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公开(公告)号：US20120276558A1
公开(公告)日：2012-11-01
申请号：US13544053
申请日：2012-07-09
申请人： David Soper , David Rosen , Todd Covey , Ying-Wen Huang , Wenday Fantl , Ralph Lin
发明人： David Soper , David Rosen , Todd Covey , Ying-Wen Huang , Wenday Fantl , Ralph Lin
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , G01N33/5011 , G01N33/5041 , G01N33/5094 , G01N33/6845 , G01N33/80 , G01N2440/14 , G01N2510/00
摘要： As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.
摘要翻译： 如本文所公开的，本发明提供用于诊断，预后，药物发现，药物开发和患者分层的试剂盒和组合物。 试剂盒可以包含用于细胞表面标记的多个结合元件，以及用于状态特异性细胞内标记物的多个结合元件。 试剂盒还可以包含针对特定细胞功能或信号传导途径的多个调节剂。 试剂盒还可以包括固定剂，渗透剂，缓冲液，容器，说明书和用于数据分析/汇编的软件。
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公开(公告)号：US20110105401A1
公开(公告)日：2011-05-05
申请号：US12968532
申请日：2010-12-15
摘要： The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.
摘要翻译： 本发明是刺激骨组织和软骨等硬组织形成的肽化合物。 本发明还涉及使用肽治疗硬组织如骨和软骨中的缺陷的方法。 本发明的方法可用于治疗或预防由类风湿性关节炎或骨关节炎引起的骨骼和软骨中的缺陷，其涉及在缺损中或周围新骨或软骨的再生。
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公开(公告)号：US07888462B2
公开(公告)日：2011-02-15
申请号：US12018080
申请日：2008-01-22
IPC分类号： C07K14/00
摘要： The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.
摘要翻译： 本发明是刺激骨组织和软骨等硬组织形成的肽化合物。 本发明还涉及使用肽治疗硬组织如骨和软骨中的缺陷的方法。 本发明的方法可用于治疗或预防由类风湿性关节炎或骨关节炎引起的骨骼和软骨中的缺陷，其涉及在缺损中或周围新骨或软骨的再生。
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公开(公告)号：US07860594B2
公开(公告)日：2010-12-28
申请号：US11787614
申请日：2007-04-17
IPC分类号： G02B1/04 , G02B1/12 , C08F290/06 , B28B17/00 , B28B1/14 , G02C7/02 , A61B3/10 , B29D11/00 , B29D7/01 , B29C35/04 , G06F19/00
CPC分类号： G03F7/0037 , B29C64/135 , B29D11/00442 , B33Y10/00 , B33Y50/00 , B33Y70/00 , B33Y80/00 , C08G18/6212 , C08G18/672 , C08L75/16 , G02B1/043 , C08G18/62 , C08G18/66
摘要： The present invention provides a method for making an ophthalmic device. In particular, the present invention provides a method for production of a contact lens by means of stereolithography. A preferred stereolithography technique is based on polymerization and solidification of a contact lens forming liquid material by actinic irradiation one layer at a time. In addition, the present invention provides systems and methods for making a contact lens for a specific patient based on the prescription.
摘要翻译： 本发明提供了一种制造眼科装置的方法。 特别地，本发明提供了一种通过立体光刻法制造隐形眼镜的方法。 优选的立体光刻技术是基于通过光化辐射形成液体材料的接触透镜聚合和凝固一次一层。 此外，本发明提供了基于处方为特定患者制造隐形眼镜的系统和方法。
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公开(公告)号：US07685231B2
公开(公告)日：2010-03-23
申请号：US11696545
申请日：2007-04-04
申请人： James John Bohannon , Andre Burgoyne , David Rosen
发明人： James John Bohannon , Andre Burgoyne , David Rosen
IPC分类号： G06F15/16
CPC分类号： G06Q30/02 , G06Q30/0601
摘要： A method and system are herein disclosed for registering a member at a targeted web-based information management system using a reduced amount of member and system interaction to confirm and establish the member's contact information. Generally, the method may communicate permission to solicit a potential member to the information management system. In one embodiment, the member previously communicated permission to receive solicitations from other systems to another web-based information management system. The method may communicate the permission from another web-based system to the present system. The permission may include member identification and/or demographic data. The method may communicate a solicitation message from the system to the member, the solicitation message comprising at least a portion of the member identification data. The member may then communicate a confirmation message to the targeted web-based information management system, wherein the confirmation message is in reply to the solicitation message and includes the portion of the member identification data. Using the confirmation, the system may then match the portion of the member identification data from the confirmation message to the portion of the member identification data from the confirmation message.
摘要翻译： 这里公开了一种方法和系统，用于使用减少的成员和系统交互的数量在目标的基于web的信息管理系统上登记成员以确认和建立成员的联系信息。 通常，该方法可以传达许可以向潜在的成员请求信息管理系统。 在一个实施例中，该成员先前传达了许可以从其他系统接收另一个基于web的信息管理系统的请求。 该方法可以将来自另一个基于web的系统的许可传达给本系统。 许可可以包括成员标识和/或人口统计数据。 该方法可以将来自系统的请求消息传达给成员，该请求消息包括成员标识数据的至少一部分。 成员然后可以向目标基于web的信息管理系统传送确认消息，其中所述确认消息是响应于所述请求消息并且包括所述成员标识数据的所述部分。 使用该确认，系统然后可以将来自确认消息的成员标识数据的部分与来自确认消息的成员标识数据的部分相匹配。
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公开(公告)号：US20090215821A1
公开(公告)日：2009-08-27
申请号：US10595298
申请日：2004-10-04
申请人： George Theodoridis , David Rosen , Shunxiang Zhang , Walter H. Yeager , Robert N. Henrie, II , Syed Z. Ahmed , Hongbin Men , Stephen Donovan
发明人： George Theodoridis , David Rosen , Shunxiang Zhang , Walter H. Yeager , Robert N. Henrie, II , Syed Z. Ahmed , Hongbin Men , Stephen Donovan
IPC分类号： A01N43/40 , C07D211/48 , C07D401/12
CPC分类号： C07D211/48 , A01N43/40 , A01N43/54 , A01N43/58 , A01N43/713 , A01N43/90 , A01N47/06 , A01N47/20 , A01N47/22 , C07D211/94 , C07D401/10 , C07D401/12 , C07D451/02 , C07D471/10
摘要： N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要翻译： 由式（I）表示的N-取代的azacycle衍生物化合物：其中m，q，r，t和u独立地选自0或1; 且p为0,1,2或3; 并且A，B，D，X，Y，R，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10和R 11在本文中被完整描述。 还公开了特别可用于包含杀虫有效量的至少一种式I化合物和杀虫相容载体的化合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。
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公开(公告)号：US20090074876A1
公开(公告)日：2009-03-19
申请号：US12018080
申请日：2008-01-22
摘要： The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.
摘要翻译： 本发明是刺激骨组织和软骨等硬组织形成的肽化合物。 本发明还涉及使用肽治疗硬组织如骨和软骨中的缺陷的方法。 本发明的方法可用于治疗或预防由类风湿性关节炎或骨关节炎引起的骨骼和软骨中的缺陷，其涉及在缺损中或周围新骨或软骨的再生。
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公开(公告)号：US20070178012A1
公开(公告)日：2007-08-02
申请号：US11488901
申请日：2006-07-18
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , B01L3/5085 , B01L9/523 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , G01N21/0303 , G01N21/55 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/0382 , G01N2201/0634
摘要： Methods and apparatus for imaging a sample using a microwell array are provided. The methods and apparatus allow side view imaging of a sample to acquire fluorescence or bright field images.
摘要翻译： 提供了使用微孔阵列成像样品的方法和装置。 所述方法和装置允许样品的侧视图成像以获取荧光或明场图像。
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9.发明授权Bone growth factors and inhibitors of bone resorption for promoting bone formation 失效骨生长因子和促进骨形成的骨吸收抑制剂
公开(公告)号：US5118667A
公开(公告)日：1992-06-02
申请号：US695310
申请日：1991-05-03
申请人： Steven W. Adams , Rosa Armstrong , David Rosen
发明人： Steven W. Adams , Rosa Armstrong , David Rosen
IPC分类号： A61K31/135 , A61K31/505 , A61K31/565 , A61K31/66 , A61K33/16 , A61K38/18 , A61K38/22 , A61K38/23 , A61K38/27 , A61K45/00 , A61K45/06 , A61P3/00 , A61P3/02 , A61P19/10 , A61P35/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/138 , A61K31/565 , A61K31/663 , A61K38/1841 , A61K38/23
摘要： Bone growth factors are used to stimulate new bone formation when administered with agents that inhibit bone resorption. These therapeutic combinations result in an enhanced rate of bone formation with an increase in bone mass.
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公开(公告)号：US4091758A
公开(公告)日：1978-05-30
申请号：US735905
申请日：1976-10-26
申请人： Carl-David Rosen
发明人： Carl-David Rosen
CPC分类号： B63H25/04
摘要： A wind-operated automatic steering gear for water-going vessels includes a wind vane, a main steering rudder, and a servo-rudder hinged to the rear end of the steering rudder. The wind vane is connected to the servo-rudder to move the latter and correct deviations in the course of vessel travel. A resetting mechanism is connected between the steering rudder and the wind vane to move the wind vane in response to movement of the steering rudder and thereby cause the wind vane to return to neutral position so that over correction of the vessel travel is prevented.
摘要翻译： 用于水龙头的风力自动舵机包括风向标，主转向舵和与转向舵的后端铰接的伺服舵。 风向标与伺服方向舵相连，以便在船舶行驶过程中纠正偏差。 转向机构连接在转向舵和风向标之间，以响应于转向舵的移动而使风向标移动，从而使风向标回到中立位置，从而防止了船舶行程的过度校正。
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