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公开(公告)号：US06902729B2
公开(公告)日：2005-06-07
申请号：US10358619
申请日：2003-02-04
申请人： Scott R. Presnell , Andrew L. Feldhaus , Zeren Gao
发明人： Scott R. Presnell , Andrew L. Feldhaus , Zeren Gao
CPC分类号： C07K14/56 , A61K38/00 , Y10S977/918 , Y10S977/927
摘要： Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. The present invention provides a new form of murine interferon-α, which has applications in diagnosis and therapy.
摘要翻译： 干扰素代表了一类重要的生物制药产品，在治疗各种医疗条件方面具有良好的记录，包括治疗某些自身免疫性疾病，治疗特定癌症，以及增强针对感染因子的免疫应答。 本发明提供了一种新型的鼠干扰素-α，其在诊断和治疗中具有应用。
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公开(公告)号：US06897292B2
公开(公告)日：2005-05-24
申请号：US09728911
申请日：2000-12-01
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
IPC分类号： C12N15/09 , A61K38/00 , A61P29/00 , C07K14/705 , C07K14/715 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C07K14/725 , C07K14/75
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
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公开(公告)号：US06803451B2
公开(公告)日：2004-10-12
申请号：US10243072
申请日：2002-09-13
IPC分类号： C07K1452
CPC分类号： C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US06312924B1
公开(公告)日：2001-11-06
申请号：US09528760
申请日：2000-03-17
申请人： Scott R. Presnell , Andrew L. Feldhaus , Zeren Gao
发明人： Scott R. Presnell , Andrew L. Feldhaus , Zeren Gao
IPC分类号： C12P2104
CPC分类号： C07K14/56 , A61K38/00 , Y10S977/918 , Y10S977/927
摘要： Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. The present invention provides a new form of murine interferon-&agr;, which has applications in diagnosis and therapy.
摘要翻译： 干扰素代表了一类重要的生物制药产品，在治疗各种医疗条件方面具有良好的记录，包括治疗某些自身免疫性疾病，治疗特定癌症，以及增强针对感染因子的免疫应答。 本发明提供了一种新型的鼠干扰素-α，其在诊断和治疗中具有应用。
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公开(公告)号：US09441034B2
公开(公告)日：2016-09-13
申请号：US12934756
申请日：2009-03-27
申请人： Pallavur V. Sivakumar , Debra G. Gilbertson , Marshall D. Snavely , George R. Mabry , Eugene C. Yi , Yue Yao , Scott R. Presnell
发明人： Pallavur V. Sivakumar , Debra G. Gilbertson , Marshall D. Snavely , George R. Mabry , Eugene C. Yi , Yue Yao , Scott R. Presnell
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/90 , C07K2317/92
摘要： Disclosed are antagonists of PDGF receptor β (PDGFRβ) and VEGF-A, including neutralizing anti-PDGFRβ and anti-VEGF-A antibodies, as well as related compositions and methods. Anti-PDGFRβ and anti-VEGF-A antibodies disclosed herein include bispecific antibodies capable of binding and neutralizing both PDGFRβ and VEGF-A. Also disclosed are methods of treating an neovascular disorder, such as cancer or an neovascular ocular disorder, using a PDGFRβ and/or VEGF-A antagonist.
摘要翻译： 公开了PDGF受体β（PDGFRβ）和VEGF-A的拮抗剂，包括中和抗PDGFRβ和抗VEGF-A抗体，以及相关的组合物和方法。 本文公开的抗PDGFRβ和抗VEGF-A抗体包括能够结合和中和PDGFRβ和VEGF-A两者的双特异性抗体。 还公开了使用PDGFRβ和/或VEGF-A拮抗剂治疗新生血管性疾病如癌症或新生血管性眼病的方法。
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公开(公告)号：US08475791B2
公开(公告)日：2013-07-02
申请号：US13342675
申请日：2012-01-03
IPC分类号： A61K39/395
CPC分类号： C07K16/24 , A61K38/00 , A61K39/00 , C07K14/54 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to ZCYTO18 polynucleotide and polypeptide molecules. The ZCYTO18 is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 本发明涉及ZCYTO18多核苷酸和多肽分子。 ZCYTO18是一种新型细胞因子。 多肽可用于在体外和体内刺激造血细胞的增殖和/或发育的方法中。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US08372602B2
公开(公告)日：2013-02-12
申请号：US13339779
申请日：2011-12-29
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20120294862A1
公开(公告)日：2012-11-22
申请号：US13534019
申请日：2012-06-27
申请人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
发明人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , George Robert Mabry, III , Stephen R. Jaspers , Monica J. Huber
IPC分类号： C07K16/46 , A61P29/00 , A61P11/06 , A61P25/00 , A61P1/00 , A61P19/02 , A61K39/395 , A61P37/00
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-17A，IL-17F和IL-23的活性。 拮抗剂包括结合IL-23并结合IL-17A或IL-17F的抗体和抗体片段，例如IL-17A和IL-17F交叉反应的抗体。 还公开了包括结合IL-23的抗体或抗体片段和在一个分子上结合IL-17A或IL-17F的抗体或抗体片段的拮抗剂。 还公开了结合IL-23和IL-17F但不结合IL-17A的抗体和抗体片段。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
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公开(公告)号：US20110189207A1
公开(公告)日：2011-08-04
申请号：US13021270
申请日：2011-02-04
申请人： Cindy A. Sprecher , Julia E. Novak , James W. West , Scott R. Presnell , Richard D. Holly , Andrew J. Nelson
发明人： Cindy A. Sprecher , Julia E. Novak , James W. West , Scott R. Presnell , Richard D. Holly , Andrew J. Nelson
IPC分类号： A61K39/395 , A61K38/17 , A61P29/00 , A61P3/10 , A61P25/00 , A61P37/06 , A61P11/06 , A61P19/02
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2317/73 , C07K2319/00
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20110183359A1
公开(公告)日：2011-07-28
申请号：US13039459
申请日：2011-03-03
IPC分类号： G01N33/53
CPC分类号： C07H21/04 , C07K14/715 , C07K16/1232 , C07K16/2866 , C07K2317/32 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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