公开(公告)号：US11649475B2

公开(公告)日：2023-05-16

申请号：US17058623

申请日：2019-05-24

Applicant: NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

Inventor： Doron Shabat ,  Michal Eli Roth-Konforti ,  Nir Hananya ,  Ori Green ,  Urs Spitz ,  Lukas Wick ,  Julian Ihssen ,  Raffael Vorberg ,  Riccardo Cribiu ,  Zuzana Babjakovà ,  Chunyan Yao

IPC: C07D321/00 ,  C07D407/04 ,  C12Q1/10 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/44 ,  C12Q1/54 ,  G01N21/76

CPC classification number: C12Q1/10 ,  C07D321/00 ,  C07D407/04 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/44 ,  C12Q1/54 ,  G01N21/76

Abstract: Dioxetane compounds represented by Formula I below, and methods of using the dioxetane compounds in the detection of presence or absence, quantification, and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, and fungi by means of chemiluminescence.

公开(公告)号：US20200093942A1

公开(公告)日：2020-03-26

申请号：US16616336

申请日：2018-05-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ori Green

IPC: A61K49/00 ,  C07D407/10

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.

公开(公告)号：US20240197924A1

公开(公告)日：2024-06-20

申请号：US18428591

申请日：2024-01-31

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ronit Satchi-Fainaro ,  Nir Hananya ,  Ori Green ,  Tal Eilon

IPC: A61K49/00 ,  C07D321/00 ,  C07F5/02 ,  C07F5/04 ,  C07F7/18 ,  C07F9/12 ,  C07F9/655 ,  C07H15/203 ,  C07H15/26 ,  C09B11/24 ,  C09B23/01 ,  C09B23/04 ,  C09B23/08 ,  C09K11/06

CPC classification number: A61K49/0052 ,  C07D321/00 ,  C07F5/025 ,  C07F5/04 ,  C07F7/1804 ,  C07F9/12 ,  C07F9/65512 ,  C07H15/203 ,  C07H15/26 ,  C09B11/24 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/083 ,  C09K11/06 ,  C09K2211/1018

Abstract: The present invention provides dioxctane-based chemiluminescence probes, more specifically fluorophore-tethered dioxctane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

公开(公告)号：US11179482B2

公开(公告)日：2021-11-23

申请号：US16850333

申请日：2020-04-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ronit Satchi-Fainaro ,  Nir Hananya ,  Ori Green ,  Tal Eilon

IPC: A61K49/00 ,  C07F5/04 ,  C07D321/00 ,  C09K11/06 ,  C07F9/655 ,  C07H15/26 ,  C09B11/24 ,  C09B23/04 ,  C09B23/08 ,  C07F9/12 ,  C09B23/01 ,  C07F5/02 ,  C07H15/203 ,  C07F7/18

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

公开(公告)号：US11931429B2

公开(公告)日：2024-03-19

申请号：US17451536

申请日：2021-10-20

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ronit Satchi-Fainaro ,  Nir Hananya ,  Ori Green ,  Tal Eilon

IPC: A61K49/00 ,  C07D321/00 ,  C07F5/02 ,  C07F5/04 ,  C07F7/18 ,  C07F9/12 ,  C07F9/655 ,  C07H15/203 ,  C07H15/26 ,  C09B11/24 ,  C09B23/01 ,  C09B23/04 ,  C09B23/08 ,  C09K11/06

CPC classification number: A61K49/0052 ,  C07D321/00 ,  C07F5/025 ,  C07F5/04 ,  C07F7/1804 ,  C07F9/12 ,  C07F9/65512 ,  C07H15/203 ,  C07H15/26 ,  C09B11/24 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/083 ,  C09K11/06 ,  C09K2211/1018

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

公开(公告)号：US11241507B2

公开(公告)日：2022-02-08

申请号：US16616336

申请日：2018-05-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ori Green

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  C07D407/10

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.

公开(公告)号：US10660974B2

公开(公告)日：2020-05-26

申请号：US16072848

申请日：2017-01-24

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron Shabat ,  Ronit Satchi-Fainaro ,  Nir Hananya ,  Ori Green ,  Tal Eilon

IPC: A61K49/00 ,  C07F5/04 ,  C07D321/00 ,  C07D405/00 ,  C07F9/655 ,  C07H15/26 ,  C09B11/24 ,  C09B23/04 ,  C09B23/08 ,  C09K11/06 ,  C07F9/12 ,  C09B23/01 ,  C07F5/02 ,  C07H15/203 ,  C07F7/18

Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.