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公开(公告)号：US06177250B1
公开(公告)日：2001-01-23
申请号：US09306737
申请日：1999-05-07
IPC分类号： C12Q168
CPC分类号： C12Q1/6818 , B82Y30/00 , C07H21/00 , C07H23/00 , C12Q1/6825 , C12Q2563/137 , C12Q2563/113 , C12Q2565/607 , C12Q2565/101 , C12Q2565/1015 , C12Q2565/401
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US6090933A
公开(公告)日：2000-07-18
申请号：US911085
申请日：1997-08-14
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
摘要翻译： 本发明涉及通过导电低聚物共价偶联到电极上的核酸。 更具体地，本发明涉及具有电子转移部分和电极的核酸的位点选择性修饰以产生新类别的生物材料，以及制备和使用它们的方法。
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公开(公告)号：US6087100A
公开(公告)日：2000-07-11
申请号：US946679
申请日：1997-10-08
CPC分类号： C07H23/00 , C07H21/00 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US6071699A
公开(公告)日：2000-06-06
申请号：US100507
申请日：1998-06-19
CPC分类号： C12Q1/6825 , C07H21/00 , C07H23/00 , C12Q1/6818
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US6013170A
公开(公告)日：2000-01-11
申请号：US96504
申请日：1998-06-12
申请人： Thomas J. Meade
发明人： Thomas J. Meade
IPC分类号： G01N27/416 , G01N27/327 , G01N33/543 , C12Q1/00 , C12Q1/70 , C25B11/00 , G01N27/26
CPC分类号： B82Y30/00 , B82Y15/00 , B82Y5/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, .lambda., of an electron transfer process.
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公开(公告)号：US6008190A
公开(公告)日：1999-12-28
申请号：US570761
申请日：1995-12-12
IPC分类号： C12N9/99 , A61K31/295 , A61K31/555 , A61K38/00 , A61P43/00 , C07C251/10 , C07C251/12 , C07C251/16 , C07F15/06 , C07H21/00 , A61K31/70 , A61K38/02
CPC分类号： C07H21/00 , C07C251/12 , C07C251/16 , C07F15/065 , Y10S424/06
摘要： The invention relates to novel cobalt compounds, having a general structure ##STR1## wherein Co is either Co(II) or Co(III), and each of the R groups is selected from the group consisting of hydrogen, alkyl, hydrophilic organic acid, alkyl amine, amine, alkyl alcohol, alcohol, polypeptide or nucleic acid. The invention further relates to methods of using such compounds to reduce the biological activity of proteins, particularly enzymes and zinc finger-containing proteins.
摘要翻译： 本发明涉及具有通式结构的新型钴化合物，其中Co是Co（II）或Co（III），并且每个R基团选自氢，烷基，亲水有机酸，烷基胺， 胺，烷基醇，醇，多肽或核酸。 本发明还涉及使用这些化合物降低蛋白质，特别是酶和含锌指蛋白质的生物学活性的方法。
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