公开(公告)号：USRE49774E1

公开(公告)日：2024-01-02

申请号：US17173898

申请日：2021-02-11

申请人： Meso Scale Technologies, LLC.

发明人： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC分类号： C12Q1/68 ,  B01L3/00 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/543 ,  G01N33/68

CPC分类号： B01L3/50853 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  G01N2458/10 ,  C12Q1/6816 ,  C12Q2563/131

摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US11148145B2

公开(公告)日：2021-10-19

申请号：US16210165

申请日：2018-12-05

申请人： Meso Scale Technologies, LLC

发明人： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC分类号： C12Q1/68 ,  B01L3/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6804 ,  G01N33/68

摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US10436784B2

公开(公告)日：2019-10-08

申请号：US14854514

申请日：2015-09-15

申请人： Meso Scale Technologies, LLC ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/53 ,  G01N33/569 ,  G01N33/68 ,  G01N33/566

摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20190178787A1

公开(公告)日：2019-06-13

申请号：US16219030

申请日：2018-12-13

申请人： Meso Scale Technologies, LLC

发明人： Nicholas Anderson ,  Jeffery Debad ,  Eli N. Glezer ,  Sudeep Kumar ,  Noel Lawrence ,  Kenneth Page ,  George Sigal ,  Sharon West

IPC分类号： G01N21/05 ,  G01N21/03 ,  G01N21/69 ,  G01N21/76 ,  G01F23/02 ,  G01F23/292 ,  B01L3/00

摘要： Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US10201812B2

公开(公告)日：2019-02-12

申请号：US15784399

申请日：2017-10-16

申请人： Meso Scale Technologies, LLC.

发明人： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC分类号： C12Q1/68 ,  B01L3/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12Q1/6804 ,  G01N33/68 ,  C12Q1/6816

摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20180246100A1

公开(公告)日：2018-08-30

申请号：US15902597

申请日：2018-02-22

申请人： Meso Scale Technologies, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/569 ,  G01N33/566 ,  G01N33/68

CPC分类号： G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20180074061A1

公开(公告)日：2018-03-15

申请号：US15813418

申请日：2017-11-15

申请人： Meso Scale Technologies, LLC.

发明人： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin ,  Srikant Vaithilingam

IPC分类号： G01N33/574

CPC分类号： G01N33/57423 ,  G01N2800/52

摘要： The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20160012208A1

公开(公告)日：2016-01-14

申请号：US14862298

申请日：2015-09-23

申请人： Meso Scale Technologies, LLC

发明人： Charles M. Clinton ,  Xinri Cong ,  Eli N. Glezer ,  Sudeep Kumar ,  Carl Stevens ,  Michael Vock ,  Jon S. Willoughby

IPC分类号： G06F19/00

CPC分类号： G16C20/20 ,  B01L3/54 ,  B01L2300/02 ,  G01N33/54306 ,  G01N35/00663 ,  G01N2035/00633 ,  G01N2035/00851 ,  G16H10/40

摘要： The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

摘要翻译： 本发明涉及用于将测定信息与生物测定中使用的测定消耗品相关联的方法，装置和系统。 提供了测定系统和相关的消耗品，其中测定系统包括读取器，其适于从与测定消耗品相关联的测定消耗品标识符读取/写入/写入信息。 描述了各种类型的测定信息，以及在通过测定系统进行测定中使用这些信息的方法。

公开(公告)号：US20140256588A1

公开(公告)日：2014-09-11

申请号：US14203638

申请日：2014-03-11

申请人： Meso Scale Technologies, LLC.

发明人： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC分类号： C12Q1/68

CPC分类号： B01L3/50853 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  G01N2458/10 ,  C12Q2563/131

摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

摘要翻译： 本发明涉及用于进行固相结合测定的方法。 一个实例是具有改进的分析物特异性的测定方法，其中特异性受到非特异性结合相互作用的存在的限制。

公开(公告)号：US12017229B2

公开(公告)日：2024-06-25

申请号：US17492207

申请日：2021-10-01

申请人： Meso Scale Technologies, LLC.

发明人： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

IPC分类号： B01L3/00 ,  F16K11/074

CPC分类号： B01L3/567 ,  B01L3/502 ,  B01L3/502738 ,  B01L3/5085 ,  F16K11/0743 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  Y10T436/2575

摘要： Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.