公开(公告)号：US08119563B2

公开(公告)日：2012-02-21

申请号：US10595298

申请日：2004-10-04

申请人： George Theodoridis ,  David Rosen ,  Shunxiang Zhang ,  Walter H. Yeager ,  Robert N. Henrie, II ,  Syed Z. Ahmed ,  Hongbin Men ,  Stephen Donovan

发明人： George Theodoridis ,  David Rosen ,  Shunxiang Zhang ,  Walter H. Yeager ,  Robert N. Henrie, II ,  Syed Z. Ahmed ,  Hongbin Men ,  Stephen Donovan

IPC分类号： A01N43/22 ,  C07D211/06

CPC分类号： C07D211/48 ,  A01N43/40 ,  A01N43/54 ,  A01N43/58 ,  A01N43/713 ,  A01N43/90 ,  A01N47/06 ,  A01N47/20 ,  A01N47/22 ,  C07D211/94 ,  C07D401/10 ,  C07D401/12 ,  C07D451/02 ,  C07D471/10

摘要： N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 由式（I）表示的N-取代的azacycle衍生物化合物：其中m，q，r，t和u独立地选自0或1; 且p为0,1,2或3; 并且A，B，D，X，Y，R，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10和R 11在本文中被完整描述。 还公开了特别可用于包含杀虫有效量的至少一种式I化合物和杀虫相容载体的化合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US20090215821A1

公开(公告)日：2009-08-27

申请号：US10595298

申请日：2004-10-04

申请人： George Theodoridis ,  David Rosen ,  Shunxiang Zhang ,  Walter H. Yeager ,  Robert N. Henrie, II ,  Syed Z. Ahmed ,  Hongbin Men ,  Stephen Donovan

发明人： George Theodoridis ,  David Rosen ,  Shunxiang Zhang ,  Walter H. Yeager ,  Robert N. Henrie, II ,  Syed Z. Ahmed ,  Hongbin Men ,  Stephen Donovan

IPC分类号： A01N43/40 ,  C07D211/48 ,  C07D401/12

CPC分类号： C07D211/48 ,  A01N43/40 ,  A01N43/54 ,  A01N43/58 ,  A01N43/713 ,  A01N43/90 ,  A01N47/06 ,  A01N47/20 ,  A01N47/22 ,  C07D211/94 ,  C07D401/10 ,  C07D401/12 ,  C07D451/02 ,  C07D471/10

摘要： N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 由式（I）表示的N-取代的azacycle衍生物化合物：其中m，q，r，t和u独立地选自0或1; 且p为0,1,2或3; 并且A，B，D，X，Y，R，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10和R 11在本文中被完整描述。 还公开了特别可用于包含杀虫有效量的至少一种式I化合物和杀虫相容载体的化合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US07365082B2

公开(公告)日：2008-04-29

申请号：US10538997

申请日：2003-12-08

申请人： Ping Ding ,  Robert N. Henrie, II ,  Daniel H. Cohen ,  John W. Lyga ,  David S. Rosen ,  George Theodoridis ,  Qun Zhang ,  Walter H. Yeager ,  Stephen F. Donovan ,  Steven Shunxiang Zhang ,  Inna Shulman ,  Seong Jae Yu ,  Guozhi Wang ,  Y. Larry Zhang ,  Ariamala Gopalsamy ,  Dennis L. Warkentin ,  Paul E. Rensner ,  Ian R. Silverman ,  Thomas G. Cullen

发明人： Ping Ding ,  Robert N. Henrie, II ,  Daniel H. Cohen ,  John W. Lyga ,  David S. Rosen ,  George Theodoridis ,  Qun Zhang ,  Walter H. Yeager ,  Stephen F. Donovan ,  Steven Shunxiang Zhang ,  Inna Shulman ,  Seong Jae Yu ,  Guozhi Wang ,  Y. Larry Zhang ,  Ariamala Gopalsamy ,  Dennis L. Warkentin ,  Paul E. Rensner ,  Ian R. Silverman ,  Thomas G. Cullen

IPC分类号： A61K31/44 ,  A61K31/445 ,  A61K31/4422 ,  C07D211/06 ,  C07D211/08 ,  C07D211/70 ,  C07D211/82

CPC分类号： C07D405/14 ,  A01N43/40 ,  A01N43/54 ,  A01N43/713 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/24 ,  C07D211/26 ,  C07D211/28 ,  C07D211/32 ,  C07D211/94 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D451/14 ,  C07D513/04

摘要： It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is CH or N; and B, D, E, R, R1, R2, R3, R4, R5, R6, R7 and R8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 现在已经发现某些新的N-（取代的芳基）-4-（二取代的甲基）哌啶和吡啶衍生物提供了意想不到的杀虫活性。 这些化合物由式（I）表示：其中m，n，q，r和s独立地选自0或1; 且p为0,1,2或3; A是CH或N; 和B，D，E，R，R 1，R 2，R 3，R 4，R 本文完全描述了本发明的第5，第6，第七和第八和第八。 此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US07683070B2

公开(公告)日：2010-03-23

申请号：US11874015

申请日：2007-10-17

申请人： Ping Ding ,  Robert N. Henrie, II ,  Daniel H. Cohen ,  John W. Lyga ,  David S. Rosen ,  George Theodoridis ,  Qun Zhang ,  Walter H. Yeager ,  Stephen F. Donovan ,  Stephen Shunxiang Zhang ,  Inna Shulman ,  Seong Jae Yu ,  Guozhi Wang ,  Y. Larry Zhang ,  Ariamala Gopalsamy ,  Dennis L. Warkentin ,  Paul E. Rensner ,  Ian R. Silverman ,  Thomas G. Cullen

发明人： Ping Ding ,  Robert N. Henrie, II ,  Daniel H. Cohen ,  John W. Lyga ,  David S. Rosen ,  George Theodoridis ,  Qun Zhang ,  Walter H. Yeager ,  Stephen F. Donovan ,  Stephen Shunxiang Zhang ,  Inna Shulman ,  Seong Jae Yu ,  Guozhi Wang ,  Y. Larry Zhang ,  Ariamala Gopalsamy ,  Dennis L. Warkentin ,  Paul E. Rensner ,  Ian R. Silverman ,  Thomas G. Cullen

IPC分类号： A61K31/4523 ,  A61K31/4545 ,  C07D211/06 ,  C07D239/02

CPC分类号： C07D405/14 ,  A01N43/40 ,  A01N43/54 ,  A01N43/713 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/24 ,  C07D211/26 ,  C07D211/28 ,  C07D211/32 ,  C07D211/94 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D451/14 ,  C07D513/04

摘要： It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R1, R2, R3, R4, R5, R6, R7 and R8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 现在已经发现某些新的N-（取代的芳基）-4-（二取代的甲基）哌啶和吡啶衍生物提供了意想不到的杀虫活性。 这些化合物由式（I）表示：其中m，n，q，r和s独立地选自0或1; 且p为0,1,2或3; A是C或CH; 本文完整地描述了B，D，E，R，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8。 此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US07300946B2

公开(公告)日：2007-11-27

申请号：US10538998

申请日：2003-12-08

申请人： Ping Ding ,  Robert N. Henrie, II ,  Daniel H. Cohen ,  John W. Lyga ,  David S. Rosen ,  George Theodoridis ,  Qun Zhang ,  Walter H. Yeager ,  Stephen F. Donovan ,  Steven Shunxiang Zhang ,  Inna Shulman ,  Seong Jae Yu ,  Guozhi Wang ,  Y. Larry Zhang ,  Ariamala Gopalsamy ,  Dennis L. Warkentin ,  Paul E. Rensner ,  Ian R. Silverman ,  Thomas G. Cullen

发明人： Ping Ding ,  Robert N. Henrie, II ,  Daniel H. Cohen ,  John W. Lyga ,  David S. Rosen ,  George Theodoridis ,  Qun Zhang ,  Walter H. Yeager ,  Stephen F. Donovan ,  Steven Shunxiang Zhang ,  Inna Shulman ,  Seong Jae Yu ,  Guozhi Wang ,  Y. Larry Zhang ,  Ariamala Gopalsamy ,  Dennis L. Warkentin ,  Paul E. Rensner ,  Ian R. Silverman ,  Thomas G. Cullen

IPC分类号： A61K31/44 ,  A61K31/445 ,  A61K31/4422 ,  C07D211/06 ,  C07D211/08 ,  C07D211/70 ,  C07D211/82

CPC分类号： C07D405/14 ,  A01N43/40 ,  A01N43/54 ,  A01N43/713 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/24 ,  C07D211/26 ,  C07D211/28 ,  C07D211/32 ,  C07D211/94 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D451/14 ,  C07D513/04

摘要： It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R1, R2, R3, R4, R5, R6, R7 and R8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present

摘要翻译： 现在已经发现，某些新的N-（取代的芳基）-4（二取代的甲基）哌啶和吡啶衍生物已经提供了意想不到的杀虫活性。 这些化合物由式（I）表示：其中m，n，q，r和s独立地选自0或1; 且p为0,1,2或3; A是C或CH; 和B，D，E，R，R 1，R 2，R 3，R 4，R 本文中充分描述了本发明的第5，第6，第七和第八和第八。 此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所

公开(公告)号：US5939438A

公开(公告)日：1999-08-17

申请号：US150424

申请日：1998-09-09

申请人： Walter H. Yeager ,  Ian R. Silverman ,  Robert N. Henrie, II ,  Thomas G. Cullen ,  Clinton J. Peake

发明人： Walter H. Yeager ,  Ian R. Silverman ,  Robert N. Henrie, II ,  Thomas G. Cullen ,  Clinton J. Peake

IPC分类号： A01N43/40 ,  A01N47/02 ,  A01N47/24 ,  C07D211/28 ,  C07D211/94 ,  C07D211/18 ,  C07D211/26

CPC分类号： C07D211/28 ,  A01N43/40 ,  A01N47/02 ,  A01N47/24 ,  C07D211/94

摘要： It has now been found that certain novel oximino and hydrazono derivatives of N-benzyl-4-benzhydryl- and 4-benhydrolpiperidines, and their corresponding N-oxides and agriculturally acceptable salts are useful as insecticides. These compounds are represented by Formula I: where R is hydrogen, halogen, alkyl, alkoxy, dialkylamino; R.sup.1 is hydrogen, alkyl, haloalkyl, alkoxyalkyl, alkylcarbonyl and alkylaminocarbonyl; X is oxygen, or NR.sup.2, Q is fluoro and hydroxy; Z is halogen, haloalkyl, haloalkoxy, pentahalothio, haloalkylthio, haloalkylsulfinyl, haloalkylsulfonyl, and --OCF.sub.2 O-- attached to two adjacent carbon atoms of the phenyl ring; n is 0 or 1; and, when X is NR.sup.2, R.sup.2 is hydrogen, alkyl, alkylcarbonyl, alkoxycarbonyl, or R.sup.1 and R.sup.2 taken together may be --C.sub.m H.sub.2.spsb.m, or --C.sub.2 H.sub.4 OC.sub.2 H.sub.4 --, where m is 3-9. Preferred compounds include those where R is hydrogen; R.sup.1 is alkyl; Q is hydroxy; X is oxygen; and Z is trifluoromethyl or trifluoromethoxy.

摘要翻译： 现已发现，N-苄基-4-二苯甲基 - 和4-苯氢哌啶的某些新的肟基和亚氨基衍生物及其相应的N-氧化物和农业上可接受的盐可用作杀虫剂。 这些化合物由式I表示：其中R是氢，卤素，烷基，烷氧基，二烷基氨基; R1是氢，烷基，卤代烷基，烷氧基烷基，烷基羰基和烷基氨基羰基; X是氧，或NR 2，Q是氟和羟基; Z是苯环的两个相邻碳原子上的卤素，卤代烷基，卤代烷氧基，五卤代硫代，卤代烷硫基，卤代烷基亚磺酰基，卤代烷基磺酰基和-OCF 2 O-。 n为0或1; 并且当X为NR 2时，R 2为氢，烷基，烷基羰基，烷氧基羰基，或者R 1和R 2一起可以是-C m H 2m或-C 2 H 4 OC 2 H 4 - ，其中m为3-9。 优选的化合物包括其中R为氢的化合物; R1是烷基; Q是羟基; X是氧; Z是三氟甲基或三氟甲氧基。

公开(公告)号：US5534518A

公开(公告)日：1996-07-09

申请号：US267340

申请日：1994-06-28

申请人： Robert N. Henrie, II ,  Clinton J. Peake ,  Thomas G. Cullen ,  Albert C. Lew ,  Munirathnam K. Chaguturu ,  Partha S. Ray ,  Walter H. Yeager ,  Ian R. Silverman ,  John W. Buser ,  James J. Fiordeliso ,  John A. Dixson

发明人： Robert N. Henrie, II ,  Clinton J. Peake ,  Thomas G. Cullen ,  Albert C. Lew ,  Munirathnam K. Chaguturu ,  Partha S. Ray ,  Walter H. Yeager ,  Ian R. Silverman ,  John W. Buser ,  James J. Fiordeliso ,  John A. Dixson

IPC分类号： A01N43/54 ,  A01N55/00 ,  C07D239/95 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  A61K31/505

CPC分类号： C07D401/12 ,  A01N43/54 ,  A01N55/00 ,  C07D239/95 ,  C07D405/04 ,  C07D409/04

摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 2,4-diaminoquinazoline compound of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.6, R.sup.7, W, X, Y, and Z are as defined herein; methods of using the same; novel 2,4-diaminoquinazolines per se; and intermediates in the preparation thereof.

公开(公告)号：US5616718A

公开(公告)日：1997-04-01

申请号：US426541

申请日：1995-04-20

申请人： Robert N. Henrie, II ,  Clinton J. Peake ,  Thomas G. Cullen ,  Walter H. Yeager ,  John W. Buser ,  James J. Fiordeliso ,  John A. Dixson

发明人： Robert N. Henrie, II ,  Clinton J. Peake ,  Thomas G. Cullen ,  Walter H. Yeager ,  John W. Buser ,  James J. Fiordeliso ,  John A. Dixson

IPC分类号： A01N43/54 ,  A01N55/00 ,  C07D239/95 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D213/26 ,  C07D323/02 ,  C07D327/04 ,  C07D339/06

CPC分类号： C07D401/12 ,  A01N43/54 ,  A01N55/00 ,  C07D239/95 ,  C07D405/04 ,  C07D409/04

摘要： A compound having the formula: ##STR1## wherein W, X, Y, and Z are as defined in the specification is useful for making 2,4-diaminoquinazolines.

摘要翻译： 具有下式的化合物：其中W，X，Y和Z如本说明书中所定义，可用于制备2,4-二氨基喹唑啉。

公开(公告)号：US5587379A

公开(公告)日：1996-12-24

申请号：US446354

申请日：1995-05-22

申请人： Robert N. Henrie, II ,  Clinton J. Peake ,  Thomas G. Cullen ,  Albert C. Lew ,  Munirathnam K. Chaguturu ,  Partha S. Ray ,  Walter H. Yeager

发明人： Robert N. Henrie, II ,  Clinton J. Peake ,  Thomas G. Cullen ,  Albert C. Lew ,  Munirathnam K. Chaguturu ,  Partha S. Ray ,  Walter H. Yeager

IPC分类号： A01N43/54 ,  A01N43/78 ,  A01N43/84 ,  A01N47/18 ,  A01N47/20 ,  A01N55/00 ,  C07D239/00 ,  C07D401/00 ,  C07D409/00 ,  C07D413/00 ,  C07F7/08

CPC分类号： C07F7/0812 ,  A01N43/54 ,  A01N43/84 ,  A01N47/18 ,  A01N47/20 ,  A01N55/00

摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a compound of the formula: ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.7, R.sup.8, m, n, and p are as defined herein, and agriculturally acceptable salts thereof, and methods of using the same.

公开(公告)号：US5622954A

公开(公告)日：1997-04-22

申请号：US398205

申请日：1995-03-02

申请人： Robert N. Henrie, II ,  Clinton J. Peake ,  Thomas G. Cullen ,  Walter H. Yeager ,  Mary E. Brown ,  John W. Buser

发明人： Robert N. Henrie, II ,  Clinton J. Peake ,  Thomas G. Cullen ,  Walter H. Yeager ,  Mary E. Brown ,  John W. Buser

IPC分类号： A01N43/54 ,  C07D239/48 ,  C07D239/49 ,  C07D401/06 ,  C07D401/14 ,  C07F7/08

CPC分类号： C07D239/49 ,  A01N43/54 ,  C07D401/06 ,  C07D401/14 ,  C07F7/0812

摘要： 5-Substituted-2,4-diaminopyrimidines, and agriculturally acceptable salts thereof, when present in insecticidally or acaricidally effective amounts, and with a suitable agricultural carrier, are useful as active ingredients in novel insecticidal and acaricidal compositions. These pyrimidines may be represented by the following formula: ##STR1## wherein Ar is ##STR2## and wherein U is an alkenylene or alkynylene moiety, and R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, V, W, X, Y, Z and n are as defined herein; also disclosed and claimed are novel intermediates thereof.

摘要翻译： 5-取代的2,4-二氨基嘧啶及其农业上可接受的盐当以杀虫或杀螨有效量存在时，并且与合适的农业载体一起可用作新的杀虫和杀螨组合物中的活性成分。 这些嘧啶可以由下式表示：其中Ar为“IMA”，其中U为亚烯基或亚炔基部分，R 1，R 2，R 3，R 4，V，W，X，Y Z和n如本文所定义; 还公开并要求保护的是其新颖的中间体。