公开(公告)号：US09717761B2

公开(公告)日：2017-08-01

申请号：US14359623

申请日：2012-11-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Sandu Pitaru ,  Javier Ganz ,  Daniel Offen ,  Eldad Melamed

IPC: C12N5/00 ,  A61K35/30 ,  C12N5/0793 ,  C12N5/079 ,  A61K35/12

CPC classification number: A61K35/30 ,  A61K2035/124 ,  C12N5/0619 ,  C12N5/0622 ,  C12N2500/38 ,  C12N2500/90 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/13 ,  C12N2501/135 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2501/999 ,  C12N2506/097

Abstract: The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.

公开(公告)号：US10570369B2

公开(公告)日：2020-02-25

申请号：US15360555

申请日：2016-11-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Sandu Pitaru

IPC: C12N5/074 ,  C12N5/071 ,  A61K35/38

Abstract: The present invention provides a new readily accessible source of adult somatic stem cells from the gastrointestinal tract in general and oral mucosa in particular, methods for isolating pluripotent stem cells from oral mucosa, cells derived therefrom and uses thereof.

公开(公告)号：US20140335059A1

公开(公告)日：2014-11-13

申请号：US14359623

申请日：2012-11-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Sandu Pitaru ,  Javier Ganz ,  Daniel Offen ,  Eldad Melamed

IPC: A61K35/30 ,  C12N5/079

CPC classification number: A61K35/30 ,  A61K2035/124 ,  C12N5/0619 ,  C12N5/0622 ,  C12N2500/38 ,  C12N2500/90 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/13 ,  C12N2501/135 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2501/999 ,  C12N2506/097

Abstract: The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.

Abstract translation: 本发明提供了从口腔粘膜的成体干细胞分化的神经细胞用于神经和精神疾病和病症的细胞治疗的方法和用途。 还提供了将口腔粘膜干细胞分化为神经元或神经元支持细胞的方向的方法。

公开(公告)号：US20170137778A1

公开(公告)日：2017-05-18

申请号：US15360555

申请日：2016-11-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Sandu Pitaru

IPC: C12N5/074 ,  A61K35/38 ,  C12N5/071

Abstract: The present invention provides a new readily accessible source of adult somatic stem cells from the gastrointestinal tract in general and oral mucosa in particular, methods for isolating pluripotent stem cells from oral mucosa, cells derived therefrom and uses thereof.