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101 条记录 (耗时 0.053 秒)

    Electronic timepiece with calendar device
    91.
    发明授权
    Electronic timepiece with calendar device 有权
    电子钟表带日历设备

    公开(公告)号：US06477114B1

    公开(公告)日：2002-11-05

    申请号：US09380155

    申请日：1999-08-26

    申请人： Takeo Mutoh ,  Yasuo Kitajima ,  Haruhiko Higuchi ,  Hiroyuki Koike

    发明人： Takeo Mutoh ,  Yasuo Kitajima ,  Haruhiko Higuchi ,  Hiroyuki Koike

    IPC分类号： G04B1924

    CPC分类号： G04C17/0066

    摘要： An electronic timepiece has a calendar advancement device resistant to external shock and capable of achieving date correction in a short time. A date dial advancement transducer (51) is activated in response to a date dial drive signal generated by a 24-hour switch. A date advancement mechanism (a date gear train) (52) employs a Geneva wheel for stabilizing the date dial (70). A bounding restraint lever is regulated using an eccentric cam or the like provided coaxially with the Geneva wheel.

    摘要翻译： 电子钟表具有耐外部冲击的日历提升装置，能够在短时间内实现日期校正。 响应于由24小时开关产生的日期拨盘驱动信号，启动日期拨盘升降换能器（51）。 日期推进机构（日期齿轮系）（52）采用日内瓦轮来稳定日期盘（70）。 使用与日内瓦轮同轴设置的偏心凸轮等来调节边界约束杆。

    Object detecting system
    92.
    发明授权
    Object detecting system 失效
    对象检测系统

    公开(公告)号：US5963162A

    公开(公告)日：1999-10-05

    申请号：US115178

    申请日：1998-07-14

    申请人： Kazuhiko Mochizuki ,  Hiroyuki Koike ,  Akira Iihoshi ,  Takashi Sugawara

    发明人： Kazuhiko Mochizuki ,  Hiroyuki Koike ,  Akira Iihoshi ,  Takashi Sugawara

    IPC分类号： B60R21/00 ,  G01S7/35 ,  G01S13/34 ,  G01S13/58 ,  G01S13/93 ,  G01S13/60

    CPC分类号： G01S13/345 ,  G01S13/584 ,  G01S13/931 ,  G01S2007/356 ,  G01S7/352

    摘要： An object detecting system detects an object using an FM-CW wave, so that even if either one of rising-side and falling-side peak frequencies is missing, a plurality of objects can be accurately recognized by accurately combining pluralities of rising-side and falling-side peak frequencies. When it is determined that either one of rising-side and falling-side peak frequencies is missing, the combination of the peak frequencies is determined by calculating the missing peak frequency based on a peak frequency which is not missing.

    摘要翻译： 物体检测系统使用FM-CW波检测物体，使得即使丢失了上升侧和下降峰值频率中的任一个，也可以通过精确地组合多个上升侧和 下降峰值频率。 当确定上升侧和下降侧峰值频率中的任一个丢失时，通过基于不丢失的峰值频率计算缺失的峰值频率来确定峰值频率的组合。

    Angiotensin II antagonist 1-biphenylmethylimidazole compounds and their therapeutic use
    93.
    发明授权
    Angiotensin II antagonist 1-biphenylmethylimidazole compounds and their therapeutic use 失效
    血管紧张素II拮抗剂1-联苯甲基咪唑化合物及其治疗用途

    公开(公告)号：US5646171A

    公开(公告)日：1997-07-08

    申请号：US465369

    申请日：1995-06-05

    申请人： Hiroaki Yanagisawa ,  Yoshiya Amemiya ,  Yasuo Shimoji ,  Takuro Kanazaki ,  Hiroyuki Koike ,  Toshio Sada

    发明人： Hiroaki Yanagisawa ,  Yoshiya Amemiya ,  Yasuo Shimoji ,  Takuro Kanazaki ,  Hiroyuki Koike ,  Toshio Sada

    IPC分类号： C07D233/90 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14 ,  C07F7/18 ,  C07D405/08 ,  C07D257/04 ,  A61K31/415 ,  A61K31/41

    CPC分类号： C07D403/10 ,  C07D233/90 ,  C07D405/12 ,  C07D405/14 ,  C07F7/1856

    摘要： An angiotensin II antagonist of the formula: ##STR1## in which: R.sub.p.sup.1 represents hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or C.sub.1 -C.sub.6 alkanoyl; R.sub.p.sup.2 represents a single bond, C.sub.1 -C.sub.4 alkylene or C.sub.1 -C.sub.4 alkylidene; R.sub.p.sup.3 and R.sub.p.sup.4 are independently selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl; R.sub.p.sup.5 represents hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl, naphthyl, benzyl, diphenylmethyl, naphthylmethyl, alkanoyloxyalkyl, cycloalkanecarbonyloxyalkyl, alkoxycarbonyloxyalkyl, cycloalkyloxycarbonyloxyalkyl, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methyl, (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl or phthalaidyl; R.sub.p.sup.6 represents a carboxy or a tetrazol-5-yl; and X.sub.p represents an oxygen or sulfur, and pharmaceutically acceptable salts thereof. The compounds have hypotensive activity and can thus be used for the treatment and prophylaxis of hypertension.

    摘要翻译： 一种下式的血管紧张素II拮抗剂：其中：Rp1表示氢，C1-C6烷基，C3-C6环烷基或C1-C6烷酰基; Rp2表示单键，C1-C4亚烷基或C1-C4亚烷基; Rp3和Rp4独立地选自氢和C1-C6烷基; R 5表示氢，C 1 -C 4烷基，苯基，萘基，苄基，二苯基甲基，萘基甲基，烷酰氧基烷基，环烷基羰氧基烷基，烷氧基羰氧基烷基，环烷氧基羰基氧基烷基，（5-苯基-2-氧代-1,3-二氧杂环戊烯-4-基） - 烷基-2-氧代-1,3-二氧杂环戊烯-4-基）甲基或邻苯二甲酰基; Rp6表示羧基或四唑-5-基; Xp表示氧或硫，以及其药学上可接受的盐。 这些化合物具有降血压活性，因此可用于治疗和预防高血压。

    Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
    94.
    发明授权
    Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use 失效
    血管紧张素II拮抗剂1-联苯甲基咪唑化合物及其治疗用途

    公开(公告)号：US5616599A

    公开(公告)日：1997-04-01

    申请号：US378650

    申请日：1995-01-26

    申请人： Hiroaki Yanagisawa ,  Koichi Fujimoto ,  Yoshiya Amemiya ,  Yasuo Shimoji ,  Takuro Kanazaki ,  Hiroyuki Koike ,  Toshio Sada

    发明人： Hiroaki Yanagisawa ,  Koichi Fujimoto ,  Yoshiya Amemiya ,  Yasuo Shimoji ,  Takuro Kanazaki ,  Hiroyuki Koike ,  Toshio Sada

    IPC分类号： C07D233/90 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14 ,  C07F7/18 ,  C07D257/04 ,  A61K31/41 ,  A61K31/415

    CPC分类号： C07D403/10 ,  C07D233/90 ,  C07D405/12 ,  C07D405/14 ,  C07F7/1856

    摘要： Compounds of the following formula (I) or the formula (I).sub.p : ##STR1## wherein R.sup.1 is alkyl or alkenyl; R.sup.2 and R.sup.3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R.sup.4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula --SiR.sup.a R.sup.b R.sup.c, in which R.sup.a, R.sup.b and R.sup.c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R.sup.5 is carboxy or --CONR.sup.8 R.sup.9, wherein R.sup.8 and R.sup.9 hydrogens or alkyl, or R.sup.8 and R.sup.9 together form alkylene; R.sup.6 is hydrogen, alkyl, alkoxy or halogen; R.sup.7 is carboxy or tetrazol-5-yl; R.sub.p.sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R.sub.p.sup.2 is a single bond, alkylene or alkylidene; R.sub.p.sup.3 and R.sub.p.sup.4 are each hydrogen or alkyl; R.sub.p.sup.6 is carboxy or tetrazol-5-yl; and X.sub.p is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.

    摘要翻译： 下式（I）或式（I）的化合物p：其中R 1是烷基或链烯基; R2和R3是与环烷基稠合的氢，烷基，烯基，环烷基，芳烷基，芳基或芳基; R4是氢，烷基，烷酰基，烯酰基，芳基羰基，烷氧基羰基，四氢吡喃基，四氢噻喃基，四氢噻吩基，四氢呋喃基，式-SiRaRbRc的基团，其中R a，R b和R c是烷基或芳基，烷氧基甲基，（烷氧基烷氧基）甲基，卤代烷氧基甲基， 芳烷基，芳基或烷酰氧基甲氧基羰基; R5是羧基或-CONR8R9，其中R8和R9的氢或烷基，或R8和R9一起形成亚烷基; R6是氢，烷基，烷氧基或卤素; R7是羧基或四唑-5-基; Rp1为氢，烷基，环烷基或烷酰基; Rp2是单键，亚烷基或亚烷基; Rp3和Rp4各自为氢或烷基; Rp6是羧基或四唑-5-基; Xp为氧或硫; 及其药学上可接受的盐和酯。 化合物是AII受体拮抗剂，因此具有低血压活性，可用于治疗和预防高血压。 该化合物可以通过使联苯甲基化合物与咪唑化合物反应来制备。

    1,4-dihydropyridine derivatives
    99.
    发明授权
    1,4-dihydropyridine derivatives 失效
    1,4-二氢吡啶衍生物

    公开(公告)号：US4992451A

    公开(公告)日：1991-02-12

    申请号：US324981

    申请日：1989-03-14

    申请人： Hiroyuki Koike ,  Hiroshi Nishino ,  Masafumi Yoshimoto

    发明人： Hiroyuki Koike ,  Hiroshi Nishino ,  Masafumi Yoshimoto

    IPC分类号： A61K31/455 ,  A61K31/495 ,  A61P3/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D211/90

    CPC分类号： C07D211/90

    摘要： 1,4-Dihydro-6-methyl-4-(substituted phenyl)pyridine-3,5-dicarboxylic acid esters have an amino group at the 2-position and at least one nitrooxy group in at least one of the ester groups. These compounds have a variety of valuable activities, including antihypertensive and Ca.sup.++ -blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted acetic acid esters.

    摘要翻译： 1,4-二氢-6-甲基-4-（取代苯基）吡啶-3,5-二羧酸酯在至少一个酯基中具有2-位的氨基和至少一个硝基氧基。 这些化合物具有多种有价值的活性，包括抗高血压和Ca ++阻断活性，导致其用于治疗循环和冠状动脉疾病。 它们可以通过合适的取代的乙酸酯的缩合来制备。