公开(公告)号：US06524580B1

公开(公告)日：2003-02-25

申请号：US09504538

申请日：2000-02-15

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K3851

CPC分类号： A61K38/4893

摘要： A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method for treating hyperthyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a sympathetic ganglion which innervates the thyroid, thereby reducing a stimulatory effect upon thyroid hormone secretion. Methods for treating calcium metabolism disorders by local administration of a neurotoxin to modulate calcitonin secretion are also disclosed.

摘要翻译： 一种通过局部施用甲状腺毒素等神经毒素治疗甲状腺功能减退的方法，从而降低对甲状腺激素分泌的抑制作用。 通过局部施用神经毒素（例如肉毒杆菌毒素）治疗甲状腺功能亢进的方法，用于支配甲状腺的交感神经节，从而降低对甲状腺激素分泌的刺激作用。 还公开了通过局部施用神经毒素以调节降钙素分泌来治疗钙代谢紊乱的方法。

公开(公告)号：US06312708B1

公开(公告)日：2001-11-06

申请号：US09624003

申请日：2000-07-21

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K3902

CPC分类号： A61K9/0024 ,  A61K38/4893 ,  Y10S514/964

摘要： A controlled release system for multiphasic, in vivo release of therapeutic amounts of botulinum toxin in a human patient over a prolonged period of time. The controlled release system can comprise a plurality of botulinum toxin incorporating polymeric microspheres.

摘要翻译： 一种用于在长时间内在人类患者体内释放治疗量的肉毒杆菌毒素的多相体内释放系统。 控制释放系统可以包含掺入聚合物微球体的多种肉毒杆菌毒素。

公开(公告)号：US09297515B2

公开(公告)日：2016-03-29

申请号：US14568615

申请日：2014-12-12

申请人： Michael Stephen Donovan ,  Gurulingamurthy M. Haralur

发明人： Michael Stephen Donovan ,  Gurulingamurthy M. Haralur

IPC分类号： C08L71/00 ,  C08L79/08 ,  F21V7/22 ,  C08G79/00 ,  C08L71/10 ,  C08J5/22 ,  F21V7/00 ,  G02B1/10 ,  G02B27/00 ,  C08L79/04

摘要： The invention relates to a moisture resistant composition comprising: a) from 20 to 80 weight percent based on the total weight of the composition of a polyetherimide copolymer made from a monomer mixture comprising 3,3′ bisphenol-A dianhydride (BPADA), and 4,4′-diaminodiphenyl sulfone (DDS); b) from 5 to 75 weight percent based on the total weight of the composition of polyetheretherketone (PEEK); and c) from 0 to 30 weight percent based on the total weight of the composition of a filler. The invention relates to a reflector substrate comprising a moisture resistant layer metalized with a reflective layer, wherein the moisture resistant layer comprising the moisture resistant composition. The invention relates to a method for producing a metalized coating without a primer comprising applying a reflective layer directly to a moisture resistant layer in the absence of a primer, wherein the moisture resistant layer comprises the moisture resistant composition.

公开(公告)号：US08912272B2

公开(公告)日：2014-12-16

申请号：US12339920

申请日：2008-12-19

申请人： Michael Stephen Donovan ,  Gurulingamurthy M. Haralur ,  Daniel Lowery

发明人： Michael Stephen Donovan ,  Gurulingamurthy M. Haralur ,  Daniel Lowery

IPC分类号： C08L71/00 ,  C08L79/08 ,  C08L71/10 ,  C08G79/00 ,  C08J5/22 ,  C08L79/04

CPC分类号： F21V7/22 ,  C08G79/00 ,  C08G2650/40 ,  C08J5/2256 ,  C08J2379/08 ,  C08L71/00 ,  C08L71/10 ,  C08L79/04 ,  F21V7/0066 ,  G02B1/10 ,  G02B27/0006 ,  Y10T428/266 ,  Y10T428/31681 ,  C08L2666/20

摘要： The invention relates to a moisture resistant composition comprising: a) from 20 to 80 weight percent based on the total weight of the composition of a polyetherimide copolymer made from a monomer mixture comprising 3,3′ bisphenol-A dianhydride (BPADA), and 4,4′-diaminodiphenyl sulfone (DDS); b) from 5 to 75 weight percent based on the total weight of the composition of polyetheretherketone (PEEK); and c) from 0 to 30 weight percent based on the total weight of the composition of a filler. The invention relates to a reflector substrate comprising a moisture resistant layer metalized with a reflective layer, wherein the moisture resistant layer comprising the moisture resistant composition. The invention relates to a method for producing a metalized coating without a primer comprising applying a reflective layer directly to a moisture resistant layer in the absence of a primer, wherein the moisture resistant layer comprises the moisture resistant composition.

摘要翻译： 本发明涉及一种防潮组合物，其包含：a）基于由包含3,3'双酚A二酐（BPADA）的单体混合物制成的聚醚酰亚胺共聚物的组合物总重量的20至80重量％ ，4'-二氨基二苯砜（DDS）; b）基于聚醚醚酮（PEEK）组合物的总重量为5至75重量％; 和c）基于填料组合物的总重量，0至30重量％。 本发明涉及一种反射器基板，其包括用反射层金属化的防潮层，其中防潮层包括防湿组合物。 本发明涉及一种生产没有底漆的金属化涂层的方法，包括在不存在底漆的情况下将反射层直接涂覆在防潮层上，其中防潮层包括防湿组合物。

公开(公告)号：US08119563B2

公开(公告)日：2012-02-21

申请号：US10595298

申请日：2004-10-04

申请人： George Theodoridis ,  David Rosen ,  Shunxiang Zhang ,  Walter H. Yeager ,  Robert N. Henrie, II ,  Syed Z. Ahmed ,  Hongbin Men ,  Stephen Donovan

发明人： George Theodoridis ,  David Rosen ,  Shunxiang Zhang ,  Walter H. Yeager ,  Robert N. Henrie, II ,  Syed Z. Ahmed ,  Hongbin Men ,  Stephen Donovan

IPC分类号： A01N43/22 ,  C07D211/06

CPC分类号： C07D211/48 ,  A01N43/40 ,  A01N43/54 ,  A01N43/58 ,  A01N43/713 ,  A01N43/90 ,  A01N47/06 ,  A01N47/20 ,  A01N47/22 ,  C07D211/94 ,  C07D401/10 ,  C07D401/12 ,  C07D451/02 ,  C07D471/10

摘要： N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 由式（I）表示的N-取代的azacycle衍生物化合物：其中m，q，r，t和u独立地选自0或1; 且p为0,1,2或3; 并且A，B，D，X，Y，R，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10和R 11在本文中被完整描述。 还公开了特别可用于包含杀虫有效量的至少一种式I化合物和杀虫相容载体的化合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US07811587B2

公开(公告)日：2010-10-12

申请号：US11749461

申请日：2007-05-16

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K39/08

CPC分类号： A61K38/4893 ,  Y02A50/469 ,  Y10S514/937 ,  Y10S514/963

摘要： Methods for treating psychiatric disorders include intracranial administration of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A, to a human patient.

摘要翻译： 用于治疗精神疾病的方法包括向人类患者施用治疗有效量的神经毒素（例如A型肉毒毒素）的颅内给药。

公开(公告)号：US07736659B2

公开(公告)日：2010-06-15

申请号：US11924880

申请日：2007-10-26

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K39/08 ,  C07K14/00

CPC分类号： C07K14/33 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/642 ,  A61K48/00 ,  C07K7/22 ,  C07K2319/00

摘要： Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.

公开(公告)号：US20090031642A1

公开(公告)日：2009-02-05

申请号：US11933379

申请日：2007-10-31

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： E04H14/00

CPC分类号： E04B1/34815 ,  E04B1/3444 ,  E04B1/3483 ,  E04H1/06 ,  E04H3/02 ,  E06B7/086 ,  F24F5/0046 ,  F24F2007/004 ,  Y02A30/272 ,  Y02B10/20 ,  Y02B10/24

摘要： A building module is disclosed which moves between a collapsed configuration, where it is sized and shaped similarly to a standard shipping container, and an erected configuration where it forms a building of greater space. Braced panels are hinged to form walls in the collapsed configuration and floors or ceilings in the erected configuration. The modules may be connected together to form a single storied or multistoried building.

摘要翻译： 公开了一种建筑模块，其在折叠构型之间移动，其中其尺寸和形状类似于标准运输容器，以及竖立构型，其中它形成更大空间的建筑物。 支撑板被铰接以形成折叠构型的墙壁和竖立构型中的地板或天花板。 模块可以连接在一起形成单层或多层建筑。

公开(公告)号：US20090028908A1

公开(公告)日：2009-01-29

申请号：US12187230

申请日：2008-08-06

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K39/08 ,  A61P25/00

CPC分类号： A61K38/046 ,  A61K38/4893 ,  A61K2300/00

摘要： The present invention relates to methods for treating neurogenic inflammation pain. The methods include administering an effective amount of a composition which includes a botulinum toxin component and a substance P component to a patient, thereby treating the neurogenic inflammation pain.

公开(公告)号：US07413742B2

公开(公告)日：2008-08-19

申请号：US11466244

申请日：2006-08-22

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K39/08 ,  C07K14/00

CPC分类号： C07K14/33 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/642 ,  A61K48/00 ,  C07K7/22 ,  C07K2319/00

摘要： Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.