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163 条记录 (耗时 0.054 秒)

    Agomelatine intermediates and preparation method thereof
    91.
    发明授权
    Agomelatine intermediates and preparation method thereof 有权
    阿莫拉坦中间体及其制备方法

    公开(公告)号：US08779199B2

    公开(公告)日：2014-07-15

    申请号：US13702388

    申请日：2011-06-08

    申请人： Peng Zhang ,  Yu Huang ,  Zhedong Yuan ,  Hanbin Shan ,  Xiong Yu

    发明人： Peng Zhang ,  Yu Huang ,  Zhedong Yuan ,  Hanbin Shan ,  Xiong Yu

    IPC分类号： C07C233/22 ,  C07C231/06 ,  C07C233/18 ,  C07C231/12

    CPC分类号： C07C231/06 ,  C07C231/12 ,  C07C233/18 ,  C07C233/22 ,  C07C2602/10

    摘要： The present invention relates to the intermediate compounds for preparation of agomelatine, as well as the preparation methods thereof The intermediate of the present invention for preparation of agomelatine is compound A as shown in the following formula. Also provided are two novel intermediate compounds. When we use these new intermediate compounds to prepare agomelatine, it is simple to manipulate, well-controlled and with high purity, without complicated operations such as rectification and column chromatography separation, and suitable for industrial production. Meanwhile, the preparation methods of the two new intermediates themselves is simple and high yield, only using the most commonly-used 7-methoxy-tetralone as original starting material and undergoing one step of reaction to obtain the intermediates, followed by one more step of converting the intermediate compounds to desired product agomelatine. Said reaction processes are greatly simplified, with the reaction yield being improved and the difficulty in purification of previous method being overcome, as compare with the previous technique for preparation of agomelatine. Typically, the yield of the present invention is over 70%.

    摘要翻译： 本发明涉及用于制备阿格美兰碱的中间体化合物及其制备方法本发明的用于制备agomelatine的中间体是如下式所示的化合物A. 还提供两种新型中间体化合物。 当我们使用这些新的中间体化合物来制备agomelatine时，其操作简单，控制良好，纯度高，无需精馏和柱层析分离等复杂操作，适用于工业生产。 同时，两种新中间体本身的制备方法简单高产，仅使用最常用的7-甲氧基 - 四氢萘酮作为起始原料，经过一步反应得到中间体，再加入一步 将中间体化合物转化成所需的产物agomelatine。 所述反应过程被大大简化，与先前用于制备agMelatine的技术相比，反应产率提高并克服了先前方法的纯化困难。 通常，本发明的产率超过70％。

    Web page ad slot identification
    92.
    发明授权
    Web page ad slot identification 有权
    网页广告位标识

    公开(公告)号：US08738448B2

    公开(公告)日：2014-05-27

    申请号：US13369281

    申请日：2012-02-08

    申请人： Peng Zhang

    发明人： Peng Zhang

    IPC分类号： G06Q30/00

    CPC分类号： G06Q30/0277 ,  G06Q30/0241

    摘要： Systems and methods of identifying ad elements of web pages via a computer network are provided. A script configured to identify an ad slot on a web page can be obtained by at least one data processing system having an ad slot evaluation module. The script can be executed to obtain advertisement parameters of the ad slot and web page parameters of the ad slot and generate a unique identifier of the ad slot. The generated unique identifier is associated with a URL identifier of the web page. The data processing system evaluates at least one database to determine one of a presence and an absence of the historical ad slot data. The data processing system provides content for display in the ad slot of the web page based at least in part on a result of the evaluation of the database.

    摘要翻译： 提供了通过计算机网络识别网页的广告元素的系统和方法。 配置为识别网页上的广告位的脚本可以由具有广告位评估模块的至少一个数据处理系统获得。 可以执行脚本以获得广告位的广告位和广告网页参数的广告参数，并生成广告位的唯一标识符。 生成的唯一标识符与网页的URL标识符相关联。 数据处理系统评估至少一个数据库以确定历史广告位数据的存在和不存在。 数据处理系统至少部分地基于数据库的评估结果来提供用于在网页的广告位中显示的内容。

    Agomelatine hydrobromide hydrate and preparation thereof
    93.
    发明授权
    Agomelatine hydrobromide hydrate and preparation thereof 有权
    氢溴酸阿莫拉坦及其制备方法

    公开(公告)号：US08729132B2

    公开(公告)日：2014-05-20

    申请号：US13635087

    申请日：2011-03-17

    申请人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

    发明人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

    IPC分类号： A01N37/18 ,  A61K31/16 ,  C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00

    CPC分类号： C07C233/18 ,  A61K31/165

    摘要： The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.

    摘要翻译： 本发明涉及其中X是Br的式I的氢溴酸阿尔美拉酸水合物，其制备和用途以及含有它的药物组合物。 通过本发明方法获得的氢溴酸氢溴酸水合物与阿魏酸相比具有显着增加的溶解度，因此更适用于制备药物制剂。 此外，该产品具有更高的稳定性和纯度。 使用本方法，可以通过简单的工艺获得高纯度的产品，没有任何复杂的步骤。

    PREDICTING VISIBILITY OF CONTENT ITEMS
    94.
    发明申请
    PREDICTING VISIBILITY OF CONTENT ITEMS 有权
    预测内容项目的可见性

    公开(公告)号：US20140019262A1

    公开(公告)日：2014-01-16

    申请号：US13546978

    申请日：2012-07-11

    申请人： Paul Schelte Albert Reitsma ,  Thomas J. Murray, IV ,  Peng Zhang

    发明人： Paul Schelte Albert Reitsma ,  Thomas J. Murray, IV ,  Peng Zhang

    IPC分类号： G06F15/16 ,  G06Q30/02

    CPC分类号： G06Q30/0254 ,  G06N5/02 ,  G06Q30/02 ,  G06Q30/0241

    摘要： Methods, systems, and apparatus, including computer programs encoded on a computer-readable storage medium, and including a method for predicting visibility of web pages. The method comprises identifying web pages that include slots for presenting content. The method further comprises, for each slot, creating a fingerprint based on a URL associated with the page and structural information associated with the slot's location on the page, determining a likelihood of the slot being visible when the web page is initially presented, the likelihood in the form of a predictive model, and saving the fingerprint and predictive model in a data structure. The method further comprises receiving a request for content from a web page, creating fingerprints associated with the web page, and comparing the fingerprints to fingerprints in the data structure. When a matching fingerprint is located, prediction data is used that is associated with a matching fingerprint for the web page.

    摘要翻译： 方法，系统和装置，包括在计算机可读存储介质上编码的计算机程序，并且包括用于预测网页的可见性的方法。 该方法包括识别包括用于呈现内容的时隙的网页。 该方法还包括：针对每个时隙，基于与页面相关联的URL和与该页面上的时隙位置相关联的结构信息创建指纹，确定在最初呈现网页时该时隙可见的可能性，可能性 以预测模型的形式，并将指纹和预测模型保存在数据结构中。 该方法还包括从网页接收对内容的请求，创建与网页相关联的指纹，以及将指纹与数据结构中的指纹进行比较。 当找到匹配的指纹时，使用与网页的匹配指纹相关联的预测数据。

    SEAMLESS CONFIGURATION UPDATE FOR OPTICAL NETWORK UNIT IN ETHERNET PASSIVE OPTICAL NETWORK
    96.
    发明申请
    SEAMLESS CONFIGURATION UPDATE FOR OPTICAL NETWORK UNIT IN ETHERNET PASSIVE OPTICAL NETWORK 有权
    以太网中光网络的无缝配置更新被动光网络

    公开(公告)号：US20120251113A1

    公开(公告)日：2012-10-04

    申请号：US13433235

    申请日：2012-03-28

    申请人： Marek Hajduczenia ,  Meiyan Zang ,  Peng Zhang

    发明人： Marek Hajduczenia ,  Meiyan Zang ,  Peng Zhang

    IPC分类号： H04B10/00 ,  H04B10/08

    CPC分类号： H04L41/082 ,  H04L41/0869 ,  H04Q11/0067 ,  H04Q2011/0079

    摘要： Techniques for updating configuration of an Optical Network Unit (ONU) in an Ethernet Passive Optical Network (EPON) include receiving a notification that an updated configuration file is available for the ONU, obtaining the updated configuration file, performing a first validation of the updated configuration file for structural errors, determining changes between a current configuration of the ONU and the updated configuration file to identify ONU resources to implement to the changes, performing a second validation about whether the ONU resources to implement the changes are available or not at the ONU and applying the changes to the ONU when it is determined that the ONU resources to implement the changes are available at the ONU.

    摘要翻译： 用于更新以太网无源光网络（EPON）中的光网络单元（ONU）的配置的技术包括接收更新的配置文件可用于ONU的通知，获得更新的配置文件，执行更新配置的第一验证 确定ONU的当前配置与更新的配置文件之间的变化，以识别实现该更改的ONU资源，对ONU执行关于实现该改变的ONU资源是否可用的第二验证;以及 当确定实现改变的ONU资源在ONU处可用时，将该改变应用于ONU。

    Automatic mounting apparatus
    97.
    发明授权
    Automatic mounting apparatus 失效
    自动安装装置

    公开(公告)号：US08210487B2

    公开(公告)日：2012-07-03

    申请号：US12542708

    申请日：2009-08-18

    申请人： Yong-Miao Fan ,  Hong-Jun Feng ,  Peng Zhang ,  Yu-Bin Guo

    发明人： Yong-Miao Fan ,  Hong-Jun Feng ,  Peng Zhang ,  Yu-Bin Guo

    IPC分类号： B23Q7/10

    CPC分类号： B23P19/084 ,  Y10T29/49947 ,  Y10T29/53 ,  Y10T29/53487 ,  Y10T29/53961

    摘要： An apparatus includes a bracket, a pushing member having a pushing surface, a magazine member to fitting about a plurality of clamping rings, a sending member, a fixing member fixed to the bracket and a resisting member fixed to the fixing member. The fixing member defines a positioning hole for fixing the magazine member, with the clamping rings freely sliding through the positioning hole. The sending member includes two guiding rods fixed to the fixing member, two elastic elements fitting about the corresponding guiding rods, and a moving board slidably mounted to the guiding rods. The elasticity of the elastic elements urges the moving board to drive one of the plurality of clamping rings to resist against the resisting member. When the pushing member is moved towards the fixing member, the pushing surface pushes the one clamping ring to clamp a shaft of a connecting piece.

    摘要翻译： 一种装置，包括支架，具有推动表面的推动构件，用于装配在多个夹紧环周围的料仓构件，发送构件，固定到支架的固定构件和固定到固定构件的抵抗构件。 固定构件限定用于固定料仓构件的定位孔，夹紧环通过定位孔自由滑动。 发送构件包括固定到固定构件的两个引导杆，围绕相应引导杆安装的两个弹性元件和可滑动地安装到引导杆的移动板。 弹性元件的弹性促使移动板驱动多个夹紧环中的一个以抵抗抵抗构件。 当推动构件朝向固定构件移动时，推动表面推动一个夹紧环来夹紧连接件的轴。

    Ultra-scalable supercomputer based on MPU architecture
    99.
    发明授权
    Ultra-scalable supercomputer based on MPU architecture 有权
    基于MPU架构的超可扩展超级计算机

    公开(公告)号：US08159973B2

    公开(公告)日：2012-04-17

    申请号：US12179657

    申请日：2008-07-25

    申请人： Yuefan Deng ,  Alexander Korobka ,  Peng Zhang

    发明人： Yuefan Deng ,  Alexander Korobka ,  Peng Zhang

    IPC分类号： H04L12/28

    CPC分类号： G06F15/803

    摘要： The invention provides an ultra-scalable supercomputer based on MPU architecture in achieving the well-balanced performance of hundreds of TFLOPS or PFLOPS range in applications. The supercomputer system design includes the interconnect topology and its corresponding routing strategies, the communication subsystem design and implementation, the software and hardware schematic implementations. The supercomputer comprises a plurality of processing nodes powering the parallel processing and Axon nodes connecting computing nodes while implementing the external interconnections. The interconnect topology can be based on MPU architecture and the communication routing logic as required by switching logics is implemented in the FPGA chips while some modular designs for accelerating particular traffic patterns from applications and meliorating the communication overhead are able to be deployed as well.

    摘要翻译： 本发明提供了一种基于MPU架构的超可扩展超级计算机，以实现应用中数百个TFLOPS或PFLOPS系列的平衡性能。 超级计算机系统设计包括互连拓扑及其对应的路由策略，通信子系统的设计与实现，软件和硬件原理图的实现。 该超级计算机包括为并行处理提供动力的多个处理节点和连接计算节点的Axon节点，同时实现外部互连。 互连拓扑可以基于MPU架构，并且切换逻辑所要求的通信路由逻辑在FPGA芯片中实现，同时也可以部署用于加速来自应用的特定流量模式并改善通信开销的一些模块化设计。