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129 条记录 (耗时 0.034 秒)

    Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
    92.
    发明授权
    Reagents for the detection of protein phosphorylation in EGFR-signaling pathways 有权
    用于检测EGFR-信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US07807789B2

    公开(公告)日：2010-10-05

    申请号：US11821130

    申请日：2007-06-21

    申请人： Ailan Guo ,  Kimberly Lee ,  Klarisa Rikova ,  Charles Farnsworth ,  Albrecht Moritz ,  Yu Li ,  Robert Polakiewicz

    发明人： Ailan Guo ,  Kimberly Lee ,  Klarisa Rikova ,  Charles Farnsworth ,  Albrecht Moritz ,  Yu Li ,  Robert Polakiewicz

    IPC分类号： C12P21/08 ,  C07K16/28

    CPC分类号： C07K16/2863 ,  C07B59/008 ,  C07K2317/34

    摘要： The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.

    摘要翻译： 本发明公开了在信号转导蛋白中识别的168个新的磷酸化位点和EGFR激酶下游和包括EGFR激酶的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点 /蛋白质，以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是以下蛋白质类型发生的位点：肌动蛋白结合蛋白，衔接/支架蛋白，钙结合蛋白，细胞周期调节蛋白，细胞骨架蛋白，DNA结合和复制蛋白，GTP酶激活蛋白，鸟嘌呤核苷酸交换因子 蛋白质，脂质激酶，受体酪氨酸激酶，受体酪氨酸激酶配体，蛋白激酶，受体和蛋白磷酸酶，转录因子蛋白，肿瘤抑制蛋白和囊泡蛋白。

    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
    93.
    发明申请
    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
    用于检测癌症信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20090061459A1

    公开(公告)日：2009-03-05

    申请号：US12074228

    申请日：2008-02-29

    申请人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    发明人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    IPC分类号： G01N33/53 ,  C07K16/18 ,  C07K14/00 ,  C12N5/18

    CPC分类号： C07K16/44 ,  G01N33/57426

    摘要： The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein kinases (including Serine/Threonine dual specificity, and Tyrosine kinases), Adaptor/Scaffold proteins, Transcription factors, Phospoatases, Tumor supressors, Ubiquitin conjugating system proteins, Translation initiation complex proteins, RNA binding proteins, Apoptosis proteins, Adhesion proteins, G protein regulators/GTPase activating protein/Guanine nucleotide exchange factor proteins, and DNA binding/replication/repair proteins, as well as other protein types.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的近443个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如 以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：蛋白激酶（包括丝氨酸/苏氨酸双特异性和酪氨酸激酶），适配器/支架蛋白，转录因子，磷酸酶，肿瘤抑制因子，泛素缀合系统蛋白，翻译起始复合体 蛋白质，RNA结合蛋白，细胞凋亡蛋白，粘附蛋白，G蛋白调节剂/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，以及DNA结合/复制/修复蛋白，以及其他蛋白质类型。

    Battery connector
    94.
    发明授权
    Battery connector 失效
    电池连接器

    公开(公告)号：US07387541B1

    公开(公告)日：2008-06-17

    申请号：US11790307

    申请日：2007-04-25

    申请人： Ming-Chun Lai ,  Yu Li

    发明人： Ming-Chun Lai ,  Yu Li

    IPC分类号： H01R24/00

    CPC分类号： H01R12/716 ,  H01M2/30 ,  H01R12/57 ,  H01R12/707 ,  H01R13/2442 ,  H01R13/41

    摘要： A battery connector includes an insulating housing and a plurality of terminals having a mounting member, a first elastic portion and a second elastic portion all accommodated in the insulating housing. The insulating housing includes two sidewalls, a top wall, a bottom wall, a front wall and a back wall. The top wall defines a plurality of receiving cavities that pass through the front wall and the back wall partly. The back wall defines a blocking portion which has a preventing surface. The front end of the mounting member bends upward and extends to form a soldering portion. A connecting portion extends from the rear end of the second elastic portion and tilts upward and is above the blocking portion. A contacting portion is exposed out of the insulating housing. As compressed, the connecting portion is supported by the blocking portion and slides along the preventing surface.

    摘要翻译： 电池连接器包括绝缘壳体和多个具有安装构件的端子，第一弹性部分和第二弹性部分全部容纳在绝缘壳体中。 绝缘壳体包括两个侧壁，顶壁，底壁，前壁和后壁。 顶壁限定多个接收腔，其部分地穿过前壁和后壁。 后壁限定具有防止表面的阻挡部分。 安装构件的前端向上弯曲并延伸以形成焊接部分。 连接部分从第二弹性部分的后端延伸并且向上倾斜并且在阻挡部分之上。 接触部分露出绝缘壳体。 被压缩时，连接部分由阻挡部分支撑并且沿防止表面滑动。

    Needle-punched non-woven filtration media and in-tank fuel filters suitable for filtering alternative fuels
    96.
    发明申请
    Needle-punched non-woven filtration media and in-tank fuel filters suitable for filtering alternative fuels 审中-公开
    针刺非织造过滤介质和适用于过滤替代燃料的罐内燃油过滤器

    公开(公告)号：US20070158277A1

    公开(公告)日：2007-07-12

    申请号：US11599689

    申请日：2006-11-15

    申请人： Clyde Bachand ,  Yu Li

    发明人： Clyde Bachand ,  Yu Li

    IPC分类号： B01D39/00

    CPC分类号： B01D39/1623 ,  B01D2239/065

    摘要： Aspects of the present disclosure provide various embodiments of filtration media and in-tank fuel filters suitable for filtration of alternative fuels. In one exemplary embodiment, an in-tank fuel filter generally includes a filter body. The filter body includes an interior and first and second panels of filtration media. The first and second panels of filtration media include needle-punched non-woven filtration media. There is an opening in the filter body for providing fluid communication with the interior of the filter body.

    摘要翻译： 本公开的方面提供适合于替代燃料过滤的过滤介质和罐内燃料过滤器的各种实施例。 在一个示例性实施例中，箱内燃料过滤器通常包括过滤器主体。 过滤体包括内部和过滤介质的第一和第二面板。 过滤介质的第一和第二面板包括针刺非织造过滤介质。 过滤器主体中有一个开口，用于与过滤器主体的内部提供流体连通。

    Uses of lp-pla2 in combination to assess coronary risk
    97.
    发明申请
    Uses of lp-pla2 in combination to assess coronary risk 审中-公开
    组合使用lp-pla2来评估冠状动脉风险

    公开(公告)号：US20070077614A1

    公开(公告)日：2007-04-05

    申请号：US10552084

    申请日：2004-04-01

    申请人： Robert Wolfert ,  Yu Maguire ,  Yu Li ,  Mark Sarno

    发明人： Robert Wolfert ,  Yu Maguire ,  Yu Li ,  Mark Sarno

    IPC分类号： C12Q1/34

    CPC分类号： G01N33/6893 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4418 ,  C12Q1/44 ,  G01N33/92 ,  G01N2333/4737 ,  G01N2333/918 ,  G01N2800/32 ,  G01N2800/324

    摘要： This invention relates to a method for assessing risk of Coronary Vascular Disease (CVD). Specifically, it relates to utilizing risk assessment from both Lipoprotein Associated Phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) in combination. In addition the invention relates to a method for assessing risk of Coronary Vascular Disease (CVD) in a patient with low to normal Low Density Lipoprotein Cholesterol (LDL) levels utilizing both LDL and Lipoprotein Associated Phospholipase A2 (Lp-PLA2). Moreover, the invention relates to the use of risk associated with Lp-PLA2, CRP and LDL in combination and specific ranges thereof to predict Coronary Vascular Disease.

    摘要翻译： 本发明涉及一种评估冠状动脉血管病（CVD）风险的方法。 具体来说，它涉及利用脂蛋白相关磷脂酶A2（Lp-PLA2）和C反应蛋白（CRP）的组合的风险评估。 此外，本发明涉及一种利用低密度脂蛋白和脂蛋白相关磷脂酶A2（Lp-PLA2）在低至正常低密度脂蛋白胆固醇（LDL）水平的患者中评估冠状动脉血管疾病（CVD）风险的方法。 此外，本发明涉及与Lp-PLA2，CRP和LDL相关的风险的组合及其特定范围用于预测冠状动脉血管疾病的用途。