公开(公告)号：US20210346654A1

公开(公告)日：2021-11-11

申请号：US17250957

申请日：2019-10-04

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Sandeep NATHAN

IPC: A61M25/09 ,  A61M25/00

Abstract: The present disclosure includes an integrated catheter system for cannulation of a LIMA graft from a right radial access point. Some integrated catheter systems include a guide catheter comprising an elongated member having an outer sheath body portion that includes an outer sheath proximal end, an outer sheath distal end, and an outer sheath lumen extending through the outer sheath between the outer sheath proximal end and the outer sheath distal end, the outer sheath including a curved section that includes: a first curved segment, a second curved segment, a third curved segment, a fourth curved segment, a first extended segment between the third curved segment and the fourth curved segment, and a second extended segment between the fourth curved segment and the outer sheath distal end.

公开(公告)号：US20210334081A1

公开(公告)日：2021-10-28

申请号：US17273938

申请日：2019-09-12

Applicant: University of Chicago

Inventor： Frederic T. Chong ,  Yunong Shi, I ,  Nelson Leung ,  Pranav Gokhale ,  Henry Hoffmann ,  David Schuster

IPC: G06F8/41 ,  G06N10/00 ,  G06F9/48

Abstract: A quantum computing system includes a quantum processor having a plurality of qubits, a classical memory, and a classical processor. The classical processor is configured to compile a quantum program into logical assembly instructions in an intermediate language, aggregate the logical assembly instructions together into a plurality of logical blocks of instructions, generate a logical schedule for the quantum program based on commutativity between the plurality of logical blocks, generate a tentative physical schedule based on the logical schedule, the tentative physical schedule includes a mapping of the logical assembly instructions in the logical schedule onto the plurality of qubits of the quantum processor, aggregate instructions together within the tentative physical schedule that do not reduce parallelism, thereby generating an updated physical schedule; generate optimized control pulses for the aggregated instructions, and execute the quantum program on the quantum processor with the optimized control pulses and the updated physical schedule.

公开(公告)号：US20210290763A1

公开(公告)日：2021-09-23

申请号：US17256403

申请日：2019-06-28

Applicant: LOYOLA UNIVERSITY OF CHICAGO

Inventor： Daniel Paul Becker ,  Marlon Ray Lutz

IPC: A61K41/00 ,  C07F7/08 ,  A61K47/54

Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.

公开(公告)号：US20210272233A1

公开(公告)日：2021-09-02

申请号：US17253840

申请日：2019-06-20

Applicant: The University of Chicago

Inventor： Imre Kondor ,  Shubhendu Trivedi ,  Zhen Lin

IPC: G06T3/00 ,  G06N3/04 ,  G06N3/08 ,  G06F17/14 ,  G06K9/62 ,  G06T15/08

Abstract: Methods and systems for computationally processing data with a multi-layer convolutional neural network (CNN) having an input and output layer, and one or more intermediate layers are described. Input data represented in a form of evaluations of continuous functions on a sphere may be received at a computing device and input to the input layer. The input layer may compute outputs as covariant Fourier space activations by transforming the continuous functions into spherical harmonic expansions. The output activations from the input layer may be processed sequentially through each of the intermediate layers. Each, intermediate layer may apply Ciebsch-Gordan transforms to compute respective covariant Fourier space activations as input to an immediately next layer, without computing any intermediate inverse Fourier transforms or forward Fourier transforms. Finally, the respective covariant Fourier space activations of the last intermediate layer may be processed in the output layer of the CNN to compute invariant activations.

公开(公告)号：US20210214773A1

公开(公告)日：2021-07-15

申请号：US17250023

申请日：2019-05-08

Applicant: The University of Chicago

Inventor： Chuan HE ,  Xiaocheng WENG ,  Tong WU

IPC: C12Q1/6806 ,  C07C69/003

Abstract: Embodiments are directed to N3-kethoxal reagents and derivatives thereof, and related methods that allow fast and reversible labeling of single-stranded nucleic acids in live cells. By way of example, one aspect is directed to a process for reversible labeling of single-stranded guanine bases in live cells, which results in an effective in vivo method for transcriptome-wide RNA secondary structure mapping and RNA G-quadruplex prediction.

公开(公告)号：US20210184329A1

公开(公告)日：2021-06-17

申请号：US17184842

申请日：2021-02-25

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： David SCHUSTER ,  Ravi NAIK ,  Srivatsan CHAKRAM

IPC: H01P7/06 ,  G06N10/00 ,  H01P1/30 ,  H01P1/16

Abstract: Technologies for a long-lived 3D multimode microwave cavity are disclosed. In the illustrative embodiment, a series of overlapping holes are drilled into a monolithic block of aluminum forming a cavity. The dimensions of the cavity formed by the overlapping holes can be made long by drilling a long series of holes in a row and can be made high by drilling holes a certain depth into the cavity. if two dimensions of the cavity are bigger than the diameter of the holes used to create the cavity, then the cavity can support electromagnetic waves that cannot propagate through the holes, leading to a long lifetime in the cavity. A superconducting qubit or other non-linear element can be inserted into the cavity, which can controllably interact with each of several modes of the cavity. In this way, the modes of the cavity can act as components in a quantum memory.

公开(公告)号：US20210177918A1

公开(公告)日：2021-06-17

申请号：US16618700

申请日：2018-06-05

Applicant: The University of Chicago

Inventor： Thomas F. Gajewski ,  Jason Luke ,  Riyue Bao ,  Vyara Matson ,  Jessica Fessler

IPC: A61K35/745 ,  A61K35/747 ,  A61P35/00 ,  C07K16/28

Abstract: Provided herein are compositions and methods comprising microbiome biomarkers of responsiveness/resistance to immunotherapy (e.g., anti-PD1/PD-L1 therapy), and diagnostic, prognostic and therapeutic uses thereof. In particular, the amount, identity, presence, and/or ratio of microflora in the microbiome of a subject is used to determine the responsiveness/resistance of the subject to immunotherapy, and/or the microbiome of a subject is manipulated to enhance the responsiveness of the subject to various immunotherapies and co-therapies.

公开(公告)号：US11034962B2

公开(公告)日：2021-06-15

申请号：US16450760

申请日：2019-06-24

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Christopher M. Gomez ,  Yu Miyazaki ,  Xiaofei Du

IPC: C12N15/113 ,  A61P25/28 ,  C12N15/86

Abstract: The invention provides methods of treating polyglutamine diseases, e.g., spinocerebellar ataxia Type 6, in a subject, comprising administering to the subject an IRES inhibitor in an amount effective for treating the SCA6 in the subject. Also provided herein are the IRES inhibitors, and pharmaceutical compositions comprising the same.

公开(公告)号：US10988735B2

公开(公告)日：2021-04-27

申请号：US15543701

申请日：2016-01-15

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development ,  The University of Chicago

Inventor： Ying Mei ,  Tan Yu ,  Dylan Richards ,  Donald R. Menick ,  Bozhi Tian

IPC: C12N5/077 ,  G01N33/50 ,  A61K35/34 ,  A61L27/30 ,  A61L27/38

Abstract: Described herein are tissues containing semiconductor nanomaterials. In some embodiments, the tissues include vascular cells, cardiomyocytes, and/or cardiac fibroblasts. The tissue may be scaffold-free. In some embodiments, the tissue includes an electrically conductive network. The tissue may exhibit synchronized electrical signal propagation within the tissue. In some embodiments, the tissue exhibits increased functional assembly of cardiac cells and/or increased cardiac specific functions compared to a cardiac tissue prepared using a conventional tissue culture method. Methods of preparing and using such tissues are also described herein.

公开(公告)号：US10987366B2

公开(公告)日：2021-04-27

申请号：US15862171

申请日：2018-01-04

Applicant: The University of Chicago

Inventor： David J. Grdina

IPC: A61K49/00 ,  A61K31/661 ,  A61K31/132 ,  A61K31/355 ,  A61K33/04 ,  A61K45/06 ,  A61B6/00 ,  A61B6/03 ,  A61K31/145

Abstract: Described are methods for preventing or inhibiting genomic instability and in cells affected by diagnostic radiology procedures employing ionizing radiation. Embodiments include methods of preventing or inhibiting genomic instability and in cells affected by computed tomography (CT) radiation. Subjects receiving ionizing radiation may be those persons suspected of having cancer, or cancer patients having received or currently receiving cancer therapy, and or those patients having received previous ionizing radiation, including those who are approaching or have exceeded the recommended total radiation dose for a person.