公开(公告)号：US20090043384A1

公开(公告)日：2009-02-12

申请号：US12088419

申请日：2006-09-22

Applicant: Kazuharu Niwa ,  Atsushi Kobayashi ,  Kosuke Satake

Inventor： Kazuharu Niwa ,  Atsushi Kobayashi ,  Kosuke Satake

IPC: A61F2/16

CPC classification number: A61F2/1635 ,  A61F2/1648 ,  A61F2250/0018

Abstract: An intraocular lens of novel structure exhibiting an excellent focus adjusting power. A hollow capsule structure is filled with a transparent liquid-like or gel-like filler (32). A front wall of the capsule structure is composed of a flexible lens front film (16), and a rear wall of the capsule structure is composed of an optical lens (18) having a diameter larger than that of the flexible lens front film (16). Under a state inserted into and attached to a capsula lentis, pressure variation of a corpus vitreum acts on the optical lens (18) to enable focal refraction power to be adjusted by utilizing swelling deformation of the lens front film (16).

Abstract translation: 具有优异的聚焦调节功率的新颖结构的眼内透镜。 中空胶囊结构填充有透明液体状或凝胶状填料（32）。 胶囊结构的前壁由柔性透镜前膜（16）构成，胶囊结构的后壁由直径大于柔性透镜前膜（16）的光学透镜（18）构成， ）。 在插入并附着于扁桃体的状态下，玻璃体的压力变化作用在光学透镜（18）上，以通过利用透镜前膜（16）的膨胀变形来调节聚焦折射力。

公开(公告)号：USD561735S1

公开(公告)日：2008-02-12

申请号：US29287341

申请日：2007-07-25

Applicant: Yuji Nagura ,  Mamoru Ueda ,  Kennosuke Chujo ,  Ryouichi Sasaoka ,  Eisuke Nakao

Designer： Yuji Nagura ,  Mamoru Ueda ,  Kennosuke Chujo ,  Ryouichi Sasaoka ,  Eisuke Nakao

公开(公告)号：US07325925B1

公开(公告)日：2008-02-05

申请号：US11683632

申请日：2007-03-08

Applicant: Satoshi Shimada

Inventor： Satoshi Shimada

IPC: A61B3/14 ,  A61B3/02

CPC classification number: A61B3/024 ,  A61B3/12

Abstract: A Perimeter is provided for designating a perimetry point for an eye to be examined with a fundus image of the eye which has already been provided so as to compensate the individual variation in the position of a blind spot to the maculalutea.

Abstract translation: 提供了一个周边，用于指定要用眼睛的眼底图像进行检查的眼睛周边点，其已经被提供以补偿盲点对黄斑的位置的个体差异。

公开(公告)号：US07325924B2

公开(公告)日：2008-02-05

申请号：US10739968

申请日：2003-12-18

Applicant: Naoki Maeda ,  Kazunori Matsumura ,  Shigeru Takimoto

Inventor： Naoki Maeda ,  Kazunori Matsumura ,  Shigeru Takimoto

IPC: A61B13/14

CPC classification number: A61B3/145 ,  A61B3/156

Abstract: An ophthalmic photographic apparatus comprises a photographic mask for defining a fundus photography range, a photographic stop for eliminating light reflected from an anterior portion of the eye, and a focusing lens for bringing the fundus into focus. The photographic mask and the photographic stop are interlocked and move as one unit relative to the movement of the focusing lens in such a way that with respect to a photographic optical system, the photographic mask is maintained at a position substantially conjugate with an imaging plane of a CCD and the photographic stop is maintained at a position substantially conjugate with an anterior portion of the eye. The CCD is located at the image-side focal plane of the image-formation lens, the mask is located on the object-side focal plane of the focusing lens, and the photographic stop is located on the image-side focal plane of the focusing lens.

Abstract translation: 一种眼科摄影装置，包括用于限定眼底摄影范围的摄影掩模，用于消除从眼前部反射的光的照相停止件，以及用于使眼底聚焦的聚焦透镜。 摄影面具和照相停止件互锁并相对于聚焦透镜的移动作为一个单元移动，使得相对于照相光学系统，照相掩模保持在基本上与成像平面共轭的位置 CCD和照相胶片保持在与眼睛前部基本共轭的位置。 CCD位于图像形成透镜的图像侧焦平面处，掩模位于聚焦透镜的物体侧焦平面上，并且拍摄停止位于聚焦的图像侧焦平面上 镜片。

公开(公告)号：US20070183760A1

公开(公告)日：2007-08-09

申请号：US11655567

申请日：2007-01-19

Applicant: Takashi Mizuno ,  Takayoshi Suzuki ,  Yutaka Mizukusa

Inventor： Takashi Mizuno ,  Takayoshi Suzuki ,  Yutaka Mizukusa

IPC: A61B3/14

CPC classification number: A61B3/14 ,  A61B3/12

Abstract: An imaging system is provided that is capable of controlling a photographic operation to provide favorable images of a fundus of an eye to be examined. When a normal photographic mode is selected, a single operation of a shutter button causes a single trigger signal to be generated. On the other hand, when a stereo photographic mode is selected, a single operation of a shutter button causes two trigger signals to be generated in succession. The generated trigger signal triggers a switching device so that a position of a photographic stop is automatically switched to a position predetermined for the photographic mode, and the photographic light source is caused to emit light a number of times that corresponds to the selected photographic mode. In such a configuration, fundus images are automatically produced a set number of times by a single operation of the shutter. Therefore, a high-quality fundus image can be obtained without concerns that an appropriate moment to capture an image will be missed.

Abstract translation: 提供一种成像系统，其能够控制摄影操作以提供要检查的眼睛的眼底的有利图像。 当选择正常拍摄模式时，快门按钮的单次操作导致产生单个触发信号。 另一方面，当选择立体摄影模式时，快门按钮的单次操作将连续产生两个触发信号。 所产生的触发信号触发切换装置，使得拍摄停止的位置自动切换到为拍摄模式预定的位置，并且使摄影光源发射与所选拍摄模式对应的次数。 在这种配置中，通过快门的单次操作自动地产生眼底图像的设定次数。 因此，可以获得高质量的眼底图像，而不用担心捕获图像的适当时刻将被遗漏。

公开(公告)号：US07109242B2

公开(公告)日：2006-09-19

申请号：US10849778

申请日：2004-05-21

Applicant: Keisuke Inoue ,  Tsutomu Toma ,  Takahiro Kitamura ,  Yukiyoshi Yamazaki ,  Tetsuya Ishikawa

Inventor： Keisuke Inoue ,  Tsutomu Toma ,  Takahiro Kitamura ,  Yukiyoshi Yamazaki ,  Tetsuya Ishikawa

IPC: A01N37/00

CPC classification number: C07C59/56 ,  Y02P20/55 ,  Y10S514/866

Abstract: A compound represented by the following general formula (1), a salt thereof, or an ester thereof: wherein m represents an integer of 0 to 4, n represents an integer of 5 to 9, and R represents hydrogen atom or a protective group of hydroxyl group, which has reducing actions of blood glucose, plasma insulin, and triglyceride, and is useful for preventive and/or therapeutic treatment of diabetes, complications of diabetes, hyperlipemia and others.

Abstract translation: 由下述通式（1）表示的化合物或其盐或其酯：其中m表示0〜4的整数，n表示5〜9的整数，R表示氢原子或保护基 具有血糖，血浆胰岛素和甘油三酯降低作用的羟基，可用于预防和/或治疗糖尿病，糖尿病并发症，高脂血症等。

公开(公告)号：US20060203194A1

公开(公告)日：2006-09-14

申请号：US11121250

申请日：2005-05-03

Applicant: Takayoshi Suzuki

Inventor： Takayoshi Suzuki

IPC: A61B3/14

CPC classification number: A61B3/10

Abstract: Exciting light from a strobe light source is projected onto the fundus of the subject eye to excite a fluorescence substance in a subject eye fundus. Natural fluorescence exited in the fundus is received by a photodiode via a stop located at a position that is conjugate with the fundus. An XY stage is used to move the stop perpendicularly to the optical axis to change the measurement location. The output of the photodiode is used to calculate the intensity of the fluorescence from the measurement location. Since the measurement location can be changed with ease, it is possible to accurately and easily measure natural fluorescence from a desired part of the fundus.

Abstract translation: 来自频闪光源的激发光投射到被检眼睛的眼底上，以激发对象眼底的荧光物质。 通过位于与眼底结合的位置处的停止物通过光电二极管接收在眼底中退出的天然荧光。 XY平台用于垂直移动光轴以改变测量位置。 光电二极管的输出用于计算测量位置的荧光强度。 由于测量位置可以容易地改变，所以可以准确和容易地从眼底的所需部分测量自然荧光。

公开(公告)号：US20050237521A1

公开(公告)日：2005-10-27

申请号：US11106776

申请日：2005-04-15

Applicant: Taisuke Hirono

Inventor： Taisuke Hirono

IPC: B01L3/00 ,  G01N1/38 ,  G01N15/14 ,  G01N21/00 ,  G01N21/64

CPC classification number: B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/502776 ,  B01L2200/10 ,  B01L2300/0867 ,  G01N15/1468 ,  G01N21/6428 ,  G01N2015/1486

Abstract: When connecting a blood collecting unit (not shown) with an adaptor, streaming blood in a first inflow passage, and streaming liquid including surfactant or fluorescent dyes in a second inflow passage, the blood and the liquid are mixed at a mixing portion, and platelets, erythrocytes and cell membranes of leukocytes in the blood are dissolved by the surfactant, and the nuclei of the leukocytes are fluorescently stained with the fluorescent dyes. Then, a fluorescent particle counting portion counts the fluorescently stained nuclei of the leukocytes during moving in an outflow passage. According to the invention, a number of leukocytes can be correctly measured with a simple operation, such as connection of a blood collecting unit or the like with the adaptor.

Abstract translation: 当将血液收集单元（未示出）与适配器连接时，在第一流入通道中流动血液，以及在第二流入通道中包含表面活性剂或荧光染料的流动液体，血液和液体在混合部分混合，并且血小板 血液中的白细胞的红细胞和细胞膜被表面活性剂溶解，白细胞的核被荧光染料荧光染色。 然后，在流出通道中移动时，荧光粒子计数部对白细胞的荧光染色核进行计数。 根据本发明，可以通过简单的操作来正确地测量多个白细胞，诸如将血液收集单元等与适配器的连接。

公开(公告)号：US06893128B2

公开(公告)日：2005-05-17

申请号：US10272634

申请日：2002-10-16

Applicant: Yutaka Mizukusa ,  Akihiro Fujita

Inventor： Yutaka Mizukusa ,  Akihiro Fujita

IPC: A61B3/12 ,  A61B3/14 ,  G06K9/00

CPC classification number: A61B3/12 ,  A61B3/14

Abstract: Multiple fundus images are obtained and stored in a memory. The images concern a same eye to be examined, but are obtained at different positions relative to the optical axis of the eyeball. An image playback portion repeatedly displays fundus images from the memory, in order at a predetermined time pitch and as obtained from the different positions. This encompasses a stereoscopic range, using display of the images one-by-one.

Abstract translation: 获得多个眼底图像并将其存储在存储器中。 这些图像涉及到要检查的相同的眼睛，但是在相对于眼球的光轴的不同位置处获得。 图像重放部分以预定的时间间隔依次从存储器显示眼底图像，并且从不同的位置获得。 这包括立体视野范围，使用图像逐一显示。

公开(公告)号：US20040038987A1

公开(公告)日：2004-02-26

申请号：US10371234

申请日：2003-02-20

Applicant: Kowa Company, Ltd.

Inventor： Kimiyuki Shibuya ,  Katsumi Kawamine ,  Yukihiro Sato ,  Toru Miura ,  Chiyoka Ozaki ,  Toshiyuki Edano ,  Mitsuteru Hirata ,  Tadaaki Ohgiya

IPC: A61K031/496 ,  C07D417/02 ,  C07D413/02 ,  C07D43/02

CPC classification number: C07D263/58 ,  C07D235/28 ,  C07D277/74 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07F9/650952 ,  C07F9/65583

Abstract: The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same. The present invention relates to a compound represented by the formula (I) or salt(s) or solvate(s) thereof. 1 (In the formula, 2 is an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene or is a vinylene group where Ar is an optionally substituted aryl group; X is nullNHnull, oxygen atom or sulfur atom; Y is nullNR1null, oxygen atom, sulfur atom, sulfoxide or sulfone; Z is a single bond or nullNR2null; R1 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group; R2 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group; l is an integer of from 0 to 15; m is an integer of 2 or 3; and n is an integer of from 0 to 3). The compound of the present invention is useful as a pharmaceutical composition, particuarly as an inhibitor of acyl coenzyme A cholesterol acyltransferase (ACAT).

Abstract translation: 本发明提供新的环状二胺化合物和含有它们的药物组合物。 本发明涉及由式（I）表示的化合物或其盐或溶剂化物。 （式中，是苯，吡啶，环己烷或萘的任意取代的二价残基，或者是亚乙烯基，其中Ar是任意取代的芳基; X是-NH-，氧原子或硫原子; Y是-NR1- ，氧原子，硫原子，亚砜或砜; Z是单键或-NR2-; R 1是氢原子，任选取代的低级烷基，任选取代的芳基或任选取代的甲硅烷基低级烷基; R 2是氢原子， 取代的低级烷基，任选取代的芳基或任选取代的甲硅烷基低级烷基; l为0至15的整数; m为2或3的整数; n为0至3的整数）。 本发明的化合物可用作药物组合物，特别是作为酰基辅酶A胆固醇酰基转移酶（ACAT）的抑制剂。