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公开(公告)号：US11892530B2
公开(公告)日：2024-02-06
申请号：US16992163
申请日：2020-08-13
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Yael Mardor , Leor Zach , David Guez , David Last , Dianne Daniels Elmakias
IPC: G01R33/28 , G01R33/56 , G01R33/48 , A61B5/055 , A61B5/00 , G06T7/00 , G16H40/40 , G16H30/40 , G16H40/63 , A61K31/166 , A61K31/7068 , A61K31/555
CPC classification number: G01R33/281 , A61B5/0042 , A61B5/055 , A61B5/4842 , A61B5/4848 , A61B5/7275 , G01R33/4806 , G01R33/5601 , G01R33/5608 , G06T7/0016 , G16H30/40 , G16H40/40 , G16H40/63 , A61B2576/026 , A61K31/166 , A61K31/555 , A61K31/7068 , A61K2300/00 , G06T2207/10096 , G06T2207/30016 , G06T2207/30096
Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
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公开(公告)号：US20240033246A1
公开(公告)日：2024-02-01
申请号：US18256747
申请日：2021-12-09
Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organiza , Tel Hashomer Medical Research Infrastructure and Services Ltd.
Inventor： Anat Elmann , Ygal Rotenstreich , Ifat Sher
IPC: A61K31/353 , A61P27/02 , A61K9/00 , A61K36/28
CPC classification number: A61K31/353 , A61P27/02 , A61K9/0048 , A61K36/28
Abstract: The invention concerns 3,5,4′-trihydroxy-6,7,3′-trimethoxyflavone (TTF) or a pharmaceutically acceptable salt or solvate thereof for use in treating, preventing, or ameliorating an eye disease or disorder, or for providing adjunct treatment to an ocular therapeutic procedure. The invention also concerns ophthalmic compositions comprising TTF.
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公开(公告)号：US20230287512A1
公开(公告)日：2023-09-14
申请号：US18130852
申请日：2023-04-04
Inventor： Eyal GREENBERG , Gilli GALORE-HASKEL , Efrat MERHAVI-SHOHAM , Gal MARKEL
IPC: C12Q1/6886 , G01N33/574
CPC classification number: C12Q1/6886 , G01N33/57484 , C12Q2600/158 , G01N2800/52
Abstract: Methods of determining suitability of a subject to be treated with a PD-1/PD-L1 based immunotherapy, comprising receiving a sample from the subject and determining HVEM levels in the sample, wherein expression of HVEM above a predetermined threshold indicates the subject is suitable to be treated by the immunotherapy or of determining suitability of a subject non-responsive to a PD-1/PD-L1 based immunotherapy to be treated by an HVEM based immunotherapy, comprising receiving a sample from the subject and determining T cell levels in the sample, wherein T cell levels above a predetermined threshold indicates the subject is suitable to be treated by the HVEM based immunotherapy are provided.
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公开(公告)号：US20230123731A1
公开(公告)日：2023-04-20
申请号：US17910304
申请日：2021-03-30
Applicant: Minovia Therapeutics Ltd. , Tel Hashomer Medical Research Infrastructure and Services Ltd.
Inventor： Natalie Yivgi-Ohana , Noa Sher , Moriya Blumkin , Elad Jacoby
IPC: A61K35/17 , C12N5/0783 , C12N15/86 , A61K38/17 , A61K35/545
Abstract: The present invention is based on the discovery that cells enriched with mitochondria are useful for treating diseases and disorders. Disclosed are pharmaceutical compositions of mitochondrially-enriched genetically engineered T cells and methods of treatment using mitochondrially-enriched genetically engineered T cells.
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公开(公告)号：US11547525B2
公开(公告)日：2023-01-10
申请号：US16972601
申请日：2019-06-06
Applicant: THE MEDICAL RESEARCH INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventor： Amihay Shinfeld , Yoav Paz , Emanuel Mendes , Joseph Feldman
Abstract: An endotracheal tube cleaning device, including a rod, and a cleaning head coupled to a distal end of the rod, including a low friction-generating surface; and a high friction-generating surface, wherein the low friction-generating surface contacts an inner surface of the endotracheal tube when moved along the tube in a first direction and the high friction-generating surface contacts the inner surface of the endotracheal tube when moved in a second, opposite direction.
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Patent Agency Ranking
公开(公告)号：US11517348B2
公开(公告)日：2022-12-06
申请号：US16609492
申请日：2018-05-03
Inventor： Waseem Abboud
Abstract: A guide device for TMJ arthroscopy including one or more pairs of arms pivotly connected at one end to a working cannula holder and defining a working cannula axis; and at the opposite end to at one or more arms via one or more pivot connections to form with the arm one or more adjustable parallelograms, an end of the arm is connected to an irrigation cannula holder defining an irrigation cannula axis, the irrigation cannula axis intersecting with the working cannula axis at an intersection, intersection and one or more of the pivot connections between connecting the arms are located at opposing vertices of one or more of the adjustable parallelograms.
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97.发明申请公开(公告)号：US20220298539A1
公开(公告)日：2022-09-22
申请号：US17631162
申请日：2020-07-23
Inventor： David ORION , Zeev ITSEKSON-HAYOSH , Efrat SHAVIT-STEIN , Joab CHAPMAN
IPC: C12Q1/56
Abstract: Provided herein are method and kits for identifying thrombus origin based on temporal thrombin activity assay, and use thereof for optimizing post-ischemic event treatment, and further preventing recurrence of secondary ischemic events.
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公开(公告)号：US20220202553A1
公开(公告)日：2022-06-30
申请号：US17604037
申请日：2020-04-16
Inventor： Ram Nozyk , Moshe Halak
Abstract: Apparatus and methods are described for capturing emboli during a medical procedure that is performed at a first location within a subjects body. An intravascular device (24) is configured to perform the medical procedure at the first location. An inner sheath (32) facilitates insertion of the intravascular device (24) into the subjects body, by the intravascular device being inserted via a lumen (31) of the inner sheath (32). A filter (34) extending from a distal-most portion (42) of the inner sheath (32) has a non-radially-constrained configuration in which the filter (34) is configured to prevent at least some emboli that are generated by the medical procedure from passing through the filter (34). Other applications are also described.
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公开(公告)号：US20220175860A1
公开(公告)日：2022-06-09
申请号：US17594084
申请日：2020-04-01
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , NIKKEN SOHONSHA CORPORATION
Inventor： Aviv SHAISH , Dror HARATS , Michal BEERI , Irit LUBITZ
Abstract: The present invention provides neuroprotective preparations, specifically, Dunaliella alga preparations and uses thereof in the treatment and prophylaxis of neurodegenerative disorders, protein misfolding and cognitive decline.
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公开(公告)号：US20220162284A1
公开(公告)日：2022-05-26
申请号：US17591620
申请日：2022-02-03
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady KOSTENICH , Mor ORON-HERMAN , Arie ORENSTEIN , Talia SHEKHTER ZAHAVI , Ehud GAZIT , Yoseph SALITRA , Ludmilla BUZHANSKY
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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