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公开(公告)号：US06653287B1
公开(公告)日：2003-11-25
申请号：US09660590
申请日：2000-09-13
IPC分类号： A61K3817
CPC分类号： C07K16/244 , A61K38/12 , A61K39/3955 , A61K2300/00
摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
摘要翻译： 单独或与内皮素拮抗剂组合的白血病抑制因子拮抗剂可用于治疗心力衰竭。 拮抗剂以治疗有效量以慢性方式施用以达到该目的。
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公开(公告)号：US09273113B2
公开(公告)日：2016-03-01
申请号：US13584241
申请日：2012-08-13
CPC分类号： C07K14/71 , A61K38/00 , C07K16/2863 , C07K2319/00 , C07K2319/30 , C07K2319/31
摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
摘要翻译： 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。
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公开(公告)号：US08557238B2
公开(公告)日：2013-10-15
申请号：US12724964
申请日：2010-03-16
IPC分类号： A61K39/395 , C07K16/22 , C07K16/46
CPC分类号： C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
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94.发明授权Composition comprising and method of using angiopoietin-like protein 3 ANGPTL3 有权组合物和使用血管生成素样蛋白3 ANGPTL3的方法公开(公告)号：US08541376B2
公开(公告)日：2013-09-24
申请号：US12128545
申请日：2008-05-28
申请人： Napoleone Ferrara , Hans-Peter Gerber , Joe Kowalski , Maria Teresa Pisabarro , Daniel Eric Sherman
发明人： Napoleone Ferrara , Hans-Peter Gerber , Joe Kowalski , Maria Teresa Pisabarro , Daniel Eric Sherman
CPC分类号： C07K14/515 , A61K48/00 , C12N2799/022
摘要： The present invention is directed to methods and means for making and using Angptl3 polypeptides. The invention specifically concerns the use of Angptl3 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angptl3 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.
摘要翻译： 本发明涉及制备和使用Angpt13多肽的方法和手段。 本发明特别涉及Angpt3多肽在诱导肝再生和血管发生中的应用。 其他方法包括使用Angpt3多肽来诊断和治疗肝脏疾病。 本文还提供结合本发明多肽的抗体。
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公开(公告)号：US08273353B2
公开(公告)日：2012-09-25
申请号：US13096723
申请日：2011-04-28
CPC分类号： C07K14/71 , A61K38/00 , C07K16/2863 , C07K2319/00 , C07K2319/30 , C07K2319/31
摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
摘要翻译： 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。
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96.发明申请公开(公告)号：US20120237514A1
公开(公告)日：2012-09-20
申请号：US13485827
申请日：2012-05-31
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： C07K16/22 , A61K38/00 , A61K38/179 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K14/71 , C07K16/18 , C07K16/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N9/96 , Y02A50/412
摘要： The present invention provides vascular endothelial cell growth factor (VEGF) antagonists and methods of using VEGF antagonists. VEGF antagonists contemplated by the invention include VEGF antibodies and VEGF receptor fusion proteins. Methods of treating edema and stroke using VEGF antagonists are also provided.
摘要翻译： 本发明提供血管内皮细胞生长因子（VEGF）拮抗剂和使用VEGF拮抗剂的方法。 本发明考虑的VEGF拮抗剂包括VEGF抗体和VEGF受体融合蛋白。 还提供了使用VEGF拮抗剂治疗水肿和中风的方法。
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97.发明申请VEGF-SPECIFIC ANTAGONISTS FOR ADJUVANT AND NEOADJUVANT THERAPY AND THE THREATMENT OF EARLY STAGE TUMORS 审中-公开VEGF特异性拮抗剂用于治疗和治疗早期治疗和早期阶段肿瘤的治疗公开(公告)号：US20120148584A1
公开(公告)日：2012-06-14
申请号：US13402645
申请日：2012-02-22
IPC分类号： A61K39/395 , A61P35/04 , A61P35/00 , A61K38/02 , A61K31/7088
CPC分类号： C07K16/22 , A61K38/179 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Disclosed herein are methods of treating benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating a subject at risk of developing benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of treating or preventing recurrence of a tumor using an anti-VEGF-specific antagonist as well as use of VEGF-specific antagonists in neoadjuvant and adjuvant cancer therapy.
摘要翻译： 本文公开了使用抗VEGF特异性拮抗剂治疗良性，癌前或非转移性肿瘤的方法。 还公开了使用抗VEGF特异性拮抗剂治疗患有发展良性，癌前或非转移性肿瘤的风险的受试者的方法。 还公开了使用抗VEGF特异性拮抗剂治疗或预防肿瘤复发以及在新辅助和辅助癌症治疗中使用VEGF特异性拮抗剂的方法。
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公开(公告)号：US20120014941A1
公开(公告)日：2012-01-19
申请号：US12975784
申请日：2010-12-22
申请人： Xiumin Wu , Yan Wu , Lanlan Yu , Napoleone Ferrara , Wei-Ching Liang , Yu-Ju G. Meng , Janet Tien
发明人： Xiumin Wu , Yan Wu , Lanlan Yu , Napoleone Ferrara , Wei-Ching Liang , Yu-Ju G. Meng , Janet Tien
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K16/24 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention concerns antibodies to Bv8 and the uses of same.
摘要翻译： 本发明涉及Bv8的抗体及其用途。
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99.发明申请公开(公告)号：US20110301339A1
公开(公告)日：2011-12-08
申请号：US13096781
申请日：2011-04-28
IPC分类号： C07K16/22
CPC分类号： C07K14/71 , A61K38/00 , C07K16/2863 , C07K2319/00 , C07K2319/30 , C07K2319/31
摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
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100.发明申请公开(公告)号：US20110301337A1
公开(公告)日：2011-12-08
申请号：US13096723
申请日：2011-04-28
IPC分类号： C07K16/22
CPC分类号： C07K14/71 , A61K38/00 , C07K16/2863 , C07K2319/00 , C07K2319/30 , C07K2319/31
摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
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