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公开(公告)号：US20230414711A1
公开(公告)日：2023-12-28
申请号：US18036704
申请日：2021-11-12
发明人： Se-Jin Lee , Emily Germain-Lee
CPC分类号： A61K38/1719 , A61P21/00
摘要： Provided herein are methods of inhibiting type 1 receptor and/or type 2 receptor signaling in subjects, optionally subjects with diseases associated with myostatin, type 1 receptor, and/or type 2 receptor signaling, or muscle loss and/or bone deterioration. Also provided are compositions for inhibition of type 1 receptor and/or type 2 receptor signaling.
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公开(公告)号：US20230407307A1
公开(公告)日：2023-12-21
申请号：US18035319
申请日：2021-11-04
IPC分类号： C12N15/113 , A61P35/00
CPC分类号： C12N15/1135 , A61P35/00 , C12N2310/11 , C12N2310/321 , C12N2310/315 , C12N2320/33
摘要： Provided herein are chemically modified antisense oligonucleotides that bind to sequences on mRNAs encoding the splicing factor TKA2β, associated with cancer.
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公开(公告)号：US20230360441A1
公开(公告)日：2023-11-09
申请号：US18245651
申请日：2021-09-16
发明人： Vivek Kumar , Brian Q. Geuther
CPC分类号： G06V40/20 , G06V20/46 , A61B5/4082 , A61B5/4088
摘要： Systems and methods described herein provide techniques for detecting subject behavior by processing video data using one or more trained models configured to detect subject behavior. The described system processes sets of frames from the video data using different trained models. The system further processes different orientations of the sets of frames. The various outputs from the different trained models and from processing the different orientations of the sets of frames may be combined to then make a final determination as to whether the subject is exhibiting a particular behavior during a particular frame.
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公开(公告)号：US20230340524A1
公开(公告)日：2023-10-26
申请号：US18015042
申请日：2021-07-07
IPC分类号： C12N15/85 , A01K67/027 , C12N9/22 , C12N15/11 , C07K14/52 , C07K14/54 , C07K14/705 , C07K14/535
CPC分类号： C12N15/8509 , A01K67/027 , C12N9/22 , C12N15/11 , C07K14/52 , C07K14/5412 , C07K14/70578 , C07K14/535 , C12N2015/8536 , A01K2267/0362 , A01K2227/105 , A01K2217/07 , C12N2310/20
摘要： The present disclosure provides immunodeficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG™) mouse models that comprise an inactivated mouse Flt3 allele and, in some models, additional genetic modifications. These mouse models useful, for example, for superior engraftment of diverse hematopoietic lineages and for immune-oncology, immunology and infectious disease studies.
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公开(公告)号：US20230298769A1
公开(公告)日：2023-09-21
申请号：US17917751
申请日：2021-04-09
发明人： Daniel Durkin , Sara Patterson , Maksym Tashchuk , Cara Statz , Taofei Yin , Tushar Deshpande , Asha Thadikemalla , Ryan Russell , Gopinath Rajadinakaran , Susan Mockus
摘要： Genetic variations associated with a patient’s cancerous tumors can be indicative of potential effective treatments for treating the patient. Systems and methods for determining relationships between gene variants of a gene, the gene variants being related to one or more cancers and being correlated to a treatment response of the one or more cancers to one or more medications, are provided. The method includes accessing, using at least one processor, a database comprising information about the gene variants, the information including at least information indicative of a treatment response of a first gene variant of the gene variants to one or more treatments; categorizing the information about the gene variants within a plurality of groups; and generating hierarchical relationships between each group of the plurality of groups. In some embodiments, a patient may be treated using a treatment selected based on the generated hierarchical relationships.
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公开(公告)号：US11730961B2
公开(公告)日：2023-08-22
申请号：US17124161
申请日：2020-12-16
发明人： Pedro Irazoqui , Simon John , Alex Kokini , Adam Willats , Alexander Chelminski , Matt Matuscak , Gabriel Simon
CPC分类号： A61N1/36046 , A61B3/16 , A61N1/3606 , A61N1/0556
摘要： An arrangement for reducing intraocular pressure includes a pulse signal source, a probe coupling, and at least one electrode. The probe coupling is configured to be supported on a portion of a living eye. The electrodes are supported on the probe coupling. The electrodes are operably coupled to receive a pulse signal from the pulse signal source.
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公开(公告)号：US20230057844A1
公开(公告)日：2023-02-23
申请号：US17787233
申请日：2020-12-18
发明人： Elissa Chesler , Michael Saul
IPC分类号： A61K31/4985 , A61P25/30 , A61K31/4045 , A61K31/422
摘要： Provided herein are methods and compositions for the treatment or prevention of certain disorders and conditions, for example, addiction using an agent to modulate 5-hydroxytryptamine 1D receptor (HTR1D) activity and/or expression. Also provided are methods for screening a candidate to determine if the candidate is suitable for the therapies disclosed herein.
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公开(公告)号：US11434484B2
公开(公告)日：2022-09-06
申请号：US15702944
申请日：2017-09-13
发明人： Haoyi Wang , Albert Cheng , Nathaniel Jillette
摘要： The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.
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公开(公告)号：US20220242933A1
公开(公告)日：2022-08-04
申请号：US17466247
申请日：2021-09-03
摘要： In certain embodiments, this present invention provides antibodies and Fc fusion proteins with enhanced pharmacokinetics, such as biotinylated antibodies or biotinylated Fc fusion polypeptides.
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100.发明授权公开(公告)号：US11369695B2
公开(公告)日：2022-06-28
申请号：US16466348
申请日：2017-12-04
摘要： The present invention relates to the use of lipid/fat droplet deposits in retinas of a human subject as a biomarker for diagnosing, prognosing, and/or monitoring retinal neurodegeneration with or without an elevated intraocular pressure in glaucoma.
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