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    Cellobiohydrolase variants and polynucleotides encoding same
    92.
    发明申请
    Cellobiohydrolase variants and polynucleotides encoding same 有权
    纤维二糖水解酶变体和编码相同的多核苷酸

    公开(公告)号：US20140017737A1

    公开(公告)日：2014-01-16

    申请号：US14034209

    申请日：2013-09-23

    Applicant: Novozymes, Inc.

    Inventor： Mark Wogulis

    IPC: C12N9/42 ,  C12P19/14

    CPC classification number: C12N9/2437 ,  C12N15/8257 ,  C12P19/02 ,  C12P19/14 ,  C12P2203/00 ,  C12Y302/01091 ,  Y02P20/52

    Abstract: The present invention relates to variants of a parent cellobiohydrolase II. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

    Abstract translation: 本发明涉及亲本纤维二糖水解酶II的变体。 本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含所述多核苷酸的宿主细胞; 以及使用这些变体的方法。

    Variants of Glycoside Hydrolases
    93.
    发明申请
    Variants of Glycoside Hydrolases 审中-公开

    公开(公告)号：US20130130353A1

    公开(公告)日：2013-05-23

    申请号：US13748328

    申请日：2013-01-23

    Applicant: Novozymes, Inc.

    Inventor： Sarah Teter ,  Connie Ward ,  Joel Cherry ,  Aubrey Jones ,  Paul Harris ,  Jung Yi

    IPC: C12N9/24

    CPC classification number: C12N9/2437 ,  C11D3/38645 ,  C12N9/2434 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01021 ,  C12Y302/01091 ,  C12Y302/01176 ,  Y02E50/16

    Abstract: The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

    Methods for producing polypeptides in protease-deficient mutants of Trichoderma
    95.
    发明授权
    Methods for producing polypeptides in protease-deficient mutants of Trichoderma 有权

    公开(公告)号：US11427847B2

    公开(公告)日：2022-08-30

    申请号：US17163033

    申请日：2021-01-29

    Applicant: Novozymes, Inc.

    Inventor： Suchindra Maiyuran ,  Abigail Jang ,  Kimberly Brown ,  Sandra Merino ,  Jeffrey Shasky ,  Eric Abbate

    IPC: C12P21/00 ,  C12N15/80 ,  C12P21/02 ,  C12N15/04 ,  C12N9/58

    Abstract: The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.

    Methods for producing polypeptides in protease-deficient mutants of trichoderma
    100.
    发明授权
    Methods for producing polypeptides in protease-deficient mutants of trichoderma 有权

    公开(公告)号：US11078508B2

    公开(公告)日：2021-08-03

    申请号：US16211632

    申请日：2018-12-06

    Applicant: Novozymes, Inc.

    Inventor： Suchindra Maiyuran ,  Abigail Jang ,  Kimberly Brown ,  Sandra Merino ,  Jeffrey Shasky ,  Eric Abbate

    IPC: C12P21/00 ,  C12P21/02 ,  C12N9/58 ,  C12N15/80 ,  C12N15/04

    Abstract: The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.

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