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公开(公告)号:US6008190A
公开(公告)日:1999-12-28
申请号:US570761
申请日:1995-12-12
IPC分类号: C12N9/99 , A61K31/295 , A61K31/555 , A61K38/00 , A61P43/00 , C07C251/10 , C07C251/12 , C07C251/16 , C07F15/06 , C07H21/00 , A61K31/70 , A61K38/02
CPC分类号: C07H21/00 , C07C251/12 , C07C251/16 , C07F15/065 , Y10S424/06
摘要: The invention relates to novel cobalt compounds, having a general structure ##STR1## wherein Co is either Co(II) or Co(III), and each of the R groups is selected from the group consisting of hydrogen, alkyl, hydrophilic organic acid, alkyl amine, amine, alkyl alcohol, alcohol, polypeptide or nucleic acid. The invention further relates to methods of using such compounds to reduce the biological activity of proteins, particularly enzymes and zinc finger-containing proteins.
摘要翻译: 本发明涉及具有通式结构的新型钴化合物,其中Co是Co(II)或Co(III),并且每个R基团选自氢,烷基,亲水有机酸,烷基胺, 胺,烷基醇,醇,多肽或核酸。 本发明还涉及使用这些化合物降低蛋白质,特别是酶和含锌指蛋白质的生物学活性的方法。
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公开(公告)号:US08640568B2
公开(公告)日:2014-02-04
申请号:US12554065
申请日:2009-09-04
IPC分类号: F16C1/10
摘要: A bicycle shift control device is provided with a shifter housing, a gear shifting mechanism, a shift operating member, and a shift switching arrangement. The gear shifting mechanism is disposed in the shifter housing with the gear shifting mechanism having a plurality of operating positions. The shift operating member is movable with respect to the shifter housing to operate the gear shifting mechanism. The shift switching arrangement includes a restricting member movably mounted with respect to the shifter housing between a non-shift restricting position and a shift restricting position. The gear shifting mechanism moves in a first set of the operating positions when the restricting member is in the non-shift restricting position, and moves in a second set of the operating positions that are different from the first set of the operating positions when the restricting member is in the shift restricting position.
摘要翻译: 一种自行车变速控制装置设置有变速器壳体,变速机构,变速操作构件和变速切换装置。 变速机构设置在变速器壳体中,变速机构具有多个操作位置。 变速操作构件可相对于换档器壳体移动以操作变速机构。 变速切换装置包括限制构件,其相对于变速器壳体可移动地安装在非换档限制位置和换档限制位置之间。 当限制构件处于非换档限制位置时,变速机构在第一组操作位置中移动,并且当限制构件处于非换挡限制位置时,在与第一组操作位置不同的第二组操作位置中移动 会员处于班次限制位置。
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公开(公告)号:US20110056319A1
公开(公告)日:2011-03-10
申请号:US12554065
申请日:2009-09-04
摘要: A bicycle shift control device is provided with a shifter housing, a gear shifting mechanism, a shift operating member, and a shift switching arrangement. The gear shifting mechanism is disposed in the shifter housing with the gear shifting mechanism having a plurality of operating positions. The shift operating member is movable with respect to the shifter housing to operate the gear shifting mechanism. The shift switching arrangement includes a restricting member movably mounted with respect to the shifter housing between a non-shift restricting position and a shift restricting position. The gear shifting mechanism moves in a first set of the operating positions when the restricting member is in the non-shift restricting position, and moves in a second set of the operating positions that are different from the first set of the operating positions when the restricting member is in the shift restricting position.
摘要翻译: 一种自行车变速控制装置设置有变速器壳体,变速机构,变速操作构件和变速切换装置。 变速机构设置在变速器壳体中,变速机构具有多个操作位置。 变速操作构件可相对于换档器壳体移动以操作变速机构。 变速切换装置包括限制构件,其相对于变速器壳体可移动地安装在非换档限制位置和换档限制位置之间。 当限制构件处于非换档限制位置时,变速机构在第一组操作位置中移动,并且当限制构件处于非换挡限制位置时,在与第一组操作位置不同的第二组操作位置中移动 会员处于班次限制位置。
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公开(公告)号:USD609252S1
公开(公告)日:2010-02-02
申请号:US29304155
申请日:2008-02-26
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公开(公告)号:US07227009B2
公开(公告)日:2007-06-05
申请号:US11253869
申请日:2005-10-18
IPC分类号: C12N15/11
CPC分类号: C12N9/6408
摘要: This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译: 本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶(称为MT-SP1),其表达升高。 在一个实施方案中,本发明提供了获得预后或在生物体中检测或分期癌症的方法。 该方法包括从生物体提供生物样品,并检测样品中膜型丝氨酸蛋白酶1(MT-SP1)的水平,其中与蛋白酶水平相比,膜型丝氨酸蛋白酶水平升高 来自正常健康生物体的生物样品表明癌症的存在或阶段。
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公开(公告)号:US07030231B1
公开(公告)日:2006-04-18
申请号:US09410362
申请日:1999-09-30
IPC分类号: C12N15/11
CPC分类号: C12N9/6408
摘要: This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
摘要翻译: 本发明提供了与癌症相关的新型膜型丝氨酸蛋白酶(称为MT-SP1),其表达升高。 在一个实施方案中,本发明提供了获得预后或在生物体中检测或分期癌症的方法。 该方法包括从生物体提供生物样品,并检测样品中膜型丝氨酸蛋白酶1(MT-SP1)的水平,其中与蛋白酶水平相比,膜型丝氨酸蛋白酶水平升高 来自正常健康生物体的生物样品表明癌症的存在或阶段。
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公开(公告)号:US09815691B2
公开(公告)日:2017-11-14
申请号:US13586126
申请日:2012-08-15
申请人: Teppei Oguni , Takeshi Osada , Toshihiko Takeuchi
发明人: Teppei Oguni , Takeshi Osada , Toshihiko Takeuchi
IPC分类号: H01M4/64 , B82Y30/00 , C25D13/02 , H01M4/04 , H01M4/13 , H01M4/133 , H01M4/134 , H01M4/139 , H01M4/1393 , H01M4/1395 , H01M4/36 , H01M4/587 , H01M10/0525 , C25D13/22 , H01M4/02
CPC分类号: B82Y30/00 , C25D13/02 , C25D13/22 , H01M4/0416 , H01M4/0452 , H01M4/13 , H01M4/133 , H01M4/134 , H01M4/139 , H01M4/1393 , H01M4/1395 , H01M4/366 , H01M4/587 , H01M10/0525 , H01M2004/027
摘要: To form graphene to a practically even thickness on an object having an uneven surface or a complex surface, in particular, an object having a surface with a three-dimensional structure due to complex unevenness, or an object having a curved surface. The object and an electrode are immersed in a graphene oxide solution, and voltage is applied between the object and the electrode. At this time, the object serves as an anode. Graphene oxide is attracted to the anode because of being negatively charged, and deposited on the surface of the object to have a practically even thickness. A portion where graphene oxide is deposited is unlikely coated with another graphene oxide. Thus, deposited graphene oxide is reduced to graphene, whereby graphene can be formed to have a practically even thickness on an object having surface with complex unevenness.
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8.
公开(公告)号:US09620769B2
公开(公告)日:2017-04-11
申请号:US13491647
申请日:2012-06-08
申请人: Toshihiko Takeuchi , Teppei Oguni , Takeshi Osada
发明人: Toshihiko Takeuchi , Teppei Oguni , Takeshi Osada
CPC分类号: H01M4/134 , H01M4/0428 , H01M4/1395 , H01M4/661 , H01M4/667 , Y02P70/54
摘要: To provide a power storage device having excellent charge/discharge cycle characteristics and a high charge/discharge capacity. The following electrode is used as an electrode of a power storage device: an electrode including a current collector and an active material layer provided over the current collector. The active material layer includes a plurality of whisker-like active material bodies. Each of the plurality of whisker-like active material bodies includes at least a core and an outer shell provided to cover the core. The outer shell is amorphous, and a portion between the current collector and the core of the active material bodies is amorphous. Note that a metal layer may be provided instead of the current collector, the active material bodies do not necessarily have to include the core, and a mixed layer may be provided between the current collector and the active material layer.
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公开(公告)号:US09102711B2
公开(公告)日:2015-08-11
申请号:US12811331
申请日:2008-12-31
申请人: Toshihiko Takeuchi
发明人: Toshihiko Takeuchi
CPC分类号: C07K16/00 , C07K16/30 , C07K16/465 , C07K2317/56 , C07K2317/92 , C12N15/102 , C12N15/1034
摘要: The present disclosure relates to methods and materials for mutagenesis, including for the generation of novel or improved proteins and libraries or arrays of mutant proteins or nucleic acids encoding such mutant proteins.
摘要翻译: 本公开涉及用于诱变的方法和材料,包括用于产生新的或改良的蛋白质和编码这种突变蛋白的突变蛋白或核酸的文库或阵列。
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公开(公告)号:US20110097340A1
公开(公告)日:2011-04-28
申请号:US12739383
申请日:2008-10-20
申请人: Sumant Ramachandra , Walter Robert Bishop , Linda Masat , Chao Bai Huang , Toshihiko Takeuchi , Seema Kantak , Chin-Yi Huang's
发明人: Sumant Ramachandra , Walter Robert Bishop , Linda Masat , Chao Bai Huang , Toshihiko Takeuchi , Seema Kantak , Chin-Yi Huang's
IPC分类号: A61K39/395 , C12P21/06 , C12N5/10 , C12N15/63 , C07K14/435 , C07K16/22 , A61P27/02 , A61P35/00 , C07H21/04 , A61P3/10
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y10S435/81
摘要: Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.
摘要翻译: 本文公开了完全人抗体及其抗原结合片段,其特异性结合人VEGF并抑制VEGF与VEGF-R1和VEGF-R2的结合,因此抑制VEGF信号传导。 本文公开的抗体和抗原结合片段可用于例如在体内和体外治疗血管生成和与血管发生相关的病症。
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