公开(公告)号：US07746601B2

公开(公告)日：2010-06-29

申请号：US12177596

申请日：2008-07-22

申请人： Hideyuki Sugiyama ,  Yoshiaki Saito

发明人： Hideyuki Sugiyama ,  Yoshiaki Saito

IPC分类号： G11B5/39 ,  G11C11/00 ,  G11C11/14

CPC分类号： G11C11/161

摘要： An area of an element can be made small and fluctuation in area can be reduced. A magneto-resistance effect element is provided with a first electrode with an end face; a magneto-resistance effect film which is formed such that a surface thereof comes in contact with the end face of the first electrode; and a second electrode which is formed on another surface of the magneto-resistance effect element opposed from the surface coming in contact with the surface of the first electrode. The magneto-resistance effect film includes a magnetization pinned layer whose magnetization direction is pinned, a magnetization free layer whose magnetization direction is changeable, and a first non-magnetic layer which is provided between the magnetization pinned layer and the magnetization free layer.

摘要翻译： 可以使元件的区域变小，并且可以减小面积的波动。 磁阻效应元件设置有具有端面的第一电极; 形成为使得其表面与第一电极的端面接触的磁阻效应膜; 以及第二电极，其形成在与从第一电极的表面接触的表面相对的磁阻效应元件的另一个表面上。 磁阻效应膜包括其磁化方向被钉扎的磁化钉扎层，其磁化方向可变的磁化自由层，以及设置在磁化钉扎层与磁化自由层之间的第一非磁性层。

公开(公告)号：US20100090262A1

公开(公告)日：2010-04-15

申请号：US12638375

申请日：2009-12-15

申请人： Yoshiaki SAITO ,  Hideyuki Sugiyama

发明人： Yoshiaki SAITO ,  Hideyuki Sugiyama

IPC分类号： H01L29/94 ,  H01L29/82

CPC分类号： H01L27/228 ,  B82Y10/00 ,  G11C11/161 ,  H01L29/66984 ,  Y10S977/932 ,  Y10S977/933 ,  Y10S977/936

摘要： A spin transistor includes a non-magnetic semiconductor substrate having a channel region, a first area, and a second area. The channel region is between the first and the second areas. The spin transistor also includes a first conductive layer located above the first area and made of a ferromagnetic material magnetized in a first direction; and a second conductive layer located above the second area and made of a ferromagnetic material magnetized in one of the first direction and a second direction that is antiparallel with respect to the first direction. The channel region introduces electron spin between the conductive layers. The spin transistor also includes a gate electrode located between the conductive layers and above the channel region; and a tunnel barrier film located between the non-magnetic semiconductor substrate and at least one of the conductive layers.

摘要翻译： 自旋晶体管包括具有沟道区，第一区和第二区的非磁性半导体衬底。 通道区域在第一和第二区域之间。 自旋晶体管还包括位于第一区域上方并由沿第一方向磁化的铁磁材料制成的第一导电层; 以及第二导电层，其位于第二区域上方并由在相对于第一方向反平行的第一方向和第二方向中的一个中被磁化的铁磁材料制成。 沟道区域在导电层之间引入电子自旋。 自旋晶体管还包括位于导电层之间并位于沟道区之上的栅电极; 以及位于非磁性半导体衬底和至少一个导电层之间的隧道阻挡膜。

公开(公告)号：US08470816B2

公开(公告)日：2013-06-25

申请号：US12314015

申请日：2008-12-02

申请人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

发明人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

IPC分类号： A61K31/5355 ,  A61K31/445 ,  A61K31/444 ,  A61K31/40 ,  C07D413/04 ,  C07D401/04 ,  C07D211/56 ,  C07D207/14

CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/14

摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

摘要翻译： 本发明涉及一种由下式表示的化合物：其中环A为任选具有取代基的含氮杂环，环B为任选具有取代基的芳环，环C为任选具有取代基的环状基团 R 1为氢原子，任选具有取代基的烃基，酰基，任选具有取代基的杂环基或任选具有取代基的氨基，R2为任选卤代的C1 -6烷基，m和n分别为0〜5的整数，m + n为2〜5的整数，为单键或双键，或其盐等。 由于该化合物具有优异的速激肽受体拮抗作用，并且可用作预防或治疗诸如下尿路疾病，胃肠道疾病，中枢神经系统疾病等各种疾病的药剂。

公开(公告)号：US20110178060A1

公开(公告)日：2011-07-21

申请号：US13119743

申请日：2009-09-18

申请人： Junya Shirai ,  Hideyuki Sugiyama ,  Taku Kamei ,  Hironobu Maezaki

发明人： Junya Shirai ,  Hideyuki Sugiyama ,  Taku Kamei ,  Hironobu Maezaki

IPC分类号： A61K31/397 ,  C07D211/58 ,  A61K31/451 ,  C07D401/06 ,  A61K31/4545 ,  C07D207/50 ,  A61K31/40 ,  C07D403/02 ,  A61K31/4178 ,  C07D401/02 ,  A61K31/4439 ,  C07D413/02 ,  A61K31/5355 ,  A61P13/00 ,  A61P1/00 ,  A61P25/00

CPC分类号： C07D401/04 ,  C07D207/14 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/08 ,  C07D413/14 ,  C07D417/08

摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain; R1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.

摘要翻译： 本发明涉及由下式表示的化合物：其中环A是含氮杂环; 环B是任选具有取代基的芳香环; 环D是任选具有取代基的芳香环; L是由式R2表示的基团，R3，R4a和R4b各自独立地为氢原子，任选卤代的C 1-6烷基或任选卤代的C 3-6环烷基，或者R 2和R 3经由亚烷基 链或亚链烯基，或者R4a和R4b任选地通过亚烷基链或亚烯基链键合; R1是氢原子或取代基; m和n各自独立地为0〜5的整数; m + n为2〜5的整数。 并且是单键或双键，或其盐; 等等。 该化合物具有优异的速激肽受体拮抗作用，可用作预防或治疗诸如下尿路疾病，消化道疾病，中枢神经疾病等各种疾病的药剂。

公开(公告)号：US20080275085A1

公开(公告)日：2008-11-06

申请号：US12081926

申请日：2008-04-23

申请人： Junya Shirai ,  Shinji Morimoto ,  Hideyuki Sugiyama ,  Nobuki Sakauchi ,  Takeshi Yoshikawa

发明人： Junya Shirai ,  Shinji Morimoto ,  Hideyuki Sugiyama ,  Nobuki Sakauchi ,  Takeshi Yoshikawa

IPC分类号： A61K31/4545 ,  C07D401/04 ,  A61P1/00 ,  A61K31/445

CPC分类号： C07D211/60 ,  C07D401/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/14 ,  C07D413/06 ,  C07D417/06

摘要： The present invention provides a novel piperidine derivative and a tachykinin receptor antagonist containing same, as well as a compound represented by the formula: wherein R1 is carbamoylmethyl, methylsulfonylethylcarbonyl and the like; R2 is methyl or cyclopropyl; R3 is a hydrogen atom or methyl; R4 is a chlorine atom or trifluoromethyl; R5 is a chlorine atom or trifluoromethyl; and a group represented by the formula: is a group represented by the formula: wherein R6 is a hydrogen atom, methyl, ethyl or isopropyl; R7 is a hydrogen atom, methyl or a chlorine atom; and R8 is a hydrogen atom, a fluorine atom, a chlorine atom or methyl; or 3-methylthiophen-2-yl, and a salt thereof.

摘要翻译： 本发明提供了一种新的哌啶衍生物和含有它的速激肽受体拮抗剂，以及由下式表示的化合物：其中R 1是氨基甲酰基甲基，甲基磺酰基乙基羰基等; R 2是甲基或环丙基; R 3是氢原子或甲基; R 4是氯原子或三氟甲基; R 5是氯原子或三氟甲基; 并且由下式表示的基团是由下式表示的基团：其中R 6是氢原子，甲基，乙基或异丙基; R 7是氢原子，甲基或氯原子; R 8是氢原子，氟原子，氯原子或甲基; 或3-甲基噻吩-2-基及其盐。

公开(公告)号：US08592454B2

公开(公告)日：2013-11-26

申请号：US13119743

申请日：2009-09-18

申请人： Junya Shirai ,  Hideyuki Sugiyama ,  Taku Kamei ,  Hironobu Maezaki

发明人： Junya Shirai ,  Hideyuki Sugiyama ,  Taku Kamei ,  Hironobu Maezaki

IPC分类号： A61K31/445 ,  A61K31/40 ,  A61K31/535 ,  A61K31/00 ,  C07D211/58 ,  C07D295/03

CPC分类号： C07D401/04 ,  C07D207/14 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/08 ,  C07D413/14 ,  C07D417/08

摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain; R1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.

摘要翻译： 本发明涉及由下式表示的化合物：其中环A是含氮杂环; 环B是任选具有取代基的芳香环; 环D是任选具有取代基的芳香环; L是由式R2表示的基团，R3，R4a和R4b各自独立地为氢原子，任选卤代的C 1-6烷基或任选卤代的C 3-6环烷基，或者R 2和R 3经由亚烷基 链或亚链烯基，或者R4a和R4b任选地通过亚烷基链或亚烯基链键合; R1是氢原子或取代基; m和n各自独立地为0〜5的整数; m + n为2〜5的整数。 并且是单键或双键，或其盐; 等等。 该化合物具有优异的速激肽受体拮抗作用，可用作预防或治疗诸如下尿路疾病，消化道疾病，中枢神经疾病等各种疾病的药剂。

公开(公告)号：US07348591B2

公开(公告)日：2008-03-25

申请号：US11502432

申请日：2006-08-11

申请人： Takashi Yamauchi ,  Chika Tanaka ,  Hideyuki Sugiyama ,  Atsuhiro Kinoshita ,  Junji Koga ,  Yuichi Motoi ,  Yoshihiko Nakano ,  Seiichi Suenaga

发明人： Takashi Yamauchi ,  Chika Tanaka ,  Hideyuki Sugiyama ,  Atsuhiro Kinoshita ,  Junji Koga ,  Yuichi Motoi ,  Yoshihiko Nakano ,  Seiichi Suenaga

IPC分类号： H01L29/06

CPC分类号： G11C13/025 ,  B82Y10/00 ,  G11C11/54 ,  G11C23/00 ,  H01H1/0094 ,  H01L43/08 ,  Y10S977/762

摘要： A switch element includes a substrate; a plurality of carbon nanotubes provided upright on the substrate; magnetic particles arranged at tip ends of the carbon nanotubes respectively; and a plurality of conductive layers formed between base ends of the carbon nanotubes and the substrate. A switching operation of the switching element is performed in such a manner that the carbon nanotubes or the magnetic particles are brought into contact with each other according to an electrical potential between the conductive layers, and the carbon nanotubes are separated from each other when an electrical current flows through the carbon nanotubes with the carbon nanotubes or the magnetic particles brought into contact with each other.

摘要翻译： 开关元件包括基板; 设置在基板上的多个碳纳米管; 分别布置在碳纳米管尖端的磁性颗粒; 以及形成在碳纳米管和基板的基端之间的多个导电层。 按照导电层之间的电位使碳纳米管或磁性粒子彼此接触的方式进行开关元件的开关动作，并且当电子元件 电流流过碳纳米管，碳纳米管或磁性颗粒彼此接触。

公开(公告)号：US20070037414A1

公开(公告)日：2007-02-15

申请号：US11502432

申请日：2006-08-11

申请人： Takashi Yamauchi ,  Chika Tanaka ,  Hideyuki Sugiyama ,  Atsuhiro Kinoshita ,  Junji Koga ,  Yuichi Motoi ,  Yoshihiko Nakano ,  Seiichi Suenaga

发明人： Takashi Yamauchi ,  Chika Tanaka ,  Hideyuki Sugiyama ,  Atsuhiro Kinoshita ,  Junji Koga ,  Yuichi Motoi ,  Yoshihiko Nakano ,  Seiichi Suenaga

IPC分类号： H01L21/00

CPC分类号： G11C13/025 ,  B82Y10/00 ,  G11C11/54 ,  G11C23/00 ,  H01H1/0094 ,  H01L43/08 ,  Y10S977/762

摘要： A switch element includes a substrate; a plurality of carbon nanotubes provided upright on the substrate; magnetic particles arranged at tip ends of the carbon nanotubes respectively; and a plurality of conductive layers formed between base ends of the carbon nanotubes and the substrate. A switching operation of the switching element is performed in such a manner that the carbon nanotubes or the magnetic particles are brought into contact with each other according to an electrical potential between the conductive layers, and the carbon nanotubes are separated from each other when an electrical current flows through the carbon nanotubes with the carbon nanotubes or the magnetic particles brought into contact with each other.

摘要翻译： 开关元件包括基板; 设置在基板上的多个碳纳米管; 分别布置在碳纳米管尖端的磁性颗粒; 以及形成在碳纳米管的基端和基板之间的多个导电层。 按照导电层之间的电位使碳纳米管或磁性粒子彼此接触的方式进行开关元件的开关动作，并且当电子元件 电流流过碳纳米管，碳纳米管或磁性颗粒彼此接触。

公开(公告)号：US20090156572A1

公开(公告)日：2009-06-18

申请号：US12314015

申请日：2008-12-02

申请人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

发明人： Yoshinori Ikeura ,  Junya Shirai ,  Hideyuki Sugiyama ,  Yuji Nishikimi ,  Taku Kamei ,  Nobuki Sakauchi

IPC分类号： A61K31/397 ,  C07D413/12 ,  A61K31/5377 ,  C07D401/12 ,  A61K31/4545 ,  C07D417/14 ,  A61K31/541 ,  C07D401/14 ,  A61K31/497 ,  C07D487/04 ,  A61K31/4985

CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/14

摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring optionally having substituent(s), ring C is a cyclic group optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group, a heterocyclic group optionally having substituent(s) or an amino group optionally having substituent(s), R2 is an optionally halogenated C1-6 alkyl group, m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof and the like. Since the compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, gastrointestinal diseases, central nervous system diseases and the like.

摘要翻译： 本发明涉及一种由下式表示的化合物：其中环A为任选具有取代基的含氮杂环，环B为任选具有取代基的芳环，环C为任选具有取代基的环状基团 R 1为氢原子，任选具有取代基的烃基，酰基，任选具有取代基的杂环基或任选具有取代基的氨基，R2为任选卤代的C1 -6烷基，m和n各自为0至5的整数，m + n为2至5的整数，并且是单键或双键，或其盐等。 由于该化合物具有优异的速激肽受体拮抗作用，并且可用作预防或治疗诸如下尿路疾病，胃肠道疾病，中枢神经系统疾病等各种疾病的药剂。