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146 条记录 (耗时 0.024 秒)

    MEDICAL DEVICES CONTAINING COMPOSITIONS OF POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF
    91.
    发明申请
    MEDICAL DEVICES CONTAINING COMPOSITIONS OF POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF 有权

    公开(公告)号：US20210046212A1

    公开(公告)日：2021-02-18

    申请号：US17006712

    申请日：2020-08-28

    申请人： Tepha, Inc.

    发明人： Simon F. Williams ,  Said Rizk ,  David P. Martin ,  Skander Limem ,  Kai Guo ,  Amit Ganatra ,  German Oswaldo Hohl Lopez

    IPC分类号： A61L27/18 ,  A61L17/10 ,  A61L31/06 ,  C08G63/16

    摘要： Resorbable implants, coverings and receptacles comprising poly(butylene succinate) and copolymers thereof have been developed. The implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing molding, pultrusion or other melt or solvent processing method. The implants, or the fibers preset therein, may be oriented. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings, receptacles and implants described herein, may be made from meshes, webs, lattices, non-wovens, films, fibers, foams, molded, pultruded, machined and 3D printed forms.

    Oriented P4HB implants containing antimicrobial agents
    94.
    发明授权
    Oriented P4HB implants containing antimicrobial agents 有权

    公开(公告)号：US10525172B2

    公开(公告)日：2020-01-07

    申请号：US14860857

    申请日：2015-09-22

    申请人： Tepha, Inc.

    发明人： David P. Martin ,  Said Rizk ,  Simon F. Williams ,  Arikha Moses

    IPC分类号： A61L31/06 ,  A61L31/08 ,  A61L31/16

    摘要： Oriented resorbable implants made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof, have been developed that contain one or more antimicrobial agents to prevent colonization of the implants, and reduce or prevent the occurrence of infection following implantation in a patient. These oriented implants are particularly suitable for use in procedures where prolonged strength retention is necessary and there is a risk of infection. Coverings and receptacles made from poly-4-hydroxybutyrate and copolymers thereof, containing antimicrobial agents, have also been developed for use with implantable devices to prevent colonization of these devices, and to reduce or prevent the occurrence of infection following implantation of these devices in a patient. These coverings and receptacles may be used to hold, or partially or fully cover, devices such as pacemakers and neurostimulators. Preferably, the coverings and receptacles are made from meshes, non-wovens, films, fibers, and foams, and contain rifampin and minocycline.

    THREE-DIMENSIONAL RESORBABLE IMPLANTS FOR TISSUE REINFORCEMENT AND HERNIA REPAIR
    96.
    发明申请
    THREE-DIMENSIONAL RESORBABLE IMPLANTS FOR TISSUE REINFORCEMENT AND HERNIA REPAIR 审中-公开

    公开(公告)号：US20190314130A1

    公开(公告)日：2019-10-17

    申请号：US16427096

    申请日：2019-05-30

    申请人： Tepha, Inc.

    发明人： Said Rizk ,  Amit Ganatra ,  Antonio Fosco ,  David P. Martin ,  Simon F. Williams

    IPC分类号： A61F2/00

    摘要： Resorbable three-dimensional implants that can be temporarily deformed, implanted by minimally invasive means, and resume their original shape in vivo, have been developed. These implants are particularly suitable for use in minimally invasive procedures for tissue reinforcement, repair of hernias, and applications where it is desirable for the implant to contour in vivo to an anatomical shape, such as the inguinofemoral region. In the preferred embodiment, the implants are made from meshes of poly-4-hydroxybutyrate monofilament that have reinforced outlying borders that allow the meshes to form three-dimensional shapes that can be temporarily deformed. These implants can resume three-dimensional shapes after being temporarily deformed that contour to the host's tissue or an anatomical shape, for example, in the repair of a hernia, and particularly a hernia in the inguinofemoral region. The implants can contour to the host's tissue for example, of the inguinofemoral region, without the implants wrinkling, bunching or folding.

    SURGIAL MESH IMPLANTS CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF
    97.
    发明申请
    SURGIAL MESH IMPLANTS CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF 审中-公开

    公开(公告)号：US20190269817A1

    公开(公告)日：2019-09-05

    申请号：US16290735

    申请日：2019-03-01

    申请人： Tepha, Inc.

    发明人： Simon F. Williams ,  Said Rizk ,  David P. Martin

    IPC分类号： A61L17/12 ,  A61L27/58 ,  A61F2/00 ,  A61L27/54

    摘要： Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.

    EXPANDABLE ABSORBABLE IMPLANTS FOR BREAST RECONSTRUCTION AND AUGMENTATION
    99.
    发明申请
    EXPANDABLE ABSORBABLE IMPLANTS FOR BREAST RECONSTRUCTION AND AUGMENTATION 审中-公开

    公开(公告)号：US20190254807A1

    公开(公告)日：2019-08-22

    申请号：US16279378

    申请日：2019-02-19

    申请人： Tepha, Inc.

    发明人： Skander Limem ,  Bhavin Shah ,  Said Rizk ,  Matthew Dubois ,  Simon F. Williams

    IPC分类号： A61F2/12 ,  A61K35/35 ,  A61F2/00 ,  A61L27/54

    摘要： Expandable absorbable implants have been developed that are suitable for breast reconstruction following mastectomy. The implants can be implanted in the vicinity of a tissue expander, for example, by suturing to the detached edge of the pectoralis major muscle to function as a pectoralis extender, and used to form a sling for a tissue expander. The implants, which permit tissue-ingrowth and slowly degrade, can be expanded in the breast using a tissue expander in order to form a pocket for a permanent breast implant. After expansion, the tissue expander can be removed and replaced with a permanent breast implant. The expandable implants help reduce patient discomfort resulting from tissue expansion, and avoid the need to use allografts or xenografts to create the pocket for the tissue expander. The expandable absorbable implant preferably comprises poly-4-hydroxybutyrate or copolymer thereof.