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154 条记录 (耗时 0.051 秒)

    DNA encoding a novel microtubule-associated protein
    91.
    发明授权
    DNA encoding a novel microtubule-associated protein 失效
    编码新型微管相关蛋白的DNA

    公开(公告)号：US5955312A

    公开(公告)日：1999-09-21

    申请号：US805117

    申请日：1997-02-24

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12N15/12 ,  C12P21/06 ,  C07H21/00 ,  C07H21/04 ,  C07K1/00

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides a human microtubule-associated protein (hLC3) and the polynucleotides which identify and encode hLC3. The invention also provides genetically engineered expression vectors, host cells, and a method for producing hLC3. The invention also provides hLC3 as well as agonists, antibodies, and antagonists of hLC3, and the use thereof for the prevention and treatment of diseases associated with the expression of hLC3. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding hLC3 for the treatment of diseases associated with the expression of hLC3. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding hLC3.

    摘要翻译： 本发明提供了人微管相关蛋白（hLC3）和识别和编码hLC3的多核苷酸。 本发明还提供基因工程表达载体，宿主细胞和生产hLC3的方法。 本发明还提供hLC3以及hLC3的激动剂，抗体和拮抗剂，以及其用于预防和治疗与hLC3表达有关的疾病的用途。 另外，本发明提供了将反义分子用于编码hLC3的多核苷酸用于治疗与hLC3表达有关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合hLC3的抗体的诊断测定法。

    DNA encoding a human membrane protein
    93.
    发明授权
    DNA encoding a human membrane protein 失效
    编码人膜蛋白的DNA

    公开(公告)号：US5863764A

    公开(公告)日：1999-01-26

    申请号：US791924

    申请日：1997-01-31

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  C07K14/435 ,  C12N15/64 ,  G01N33/58

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention provides a human membrane protein (NHMP1) and polynucleotides which identify and encode NHMP1. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHMP1 and a method for producing NHMP1. The invention also provides for agonists, antibodies, or antagonists specifically binding NHMP1, and their use, in the prevention and treatment of diseases associated with expression of NHMP1. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHMP1 for the treatment of diseases associated with the expression of NHMP1. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHMP1.

    摘要翻译： 本发明提供了人膜蛋白（NHMP1）和识别和编码NHMP1的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码NHMP1的核酸序列的宿主细胞和生产NHMP1的方法。 本发明还提供特异性结合NHMP1的激动剂，抗体或拮抗剂及其在预防和治疗与NHMP1表达有关的疾病中的用途。 此外，本发明提供了反义分子用于编码NHMP1的多核苷酸用于治疗与NHMP1表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHMP1的抗体的诊断测定法。

    Human zinc binding proteins
    94.
    发明授权
    Human zinc binding proteins 失效
    人锌结合蛋白

    公开(公告)号：US5861495A

    公开(公告)日：1999-01-19

    申请号：US786606

    申请日：1997-01-21

    申请人： Jennifer L. Hillman ,  Janice Au-Young ,  Roger Coleman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Janice Au-Young ,  Roger Coleman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K14/4702 ,  A61K38/00

    摘要： The present invention provides three zinc binding proteins (designated individually as ZB-1, ZB-2, and ZB-3, and collectively as ZB) and polynucleotides which identify and encode ZB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding ZB and a method for producing ZB. The invention also provides for use of ZB and agonists, antibodies, or antagonists specifically binding ZB, in the prevention and treatment of diseases associated with expression of ZB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding ZB for the treatment of diseases associated with the expression of ZB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding ZB.

    摘要翻译： 本发明提供三种锌结合蛋白（分别命名为ZB-1，ZB-2和ZB-3，统称为ZB）和识别和编码ZB的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码ZB的核酸序列和生产ZB的方法。 本发明还提供使用ZB和特异性结合ZB的激动剂，抗体或拮抗剂在预防和治疗与ZB表达相关的疾病中的用途。 另外，本发明提供反义分子用于编码ZB的多核苷酸用于治疗与ZB表达有关的疾病。 本发明还提供利用多核苷酸或其片段或其互补体和特异性结合ZB的抗体的诊断测定法。

    Human thioredoxin
    96.
    发明授权
    Human thioredoxin 失效
    人硫氧还蛋白

    公开(公告)号：US5831049A

    公开(公告)日：1998-11-03

    申请号：US775978

    申请日：1997-01-03

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C12N9/02 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N9/0036 ,  A61K38/00

    摘要： The present invention provides a human thioredoxin (TRDX) and polynucleotides which identify and encode TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX and a method for producing TRDX. The invention also provides for agonists, antibodies, or antagonists specifically binding TRDX, and their use, in the prevention and treatment of diseases associated with expression of TRDX. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TRDX for the treatment of diseases associated with the expression of TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX in the production of recombinant proteins. The invention also provides for the use of purified TRDX in the production of recombinant proteins. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TRDX.

    摘要翻译： 本发明提供鉴定和编码TRDX的人硫氧还蛋白（TRDX）和多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码TRDX的核酸序列和生产TRDX的方法。 本发明还提供了特异性结合TRDX的激动剂，抗体或拮抗剂及其在预防和治疗与TRDX表达相关的疾病中的用途。 另外，本发明提供了反义分子用于编码TRDX的多核苷酸用于治疗与TRDX表达相关的疾病的用途。 本发明还提供了在重组蛋白的产生中包含编码TRDX的核酸序列的基因工程表达载体和宿主细胞。 本发明还提供了纯化的TRDX在重组蛋白的生产中的应用。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合TRDX的抗体的诊断测定法。

    CDNA encoding a human ATP synthase Fo subunit (ASYSD)
    98.
    发明授权
    CDNA encoding a human ATP synthase Fo subunit (ASYSD) 失效
    CDNA编码人类ATP合成酶Fo亚基（ASYSD）

    公开(公告)号：US5763248A

    公开(公告)日：1998-06-09

    申请号：US948195

    申请日：1997-10-09

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C12N9/14 ,  C12N15/00 ,  C12N15/63 ,  C12N15/85 ,  C07H71/04

    CPC分类号： C12N9/14 ,  A61K38/00

    摘要： The present invention provides a human ATP synthase d subunit (ASYSD) and polynucleotides which encode ASYSD. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYSD and for treating disorders associated with expression of ASYSD.

    摘要翻译： 本发明提供了人ATP合成酶d亚基（ASYSD）和编码ASYSD的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。 本发明还提供了用于产生ASYSD和用于治疗与ASYSD表达相关的疾病的方法。

    Human DBI/ACBP-like protein
    100.
    发明授权
    Human DBI/ACBP-like protein 失效
    人类DBI / ACBP样蛋白

    公开(公告)号：US5734038A

    公开(公告)日：1998-03-31

    申请号：US700626

    申请日：1996-08-16

    申请人： Janice Au-Young ,  Jennifer L. Hillman ,  Surya K. Goli

    发明人： Janice Au-Young ,  Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K45/08 ,  A61K48/00 ,  A61P25/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12N15/00 ,  C07H21/04 ,  C12N1/20 ,  C12P21/06

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides polynucleotides which identify and encode a novel human Diazepam binding inhibitor/acyl-CoA binding protein (DBI/ACBP)-like protein (DBIH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding DBIH. The invention also provides for the use of substantially purified DBIH for drug delivery as well as for the production of recombinant proteins for the treatment of diseases associated with the expression of DBIH. Additionally, the invention provides for the use of antisense molecules to DBIH in the treatment of diseases associated with the expression of DBIH. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding DBIH and antibodies which specifically bind to the protein.

    摘要翻译： 本发明提供鉴定并编码新的人地西泮结合抑制剂/酰基辅酶A结合蛋白（DBI / ACBP）样蛋白（DBIH）的多核苷酸。 本发明提供了包含编码DBIH的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供使用基本上纯化的DBIH用于药物递送以及用于产生用于治疗与DBIH表达相关的疾病的重组蛋白质。 另外，本发明提供了用于治疗与DBIH表达有关的疾病的DBIH反义分子的用途。 本发明还描述了利用包含与编码DBIH的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。