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公开(公告)号：USRE49774E1
公开(公告)日：2024-01-02
申请号：US17173898
申请日：2021-02-11
发明人： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC分类号： C12Q1/68 , B01L3/00 , C12Q1/6804 , C12Q1/6816 , C12Q1/6876 , G01N33/543 , G01N33/68
CPC分类号： B01L3/50853 , C12Q1/6804 , C12Q1/6816 , C12Q1/6876 , G01N33/54306 , G01N33/54353 , G01N33/6845 , B01L2300/021 , B01L2300/043 , B01L2300/0609 , B01L2300/0829 , G01N2458/10 , C12Q1/6816 , C12Q2563/131
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US11148145B2
公开(公告)日：2021-10-19
申请号：US16210165
申请日：2018-12-05
发明人： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC分类号： C12Q1/68 , B01L3/00 , C12Q1/6876 , G01N33/543 , C12Q1/6816 , C12Q1/6804 , G01N33/68
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US20210285966A1
公开(公告)日：2021-09-16
申请号：US17213954
申请日：2021-03-26
发明人： George Sigal
IPC分类号： G01N33/68 , G01N33/576
摘要： The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.
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公开(公告)号：US20200240903A1
公开(公告)日：2020-07-30
申请号：US16845560
申请日：2020-04-10
发明人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
摘要： Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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公开(公告)号：US20190391140A1
公开(公告)日：2019-12-26
申请号：US16564208
申请日：2019-09-09
发明人： Anahit Aghvanyan , Eli N. Glezer , John Kenten , George Sigal , Martin Stengelin , David Routenberg
IPC分类号： G01N33/543 , C12Q1/6844 , C12Q1/6837 , C12Q1/6832
摘要： The present invention is directed to methods for improving assay specificity and performance in binding assays.
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公开(公告)号：US10436784B2
公开(公告)日：2019-10-08
申请号：US14854514
申请日：2015-09-15
申请人： Meso Scale Technologies, LLC , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/53 , G01N33/569 , G01N33/68 , G01N33/566
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US20190178787A1
公开(公告)日：2019-06-13
申请号：US16219030
申请日：2018-12-13
发明人： Nicholas Anderson , Jeffery Debad , Eli N. Glezer , Sudeep Kumar , Noel Lawrence , Kenneth Page , George Sigal , Sharon West
摘要： Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
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公开(公告)号：US10281678B2
公开(公告)日：2019-05-07
申请号：US14147216
申请日：2014-01-03
发明人： Ian Chamberlin , Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Manish Kochar , Sandor Kovacs , D. T. Le , Aaron Leimkuehler , George Sigal , Leo Tabakin , Jon Willoughby
摘要： Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
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公开(公告)号：US10201812B2
公开(公告)日：2019-02-12
申请号：US15784399
申请日：2017-10-16
发明人： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC分类号： C12Q1/68 , B01L3/00 , C12Q1/6876 , G01N33/543 , C12Q1/6804 , G01N33/68 , C12Q1/6816
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US20180246100A1
公开(公告)日：2018-08-30
申请号：US15902597
申请日：2018-02-22
申请人： Meso Scale Technologies, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F. Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/569 , G01N33/566 , G01N33/68
CPC分类号： G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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