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111 条记录 (耗时 0.025 秒)

    Organic tricyclic compounds
    93.
    发明授权
    Organic tricyclic compounds 失效
    有机三环化合物

    公开(公告)号：US4224344A

    公开(公告)日：1980-09-23

    申请号：US639974

    申请日：1975-12-11

    申请人： Makoto Sunagawa ,  Hiromi Sato ,  Junki Katsube ,  Hisao Yamamoto

    发明人： Makoto Sunagawa ,  Hiromi Sato ,  Junki Katsube ,  Hisao Yamamoto

    IPC分类号： C07C47/235 ,  C07C47/238 ,  C07C47/453 ,  C07C57/50 ,  C07C61/39 ,  C07D295/02 ,  C07D295/03 ,  C07D295/125 ,  C07C87/28 ,  A01N9/24

    CPC分类号： C07D295/03 ,  C07C47/235 ,  C07C47/238 ,  C07C47/453 ,  C07C57/50 ,  C07C61/39 ,  C07D295/125

    摘要： Novel 9-aminoalkyl-methanoanthracenes of the formula: ##STR1## wherein A is C.sub.1 -C.sub.4 alkylene or C.sub.3 -C.sub.4 alkenylene and R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl(C.sub.1 -C.sub.3)alkyl, ar(C.sub.1 -C.sub.3)alkyl or polyhalo(C.sub.2 -C.sub.4)alkyl or, when taken together with the adjacent nitrogen atom, they may form a 5 to 7-membered nitrogen-containing heterocyclic ring which may contain an additional hetero atom, and their non-toxic salts, which are useful as anti-anxiety, anti-depressant, major tranquilizer, anti-histamine and anti-allergy drugs and can be prepared through a novel key intermediate, i.e., 9-formyl-9,10-dihydro-9,10-methanoanthracene, by various methods.

    摘要翻译： 其中A为C 1 -C 4亚烷基或C 3 -C 4亚烯基，R 1和R 2各自为氢，C 1 -C 4烷基，C 3 -C 4烯基，C 3 -C 4炔基，C 3 -C 4炔基， C 1 -C 8环烷基（C 1 -C 3）烷基，芳（C 1 -C 3）烷基或多卤代（C 2 -C 4）烷基，或与相邻的氮原子一起形成5至7元含氮杂环， 可以含有另外的杂原子及其无毒盐，它们可用作抗焦虑剂，抗抑郁剂，主要镇静剂，抗组胺和抗过敏药物，可以通过一种新的关键中间体即9 - 甲酰基-9,10-二氢-9,10-甲烷基蒽。

    Novel morpholine derivatives and treating depression therewith
    94.
    发明授权
    Novel morpholine derivatives and treating depression therewith 失效
    新型吗啉衍生物和治疗抑郁症

    公开(公告)号：US4169146A

    公开(公告)日：1979-09-25

    申请号：US811944

    申请日：1977-06-30

    申请人： Junki Katsube ,  Atsuyuki Kojima ,  Makoto Sunagawa ,  Yoshinori Takashima ,  Yoshito Kameno ,  Hisao Yamamoto

    发明人： Junki Katsube ,  Atsuyuki Kojima ,  Makoto Sunagawa ,  Yoshinori Takashima ,  Yoshito Kameno ,  Hisao Yamamoto

    IPC分类号： C07D265/30 ,  C07D267/10 ,  A61K27/00

    CPC分类号： C07D265/30 ,  C07D267/10

    摘要： Novel morpholine compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, aryl-(C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.4)alkyl, polyhalo(C.sub.2 -C.sub.4) alkyl or hydroxy(C.sub.2 -C.sub.4)alkyl, A represents straight or branched C.sub.2 -C.sub.4 alkylene, B represents a divalent radical selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 --O--, --CH.sub.2 --S--, --S-- and --O--, >D--E-- represents a trivalent radical selected from the group consisting of >CH--CH.sub.2 -- and >C.dbd.CH-- and C.sub.1 and C.sub.2 each represent 1,2-phenylene optionally substituted with one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, and their non-toxic salts, which are useful as antidepressants and can be produced by various methods.

    摘要翻译： 式中：R1代表氢或C1-C4烷基，R2代表氢，C1-C4烷基，C3-C5烯基，C3-C5炔基，芳基 - （C1-C4）烷基，（C3 -C 6）环烷基（C 1 -C 4）烷基，多卤代（C 2 -C 4）烷基或羟基（C 2 -C 4）烷基，A表示直链或支链C 2 -C 4亚烷基，B表示选自-CH 2 -CH 2 - ， - CH = CH-， -CH 2 -O-，-CH 2 -S-，-S-和-O-，> DE-表示选自下组的三价基团：CH-CH 2 - 和> C = CH-和C1和C2各自表示任选被一个或多个选自卤素，C 1 -C 4烷基和C 1 -C 4烷氧基的取代基取代的1,2-亚苯基及其无毒盐， 其可用作抗抑郁药并且可以通过各种方法制备。

    Burner
    95.
    发明授权
    Burner 失效
    刻录机

    公开(公告)号：US4144016A

    公开(公告)日：1979-03-13

    申请号：US767144

    申请日：1977-02-09

    申请人： Yasuro Takahashi ,  Hisao Yamamoto ,  Masayasu Sakai ,  Toshiyuki Takegawa

    发明人： Yasuro Takahashi ,  Hisao Yamamoto ,  Masayasu Sakai ,  Toshiyuki Takegawa

    IPC分类号： F23C99/00 ,  F23C7/00 ,  F23C7/02 ,  F23D11/00 ,  F23C5/00

    CPC分类号： F23C7/008 ,  F23D11/00

    摘要： A burner includes a plurality of air nozzles open toward a furnace and which are disposed unsymmetrically with respect to the central axis of the burner and so combined that the velocity of combustion air to issue from one or more of the nozzles is higher than the mean air velocity through the total air nozzle opening area and the velocity of combustion air from the rest of the nozzles is lower than the mean velocity. The opening area of the lower-velocity air nozzle or nozzles accounts for from 30 to 60% of the total opening area. A fuel nozzle or nozzles are located within or adjacent the lower-velocity air nozzle or nozzles. The amount of air to issue from the lower-velocity air nozzle or nozzles is not more than 70% of the theoretical air for the fuel to jet out of the burner.

    摘要翻译： 燃烧器包括朝向炉子开放的多个空气喷嘴，其相对于燃烧器的中心轴线不对称地设置，并且结合在一起，使得从一个或多个喷嘴发出的燃烧空气的速度高于平均空气 通过总空气喷嘴开口面积的速度和来自其余喷嘴的燃烧空气的速度低于平均速度。 低速空气喷嘴或喷嘴的开口面积占总开口面积的30％至60％。 燃料喷嘴或喷嘴位于低速空气喷嘴或喷嘴内或附近。 从低速空气喷嘴或喷嘴发出的空气量不超过燃料喷出燃烧器的理论空气的70％。

    Quinazolinone derivatives and a process for production thereof
    96.
    发明授权
    Quinazolinone derivatives and a process for production thereof 失效
    喹唑啉酮衍生物及其生产方法

    公开(公告)号：US4099002A

    公开(公告)日：1978-07-04

    申请号：US495829

    申请日：1974-08-08

    申请人： Shigeho Inaba ,  Michihiro Yamamoto ,  Kikuo Ishizumi ,  Kazuo Mori ,  Masao Koshiba ,  Hisao Yamamoto

    发明人： Shigeho Inaba ,  Michihiro Yamamoto ,  Kikuo Ishizumi ,  Kazuo Mori ,  Masao Koshiba ,  Hisao Yamamoto

    IPC分类号： C07D239/82 ,  C07D403/06 ,  C07D413/06

    CPC分类号： C07D403/06 ,  C07D239/82 ,  C07D413/06

    摘要： 3,4-Dihydro-2(1H)-quinazolinone derivatives of the formula, ##STR1## wherein R.sub.1 and R.sub.2 signify individually a hydrogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, a trifluoromethyl group, a lower alkylthio group, a lower alkylsulfonyl group or a halogen atom; R.sub.3 signifies a phenyl group, a halophenyl group, a lower alkylphenyl group, a lower alkoxyphenyl group, a trifluoromethylphenyl group, a lower cycloalkyl group, a lower cycloalkenyl group, a pyridyl group, a pyrrolyl group, a furyl group, a thienyl group or a naphthyl group; R.sub.4 signifies a lower alkyl group, a lower alkenyl group, an aralkyl group, a lower cycloalkylalkyl group, a lower cycloalkyl group, a lower alkoxyalkyl group, a lower alkylthioalkyl group, a lower hydroxyalkyl group, a lower alkanoyloxyalkyl group, a phenyl group, a halophenyl group, a trifluoromethylphenyl group, a lower alkylphenyl group a lower alkoxyphenyl group, a pyridyl group or a group of the formula ##STR2## wherein n signifies an integer of 1 to 4; and R.sub.5 and R.sub.6 signify individually a lower alkyl group, provided that they may form together with the adjacent nitorgen atom an optionally substituted 5- or 6-membered heterocyclic ring, which may further contain a hetero atom); and R signifies a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkoxyalkyl group, a lower alkylthioalkyl group, an aralkyl group, a lower cycloalkylalkyl group, a lower trihalomethylalkyl group or a group of the formula ##STR3## (wherein n, R.sub.5 and R.sub.6 signify the same as defined above), which have excellent pharmacological properties such as central nervous system depressant, anti-inflammatory, analgestic and anti-microbial activities, can be produced by reducing a compound of the formula, ##STR4## wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the same meanings as defined above; and X.sub.1, X.sub.2 and X.sub.3 signify individually a halogen atom, or by the substitution reaction of the ring nitrogen atom of a 1 or 3-unsubstituted 3,4-dihydro-2(1H)-quinazolinone derivative.

    Analgetic composition
    99.
    发明授权
    Analgetic composition 失效
    笔画组成

    公开(公告)号：US4029798A

    公开(公告)日：1977-06-14

    申请号：US582757

    申请日：1975-06-02

    申请人： Hisao Yamamoto ,  Toshiya Inukai ,  Yoshihiko Koga

    发明人： Hisao Yamamoto ,  Toshiya Inukai ,  Yoshihiko Koga

    IPC分类号： C07D209/28 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/435 ,  A61K31/445 ,  A61K31/485 ,  A61P25/04 ,  C07D211/64 ,  C07D221/28

    CPC分类号： A61K31/485 ,  A61K31/435 ,  A61K31/445

    摘要： An alalgetic composition which comprises, as an active ingredient, a therapeutically effective amount of a synergistic mixture of an indole-3-acetic acid derivative of the formula, ##STR1## wherein R is a halobenzoyl, piperonyloyl or cinnamoyl group and R.sub.1 is a 5-methoxy or 5,6-methylenedioxy group; and a narcotic or anti-narcotic analgesic selected from the group consisting of a compound of the formula, ##STR2## wherein R.sub.2 and R.sub.3 are each a C.sub.1 - C.sub.3 alkyl group and R.sub.4 is a 4-(4-fluorophenyl)-4-oxobutyl, cyclopropylmethyl or 3-methyl-2-butenyl group; a compound of the formula, ##STR3## wherein R.sub.5 is a hydrogen atom or a C.sub.1 - C.sub.3 alkyl group; a compound of the formula, ##STR4## and a compound of the formula, ##STR5## wherein R.sub.6 is a C.sub.1 - C.sub.3 alkyl group; and a pharmaceutically acceptable carrier or diluent and its preparation and a method of obtaining analgesia which comprises administering the same to a patient.

    摘要翻译： 其包含作为活性成分的治疗有效量的下式的吲哚-3-乙酸衍生物，其中R是卤代苯甲酰基，哌嗪基或肉桂酰基的吲哚-3-乙酸衍生物和R1是5 - 甲氧基或5,6-亚甲二氧基; 以及选自由下式化合物组成的组的麻醉或抗麻醉止痛剂，其中R2和R3各自为C1-C3烷基，R4为4-（4-氟苯基）-4-氧代丁基 ，环丙基甲基或3-甲基-2-丁烯基; 下式的化合物，其中R 5是氢原子或C 1 -C 3烷基; 下式的化合物和下式的化合物，其中R 6是C 1 -C 3烷基; 和药学上可接受的载体或稀释剂及其制备方法和获得镇痛的方法，其包括将其施用于患者。