公开(公告)号：US20100140503A1

公开(公告)日：2010-06-10

申请号：US12527780

申请日：2007-08-27

Applicant: Tadao Sugiura ,  Masato Mori ,  Eiji Inamoto

Inventor： Tadao Sugiura ,  Masato Mori ,  Eiji Inamoto

IPC: G01N21/64

CPC classification number: G01N21/648 ,  G01N21/6452 ,  G01N21/6458

Abstract: It is an objection of the present invention to provide a fluorescence reading apparatus in view of the influence of fluorescence derived from a fluorescence substance that is not involved with an interaction between a probe substance and a target substance.The above-mentioned problem is solved by a fluorescence reading apparatus 12 comprising an incidence angle adjusting means 10 for adjusting an incidence angle when light from a light source 7 is incident on a substrate 2; and a controller 11 that controls an amount of the incidence angle adjusted by the incidence angle adjusting means 10 and also comprises a means for receiving information on the incidence angle and information on the fluorescence intensities or fluorescence images at a plurality of incidence angles and obtaining the penetration depths of the evanescent fields with respect to the plurality of incidence angles from the information on the incidence angles; and a means for obtaining information on the fluorescence intensities in the obtained plurality of penetration depths.

Abstract translation: 考虑到不涉及探针物质和目标物质之间的相互作用的荧光物质的荧光的影响，本发明的目的是提供一种荧光读取装置。 通过荧光读取装置12解决上述问题，该装置12包括入射角调整装置10，用于当来自光源7的光入射到基板2上时调节入射角; 以及控制器11，其控制由入射角调节装置10调节的入射角的量，并且还包括用于接收关于入射角的信息和关于荧光强度的信息或多个入射角的荧光图像的信息的装置，并获得 相对于入射角度的信息，相对于多个入射角的渐逝场的穿透深度; 以及获得所获得的多个穿透深度中的荧光强度的信息的手段。

公开(公告)号：US07728893B2

公开(公告)日：2010-06-01

申请号：US11666424

申请日：2005-10-04

Applicant: Keiichiro Kagawa ,  Yuki Maeda ,  Jun Ohta

Inventor： Keiichiro Kagawa ,  Yuki Maeda ,  Jun Ohta

IPC: H04N3/14 ,  H04N5/335

CPC classification number: H04N5/23241 ,  H04N5/341 ,  H04N5/3765 ,  H04N5/378

Abstract: Each pixel cell (12) of an image sensor (10) is made of a 4-Tr structure, in which only one Tr for resetting a column (X) is so added to an ordinary 3-Tr APS as to reset only an arbitrary pixel selectively, thereby to confine the pixel size. When a pixel signal is to be read, the period, for which the pixel signals composing an ordinary image of one frame are read, is finely divided so that the pixel signals of the pixels receiving an ID light for the period are read out bit by bit and repeatedly. At this time, for only the column being read, an electric current is fed to a read amplifier in the pixel cell (12) or a variable gain amplifier in an output unit (14), thereby to suppress the power consumption. As a result, a lower power consumption and a higher pixel formation can be attained in an image pickup device for picking up an image and for acquiring the ID information of a light beacon existing in the image pickup range.

Abstract translation: 图像传感器（10）的每个像素单元（12）由4-Tr结构构成，其中仅一个用于复位列（X）的Tr被添加到普通的3-Tr APS，以仅复位任意 像素选择性，从而限制像素大小。 当要读取像素信号时，对构成一帧的普通图像的像素信号进行读取的周期被细分，使得接收该周期的ID光的像素的像素信号被一比特地读出 位和反复。 此时，仅读取列，向像素单元（12）中的读取放大器或输出单元（14）中的可变增益放大器馈送电流，从而抑制功耗。 结果，在用于拾取图像并用于获取存在于图像拾取范围内的光信标的ID信息的图像拾取装置中可以获得较低的功率消耗和较高的像素形成。

公开(公告)号：US07642401B2

公开(公告)日：2010-01-05

申请号：US11815014

申请日：2005-08-01

Applicant: Kenji Kohno ,  Pedro Herrera ,  Virginie Nepote

Inventor： Kenji Kohno ,  Pedro Herrera ,  Virginie Nepote

IPC: A01K67/027 ,  C12N15/00

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/035 ,  G01N33/5088 ,  G01N2800/042

Abstract: We prepared a transgene comprising human HB-EGF precursor cDNA, as a diphtheria toxin receptor gene, at the downstream of an insulin promoter, and introduced this transgene into a mouse fertilized egg, to produce a transgenic mouse of the present invention. In this mouse, human HB-EGF precursors are expressed specifically in islet beta cells, and by injection of diphtheria toxin, islet beta cells are selectively destroyed, resulting in that the mouse shows diabetes two or three days after the injection. This mouse can be utilized in screening and development of new medicines and therapy protocols for diabetes.

Abstract translation: 我们在胰岛素启动子的下游制备了包含人HB-EGF前体cDNA作为白喉毒素受体基因的转基因，并将该转基因引入小鼠受精卵中，从而产生本发明的转基因小鼠。 在该小鼠中，人HB-EGF前体在胰岛β细胞中特异性表达，通过注射白喉毒素，胰岛β细胞被选择性地破坏，导致小鼠在注射后两三天显示糖尿病。 该小鼠可用于筛选和开发新药和糖尿病治疗方案。

公开(公告)号：US07577852B2

公开(公告)日：2009-08-18

申请号：US11182049

申请日：2005-07-13

Applicant: Atsuya Okazaki ,  Masaki Nakanishi ,  Shigeru Yamashita ,  Katsumasa Watanabe

Inventor： Atsuya Okazaki ,  Masaki Nakanishi ,  Shigeru Yamashita ,  Katsumasa Watanabe

IPC: G06F11/30 ,  G06F12/14

CPC classification number: G06F21/79 ,  G06F21/52 ,  G06F21/64 ,  G06F2221/2105 ,  H04L9/0897 ,  H04L9/3247 ,  H04L63/12 ,  H04L2209/60

Abstract: A node terminal including an internal memory for saving a program transmitted from a server, a CPU for executing the program, a hash value calculating section for performing an operation of the program using a specified hash function when the execution of the program is completed, and a digital signature executing section for digitally signing the program operated using the hash function and the execution result of the program, using a secret key peculiar to the node and saved in a secret key storage, and a microprocessor capable of guaranteeing that the content of a memory is not unjustly falsified during the execution of the program.

Abstract translation: 一种节点终端，包括用于保存从服务器发送的程序的内部存储器，用于执行程序的CPU，散列值计算部分，用于当程序的执行完成时，使用指定的散列函数执行程序的操作;以及 数字签名执行部分，用于使用所述散列函数操作的程序和所述程序的执行结果，使用所述节点特有的秘密密钥并保存在秘密密钥存储器中进行数字签名;以及微处理器，其能够保证所述内容的 记忆在执行程序期间不会被不公正地伪造。

公开(公告)号：US20090166514A1

公开(公告)日：2009-07-02

申请号：US12226687

申请日：2007-04-12

Applicant: Takashi Tokuda ,  Jun Ohta

Inventor： Takashi Tokuda ,  Jun Ohta

IPC: H01L31/042 ,  H01L31/0224

CPC classification number: H01L27/14623 ,  G01N27/3275 ,  H01L27/14603 ,  H01L27/14609 ,  H01L27/14634 ,  H01L27/14636

Abstract: The uppermost metallic wiring layer in light-blocking layers constituted by multilevel metallic wiring that prevents light from impinging on areas other than the light-receiving area of a photodiode in each picture cell is used as a measurement electrode to be directly contacted with a specimen to measure electrical signals. Furthermore, in each picture cell including a circuit for reading out electrical signals collected through the measurement electrode, another circuit for reading out electrical signals generated by the photodiode is provided in an independent or shared form. This configuration enables the photodiode for optical measurements and the measurement electrode for electrical measurements to be provided in every picture cell. Thus, in a hybrid image sensor having an optical measurement function for obtaining optical information due to specimen and an electrical measurement functions for obtaining electrical information due to the specimen, the spatial resolution of both types of two-dimensional images can be simultaneously improved.

Abstract translation: 作为测定用电极，与被检体直接接触，使用由多层金属布线构成的遮光层中最上层的金属布线层，该多层金属布线防止光照射到各图像单元的光电二极管的受光面以外的区域 测量电信号。 此外，在包括用于读取通过测量电极收集的电信号的电路的每个图像单元中，用于读出由光电二极管产生的电信号的另一电路以独立或共享的形式提供。 该配置使得能够在每个图像单元中提供用于光学测量的光电二极管和用于电测量的测量电极。 因此，在具有用于获取样本的光学信息的光学测量功能的混合图像传感器和用于获得由于样本导致的电信息的电测量功能的情况下，可以同时提高两种类型的二维图像的空间分辨率。

公开(公告)号：US07502053B2

公开(公告)日：2009-03-10

申请号：US11490259

申请日：2006-07-21

Applicant: Keiichrio Kagawa ,  Jun Ohta ,  Yuki Maeda ,  Yasuo Masaki ,  Hideki Tanabe ,  Yasunari Miyake

Inventor： Keiichrio Kagawa ,  Jun Ohta ,  Yuki Maeda ,  Yasuo Masaki ,  Hideki Tanabe ,  Yasunari Miyake

IPC: H04N5/228 ,  H04N5/335 ,  G01S3/52

CPC classification number: G06T1/00

Abstract: For an information terminal to be operated by users for collecting predetermined pieces of information from remote information devices by free-space optical communication, the present invention provides a technique for suppressing the power consumption of the information terminal by minimizing the amount of calculation performed to collect the aforementioned information. According to the present invention, each information device emits ID light on which a low-frequency pilot signal is superimposed. The information terminal captures a series of frames of images including the ID light and locates the ID light within the images by the following steps: (1) creating multiple levels of binned images having different resolutions for each frame of the image; (2) calculating an evaluation index for each pixel within a target range of the binned images at each level, from the lowest to the highest resolution, where the target range is narrowed every time the process switches over to a lower level. In (2), the evaluation index is calculated by an evaluation function including fast Fourier transformation performed throughout the series of frames of images. The evaluation index thus calculated is compared with a threshold to determine whether the pixel concerned is receiving ID light. The present technique significantly reduces the number of pixel to be analyzed and evaluated, thereby decreasing the total number of arithmetic operations to be performed using the evaluation function. Thus, the power consumption is suppressed.

Abstract translation: 为了由用户操作的用于通过自由空间光通信从远程信息设备收集预定信息的信息终端，本发明提供了一种通过使收集的计算量最小化来抑制信息终端的功耗的技术 上述信息。 根据本发明，每个信息装置发射叠加有低频导频信号的ID光。 信息终端捕获包括ID光的一系列图像帧，并通过以下步骤来定位图像内的ID光：（1）为图像的每个帧创建具有不同分辨率的多层分箱图像; （2）从最低分辨率到最高分辨率的每个级别的分色图像的目标范围内的每个像素的评估指标计算出，每当过程切换到较低的水平时，目标范围变窄。 在（2）中，通过在整个图像帧中执行的包括快速傅立叶变换的评估函数来计算评价指标。 将如此计算的评估指标与阈值进行比较，以确定相关像素是否接收ID光。 本技术显着地减少要分析和评估的像素的数量，从而减少使用评估函数执行的算术运算的总数。 因此，功耗被抑制。

公开(公告)号：US20080298422A1

公开(公告)日：2008-12-04

申请号：US12087589

申请日：2007-01-26

Applicant: Tsuyoshi Kawai ,  Takuya Nakashima

Inventor： Tsuyoshi Kawai ,  Takuya Nakashima

IPC: H01S3/20

CPC classification number: H01S3/213 ,  C07D233/58 ,  G01N21/75 ,  H01S3/20

Abstract: Although having been used for conventional dye laser solvents, organic solvents have a disadvantage of volatility and inflammability, which makes a dye laser device large and cumbersome. In the present invention, which has been developed to solve this problem, an ionic liquid is used as the dye laser solvent. An organic dye stably dissolves in an ionic liquid and the light-emitting property is almost comparable to the case where an organic solvent is used. Since ionic liquids do not have volatility and inflammability, the dye laser medium according to the present invention is extremely easy to handle. In addition, it also has a property that the photobleach is extremely low compared to conventional dye laser mediums using an organic solvent as the solvent thereof. It is easy to obtain a laser sensor for detecting a predetermined specimen with high sensitivity using the dye laser medium according to the present invention.

Abstract translation: 虽然已经用于常规的染料激光溶剂，但有机溶剂具有挥发性和易燃性的缺点，这使得染料激光装置大而繁琐。 在为了解决这个问题而开发的本发明中，使用离子液体作为染料激光溶剂。 有机染料稳定地溶解在离子液体中，并且发光性能几乎与使用有机溶剂的情况相当。 由于离子液体不具有挥发性和易燃性，所以根据本发明的染料激光介质是非常容易处理的。 此外，与使用有机溶剂作为其溶剂的常规染料激光介质相比，它还具有光漂白剂非常低的性质。 使用根据本发明的染料激光介质，可以容易地获得用于以高灵敏度检测预定样本的激光传感器。

公开(公告)号：US20080253610A1

公开(公告)日：2008-10-16

申请号：US11906557

申请日：2007-10-02

Applicant: Mikio Shimizu ,  Naoki Fukaya ,  Takashi Bando ,  Tomohiro Shibata ,  Shin Ishii

Inventor： Mikio Shimizu ,  Naoki Fukaya ,  Takashi Bando ,  Tomohiro Shibata ,  Shin Ishii

IPC: G06K9/00 ,  G06K9/46

CPC classification number: G06K9/00248 ,  G06K9/00281

Abstract: A face model providing portion provides an stored average face model to an estimation portion estimating an affine parameter for obtaining a head pose. An individual face model learning portion obtains a result of tracking feature points by the estimation portion and learns an individual face model. The individual face model learning portion terminates the learning when a free energy of the individual face model is over a free energy of the average face model, and switches a face model provided to the estimation portion from the average face model to the individual face model. While learning the individual face mode, an observation matrix is factorized using a reliability matrix showing reliability of each observation value forming the observation matrix with emphasis on the feature point having higher reliability.

Abstract translation: 面部模型提供部分将估计部分的存储的平均面部模型提供给用于获得头部姿势的仿射参数。 个人面部模型学习部分通过估计部分获得跟踪特征点的结果，并学习个人面部模型。 当个人面部模型的自由能超过平均面部模型的自由能时，个人面部模型学习部分终止学习，并将提供给估计部分的面部模型从平均面部模型切换到个人面部模型。 在学习个人面部模式的同时，使用显示形成观察矩阵的每个观察值的可靠性的可靠度矩阵来分解观察矩阵，强调特征点具有较高的可靠性。

公开(公告)号：US20080216592A1

公开(公告)日：2008-09-11

申请号：US12068282

申请日：2008-02-05

Applicant: Jun Ueda ,  Tsukasa Ogasawara ,  Ming Ding

Inventor： Jun Ueda ,  Tsukasa Ogasawara ,  Ming Ding

IPC: A61B5/22

CPC classification number: B25J9/0006

Abstract: [Technical Problem]: To reduce time required to calculate a driving force of the driving section of the power assisting device[Technical Solution]: A driving force calculating device (1) includes: a setting information acquiring section (23) which acquires (a) muscle specifying information that specifies a target muscle, which is a muscle whose function is assisted or resisted by a driving section and (b) a target value of muscle force to be produced by the target muscle at the time of rotational motion under assistance or resistance of the driving section; and a target muscle force evaluating section (24) which acquires an estimated muscle force table (58) and musculoskeletal model data (53) and evaluates the feasibility of the target value of the target muscle. With this arrangement, it is possible to reduce time required to calculate a driving force of the driving section of the power assisting device.

Abstract translation: 技术问题：减少计算助力装置的驱动部分的驱动力所需的时间[技术方案]：驱动力计算装置（1）包括：设置信息获取部（23），其获取（a ）指定目标肌肉的肌肉指定信息，所述目标肌肉是由功能被驱动部分辅助或抵抗的肌肉，以及（b）在辅助下旋转运动时由目标肌肉产生的肌肉力的目标值，或 驱动部分的阻力; 以及获取估计肌力表（58）和肌骨骼模型数据（53）的目标肌力评价部（24），并评价目标肌肉的目标值的可行性。 通过这种布置，可以减少计算动力辅助装置的驱动部的驱动力所需的时间。

公开(公告)号：US20080120737A1

公开(公告)日：2008-05-22

申请号：US11520036

申请日：2006-09-13

Applicant: Takashi Hashimoto ,  Masataka Kajikawa

Inventor： Takashi Hashimoto ,  Masataka Kajikawa

IPC: A01H5/00 ,  C12N15/82

CPC classification number: C12N15/8243 ,  A01H1/02 ,  A24B13/00 ,  A24B13/02 ,  A24B15/10 ,  A24D1/00 ,  A61K31/465 ,  A61K36/81

Abstract: Four genes, A622, NBB1, PMT, and QPT, can be influenced for increasing nicotinic alkaloid levels in Nicotiana plants, as well as for synthesizing nicotinic alkaloids in non-nicotine producing plants and cells. In particular, overexpressing one or more of A622, NBB1, PMT, and QPT may be used to increase nicotine and nicotinic alkaloid levels in tobacco plants. Non-nicotine producing cells can be engineered to produce nicotine and related compounds by overexpressing A622 and

Abstract translation: 可以影响四种基因A622，NBB1，PMT和QPT，以增加烟草植物中烟碱型生物碱水平，以及在非尼古丁生产植物和细胞中合成烟碱生物碱。 特别地，过表达A622，NBB1，PMT和QPT中的一种或多种可以用于增加烟草植物中的尼古丁和烟碱型生物碱水平。 非尼古丁生产细胞可以通过过表达A622而工程化生产尼古丁和相关化合物