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    Process for producing 1,2-dialkoxy-3-fluorobenzene
    91.
    发明授权
    Process for producing 1,2-dialkoxy-3-fluorobenzene 失效

    公开(公告)号：US07786330B2

    公开(公告)日：2010-08-31

    申请号：US12379553

    申请日：2009-02-24

    申请人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

    发明人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

    IPC分类号： C07C37/04 ,  C07C41/26

    CPC分类号： C07C39/27 ,  C07C41/16 ,  C07C41/26 ,  C07C43/225 ,  C07C43/23

    摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

    Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof
    92.
    发明申请
    Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof 失效
    蛋白酪氨酸磷酸酶1B抑制剂，其制备方法和用途

    公开(公告)号：US20100197927A1

    公开(公告)日：2010-08-05

    申请号：US12530281

    申请日：2008-02-26

    申请人： Fajun Nan ,  Jia Li ,  Yi Wei ,  Wei Zhang ,  Jingya Li ,  Lei Shi

    发明人： Fajun Nan ,  Jia Li ,  Yi Wei ,  Wei Zhang ,  Jingya Li ,  Lei Shi

    IPC分类号： C07D277/30 ,  C07D417/12

    CPC分类号： C07D277/30 ,  C07D417/12

    摘要： PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.

    摘要翻译： 具有以下结构的PTP1B抑制剂（式I）。 实验表明，这些抑制剂能有效抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性。 它们可以用作胰岛素敏化剂。 它们可用于预防，延迟或治疗与PTP1B介导的胰岛素拮抗相关的疾病，特别是II型糖尿病和肥胖症。 本发明还提供了制备这些抑制剂的方法。

    ARRANGEMENT COMPRISING MEDICAL TREATMENT UNITS AND PERIPHERAL DEVICES AS WELL AS A PERIPHERAL DEVICE AND TREATMENT UNIT FOR USE IN SUCH AN ARRANGEMENT
    93.
    发明申请
    ARRANGEMENT COMPRISING MEDICAL TREATMENT UNITS AND PERIPHERAL DEVICES AS WELL AS A PERIPHERAL DEVICE AND TREATMENT UNIT FOR USE IN SUCH AN ARRANGEMENT 有权
    包括医疗治疗单位和外围设备的安排，作为外围设备和治疗单元，用于这种安排

    公开(公告)号：US20100114639A1

    公开(公告)日：2010-05-06

    申请号：US12596613

    申请日：2008-04-17

    申请人： Claus Leiendecker ,  Carsten Müller ,  Elke Schulte ,  Wei Zhang

    发明人： Claus Leiendecker ,  Carsten Müller ,  Elke Schulte ,  Wei Zhang

    IPC分类号： G06Q10/00 ,  A61M1/14 ,  G06F15/16

    CPC分类号： A61M1/14 ,  A61B5/002 ,  A61B5/021 ,  A61B5/024 ,  A61B90/90 ,  A61B90/98 ,  A61B2017/00119 ,  A61B2017/00221 ,  A61B2017/00482 ,  A61B2562/08 ,  A61M2205/3569 ,  A61M2205/3576 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/8237 ,  A61M2205/84 ,  G06F19/00 ,  G06Q50/24 ,  G16H10/60

    摘要： An assembly includes at least two medical treatment units, each of which can be allocated to a patient and at least two peripheral devices, each of which can be allocated to a patient. The peripheral devices and the treatment units have means for allocating a peripheral device to a treatment unit and means for verifying the allocation of a peripheral device to a patient. To allocate a peripheral device to a treatment unit, the peripheral device is placed by operators in a receiving unit belonging to the treatment unit. Said receiving unit is preferably designed as a charging station for the battery of the peripheral device. In the event of a successful allocation of peripheral device and patient, confirmed by the receipt of physiological data of the patient, the operators verify the correct allocation of a peripheral device to the patient and must confirm the correct allocation by confirmation means. The peripheral device is only released if the operator has confirmed the correct allocation, preferably within a predefined time period.

    摘要翻译： 组件包括至少两个医疗单元，每个医疗单元可以分配给患者和至少两个外围设备，每个外围设备可以分配给患者。 外围设备和治疗单元具有用于将外围设备分配给治疗单元的装置和用于验证外围设备对患者的分配的装置。 为了将外围设备分配给治疗单元，外围设备由操作员放置在属于治疗单元的接收单元中。 所述接收单元优选地被设计为用于外围设备的电池的充电站。 在外部设备和患者的成功分配的情况下，通过接收患者的生理数据确认，操作者验证外部设备对患者的正确分配，并且必须通过确认手段确认正确的分配。 如果操作者已经确定了正确的分配，则优选地在预定的时间段内，外围设备才被释放。

    Smoke and fire detection in aircraft cargo compartments
    95.
    发明授权
    Smoke and fire detection in aircraft cargo compartments 有权
    飞机货舱中的烟雾和火灾探测

    公开(公告)号：US07688199B2

    公开(公告)日：2010-03-30

    申请号：US11555992

    申请日：2006-11-02

    申请人： Wei Zhang ,  Chao-Hsin Lin

    发明人： Wei Zhang ,  Chao-Hsin Lin

    IPC分类号： G08B1/08 ,  G08B21/00 ,  G08B25/00

    CPC分类号： G08B17/00 ,  A62C3/08 ,  G08B31/00

    摘要： A detection system may include at least one sensor located in an enclosable space, each sensor being configured to detect at least one environmental feature and provide a corresponding at least one environmental feature signal. The system may process the at least one environmental feature signal and provide at least one processed feature signal, the at least one processed feature signal corresponding to a transformed at least one environmental feature signal. The system may further provide a hosted function configured to provide instructions for processing, the hosted function comprising a computational algorithm adapted to perform numerical transformation operations based on the at least one environmental feature signal, the hosted function being configured to provide a map image based on the at least one processed feature signal.

    摘要翻译： 检测系统可以包括位于可封闭空间中的至少一个传感器，每个传感器被配置成检测至少一个环境特征并提供对应的至少一个环境特征信号。 所述系统可以处理所述至少一个环境特征信号并提供至少一个经处理的特征信号，所述至少一个经处理的特征信号对应于经变换的至少一个环境特征信号。 所述系统还可以提供被配置为提供用于处理的指令的托管功能，所述托管功能包括适于基于所述至少一个环境特征信号执行数字变换操作的计算算法，所述托管功能被配置为基于 所述至少一个经处理的特征信号。

    LEARNING-BASED PARTIAL DIFFERENTIAL EQUATIONS FOR COMPUTER VISION
    96.
    发明申请
    LEARNING-BASED PARTIAL DIFFERENTIAL EQUATIONS FOR COMPUTER VISION 审中-公开
    用于计算机视觉的基于学习的部分差分方程

    公开(公告)号：US20100074551A1

    公开(公告)日：2010-03-25

    申请号：US12235488

    申请日：2008-09-22

    申请人： Zhouchen Lin ,  Wei Zhang

    发明人： Zhouchen Lin ,  Wei Zhang

    IPC分类号： G06K9/40

    CPC分类号： G06K9/40 ,  G06T5/001 ,  G06T7/10 ,  G06T2207/20081

    摘要： Partial differential equations (PDEs) are used in the invention for various problems in computer the vision space. The present invention provides a framework for learning a system of PDEs from real data to accomplish a specific vision task. In one embodiment, the system consists of two PDEs. One controls the evolution of the output. The other is for an indicator function that helps collect global information. Both PDEs are coupled equations between the output image and the indicator function, up to their second order partial derivatives. The way they are coupled is suggested by the shift and rotational invariance that the PDEs should hold. The coupling coefficients are learnt from real data via an optimal control technique. The invention provides learning-based PDEs that make a unified framework for handling different vision tasks, such as edge detection, denoising, segementation, and object detection.

    摘要翻译： 局部微分方程（PDE）用于本发明的计算机视觉空间中的各种问题。 本发明提供了一种用于从实际数据学习PDE系统以完成特定视觉任务的框架。 在一个实施例中，系统由两个PDE组成。 一个控制输出的演变。 另一个是用于帮助收集全球信息的指标功能。 两个PDE是输出图像和指示符函数之间的耦合方程，直到它们的二阶偏导数。 它们耦合的方式是由PDE应该保持的移动和旋转不变性来提出的。 通过最优控制技术从实数数据中学习耦合系数。 本发明提供了基于学习的PDE，其构成用于处理不同视觉任务的统一框架，例如边缘检测，去噪，分割和对象检测。

    Processing medical image information to detect anatomical abnormalities
    97.
    发明授权
    Processing medical image information to detect anatomical abnormalities 有权
    处理医学图像信息以检测解剖异常

    公开(公告)号：US07672494B2

    公开(公告)日：2010-03-02

    申请号：US11419980

    申请日：2006-05-23

    申请人： Takeshi Doi ,  Wei Zhang

    发明人： Takeshi Doi ,  Wei Zhang

    IPC分类号： G06K9/00 ,  A61B6/04

    CPC分类号： G06T7/0012 ,  G06T2207/30068

    摘要： A method, system, and related computer program products are provided for processing a medical image of a body part according to a computer-aided detection (CAD) algorithm, the medical image having an image border, the body part comprising imaged tissue appearing inside the image border and outlying tissue not appearing in the medical image, wherein likely anatomical abnormalities in the outlying tissue near the imaged tissue border are detected by the CAD algorithm. In one example, the detected likely abnormalities in the outlying tissue are located within a first distance from the imaged tissue border, wherein the first distance corresponds to a spatial ambit of a neighborhood-based feature computed by the CAD algorithm.

    摘要翻译： 提供了一种根据计算机辅助检测（CAD）算法来处理身体部位的医学图像的方法，系统和相关的计算机程序产品，所述医学图像具有图像边界，所述身体部分包括出现在内部的成像组织 图像边界和不存在于医学图像中的外围组织，其中通过CAD算法检测在成像组织边界附近的外围组织中可能的解剖异常。 在一个示例中，所检测到的外围组织中可能的异常位于距成像组织边界的第一距离内，其中第一距离对应于由CAD算法计算的基于邻域的特征的空间范围。

    In-memory space management for database systems
    98.
    发明授权
    In-memory space management for database systems 有权
    数据库系统的内存空间管理

    公开(公告)号：US07664799B2

    公开(公告)日：2010-02-16

    申请号：US11830568

    申请日：2007-07-30

    申请人： Niloy Mukherjee ,  Amit Ganesh ,  Sujatha Muthulingam ,  Wei Zhang

    发明人： Niloy Mukherjee ,  Amit Ganesh ,  Sujatha Muthulingam ,  Wei Zhang

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30595 ,  G06F9/5005 ,  G06F9/5016 ,  G06F9/526 ,  Y10S707/99956

    摘要： A framework for in-memory space management for content management database systems is provided. A per-instance in-memory dispenser is partitioned. An incoming transaction takes a latch on a partition and obtains sufficient block usage to perform and complete the transaction. Generating redo information is decoupled from transaction level processing and, instead, is performed when block requests are loaded into the in-memory dispenser or synced therefrom to a per-instance on-disk structure.

    摘要翻译： 提供了内容管理数据库系统的内存空间管理框架。 每个实例的内存分配器被分区。 传入的事务在分区上占用一个锁存器，并获得足够的块使用来执行和完成事务。 生成重做信息与事务级别处理分离，而是将块请求加载到内存分配器中或从其同步到每个实例磁盘结构时执行。

    Piezoelectric quartz level sensor
    100.
    发明授权
    Piezoelectric quartz level sensor 失效
    压电石英液位传感器

    公开(公告)号：US07603786B2

    公开(公告)日：2009-10-20

    申请号：US11906201

    申请日：2007-09-29

    申请人： Fuxue Zhang ,  Wei Zhang

    发明人： Fuxue Zhang ,  Wei Zhang

    IPC分类号： G01C9/06

    CPC分类号： G01C9/06 ,  H01L41/053 ,  H01L41/0533 ,  H01L41/1132

    摘要： The present invention relates to a new piezoelectric quartz level sensor mainly applied in the attitude stabilized and control system of the aircraft, robot, vehicle, ship, oil drilling platform, construction, industrial automation equipment, radar, and satellite, comprising a sensitive element, signal processing circuit, base, outer case and socket. The piezoelectric quartz level sensor transfers the deflection angle of the object to the force exerted on two symmetrical mounted round piezoelectric quartz wafers, and then utilizing the prominent force sensitivity of the piezoelectric quartz, the level attitude parameter of an objected can be detected through the frequency variation due to the force exerted on the two piezoelectric quartz wafers. Therefore, the present invention can satisfy the demand of high stability and resolution, low non-linear degree, quick start time, wide measuring range and operating temperature, good ability to resist shock, and digital output.

    摘要翻译： 本发明涉及一种主要应用在飞机，机器人，车辆，船舶，石油钻井平台，建筑，工业自动化设备，雷达和卫星的姿态稳定和控制系统中的新的压电石英液位传感器，包括敏感元件， 信号处理电路，底座，外壳和插座。 压电石英电平传感器将物体的偏转角传递到两个对称安装的圆形压电石英晶片上的力，然后利用压电石英的突出的力灵敏度，可以通过频率检测被测对象的水平姿态参数 由于施加在两个压电石英晶片上的力的变化。 因此，本发明可以满足高稳定性，分辨率，低非线性度，启动时间快，测量范围宽，工作温度高，抗冲击能力强和数字输出的要求。