公开(公告)号：US20080125351A1

公开(公告)日：2008-05-29

申请号：US11878159

申请日：2007-07-20

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

IPC: A61K38/02

CPC classification number: A61K47/34 ,  A61K9/0002 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/573 ,  A61K38/2278 ,  A61K38/26

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

公开(公告)号：US20080051561A1

公开(公告)日：2008-02-28

申请号：US11826382

申请日：2007-07-13

Applicant: Michael Rickey ,  J. Ramstack ,  Rajesh Kumar

Inventor： Michael Rickey ,  J. Ramstack ,  Rajesh Kumar

IPC: C07K14/00

CPC classification number: A61K38/09 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1682 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/519 ,  B01J8/025 ,  B01J13/08 ,  B01J13/12 ,  B01J13/206 ,  B01J14/00 ,  B01J19/121 ,  B01J19/122 ,  B01J19/2415 ,  B01J2219/0877

Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.

公开(公告)号：US20080033240A1

公开(公告)日：2008-02-07

申请号：US11583963

申请日：2006-10-19

Applicant: Brian Hoffman ,  Rajesh Kumar ,  David Larkin ,  Giuseppe Prisco ,  Nitish Swarup ,  Guanghua Zhang

Inventor： Brian Hoffman ,  Rajesh Kumar ,  David Larkin ,  Giuseppe Prisco ,  Nitish Swarup ,  Guanghua Zhang

IPC: A61B1/045

Abstract: To assist a surgeon performing a medical procedure, auxiliary images generally indicating internal details of an anatomic structure being treated are displayed and manipulated by the surgeon on a computer display screen to supplement primary images generally of an external view of the anatomic structure. A master input device controlling a robotic arm in a first mode may be switched by the surgeon to a second mode in order to function instead as a mouse-like pointing device to facilitate the surgeon performing such auxiliary information display and manipulation.

Abstract translation: 为了帮助外科医生执行医疗程序，通常由显示屏和外科医生在计算机显示屏幕上显示和操作通常指示正在治疗的解剖结构的内部细节的辅助图像，以补充大体上解剖结构的外部视图的主要图像。 控制第一模式中的机器人手臂的主输入装置可以由外科医生切换到第二模式，以便改为用作鼠标式指示装置，以便于外科医生执行这种辅助信息的显示和操作。

公开(公告)号：US20070200117A1

公开(公告)日：2007-08-30

申请号：US11785276

申请日：2007-04-17

Applicant: Rajesh Kumar ,  Andrei Mihaila ,  Florin Udrea

Inventor： Rajesh Kumar ,  Andrei Mihaila ,  Florin Udrea

IPC: H01L31/0312

CPC classification number: H01L29/1608 ,  H01L29/66068 ,  H01L29/8083 ,  Y10S438/931

Abstract: A silicon carbide semiconductor device includes a substrate and a junction field effect transistor. The transistor includes: a first semiconductor layer disposed on the substrate; a first gate layer disposed on a surface of the first semiconductor layer; a first channel layer adjacent to the first gate layer on the substrate; a first source layer connecting to the first channel layer electrically; a second gate layer adjacent to the first channel layer to sandwich the first channel layer; a second channel layer adjacent to the second gate layer to sandwich the second gate layer; a third gate layer adjacent to the second channel layer to sandwich the second channel layer; and a second source layer connecting to the second channel layer electrically.

公开(公告)号：US20070196499A1

公开(公告)日：2007-08-23

申请号：US11785638

申请日：2007-04-19

Applicant: Michael Rickey ,  J. Ramstack ,  Rajesh Kumar

Inventor： Michael Rickey ,  J. Ramstack ,  Rajesh Kumar

IPC: A61K9/28 ,  A61K9/14

CPC classification number: A61K38/09 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1682 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/519 ,  B01J8/025 ,  B01J13/08 ,  B01J13/12 ,  B01J13/206 ,  B01J14/00 ,  B01J19/121 ,  B01J19/122 ,  B01J19/2415 ,  B01J2219/0877

Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.

Abstract translation: 制备具有降低的残留溶剂水平的微粒的方法。 微粒与非水洗涤体系接触以降低微粒中残留溶剂的含量。 优选的非水洗涤系统包括100％乙醇和乙醇与庚烷的混合物。 可以使用硬化溶剂和洗涤溶剂的溶剂共混物在一个步骤中硬化和洗涤微粒，从而不需要后硬化洗涤步骤。

公开(公告)号：US20070166352A1

公开(公告)日：2007-07-19

申请号：US11521091

申请日：2006-09-14

Applicant: Steven Wright ,  Troy Christenson ,  Thean Yeoh ,  Michael Rickey ,  Joyce Hotz ,  Rajesh Kumar ,  Mark Fineman ,  Christine Smith ,  John Ong ,  David Lokensgard ,  Henry Costantino

Inventor： Steven Wright ,  Troy Christenson ,  Thean Yeoh ,  Michael Rickey ,  Joyce Hotz ,  Rajesh Kumar ,  Mark Fineman ,  Christine Smith ,  John Ong ,  David Lokensgard ,  Henry Costantino

IPC: A61K39/395 ,  A61K38/28 ,  A61K38/27 ,  A61K38/26 ,  A61K38/43

CPC classification number: A61K47/34 ,  A61K9/0002 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/573 ,  A61K38/2278 ,  A61K38/26

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

Abstract translation: 本发明涉及用于持续释放生物活性多肽的组合物，以及形成和使用所述组合物用于持续释放生物活性多肽的方法。 本发明的缓释组合物包含分散在其中的生物相容性聚合物，生物活性多肽和糖。

公开(公告)号：US07230275B2

公开(公告)日：2007-06-12

申请号：US10984957

申请日：2004-11-10

Applicant: Rajesh Kumar ,  Andrei Mihaila ,  Florin Udrea

Inventor： Rajesh Kumar ,  Andrei Mihaila ,  Florin Udrea

IPC: H01L29/15

CPC classification number: H01L29/1608 ,  H01L29/66068 ,  H01L29/8083 ,  Y10S438/931

Abstract: A silicon carbide semiconductor device includes a substrate and a junction field effect transistor. The transistor includes: a first semiconductor layer disposed on the substrate; a first gate layer disposed on a surface of the first semiconductor layer; a first channel layer adjacent to the first gate layer on the substrate; a first source layer connecting to the first channel layer electrically; a second gate layer adjacent to the first channel layer to sandwich the first channel layer; a second channel layer adjacent to the second gate layer to sandwich the second gate layer; a third gate layer adjacent to the second channel layer to sandwich the second channel layer; and a second source layer connecting to the second channel layer electrically.

Abstract translation: 碳化硅半导体器件包括衬底和结场效应晶体管。 晶体管包括：设置在基板上的第一半导体层; 设置在所述第一半导体层的表面上的第一栅极层; 与所述基板上的所述第一栅极层相邻的第一沟道层; 电连接到第一沟道层的第一源极层; 与所述第一沟道层相邻以夹住所述第一沟道层的第二栅极层; 与所述第二栅极层相邻以夹住所述第二栅极层的第二沟道层; 与所述第二沟道层相邻以夹住所述第二沟道层的第三栅极层; 以及电连接到第二沟道层的第二源极层。

公开(公告)号：US20060178559A1

公开(公告)日：2006-08-10

申请号：US11319012

申请日：2005-12-27

Applicant: Rajesh Kumar ,  Brian Hoffman ,  Giuseppe Prisco ,  David Larkin ,  William Nowlin ,  Frederic Moll ,  Stephen Blumenkranz ,  Gunter Niemeyer ,  J. Salisbury ,  Yulun Wang ,  Modjtaba Ghodoussi ,  Darrin Uecker ,  James Wright ,  Amante Mangaser ,  Ranjan Mukherjee

Inventor： Rajesh Kumar ,  Brian Hoffman ,  Giuseppe Prisco ,  David Larkin ,  William Nowlin ,  Frederic Moll ,  Stephen Blumenkranz ,  Gunter Niemeyer ,  J. Salisbury ,  Yulun Wang ,  Modjtaba Ghodoussi ,  Darrin Uecker ,  James Wright ,  Amante Mangaser ,  Ranjan Mukherjee

IPC: A61B1/04

CPC classification number: G09B23/28 ,  A61B1/00193 ,  A61B34/30 ,  A61B34/37 ,  A61B34/70 ,  A61B90/361 ,  A61B90/37 ,  A61B2017/00017 ,  Y10S901/16

Abstract: A multi-user medical robotic system for collaboration or training in minimally invasive surgical procedures includes first and second master input devices, a first slave robotic mechanism, and at least one processor configured to generate a first slave command for the first slave robotic mechanism by switchably using one or both of a first command indicative of manipulation of the first master input device by a first user and a second command indicative of manipulation of the second master input device by a second user. To facilitate the collaboration or training, both first and second users communicate with each other through an audio system and see the minimally invasive surgery site on first and second displays respectively viewable by the first and second users.

公开(公告)号：US20050260598A1

公开(公告)日：2005-11-24

申请号：US10631558

申请日：2003-07-31

Applicant: Girish Sahni ,  Rajesh Kumar ,  Chaiti Roy ,  Kammara Rajagopal ,  Deepak Nihalani ,  Vasudha Sundaram ,  Mahavir Yadav

Inventor： Girish Sahni ,  Rajesh Kumar ,  Chaiti Roy ,  Kammara Rajagopal ,  Deepak Nihalani ,  Vasudha Sundaram ,  Mahavir Yadav

IPC: A61K38/00 ,  C07H21/04 ,  C07K14/315 ,  C07K14/78 ,  C07K19/00 ,  C12N1/21 ,  C12N9/12 ,  C12N9/70 ,  C12N15/58 ,  C12Q1/68

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/3153 ,  C07K19/00 ,  C07K2319/70

Abstract: Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.

Abstract translation: 具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质，包括增强的纤维蛋白选择性。 这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。 还公开了制备蛋白质的方法。

公开(公告)号：US06316581B1

公开(公告)日：2001-11-13

申请号：US09780213

申请日：2001-02-09

Applicant: Richard A. Gross ,  Rajesh Kumar

Inventor： Richard A. Gross ,  Rajesh Kumar

IPC: C08G6400

CPC classification number: C08G64/02 ,  A61K9/204 ,  C08G63/64 ,  C08G69/44

Abstract: A bioresorbable copolymer composition comprising products of a reaction between a first comonomer comprising cyclic carbonates, lactones, lactides, lactams, thiolactones, functionalized cyclic carbonates and nonfunctionalized cyclic carbonates; and a second, functionalized, cyclic carbonate comonomer, wherein said second comonomer is a ring structure, wherein comprising a functional group.

Abstract translation: 包含环状碳酸酯，内酯，丙交酯，内酰胺，硫内酯，官能化环状碳酸酯和非官能化环状碳酸酯的第一共聚单体之间的反应产物的生物可再吸收共聚物组合物; 和第二官能化环状碳酸酯共聚单体，其中所述第二共聚单体是环结构，其中包含官能团。