公开(公告)号：US10660974B2

公开(公告)日：2020-05-26

申请号：US16072848

申请日：2017-01-24

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ronit Satchi-Fainaro ,  Nir Hananya ,  Ori Green ,  Tal Eilon

IPC: A61K49/00 ,  C07F5/04 ,  C07D321/00 ,  C07D405/00 ,  C07F9/655 ,  C07H15/26 ,  C09B11/24 ,  C09B23/04 ,  C09B23/08 ,  C09K11/06 ,  C07F9/12 ,  C09B23/01 ,  C07F5/02 ,  C07H15/203 ,  C07F7/18

Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.

公开(公告)号：US20200155612A1

公开(公告)日：2020-05-21

申请号：US16630954

申请日：2018-07-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Sandu PITARU

IPC: A61K35/38 ,  A61K38/18 ,  A61K38/19 ,  A61K38/22 ,  A61K31/713 ,  A61K38/44 ,  A61P17/02

Abstract: The present invention provides secretome derived from human oral mucosa stem cells (hOMSC), and cell-free compositions comprising hOMSC-derived secretome. Methods for obtaining, manipulating and using hOMSC-derived secretome in therapy, cosmetics and tissue regeneration are also provided.

公开(公告)号：US10570369B2

公开(公告)日：2020-02-25

申请号：US15360555

申请日：2016-11-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Sandu Pitaru

IPC: C12N5/074 ,  C12N5/071 ,  A61K35/38

Abstract: The present invention provides a new readily accessible source of adult somatic stem cells from the gastrointestinal tract in general and oral mucosa in particular, methods for isolating pluripotent stem cells from oral mucosa, cells derived therefrom and uses thereof.

公开(公告)号：US10565716B2

公开(公告)日：2020-02-18

申请号：US15899394

申请日：2018-02-20

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Harel Haim ,  Emanuel Marom ,  Alex Bronstein

IPC: G06T7/50 ,  G06T5/00 ,  G06T5/50 ,  G06T7/571

Abstract: A method of processing an image is disclosed. The method comprises decomposing the image into a plurality of channels, each being characterized by a different depth-of-field, and accessing a computer readable medium storing an in-focus dictionary defined over a plurality of dictionary atoms, and an out-of-focus dictionary defined over a plurality of sets of dictionary atoms, each set corresponding to a different out-of-focus condition. The method also comprises computing one or more sparse representations of the decomposed image over the dictionaries.

公开(公告)号：US10561712B2

公开(公告)日：2020-02-18

申请号：US15312928

申请日：2015-05-21

Applicant: UNIVERSITY OF MARYLAND, BALTIMORE ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Wuyuan Lu ,  Issac Witz ,  Shelly Maman

IPC: A61K38/10 ,  A61K38/42 ,  C07K7/08 ,  C07K14/805 ,  G01N33/574 ,  G01N33/72 ,  A61K38/17 ,  C12N5/09 ,  G01N30/22 ,  G01N30/72 ,  G01N30/88 ,  G01N33/53 ,  A61K38/16 ,  G01N33/68

Abstract: The beta 2 subunit of mouse hemoglobin (HBB2) has been identified as soluble factor from mouse lungs that exhibits cytostatic/cytotoxic activity against neuroblastoma lung micrometastases. The beta subunit of human hemoglobin (HBB) has been found to have similar activity. Methods of using these proteins and fragments thereof in the treatment of cancer and inhibition of metastasis are provided, along with methods of screening a subject for micrometastases by detecting HBB in a biological sample.

公开(公告)号：US10543278B2

公开(公告)日：2020-01-28

申请号：US14427711

申请日：2013-09-12

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ranit Kedmi ,  Dan Peer

IPC: C07K16/00 ,  A61K47/48 ,  C07K16/28 ,  C07K16/42 ,  C07K16/30 ,  A61K39/00

Abstract: A pharmaceutical composition comprising an immunoparticle is provided. The pharmaceutical composition comprising a monoclonal secondary antibody immunocomplexed with a primary antibody, wherein said monoclonal secondary antibody is coupled on an outer surface of a particle and wherein said particle is loaded with a pharmaceutical agent.

公开(公告)号：US20200017484A1

公开(公告)日：2020-01-16

申请号：US16485577

申请日：2018-02-22

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Or KAKHLON ,  Miguel Enrique WEIL ,  Leonardo Javier SOLMESKY

IPC: C07D409/12 ,  C07D487/08 ,  A61P25/28

Abstract: Compounds represented by general Formulae I to IV as described herein are disclosed. Further disclosed are composition utilizing the herein disclosed compounds and using the same for the treatment of glycogen storage disorders.

公开(公告)号：US10536200B2

公开(公告)日：2020-01-14

申请号：US16164799

申请日：2018-10-19

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Uri Erez ,  Elad Domanovitz

IPC: H04B7/0417 ,  H04B7/06 ,  H04L1/00 ,  H04L25/03 ,  H01Q3/26

Abstract: A method that may include receiving, by multiple antennas of a receiver, received signals that are received with diversity and represent transmitted signals; and processing, by at least one processor of the receiver, the received signals to provide processed signals that are indicative of the transmitted signals; wherein the processing comprises applying a dimension-reducing process. The dimension-reducing process may be channel independent.

公开(公告)号：US20190383815A1

公开(公告)日：2019-12-19

申请号：US16480342

申请日：2018-01-25

Applicant: MOR RESEARCH APPLICATIONS LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Esther RABIZADEH ,  Izchak CHERNY ,  Aida INBAL

IPC: G01N33/574 ,  G01N33/86

Abstract: A method for diagnosing a malignant proliferative disease or disorder in a subject, and/or for following up, monitoring or prognosticating the therapy of a malignant proliferative disease or disorder in a subject is disclosed. The method is based on measurement of platelet-mediated fibrinogen-like protein 2 (FGL2) activity in a sample essentially comprising platelets obtained from the subject. In accordance with the disclosed method, platelet-mediated FGL2 activity level higher than control is indicative of the presence of a malignant proliferative disease or disorder in a subject.

公开(公告)号：US10465004B2

公开(公告)日：2019-11-05

申请号：US15109173

申请日：2015-01-01

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Benjamin Dekel ,  Naomi Pode-Shakked ,  Orit Harai-Steinberg ,  Michal Mark-Danieli ,  Einav Vax

IPC: C07K16/30 ,  C07K16/28 ,  A61K39/00

Abstract: The invention provides antibodies or an antigen-binding portion thereof, which recognize the human Frizzled 7 receptor. Further, the invention provides methods of using these antibodies for the treatment cancer in a subject.