公开(公告)号：US20210349104A1

公开(公告)日：2021-11-11

申请号：US17246364

申请日：2021-04-30

Applicant: Meso Scale Technologies, LLC. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  James WILBUR ,  Jeffery DEBAD ,  Christopher CAMPBELL ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Pu LIU ,  Paul GOODWIN ,  Adrian MCDERMOTT ,  Sarah O'CONNELL ,  Sandeep NARPALA

IPC: G01N33/68

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US11148145B2

公开(公告)日：2021-10-19

申请号：US16210165

申请日：2018-12-05

Applicant: Meso Scale Technologies, LLC

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: C12Q1/68 ,  B01L3/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6804 ,  G01N33/68

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20210285966A1

公开(公告)日：2021-09-16

申请号：US17213954

申请日：2021-03-26

Applicant: Meso Scale Technologies, LLC.

Inventor： George Sigal

IPC: G01N33/68 ,  G01N33/576

Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.

公开(公告)号：US11119111B2

公开(公告)日：2021-09-14

申请号：US16319731

申请日：2017-01-20

Applicant: Meso Scale Technologies, LLC.

Inventor： Manish Kochar ,  Bandele Jeffrey-Coker ,  Aaron H. Leimkuehler ,  Louis W. Pang ,  Jennifer Parker

IPC: G16H40/67 ,  G16H10/40 ,  G16H40/40 ,  F24F11/30 ,  G06Q10/10 ,  H04B1/3827 ,  G01N35/00 ,  B01L3/00 ,  B01L9/00 ,  G06K7/14 ,  G06Q10/08

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

公开(公告)号：USD925330S1

公开(公告)日：2021-07-20

申请号：US29707949

申请日：2019-10-02

Applicant: Meso Scale Technologies, LLC.

Designer： Aaron Leimkuehler ,  Rodger Darin Osborne ,  Jacob N. Wohlstadter

公开(公告)号：US20210087709A1

公开(公告)日：2021-03-25

申请号：US16971752

申请日：2019-02-22

Applicant: Meso Scale Technologies, LLC.

Inventor： Ka Y. KWONG ,  Ilia V. DAVYDOV

IPC: C40B30/04 ,  C07K16/26 ,  C07K16/00

Abstract: The invention provides singleplex and multiplex assays for screening of antigen-binding molecules for their affinity to antigens by normalizing for the concentration of the antigen-binding molecule.

公开(公告)号：US10935547B2

公开(公告)日：2021-03-02

申请号：US15222674

申请日：2016-07-28

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Joseph M. Leginus ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Koustubh A. Phalnikar ,  Sriram Jambunathan

IPC: G01N33/543 ,  B01L3/00 ,  B01L9/00 ,  C12Q1/00 ,  G01N27/30 ,  G01N21/76 ,  B01J19/00 ,  B33Y80/00 ,  C40B40/10

Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

公开(公告)号：US20210048431A1

公开(公告)日：2021-02-18

申请号：US16978464

申请日：2019-03-08

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  GEORGETOWN UNIVERSITY ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jeff DEBAD ,  Joshua GATSON ,  Mark BURNS ,  Arianna BIESSO

IPC: G01N33/53 ,  G01N21/66 ,  G01N35/02

Abstract: The present invention relates to assays, methods, and kits to assess traumatic brain injury (TBI) in a subject. The present invention also relates to ultrasensitive assays for GFAP, tau, CKBB, IL-1β, IL-2, IL-6, IL-10, IL-22, IP-10, TNFα, TSLP, NFL, and/or NFH.

公开(公告)号：US20210016288A1

公开(公告)日：2021-01-21

申请号：US16929757

申请日：2020-07-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Gary I. KRIVOY ,  Cecilia ZIMMERMAN ,  Jules VANDERSARL ,  Sandor KOVACS ,  Aaron H. LEIMKUEHLER ,  Leo TABAKIN ,  Jon WILLOUGHBY ,  Manish KOCHAR ,  Charles M. Clinton

IPC: B01L9/00

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. The apparatuses, systems, method, reagents, and kits may be employed in conducting automated analysis in a multi-well plate assay format.

公开(公告)号：USD907878S1

公开(公告)日：2021-01-12

申请号：US29724913

申请日：2020-02-20

Applicant: Meso Scale Technologies, LLC.

Designer： Jacob N. Wohlstadter ,  Rodger Darin Osborne ,  Jennifer Parker ,  Aaron Leimkuehler ,  Manish Kochar ,  Peter Bosco ,  Michael Wade