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148 条记录 (耗时 0.024 秒)

    Method of producing peptides
    91.
    发明授权
    Method of producing peptides 失效
    生产肽的方法

    公开(公告)号：US5369018A

    公开(公告)日：1994-11-29

    申请号：US231174

    申请日：1994-04-22

    申请人： Hans-Dieter Jakubke ,  Dirk Ullmann ,  Karlheinz Drauz ,  Andreas Bommarius

    发明人： Hans-Dieter Jakubke ,  Dirk Ullmann ,  Karlheinz Drauz ,  Andreas Bommarius

    IPC分类号： C12P21/00 ,  C07K1/02 ,  C12P21/02

    CPC分类号： C12P21/02 ,  C07K1/023

    摘要： The biocatalytic production of a peptide is carried out with a zymogen instead of the customarily used protease. Since zymogens are proteolytically inactive precursors of proteases, proteolytic side reactions are largely suppressed. Preferably, amino acid esters or peptide esters and C-terminally derivatized amino acids or peptide fragments are coupled to each other. The reaction can also take place in a frozen, aqueous medium. In particular, chymotrypsinogen, trypsinogen, pepsinogen, prorennin or procarboxypeptidase are suitable as zymogens.

    摘要翻译： 肽的生物催化生产用酶原代替常规使用的蛋白酶进行。 由于酶原是蛋白酶的蛋白水解无活性前体，因此蛋白水解副反应被大大抑制。 优选地，氨基酸酯或肽酯和C末端衍生的氨基酸或肽片段彼此偶联。 反应也可以在冷冻的水性介质中进行。 特别地，胰凝乳蛋白酶原，胰蛋白酶原，胃蛋白酶原，前列腺素或前羧肽酶适合作为酶原。

    Derivatives of 2-pyrrolidone-5-carboxylic acid and method of obtaining them
    93.
    发明授权
    Derivatives of 2-pyrrolidone-5-carboxylic acid and method of obtaining them 失效
    2-吡咯烷酮-5-羧酸的衍生物及其获得方法

    公开(公告)号：US4952706A

    公开(公告)日：1990-08-28

    申请号：US417089

    申请日：1989-10-04

    申请人： Hans-Peter Krimmer ,  Karlheinz Drauz

    发明人： Hans-Peter Krimmer ,  Karlheinz Drauz

    IPC分类号： C07D207/28

    CPC分类号： C07D207/28

    摘要： The new, crystalline trihydrates of sodium L- and D-2-pyrrolidone-5-carboxylate. These trihydrates can be obtained by adjusting the concentration and the temperature in an aqueous solution of sodium L- or D-2-pyrrolidone-5-carboxlate in such a manner that the solubility of the desired trihydrate is exceeded.

    摘要翻译： L-和D-2-吡咯烷酮-5-羧酸钠的新的结晶三水合物。 这些三水合物可以通过调节L型或D-2-吡咯烷酮-5-甲酸钠水溶液的浓度和温度，从而超过所需三水合物的溶解度。

    Process for the production of non-aqueous hydrogen peroxide solutions and their use
    94.
    发明授权
    Process for the production of non-aqueous hydrogen peroxide solutions and their use 失效
    用于生产非水过氧化氢溶液及其用途的方法

    公开(公告)号：US4760199A

    公开(公告)日：1988-07-26

    申请号：US81366

    申请日：1987-08-04

    申请人： Karlheinz Drauz ,  Axel Kleemann

    发明人： Karlheinz Drauz ,  Axel Kleemann

    IPC分类号： C07C37/58 ,  B01J27/00 ,  C01B15/017 ,  C07C27/00 ,  C07C67/00 ,  C07C37/60

    CPC分类号： C01B15/017

    摘要： The production of solutions of hydrogen peroxide in phenol or its derivatives, e.g. hydrocarbyl substituted phenols, halo substituted phenols or phenol ethers, is carried out in a single step. Practically no loss of hydrogen peroxide occurs since a total distillation of hydrogen peroxide together with phenol or phenol derivative is avoided. Simultaneously the solutions obtained are practically free from water. The mixture of phenol or phenol derivative and aqueous hydrogen peroxide is treated with a material that boils below the boiling point of hydrogen peroxide, phenol or phenol derivative or forms an azeotrope with water that boils below the boiling point of hydrogen peroxide, phenol or phenol derivative and the water removed as an azeotrope. The solution of hydrogen peroxide in phenol or phenol derivative which remains behind is suitable for carrying out oxidation reactions and above all, also for hydroxylation reactions. The latter as especially advantageously carried out in the presence of sulfur-, selenium-, or tellurium oxide.

    摘要翻译： 生产苯酚或其衍生物中过氧化氢的溶液，例如。 烃基取代的酚，卤代酚或苯酚醚在一个步骤中进行。 实际上不会发生过氧化氢的损失，因为避免了与苯酚或苯酚衍生物一起完全蒸馏过氧化氢。 同时获得的溶液实际上不含水。 苯酚或苯酚衍生物与过氧化氢水溶液的混合物用沸点低于过氧化氢，苯酚或苯酚衍生物的沸点的物质处理，或与沸点低于过氧化氢，苯酚或苯酚衍生物沸点的水形成共沸物 并将水作为共沸物除去。 过氧化氢在苯酚或苯酚衍生物中残留的溶液适用于进行氧化反应，尤其是羟基化反应。 后者特别有利地在硫，硒或氧化碲的存在下进行。

    PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED AMINES AND AMIDES BY ENZYMATIC RESOLUTION
    97.
    发明申请
    PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED AMINES AND AMIDES BY ENZYMATIC RESOLUTION 失效
    通过酶分解制备高效的氨基酸和酰胺的方法

    公开(公告)号：US20070298471A1

    公开(公告)日：2007-12-27

    申请号：US11766164

    申请日：2007-06-21

    申请人： Harald Groeger ,  Oliver May ,  Kai Rossen ,  Karlheinz Drauz

    发明人： Harald Groeger ,  Oliver May ,  Kai Rossen ,  Karlheinz Drauz

    IPC分类号： C12P13/00

    CPC分类号： C12P11/00 ,  C12P13/001 ,  C12P13/02 ,  C12P41/007

    摘要： A process for the preparation of an enantiomerically enriched amine, is performed by a) cleaving a racemic mixture of a reaction product of i) a chiral amine and ii) an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically enriched amine; or b) reacting an amine with an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically enriched amine; and c) separating the enantiomerically enriched amide from the enantiomerically enriched amine, wherein the acyl donor is a sulphonylacetic acid ester. The process (1) leads to high enantioselectivities, and (2) high reactivities, (3) is based on an acyl donor accessible in a simple manner, (4) is suitable for a large number of very different substrates and/or (5) is suitable for carrying out at high substrate concentrations.

    摘要翻译： 通过a）在水解酶存在下，将i）手性胺和ii）酰基供体的反应产物的外消旋混合物切割，制备对映体富集的胺的方法，得到 对映异构体富集的酰胺和对映体富集的胺; 或b）在水解酶存在下使胺与酰基供体反应，得到对映体富集的酰胺和对映体富集的胺的混合物; 和c）从对映异构体富集的胺分离对映体富集的酰胺，其中所述酰基供体是磺酰基乙酸酯。 方法（1）导致高对映选择性，和（2）高反应性，（3）基于可以简单方式获得的酰基供体，（4）适用于大量非常不同的底物和/或（5 ）适用于在高底物浓度下进行。

    Method of producing amino carboxylic acids
    100.
    发明授权
    Method of producing amino carboxylic acids 失效
    制备氨基羧酸的方法

    公开(公告)号：US06916947B2

    公开(公告)日：2005-07-12

    申请号：US10303078

    申请日：2002-11-25

    申请人： Oliver Meyer ,  Thomas Kalz ,  Karlheinz Drauz

    发明人： Oliver Meyer ,  Thomas Kalz ,  Karlheinz Drauz

    IPC分类号： C07C227/00 ,  C07C227/04 ,  C07C227/20 ,  C07C229/00 ,  C07D209/20 ,  C07D233/64

    CPC分类号： C07C227/06 ,  C07C229/08

    摘要： The present invention is directed to a method for producing amino acids by reacting halogenated carboxylic acid ester (haloacid esters) with a metal cyanate in the presence of an alcohol and by subsequent acidic saponification of the urethane carbonic acid formed. The method is characterized by the metal cyanate being placed at an elevated temperature in an organic solvent and the other reactants being continuously charged into the mixture over a defined time period.

    摘要翻译： 本发明涉及通过卤化羧酸酯（卤代酸酯）与金属氰酸酯在醇的存在下反应并随后所形成的氨基甲酸酯碳酸进行酸性皂化来制备氨基酸的方法。 该方法的特征在于将金属氰酸盐置于高温下在有机溶剂中，其它反应物在规定的时间段内连续加入到混合物中。