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公开(公告)号：US20220347470A1
公开(公告)日：2022-11-03
申请号：US17415592
申请日：2019-12-16
Applicant: Galvani Bioelectronics Limited
Inventor： Christopher Shen-Yuan Lai , Kenneth Douglas Rys , Matteo Donega , Isha Gupta
IPC: A61N1/36
Abstract: A neurostimulation device 1 for non-destructively stimulating neural activity in a nerve 3 in proximity to a blood vessel 5. The neurostimulation device 1 comprises a catheter 7 for insertion into the blood vessel 5; a proximal electrode 11 offset from a distal electrode 9 along a length of the catheter 7; and an insulator 13 positioned between the proximal electrode 11 and the distal electrode 9 on the catheter 7. The insulator 13 has a contracted configuration in which the size of the insulator 13 allows the catheter 7 to travel inside the blood vessel 5. The insulator 13 has an expanded configuration in which the insulator 13 blocks blood flowing through the blood vessel between the proximal electrode 11 and the distal electrode 9. The neurostimulation device 1 comprises a stimulator 15 arranged to apply an electrical signal between the proximal electrode 11 and the distal electrode 9 when the insulator 13 is in the expanded configuration, thus inducing electrical activity in a wall portion of the blood vessel between the proximal and distal electrodes 9, 11. There is also an insulation portion between the distal electrode 9 and a distal end of the catheter 7 for offsetting the distal electrode 9 from a wall of the blood vessel 5.
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公开(公告)号：US11464976B2
公开(公告)日：2022-10-11
申请号：US16771441
申请日：2018-12-11
Applicant: Galvani Bioelectronics Limited
Inventor： Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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公开(公告)号：US20220305268A1
公开(公告)日：2022-09-29
申请号：US17619567
申请日：2020-06-17
Inventor： Sarah Faridah Hassan , Stephen J. Lewis , Sheridan McMurray , Arun Sridhar , Ibrahim Salman
Abstract: This invention relates to devices, methods and substances for use in the treatment of hypertension and/or elevated blood pressure in a subject.
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公开(公告)号：US11452872B2
公开(公告)日：2022-09-27
申请号：US16080203
申请日：2017-02-27
Inventor： Alessandra Giarola , Yee-Hsee Hsieh , Stephen J. Lewis , Arun Sridhar
Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
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95.发明申请公开(公告)号：US20220233856A1
公开(公告)日：2022-07-28
申请号：US17619221
申请日：2020-06-17
Applicant: Galvani Bioelectronics Limited
Inventor： Isha Gupta , Matteo Donega
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging, shock, acute respiratory distress syndrome (ARDS), severe respiratory distress syndrome (SARS), and coronavirus disease 19 (COVID-19).
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Patent Agency Ranking
公开(公告)号：US11369793B2
公开(公告)日：2022-06-28
申请号：US16328090
申请日：2017-08-25
Inventor： Jeffrey Laurence Ardell , Kalyanam Shivkumar , Arun Sridhar
Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.
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公开(公告)号：US20220193408A1
公开(公告)日：2022-06-23
申请号：US17690974
申请日：2022-03-09
Applicant: Galvani Bioelectronics Limited
Inventor： Brian Marc PEPIN , Brian OTIS
IPC: A61N1/36 , H02J50/80 , H02J50/10 , H02J50/20 , H02J50/40 , A61N1/05 , A61N1/372 , A61N1/378 , H02J7/02 , H02J7/34
Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.
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公开(公告)号：US20220193400A1
公开(公告)日：2022-06-23
申请号：US17594622
申请日：2020-04-24
Applicant: Faisal ZAIDI , GALVANI BIOELECTRONICS LIMITED
Inventor： Faisal ZAIDI
Abstract: A neuromodulation system is described in which electrodes are mounted within a neural interface device configured to include elastic self-pulsatile or IPG-controlled pneumatic/hydraulic collars in a distal end of the system. One or more electrodes are mounted in each collar. Each collar is connected to an implanted pulse generator (IPG) at the proximal end of the neuromodulation system via a lead body that includes pneumatic/hydraulic lines to the collars and electrical wiring to the electrodes. Gas or fluid pressure supplied to each collar can be controlled by one or more precision step motors inside the IPG. Proximal connectors to the lead body have one or more gas or liquid (biocompatible) reservoirs whose pressure is individually or collectively controlled by the one or more precision motors inside the IPG. The IPG can drive one common or multiple independent precision motors lined around each reservoir to drive one or more collars in the neural interface device.
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公开(公告)号：US20220023635A1
公开(公告)日：2022-01-27
申请号：US17450308
申请日：2021-10-08
Applicant: Galvani Bioelectronics Limited
Inventor： Brian PEPIN , Shiv SABESAN
Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.
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公开(公告)号：US20210402194A1
公开(公告)日：2021-12-30
申请号：US17471542
申请日：2021-09-10
Applicant: Greatbatch Ltd. , Galvani Bioelectronics Limited
Inventor： Ignacio A. Armesto , Luis Daniel Villamil , Refet Firat Yazicioglu , Kristina Schlegel , Kent Leyde
IPC: A61N1/375
Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.
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