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    Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif or a Sumoylated Lysine-Containing Motif
    4.
    发明申请
    Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif or a Sumoylated Lysine-Containing Motif 有权
    特异性和上下文独立的抗体，其特异性结合到切割的半胱天冬酶母体或含有Sumoylated赖氨酸的基序

    公开(公告)号：US20120208985A1

    公开(公告)日：2012-08-16

    申请号：US13289651

    申请日：2011-11-04

    申请人： Michael Comb ,  Ailan Guo ,  John Edward Rush, II ,  Jun-Ming Cai ,  Jing Li ,  Jing Zhou

    发明人： Michael Comb ,  Ailan Guo ,  John Edward Rush, II ,  Jun-Ming Cai ,  Jing Li ,  Jing Zhou

    IPC分类号： C07K16/00

    CPC分类号： C07K16/18 ,  C07K16/44 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/34

    摘要： There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.

    摘要翻译： 提供了一种特异性基因，独立于上下文的抗体，其特异性结合由（i）至少一个sumoylated赖氨酸残基组成的复发性修饰基序，和（ii）通过肽键与所述sumoylated结合的一个或多个简并氨基酸 赖氨酸残基，所述抗体特异性结合所述基序在其再次发生的生物体内的多个非同源肽或蛋白质中。 还提供了一种特异性基因，独立于上下文的抗体，其特异性结合由（i）C末端天冬氨酸残基组成的重复修饰基序，和（ii）一个或多个与肽键结合的简并氨基酸与所述 C末端天冬氨酸残基，所述抗体特异性结合所述基序在复制的生物体内的多个非同源肽或蛋白质。

    Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
    5.
    发明授权
    Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif 有权
    与特异性结合切割的半胱天冬酶基序的母体特异性和上下文相关抗体

    公开(公告)号：US09249231B2

    公开(公告)日：2016-02-02

    申请号：US13289651

    申请日：2011-11-04

    申请人： Michael Comb ,  Ailan Guo ,  John Edward Rush, II ,  Jun-Ming Cai ,  Jing Li ,  Jing Zhou

    发明人： Michael Comb ,  Ailan Guo ,  John Edward Rush, II ,  Jun-Ming Cai ,  Jing Li ,  Jing Zhou

    IPC分类号： C07K16/44 ,  C07K16/00 ,  C12N5/07

    CPC分类号： C07K16/18 ,  C07K16/44 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/34

    摘要： There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.

    摘要翻译： 提供了一种特异性基因，独立于上下文的抗体，其特异性结合由（i）至少一个sumoylated赖氨酸残基组成的复发性修饰基序，和（ii）通过肽键与所述sumoylated结合的一个或多个简并氨基酸 赖氨酸残基，所述抗体特异性结合所述基序在其再次发生的生物体内的多个非同源肽或蛋白质中。 还提供了一种特异性基因，独立于上下文的抗体，其特异性结合由（i）C末端天冬氨酸残基组成的重复修饰基序，和（ii）一个或多个与肽键结合的简并氨基酸与所述 C末端天冬氨酸残基，所述抗体特异性结合所述基序在其再次发生的生物体内的多个非同源肽或蛋白质中。

    PRIMER GROUP FOR DETECTING CPG ISLAND METHYLATION OF P16 GENE USING METHYLATION- SPECIFIC FLUORESCENCE TECHNIQUE
    6.
    发明申请
    PRIMER GROUP FOR DETECTING CPG ISLAND METHYLATION OF P16 GENE USING METHYLATION- SPECIFIC FLUORESCENCE TECHNIQUE 有权
    使用甲基特异性荧光技术检测P16基因的CPG岛状甲基化的前体组

    公开(公告)号：US20150218642A1

    公开(公告)日：2015-08-06

    申请号：US13978956

    申请日：2011-01-01

    申请人： Dajun Deng ,  Jing Zhou

    发明人： Dajun Deng ,  Jing Zhou

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/154

    摘要： The invention provides a primer group for detecting CpO island methylation of p16 gene using methylation specific fluorescence technique. The primer group comprises a pair of oligonucleotide primers and a fluorescence-labeled probe. Said oligonucleotide primer pair has base sequence represented by SEQ ID NO.1 and SEQ ID NO.2. Said fluorescence-labeled probe has base sequence represented by SEQ ID NO.3 or SEQ NO.4.

    摘要翻译： 本发明提供使用甲基化特异性荧光技术检测p16基因的CpO岛甲基化的引物组。 引物组包含一对寡核苷酸引物和荧光标记探针。 所述寡核苷酸引物对具有由SEQ ID NO.1和SEQ ID NO.2表示的碱基序列。 所述荧光标记探针具有由SEQ ID NO.3或SEQ ID NO.4表示的碱基序列。

    Method of and apparatus for organizing data records in a relational database
    7.
    发明授权
    Method of and apparatus for organizing data records in a relational database 有权
    在关系数据库中组织数据记录的方法和装置

    公开(公告)号：US08972403B2

    公开(公告)日：2015-03-03

    申请号：US13365394

    申请日：2012-02-03

    申请人： You-Chin Fuh ,  Ke Wei Wei ,  Xin Ying Yang ,  Jian Wei Zhang ,  Jing Zhou ,  Xiang Zhou

    发明人： You-Chin Fuh ,  Ke Wei Wei ,  Xin Ying Yang ,  Jian Wei Zhang ,  Jing Zhou ,  Xiang Zhou

    IPC分类号： G06F17/30 ,  G06F7/00

    CPC分类号： G06F17/30312

    摘要： Embodiments of the invention relate to organizing data records in a relational database. An aspect of the invention includes creating index items for a plurality of data records. Each index item includes a counter and the creating results in a plurality of counters. The numerical values of counters in corresponding index items are updated for data records in the plurality of data records that are subjected to random access. The plurality of data records are reorganized based upon the numerical values of the plurality of counters.

    摘要翻译： 本发明的实施例涉及在关系数据库中组织数据记录。 本发明的一个方面包括创建多个数据记录的索引项。 每个索引项目包括计数器，并且在多个计数器中创建结果。 针对经过随机存取的多个数据记录中的数据记录，对相应索引项中的计数器的数值进行更新。 基于多个计数器的数值重新组织多个数据记录。

    Anilox metering system for electrographic printing
    8.
    发明授权
    Anilox metering system for electrographic printing 有权
    用于电印的网纹计量系统

    公开(公告)号：US08820233B2

    公开(公告)日：2014-09-02

    申请号：US12566568

    申请日：2009-09-24

    申请人： Eugene M. Chow ,  Jing Zhou ,  Gerald A. Domoto ,  Grace T. Brewington

    发明人： Eugene M. Chow ,  Jing Zhou ,  Gerald A. Domoto ,  Grace T. Brewington

    IPC分类号： B41F9/10 ,  B41F31/04 ,  B41M1/42 ,  G03G15/10

    CPC分类号： G03G15/104

    摘要： A method and apparatus to meter ink for electrographic printing is disclosed. An ink loading mechanism having an anilox roller fills ink from an ink supply into cells in the anilox roller having a plurality of valleys and lands that form the cells. The ink loading mechanism causes the valleys to be full or nearly full with the ink. The anilox roller rotates in a first direction. In one embodiment, a soft blade positioned slightly below surface of the lands removes ink from the cells and causes the valleys to be partially filled as the anilox roller rotates. A hard blade positioned at the surface of the lands to clean residue of ink on the surface of the lands as the anilox roller rotates. In another embodiment, a blanket roller rotationally engaged with the anilox roller pulls ink out of the cells and causes the valleys to be partially filled. The blanket roller rotates in a second direction. A first cleaning blade cleans tops of the lands of the cells.

    摘要翻译： 公开了一种用于电印印刷的墨水计量方法和装置。 具有网纹辊的墨水装载机构将油墨从墨水供给装入具有形成该单元的多个谷和平台的网纹辊中的单元中。 墨水装载机构使墨水充满或接近满。 网纹辊沿第一方向旋转。 在一个实施例中，稍微位于焊盘表面下方的软刀片从电池中去除墨水，并且当网纹辊旋转时使谷部分被填充。 位于平台表面的硬刀片，以在网纹辊旋转时清洁焊盘表面上的油墨残留物。 在另一个实施例中，与网纹辊旋转接合的橡皮布辊将墨水从电池中拉出并导致谷部分地被填充。 橡皮布滚筒沿第二个方向旋转。 第一清洁刀片清洁细胞的脊部的顶部。

    STAPLE CHAMBER ASSEMBLY AND LINEAR SURGICAL STITCHING DEVICE USING SAID STAPLE CHAMBER ASSEMBLY
    9.
    发明申请
    STAPLE CHAMBER ASSEMBLY AND LINEAR SURGICAL STITCHING DEVICE USING SAID STAPLE CHAMBER ASSEMBLY 有权
    书架式组装和线性外科手术装置

    公开(公告)号：US20130327808A1

    公开(公告)日：2013-12-12

    申请号：US13993070

    申请日：2011-12-05

    申请人： Wangdong Chen ,  Yongwang Pei ,  Jing Zhou

    发明人： Wangdong Chen ,  Yongwang Pei ,  Jing Zhou

    IPC分类号： A61B17/072

    CPC分类号： A61B17/07207 ,  A61B2017/07285 ,  A61B2090/08021

    摘要： A linear surgical stapler includes an upper staple cartridge receiving half-section, a lower staple cartridge receiving half-section and a staple cartridge assembly. The staple cartridge assembly includes a cutting groove in which a reciprocating movement cutter is mounted. The cutter includes a bottom surface and a knife blade located at a far end of the cutter. The staple cartridge assembly includes a restricting member mounted therein and an elastic stopper. The elastic stopper abuts against the restricting member when the staple cartridge assembly is in an initial state. The restricting member breaks away from the staple cartridge assembly when the staple cartridge assembly is in a firing complete state, thereby preventing the cutter from sliding towards the far end of the staple cartridge. As a result, misfiring throughout the whole operation of the linear surgical stapler is prevented.

    摘要翻译： 线性外科缝合器包括接收半部分的上部钉仓，下部钉仓接收半部分和钉仓组件。 钉仓组件包括其中安装有往复运动切割器的切割槽。 切割器包括位于切割器远端的底面和刀片。 钉仓组件包括安装在其中的限制构件和弹性塞子。 当钉仓组件处于初始状态时，弹性止动件抵靠限制构件。 当钉仓组件处于点火完成状态时，限制构件脱离钉仓组件，从而防止刀具朝向钉仓的远端滑动。 结果，可以防止线性外科缝合器整个操作过程中的点火不足。

    Instrument for anorectal surgery
    10.
    发明授权
    Instrument for anorectal surgery 有权
    肛门直肠手术器械

    公开(公告)号：US08585719B2

    公开(公告)日：2013-11-19

    申请号：US12810693

    申请日：2008-12-25

    申请人： Wangdong Chen ,  Shuicheng Ding ,  Jing Zhou

    发明人： Wangdong Chen ,  Shuicheng Ding ,  Jing Zhou

    IPC分类号： A61B17/04

    CPC分类号： A61M29/00 ,  A61B1/31 ,  A61B17/02 ,  A61B17/3421 ,  A61B2017/0046 ,  A61B2017/3452 ,  A61B2090/062

    摘要： The present invention provides an instrument for anorectal surgery, comprising a hollow main body, a suture junction disposed at a rear end of the main body and an inserting guider disposed at a front end of the main body. At an operating position, all or part of mucosa and tissues can get through the main body. At least one opening is made in the wall of the main body, and all or part of the mucosa and tissues can get into a hollow interior of the main body through the opening. Because of the openings on the wall of the main body, the present invention can be operated to perform the anorectal surgery of local and non-annular cutting, which facilitates a quick surgical operation, further allays the pain of the patients, and a better operation effect is obtained.

    摘要翻译： 本发明提供了一种肛门直肠手术器械，包括中空主体，设置在主体后端的缝线接头和设置在主体前端的插入引导件。 在一个操作的位置，全部或部分粘膜和组织可以穿过主体。 在主体的壁上形成至少一个开口，并且全部或部分粘膜和组织可以通过开口进入主体的中空内部。 由于主体壁上的开口，本发明可以被操作以执行局部和非环形切割的肛门直肠手术，这有助于快速的外科手术，进一步使患者的疼痛和更好的操作 效果得到。