can be trimmed back to the surrounding flange. Plastics material may be applied to the surface of the frame which is to receive the new wirecloth, before the latter is fitted, to provide additional plastics material for bonding the wirecloth to the frame. Alternatively the stripped frame may be inserted in a mould, and fresh polymer material is injected into the mould so as to reform ridges on the surfaces of the frame similar to those which existed when the frame was first manufactured, before the wirecloth is applied thereto.

Abstract translation: 描述了一种修复或翻新滤网的方法。 屏幕类型在规范中定义。 修理或翻新是通过从框架表面剥去磨损或损坏的布线，并将新鲜布放置在框架上并适当张紧来实现的。 然后施加热量以软化被拉伸的布线的框架的表面，使得后者可以穿透表面中的软化塑料材料并嵌入其中。 将框架及其相关的新鲜布子冷却，之后除去所施加的张力。 线缆的暴露边缘可以修剪回到周围的法兰上。 塑料材料可以被施加到框架的表面，该框架的表面将在其装配之前被接纳新的布线，以提供用于将布线粘合到框架的附加塑料材料。 或者，剥离的框架可以插入模具中，并且将新鲜的聚合物材料注入到模具中，以便在将布线施加到框架之前改变与框架首次制造时存在的那些相似的框架表面上的脊。

公开(公告)号：US06613555B2

公开(公告)日：2003-09-02

申请号：US09816760

申请日：2001-03-23

Applicant: Rachel Meyers ,  William James Cook ,  Mark Williamson ,  Laura A. Rudolph-Owen

Inventor： Rachel Meyers ,  William James Cook ,  Mark Williamson ,  Laura A. Rudolph-Owen

IPC: C12N904

CPC classification number: C12N9/0004 ,  C07K2319/00

Abstract: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract translation: 本发明提供编码新型DHDR相关脱氢酶分子的分离的核酸分子，命名为DHDR核酸分子。 本发明还提供了反义核酸分子，含有DHDR核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及DHDR基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的DHDR蛋白，融合蛋白，抗原肽和抗DHDR抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US06447770B1

公开(公告)日：2002-09-10

申请号：US09395861

申请日：1999-09-14

Applicant: Jos M. Raaijmakers ,  David M. Weller ,  Linda S. Thomashow ,  R. James Cook

Inventor： Jos M. Raaijmakers ,  David M. Weller ,  Linda S. Thomashow ,  R. James Cook

IPC: A01N6300

CPC classification number: C12R1/38 ,  A01N63/00 ,  C12N15/52 ,  C12N15/78 ,  C12R1/39 ,  Y10S435/876

Abstract: Fluorescent Pseudomonas spp. are described which are effective for the control of diseases caused by the soil-borne fungus, Gaeumannomyces graminis (Gg), such as take-all, in small grain crops or turf grass. The subject biocontrol strains have a unique genotype as shown by a characteristic banding pattern, and exhibit root-colonizing ability which is characterized by both higher population density on roots and extended colonizing activity compared to known Gg-suppressive strains. A further property is the ability of a strain to duplicate the level of biocontrol obtained naturally in a take-all decline soil. Methods for isolation and identification of the strains and their use to control diseases caused by Gg are provided. In particular, strains of P. fluorescens NRRL B-21806 and NRRL B-21807.

Abstract translation: 荧光假单胞菌 被描述为有效地控制由土壤传播的真菌，禾谷镰刀菌（Gg），如小麦作物或草坪草中所有的所有疾病引起的疾病。 主题生物防治菌株具有独特的基因型，如特征条带图案所示，并且表现出根瘤定殖能力，其特征在于与已知的Gg抑制菌株相比，根系的群体密度较高和延长的定居活动。 另一个属性是菌株复制在全部衰退土壤中自然获得的生物防治水平的能力。 提供了用于分离和鉴定菌株及其用于控制​​由Gg引起的疾病的方法。 特别是荧光假单胞菌NRRL B-21806和NRRL B-21807的菌株。

公开(公告)号：US06277625B1

公开(公告)日：2001-08-21

申请号：US08994035

申请日：1997-12-18

Applicant: Zhengyu Huang ,  Linda S. Thomashow ,  Dmitri V. Mavrodi ,  Jos M. Raaijmakers ,  David M. Weller ,  R. James Cook

Inventor： Zhengyu Huang ,  Linda S. Thomashow ,  Dmitri V. Mavrodi ,  Jos M. Raaijmakers ,  David M. Weller ,  R. James Cook

IPC: C12N1578

CPC classification number: C12R1/38 ,  A01N63/00 ,  C12N15/52 ,  C12N15/78 ,  C12R1/39 ,  Y10S435/876

Abstract: Transgenic fluorescent Pseudomonas spp. are described which have a biosynthetic locus which encodes for the production of the antibiotic phenazine-1-carboxylic acid stably introduced into the genome, have a locus which encodes for the production of the antibiotic 2,4-diacetylphloroglucinol, and are effective for control of diseases caused by the soil-borne fungus, Rhizoctonia. Strains are also described which control diseases caused by Gaeumannomyces graminis or Pythium, in addition to Rhizoctonia, or have the ability to control all three diseases.

Abstract translation: 转基因荧光假单胞菌 描述了具有编码产生稳定导入基因组中的抗生素吩嗪-1-羧酸的生物合成基因座，具有编码抗生素2,4-二乙酰基叶绿素的生产的场所，并且有效地控制 由土传真菌，丝核菌引起的疾病。 还描述了除了丝核菌之外还控制由禾谷镰刀菌（Gaeumannomyces graminis）或腐霉属（Pythium）引起的疾病或具有控制所有三种疾病的能力的菌株。