公开(公告)号：US07655632B2

公开(公告)日：2010-02-02

申请号：US12104890

申请日：2008-04-17

申请人： Hirotaka Teranishi ,  Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Kazuo Shimizu ,  Toshihide Shibazaki ,  Masayuki Isaji

发明人： Hirotaka Teranishi ,  Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Kazuo Shimizu ,  Toshihide Shibazaki ,  Masayuki Isaji

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： C07H17/02

摘要： The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6 alkylene group etc.; Z represents CO or SO2; R4 and R5 represent H, an optionally substituted C1-6 alkyl group etc.; and R3, R6 and R7 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.

摘要翻译： 本发明提供由以下通式表示的吡唑衍生物：其中R1表示H，任选取代的C 1-6烷基等; Q和T之一表示由通式表示的基团或由通式表示的基团：而另一个表示任选取代的C 1-6烷基等; R2表示H，卤素原子，OH，任意取代的C 1-6烷基等; X表示单键，O或S; Y表示单键，C1-6亚烷基等; Z表示CO或SO2; R4和R5代表H，任选取代的C 1-6烷基等; R 3，R 6和R 7表示H，卤素原子等，其药学上可接受的盐或其前药，其在人SGLT1中表现出优异的抑制活性，并且可用作预防或治疗与高血糖相关的疾病 糖尿病，糖尿病并发症或肥胖症，以及包含该药物组合物的药物组合物，其药学用途及其生产用中间体。

公开(公告)号：US20080312153A1

公开(公告)日：2008-12-18

申请号：US12104890

申请日：2008-04-17

申请人： Hirotaka Teranishi ,  Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Kazuo Shimizu ,  Toshihide Shibazaki ,  Masayuki Isaji

发明人： Hirotaka Teranishi ,  Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Kazuo Shimizu ,  Toshihide Shibazaki ,  Masayuki Isaji

IPC分类号： A61K31/7056 ,  A61K38/18 ,  A61P3/00

CPC分类号： C07H17/02

摘要： The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6 alkylene group etc.; Z represents CO or SO2; R4 and R5 represent H, an optionally substituted C1-6 alkyl group etc.; and R3, R6 and R7 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.

摘要翻译： 本发明提供由以下通式表示的吡唑衍生物：其中R1表示H，任选取代的C 1-6烷基等; Q和T之一表示由通式表示的基团或由通式表示的基团：而另一个表示任选取代的C 1-6烷基等; R2表示H，卤素原子，OH，任意取代的C 1-6烷基等; X表示单键，O或S; Y表示单键，C1-6亚烷基等; Z表示CO或SO2; R4和R5代表H，任选取代的C 1-6烷基等; R 3，R 6和R 7表示H，卤素原子等，其药学上可接受的盐或其前药，其在人SGLT1中表现出优异的抑制活性，并且可用作预防或治疗与高血糖相关的疾病 糖尿病，糖尿病并发症或肥胖症，以及包含该药物组合物的药物组合物，其药学用途及其生产用中间体。

公开(公告)号：US07375087B2

公开(公告)日：2008-05-20

申请号：US10523820

申请日：2003-08-07

申请人： Hirotaka Teranishi ,  Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Kazuo Shimizu ,  Toshihide Shibazaki ,  Masayuki Isaji

发明人： Hirotaka Teranishi ,  Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Kazuo Shimizu ,  Toshihide Shibazaki ,  Masayuki Isaji

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/00

CPC分类号： C07H17/02

摘要： The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6 alkylene group etc.; Z represents CO or SO2; R4 and R5 represent H, an optionally substituted C1-6 alkyl group etc.; and R3, R6 and R7 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.

摘要翻译： 本发明提供由以下通式表示的吡唑衍生物：其中R 1表示H，任选取代的C 1-6烷基等; Q和T之一表示由通式表示的基团或由通式表示的基团：而另一个表示任选取代的C 1-6烷基等; R 2表示H，卤素原子，OH，任选取代的C 1-6烷基等; X表示单键，O或S; Y表示单键，C 1-6亚烷基等; Z表示CO或SO 2; R 4和R 5表示H，任选取代的C 1-6烷基等; R 3，R 6和R 7表示H，卤素原子等，其药学上可接受的盐或其前药，其表现出 在人SGLT1中具有优异的抑制活性，并且可用作预防或治疗与糖尿病，糖尿病并发症或肥胖症等高血糖相关的疾病的药剂，以及含有该疾病的药物组合物，其药学用途及其生产用中间体。

公开(公告)号：US07258595B2

公开(公告)日：2007-08-21

申请号：US10739134

申请日：2003-12-19

申请人： Mitsuo Tada ,  Kazuo Shimizu

发明人： Mitsuo Tada ,  Kazuo Shimizu

IPC分类号： B24B19/00

CPC分类号： B24B37/005 ,  B24B49/10

摘要： A polishing apparatus comprises a polishing table having a polishing surface and a top ring for holding a substrate to be polished, in which the substrate when held by the top ring is pressed against the polishing surface of the polishing table and thus polished. A capacitance type sensor and/or an eddy-current type sensor is disposed at one or more location(s) in the vicinity of the top ring. The capacitance type sensor detects escaping of the substrate to be polished based on a change in capacitance between the capacitance type sensor and a top surface of the polishing table. The eddy-current type sensor detects escaping of the substrate to be polished based on a change in electrical resistance between the eddy-current type sensor and the top surface of the polishing table.

摘要翻译： 抛光装置包括具有抛光表面的抛光台和用于保持要抛光的基板的顶环，其中由顶环保持的基板被压在抛光台的抛光表面上并由此抛光。 电容式传感器和/或涡流型传感器设置在顶环附近的一个或多个位置处。 电容型传感器基于电容式传感器与研磨台的上表面之间的电容变化来检测待研磨的基板的逸出。 涡流型传感器基于涡电流型传感器与研磨台的上表面之间的电阻变化来检测待抛光基板的逸出。

公开(公告)号：US20070154626A1

公开(公告)日：2007-07-05

申请号：US11707091

申请日：2007-02-16

申请人： Hiroshi Sasaki ,  Makoto Kurosawa ,  Kazuo Shimizu

发明人： Hiroshi Sasaki ,  Makoto Kurosawa ,  Kazuo Shimizu

IPC分类号： B32B3/00 ,  C23C26/00 ,  B05D3/02 ,  B28B19/00

CPC分类号： H05K3/1208 ,  H05K3/125 ,  H05K3/386 ,  H05K2201/015 ,  H05K2201/0209 ,  H05K2203/013 ,  H05K2203/1173 ,  Y10T428/24917

摘要： A substrate is provided on which wires can be formed satisfactorily using a dispersion liquid of metal microparticles without causing disconnection or short circuit. The wiring substrate comprises a substrate, an organic membrane formed on the substrate, and a metal wire formed on the organic membrane. An arithmetic mean deviation Ra of the profile of the surface of the organic membrane where the metal wire is formed is not less than 60 nm and not more than 5×10−2 D, where D is the width of the metal wire. The contact angle with respect to water on the surface of the organic membrane where the metal wire is formed is not less than 110°.

摘要翻译： 提供一种基板，其上可以令人满意地使用金属微粒的分散液形成导线，而不会导致断开或短路。 布线基板包括基板，形成在基板上的有机膜和形成在有机膜上的金属线。 形成金属线的有机膜表面的轮廓的算术平均偏差Ra不小于60nm且不大于5×10 -2 D，其中D是 金属丝。 形成金属线的有机膜表面上的水的接触角不小于110°。

公开(公告)号：US20060247179A1

公开(公告)日：2006-11-02

申请号：US10551648

申请日：2004-03-24

申请人： Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Hideyuki Muranaka ,  Hiroaki Shiohara ,  Hirotaka Teranishi ,  Kazuo Shimizu ,  Fumiaki Ito ,  Masayuki Isaji

发明人： Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Hideyuki Muranaka ,  Hiroaki Shiohara ,  Hirotaka Teranishi ,  Kazuo Shimizu ,  Fumiaki Ito ,  Masayuki Isaji

IPC分类号： A61K31/7052 ,  C07H17/02

CPC分类号： C07H15/203 ,  C07H17/00 ,  C07H17/02 ,  C07H17/04

摘要： The present invention provides fused heterocyclic derivatives represented by the general formula: wherein R1 represents H, halogen, OH, etc.; R2 represents H, halogen or an alkyl group; R3 and R4 represent H, OH, halogen, etc.; Q represents alkylene, etc.; ring A represents aryl or heteroaryl; and G represents , or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.

摘要翻译： 本发明提供由以下通式表示的稠合杂环衍生物：其中R 1表示H，卤素，OH等; R 2表示H，卤素或烷基; R 3和R 4代表H，OH，卤素等; Q表示亚烷基等。 环A表示芳基或杂芳基; 和G表示其药学上可接受的盐或其前药，其在人SGLT中表现出优异的抑制活性，并且可用作预防或治疗与高血糖相关的疾病如糖尿病，餐后高血糖，葡萄糖耐量异常， 糖尿病并发症或肥胖，包含其的药物组合物及其药物用途。

公开(公告)号：US20060121189A1

公开(公告)日：2006-06-08

申请号：US11237906

申请日：2005-09-29

申请人： Osamu Machida ,  Makoto Kurosawa ,  Kazuo Shimizu

发明人： Osamu Machida ,  Makoto Kurosawa ,  Kazuo Shimizu

IPC分类号： B05D1/00 ,  B05B13/02

CPC分类号： B41J3/28 ,  B05B13/0431 ,  B05D1/02 ,  B05D2252/10 ,  B41J3/407 ,  B41J11/0085

摘要： To coat a solution on both surfaces continuously in such a state that an edge portion of the substrate is so constructed as to be fixed, and the substrate is attached to a substrate fixing frame having a positioning mechanism.

摘要翻译： 在两个表面上连续地涂布溶液，使得基板的边缘部分被构造成固定，并且将基板安装到具有定位机构的基板固​​定框架上。

公开(公告)号：US07018010B2

公开(公告)日：2006-03-28

申请号：US09805216

申请日：2001-03-14

申请人： Shinya Kobayashi ,  Takahiro Yamada ,  Kazuo Shimizu ,  Kunio Satou ,  Hitoshi Kida

发明人： Shinya Kobayashi ,  Takahiro Yamada ,  Kazuo Shimizu ,  Kunio Satou ,  Hitoshi Kida

IPC分类号： B41J29/393

CPC分类号： B41J2/2135 ,  B41J2/075

摘要： A computer portion 201 of a printer includes a memory storing a printer driver software 201a and nozzle profile data 211. The printer driver software 201a includes a raster image processor (RIP) 203. When the RIP 203 receives document data 209, the RIP 203 converts the document data 209 into bitmap data 210 which is one dot/one bit data for 300 data/inch. Then, the nozzle data converting portion 204 converts the bitmap data 210 into driving data 212 based on the nozzle profile data 211. At this time, each bit of the bitmap data 210 is replaced by 16 bits. That is, the data amount is increased to 16 times of the bitmap data 210. Accordingly, fine control of ink ejection can be achieved.

摘要翻译： 打印机的计算机部分201包括存储打印机驱动程序软件201a和喷嘴简档数据211的存储器。 打印机驱动程序201a包括光栅图像处理器（RIP）203。 当RIP 203接收到文档数据209时，RIP 203将文档数据209转换为位数据210，其为300个数据/英寸的一个点/一位数据。 然后，喷嘴数据转换部分204基于喷嘴轮廓数据211将位图数据210转换成驾驶数据212。 此时，位图数据210的每一位被16位代替。 也就是说，数据量增加到位图数据210的16倍。 因此，可以实现油墨喷射的精细控制。

公开(公告)号：US20050272669A1

公开(公告)日：2005-12-08

申请号：US10525197

申请日：2003-08-21

申请人： Nobuhiko Fushimi ,  Kazuo Shimizu ,  Shigeru Yonekubo ,  Hirotaka Teranishi ,  Masaki Tomae ,  Masayuki Isaji

发明人： Nobuhiko Fushimi ,  Kazuo Shimizu ,  Shigeru Yonekubo ,  Hirotaka Teranishi ,  Masaki Tomae ,  Masayuki Isaji

IPC分类号： A61K31/00 ,  A61K31/10 ,  A61K31/205 ,  A61K31/37 ,  A61K31/4166 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/737 ,  A61K38/18 ,  A61K38/28 ,  A61K45/00 ,  A61K45/06 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/48 ,  A61P7/10 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  A61P43/00 ,  C07H17/02 ,  A61K31/7052

CPC分类号： A61K38/185 ,  A61K31/00 ,  A61K31/10 ,  A61K31/205 ,  A61K31/37 ,  A61K31/4166 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/737 ,  A61K38/1858 ,  A61K38/28 ,  A61K45/06 ,  C07H17/02 ,  A61K2300/00

摘要： The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents an optionally substituted C1-6 alkylene group etc.; Z represents —RB, —CORC etc. in which RB represents an optionally substituted C1-6 alkyl group etc.; and RC represents an optionally substituted C1-6 alkyl group etc.; R4 represents H, an optionally substituted C1-6 alkyl group etc.; and R3, R5 and R6 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, impaired glucose tolerance, impaired fasting glycemia, diabetic complications or obesity, and a disease associated with the increase of blood galactose level such as galactosemia, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.

摘要翻译： 本发明提供由以下通式表示的吡唑衍生物：其中R 1表示H，任选取代的C 1-6烷基等; Q和T之一表示由通式表示的基团或由通式表示的基团：而另一个表示任选取代的C 1-6烷基等; R 2表示H，卤素原子，OH，任选取代的C 1-6烷基等; X表示单键，O或S; Y表示任选取代的C 1-6亚烷基等; Z表示-R B，C，C，C等。 其中R B表示任选取代的C 1-6烷基等; 且R C表示任选取代的C 1-6烷基等; R 4表示H，任选取代的C 1-6烷基等; R 3，R 5和R 6表示H，卤素原子等，其药学上可接受的盐或其前药，其表现出 在人SGLT1中具有优异的抑制活性，并且可用作预防或治疗与糖尿病，葡萄糖耐量降低，空腹血糖受损，糖尿病并发症或肥胖症相关的高血糖疾病的药剂，以及与血液半乳糖水平升高有关的疾病 例如半乳糖血症，以及包含其的药物组合物，其药学用途及其生产用中间体。

公开(公告)号：US06746095B2

公开(公告)日：2004-06-08

申请号：US09956861

申请日：2001-09-21

申请人： Shinya Kobayashi ,  Takahiro Yamada ,  Hitoshi Kida ,  Kunio Satou ,  Katsunori Kawasumi ,  Kazuo Shimizu

发明人： Shinya Kobayashi ,  Takahiro Yamada ,  Hitoshi Kida ,  Kunio Satou ,  Katsunori Kawasumi ,  Kazuo Shimizu

IPC分类号： B41J2165

CPC分类号： B41J2/16579

摘要： When ink droplets are ejected, angled or splashed where a plurality of minute ink droplets are generated, angled or splashed ink clings on an electrode 401, 402 and increases the amount of electric current conducted therethrough. Hence, the defectiveness of ink ejection can be detected by monitoring the amount of the electric current. When the defectiveness of ink ejection is detected, ejection data D is retrieved and updates the ejection data D based on a condition register S, and set to a defect register E. When the defect register E has only one element that takes a condition value of 1 indicating defectiveness, the corresponding nozzle is identified as defective. The restoring means reallocates dots, which have been originally allocated to the defective nozzle, to neighboring nozzle.

摘要翻译： 当墨滴被喷射时，在产生多个微小墨滴的地方倾斜或飞溅，在电极401,402上成角度或飞溅的墨粘附，并增加通过其传导的电流量。 因此，可以通过监视电流量来检测喷墨的缺陷。 当检测到喷墨的缺陷时，检索出喷射数据D，并根据条件寄存器S更新喷射数据D，并将其设置到缺陷寄存器E.当缺陷寄存器E仅具有条件值为 1表示缺陷，相应的喷嘴被识别为有缺陷。 恢复装置将最初分配给缺陷喷嘴的点重新分配给相邻喷嘴。