Benzisoxazole derivatives
    2.
    发明授权
    Benzisoxazole derivatives 失效
    苯并异恶唑衍生物

    公开(公告)号:US4217349A

    公开(公告)日:1980-08-12

    申请号:US919221

    申请日:1978-06-26

    CPC分类号: C07D261/20

    摘要: Novel benzisoxazole compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, ar(C.sub.1 -C.sub.3)alkoxy or halogen or, when taken together, they form C.sub.1 -C.sub.2 alkylenedioxy, Alk is C.sub.1 -C.sub.4 alkylene and A is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each C.sub.1 -C.sub.4 alkyl or, when taken together with the adjacent nitrogen atom, they represent a 5-6 membered nitrogen-containing heterocyclic ring which may contain any additional hetero atom and R.sub.5 is C.sub.1 -C.sub.4 alkyl or aryl), and non-toxic salts thereof, which possess various pharmaceutical activities.

    摘要翻译: 新的苯并恶唑化合物,其结构式如下:其中R 1和R 2各自为氢,C 1 -C 4烷基,C 1 -C 4烷氧基,芳(C 1 -C 3)烷氧基或卤素,或者一起形成C 1 -C 2亚烷基二氧基, Alk是C 1 -C 4亚烷基,A是下式的基团:其中R 3和R 4各自是C 1 -C 4烷基,或者当与相邻的氮原子一起时,它们代表5-6元含氮的 可含有任何另外的杂原子的杂环,R 5为C 1 -C 4烷基或芳基)及其无毒盐,其具有各种药物活性。

    3-(Piperazinoalkyl)-benz-2,1-isoxazoles
    3.
    发明授权
    3-(Piperazinoalkyl)-benz-2,1-isoxazoles 失效
    3-(哌嗪基烷基) - 苯并-2,1 - 异恶唑

    公开(公告)号:US4122176A

    公开(公告)日:1978-10-24

    申请号:US755139

    申请日:1976-12-29

    CPC分类号: C07D261/20 Y10S514/826

    摘要: Novel benzisoxazole compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, ar(C.sub.1 14 C.sub.3) alkoxy or halogen or, when taken together, they form C.sub.1 -C.sub.2 alkylenedioxy, Alk is C.sub.1 -C.sub.4 alkylene and A is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each C.sub.1 -C.sub.4 alkyl or, when taken together with the adjacent nitrogen atom, they represent a 5-6 membered nitrogen-containing heterocyclic ring which may contain any additional hetero atom and R.sub.5 is C.sub.1 -C.sub.4 alkyl or aryl), and non-toxic salts thereof, which possess various pharmaceutical activities.

    摘要翻译: 下式的新型苯并异恶唑化合物:其中R 1和R 2各自为氢,C 1 -C 4烷基,C 1 -C 4烷氧基,芳(C 11 43 C 3)烷氧基或卤素,或者当它们一起形成C 1 -C 2亚烷基二氧基,Alk 是C 1 -C 4亚烷基,A是下式的基团:其中R 3和R 4各自是C 1 -C 4烷基,或者当与相邻的氮原子一起时,它们代表5-6元含氮杂环 可以含有任何另外的杂原子的环,R 5是C 1 -C 4烷基或芳基)及其无毒盐,其具有各种药物活性。

    N-substituted heterocyclic derivatives and preparation thereof
    6.
    发明授权
    N-substituted heterocyclic derivatives and preparation thereof 失效
    N-取代的杂环衍生物及其制备

    公开(公告)号:US4080328A

    公开(公告)日:1978-03-21

    申请号:US484274

    申请日:1974-06-28

    IPC分类号: C07D401/04

    摘要: Novel N-substituted heterocyclic derivatives represented by the formula, ##STR1## wherein R is hydrogen or lower alkanoyl; R.sub.1 is hydrogen, lower alkyl, lower alkoxy, halogen, nitro, trifluoromethyl, amino or N-lower alkanoylamino; R.sub.2 is hydrogen, halogen, amino or N-lower alkanoylamino; W is oxygen, sulfur, sulfinyl or sulfonyl; and Y is ##STR2## (wherein R.sub.3 is hydrogen, lower alkyl or lower alkanoyl; and R.sub.4 is hydrogen, halogen or lower alkyl), and pharmaceutically acceptable salts thereof, which have excellent anti-inflammatory, analgesic, sedative, anti-convulsive or anti-hypertensive activities.

    摘要翻译: 由下式表示的新型N-取代的杂环衍生物,其中R是氢或低级烷酰基; R 1是氢,低级烷基,低级烷氧基,卤素,硝基,三氟甲基,氨基或N-低级烷酰基氨基; R2是氢,卤素,氨基或N-低级烷酰氨基; W是氧,硫,亚磺酰基或磺酰基; (其中R3为氢,低级烷基或低级烷酰基,R4为氢,卤素或低级烷基)及其药学上可接受的盐,其具有优异的抗炎,止痛,镇静作用 ,抗惊厥或抗高血压活动。

    N-(.omega.-Amino)alkylaniline derivatives
    8.
    发明授权
    N-(.omega.-Amino)alkylaniline derivatives 失效
    N - ({107 - 氨基)烷基苯胺衍生物

    公开(公告)号:US4017624A

    公开(公告)日:1977-04-12

    申请号:US603240

    申请日:1975-08-08

    CPC分类号: C07D211/52 C07D295/12

    摘要: An N-(.omega.-amino)alkylaniline derivative of the formula: ##STR1## and its pharmaceutically acceptable salts, which are useful as neuroleptic agents and can be prepared by reacting a compound of the formula: ##STR2## with a compound of the formula:H--A[wherein R is hydrogen, C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.7 alkanoyl or aroyl, R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.7 alkyl or C.sub.1 -C.sub.7 alkoxy,A is ##STR3## (wherein R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.7 alkoxy or trifluoromethyl), ##STR4## (wherein R.sub.2 is as defined above and R.sub.3 is hydrogen, C.sub.1 -C.sub.7 alkyl or C.sub.1 -C.sub.7 alkanoyl), ##STR5## (wherein R.sub.2 is as defined above or ##STR6## (wherein R.sub.2 and R.sub.3 are each as defined above) and n is 2, 3 or 4].

    摘要翻译: 下式的N-(ω-氨基)烷基苯胺衍生物及其药学上可接受的盐,其可用作抗精神病药,并且可以通过使下式化合物与下式化合物反应来制备:< IMAGE> :