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139 条记录 (耗时 0.031 秒)

    Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
    93.
    发明授权
    Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines 失效
    寻求Tc-99m复合物的聚酰胺胺的膦酸酯衍生物

    公开(公告)号：US4606907A

    公开(公告)日：1986-08-19

    申请号：US626816

    申请日：1984-07-02

    申请人： Jaime Simon ,  Wynn A. Volkert ,  David A. Wilson

    发明人： Jaime Simon ,  Wynn A. Volkert ,  David A. Wilson

    IPC分类号： A61K51/04 ,  A61K43/00 ,  A61K49/00 ,  A61K49/02

    CPC分类号： A61K51/0489 ,  A61K51/0478 ,  A61K2123/00 ,  Y10S424/16

    摘要： New stable complexing agents for radionuclides which are phosphonate derivatives of certain polyamidoamines have been found which are useful in imaging the skeletal system in animals. Even though the complexing agents have high molecular weights the complexes clear rapidly and very efficiently through the kidneys, with large amounts being taken up in the bone. The ratio of uptake in bone to that in surrounding soft tissue is high even at relatively short times after injection.

    摘要翻译： 已经发现了用于某些聚酰胺胺的膦酸酯衍生物的放射性核素的新的稳定的络合剂，其可用于动物中骨骼系统的成像。 即使络合剂具有高分子量，复合物通过肾脏快速且非常有效地清除，大量的骨吸收。 即使在注射后相对短的时间内，骨骼中摄取与周围软组织的吸收比也很高。

    Metal ion control agents based on dicyclopentadiene derivatives
    94.
    发明授权
    Metal ion control agents based on dicyclopentadiene derivatives 失效
    基于二环戊二烯衍生物的金属离子控制剂

    公开(公告)号：US4575454A

    公开(公告)日：1986-03-11

    申请号：US612109

    申请日：1984-05-21

    申请人： David A. Wilson

    发明人： David A. Wilson

    IPC分类号： C02F5/12 ,  C02F5/14 ,  C07F9/38 ,  C01G1/00

    CPC分类号： C07F9/3817 ,  C02F5/12 ,  C02F5/14 ,  Y10S423/14

    摘要： New compounds have been prepared from dicyclopentadiene bis(methylamine) which have the following formula ##STR1## wherein substituents A, B, X and Y each are independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) phosphonic, sulfonic, hydroxyethyl- and hydroxypropylsulfonic, methylenephosphonic methylene-, ethylene- and propylenesulfonic, alkylcarboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts of any of the phosphonic, sulfonic or carboxylic acid derivatives. At least one of the substituents must be other than a hydrogen. These compounds are useful chelating agents and those containing the methylenephosphonic substituents are good threshold agents.

    摘要翻译： 新化合物已经由具有下式的二环戊二烯双（甲胺）制备：其中取代基A，B，X和Y各自独立地选自氢，羟烷基（其中烷基含2-6个碳原子） 膦酸，磺酸，羟乙基 - 和羟基丙基磺酸，亚甲基膦酸亚甲基 - ，乙烯 - 和丙烯磺酸，烷基羧酸基（具有2-4个碳原子）和碱金属或碱土金属，任何膦酸，磺酸或羧酸的氨和胺盐 酸衍生物。 至少一个取代基必须不是氢。 这些化合物是有用的螯合剂，含有亚甲基膦取代基的那些是良好的阈值剂。

    Alkylene phosphonic acid scale inhibitor compositions
    96.
    发明授权
    Alkylene phosphonic acid scale inhibitor compositions 失效
    亚烷基膦酸阻垢剂组合物

    公开(公告)号：US4540508A

    公开(公告)日：1985-09-10

    申请号：US439964

    申请日：1982-11-08

    申请人： David A. Wilson ,  Druce K. Crump

    发明人： David A. Wilson ,  Druce K. Crump

    IPC分类号： C02F5/14 ,  C02F5/10

    CPC分类号： C02F5/14

    摘要： Compositions comprising methylene phosphonic acid derivatives of piperazine or aminoethylpiperazine (AEP) in combination with certain phosphonic acid derivatives of aliphatic acids or, methylene phosphonic acid derivatives of ammonia, amines and polyamines. These provide a synergistic effect with respect to the threshold activity in preventing metal ion precipitation.

    摘要翻译： 包含哌嗪或氨基乙基哌嗪（AEP）的亚甲基膦酸衍生物与脂族酸的某些膦酸衍生物或氨，胺和多胺的亚甲基膦酸衍生物组合的组合物。 这些对于防止金属离子沉淀的阈值活性提供协同效应。

    Metal ion control agents based on dicyclopentadiene derivatives
    98.
    发明授权
    Metal ion control agents based on dicyclopentadiene derivatives 失效
    基于二环戊二烯衍生物的金属离子控制剂

    公开(公告)号：US4500470A

    公开(公告)日：1985-02-19

    申请号：US486122

    申请日：1983-04-18

    申请人： David A. Wilson

    发明人： David A. Wilson

    IPC分类号： C02F5/12 ,  C02F5/14 ,  C07C67/00 ,  C07C213/00 ,  C07C215/14 ,  C07C301/00 ,  C07C309/14 ,  C07F9/38 ,  C07F9/40 ,  C07C143/21

    CPC分类号： C07F9/3817 ,  C02F5/12 ,  C02F5/14

    摘要： New compounds have been prepared from dicyclopentadiene bis(methylamine) which have the following formula ##STR1## wherein substituents A, B, X and Y each are independently selected from radicals including hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms) phosphonic, sulfonic, hydroxyethyl- and hydroxypropyl-sulfonic, methylenephosphonic methylene-, ethylene- and propylenesulfonic, alkylcarboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonia and amine salts of any of the phosphonic, sulfonic or carboxylic acid derivatives. At least one of the substituents must be other than a hydrogen.

    摘要翻译： 新化合物已经由具有下式的二环戊二烯双（甲胺）制备：其中取代基A，B，X和Y各自独立地选自氢，羟烷基（其中烷基含2-6个碳原子） 膦酸，磺酸，羟基乙酯和羟基丙磺酸，亚甲基膦酸亚甲基酯，乙烯 - 和丙烯磺酸，烷基羧酸基团（具有2-4个碳原子）和碱金属或碱土金属，任何膦酸，磺酸的氨和胺盐 或羧酸衍生物。 至少一个取代基必须不是氢。

    Ultrasonic imaging system with correction for velocity inhomogeneity and multipath interference using an ultrasonic imaging array
    100.
    发明授权
    Ultrasonic imaging system with correction for velocity inhomogeneity and multipath interference using an ultrasonic imaging array 失效
    超声波成像系统使用超声波成像阵列校正速度不均匀性和多径干扰

    公开(公告)号：US4471785A

    公开(公告)日：1984-09-18

    申请号：US427735

    申请日：1982-09-29

    申请人： David A. Wilson ,  James L. Buxton ,  Philip S. Green ,  Donald J. Burch ,  John F. Holzemer ,  S. David Ramsey, Jr.

    发明人： David A. Wilson ,  James L. Buxton ,  Philip S. Green ,  Donald J. Burch ,  John F. Holzemer ,  S. David Ramsey, Jr.

    IPC分类号： A61B8/00 ,  G01S7/52 ,  G10K11/32 ,  G01N29/04 ,  G01N9/24 ,  G06G7/12

    CPC分类号： G10K11/32 ,  G01S7/52026 ,  G01S7/52049

    摘要： An ultrasonic imaging system (50) has an array (52) of transducer elements (54-1 through 54-21) for receiving ultrasonic signals reflected from within an inhomogeneous object (16) being examined. The system (50) has a means (80, 84, 88, 94) connected to generate an image in response to the ultrasonic signals. A cross-correlator (70) is connected to compare the signals received by the transducer elements (54-1 through 54-21). An output addressing circuit (130) is connected to inhibit or otherwise modify gain of selected ones of the signals based on the comparison to reduce multipath ultrasonic wave interference, refraction or obstruction image distortion or degradation. A preferred ultrasonic imaging array (52) for this purpose and for time delay image distortion correction has a plurality of segmented, annular transducer elements (54-2 through 54-21). The elements (54-2 through 54-21) are formed as sectors of circles with substantially equal arc lengths. A digital signal processing circuit for the system (50) has a plurality of dual port RAMs (66-1 through 66-21) as delay lines and a cross-correlator (70) including an output addressing circuit (130) controlled by a microcomputer (128). The output addressing circuit (130) generates addresses for output of information from the dual port RAM delay lines (66-1 through 66-21) to accomplish time delay correction and elimination or other gain modification of ultrasonic signals with multipath interference, refraction or obstruction.

    摘要翻译： 超声波成像系统（50）具有用于接收从被检查的不均匀物体（16）内反射的超声波信号的换能器元件（54-1至54-21）的阵列（52）。 系统（50）具有连接以响应于超声信号产生图像的装置（80,84,88,94）。 连接互相关器（70）以比较由换能器元件（54-1至54-21）接收的信号。 输出寻址电路（130）被连接以基于该比较来抑制或以其他方式修改选定信号的增益，以减少多径超声波干扰，折射或阻塞图像失真或劣化。 用于此目的的优选的超声成像阵列（52）和用于时间延迟图像失真校正的多个分段的环形换能器元件（54-2至54-21）。 元件（54-2至54-21）形成为具有基本相等的弧长的圆形扇形。 用于系统（50）的数字信号处理电路具有作为延迟线的多个双端口RAM（66-1至66-21）和包括由微计算机控制的输出寻址电路（130）的交叉相关器（70） （128）。 输出寻址电路（130）产生用于从双端口RAM延迟线（66-1至66-21）输出信息的地址，以实现具有多径干扰，折射或阻塞的超声波信号的时间延迟校正和消除或其他增益修改 。