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    Packing material for separation of optical isomer and method of separating optical isomer with the same
    91.
    发明授权
    Packing material for separation of optical isomer and method of separating optical isomer with the same 有权
    用于分离光学异构体的包装材料和与其分离光学异构体的方法

    公开(公告)号：US07399409B2

    公开(公告)日：2008-07-15

    申请号：US10398937

    申请日：2001-10-12

    申请人： Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

    发明人： Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

    IPC分类号： B01D15/08

    CPC分类号： B01J20/29 ,  B01D15/1821 ,  B01D15/185 ,  B01D15/3833 ,  B01D2215/023 ,  B01J20/286 ,  B01J20/327 ,  B01J20/3274 ,  B01J20/328 ,  C07B57/00

    摘要： The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, and to provide a process for separating optical isomers by a simulated moving bed chromatography utilizing the filler. This invention provides a filler made of a carrier supporting a specific amount of an optically active high molecular weight compound. Separation by the simulated moving bed chromatography using the filler is carried out under the condition that the capacity factors have specific values.

    摘要翻译： 本发明的目的是提供一种用于分离光学异构体的填料，其能够有效地进行光学异构体混合物的光学拆分，并提供通过使用填料的模拟移动床色谱分离光学异构体的方法。 本发明提供了由支持特定量的光学活性高分子量化合物的载体制成的填料。 在容量因子具有特定值的条件下，通过使用填料的模拟移动床层析法进行分离。

    Sample supply apparatus for simulated moving bed chromatographic device
    92.
    发明授权
    Sample supply apparatus for simulated moving bed chromatographic device 失效
    模拟移动床色谱装置的供样装置

    公开(公告)号：US06896797B2

    公开(公告)日：2005-05-24

    申请号：US10283257

    申请日：2002-10-30

    申请人： Kazuyuki Akita

    发明人： Kazuyuki Akita

    IPC分类号： G01N30/24 ,  B01D15/00 ,  B01D15/14 ,  B01D15/18 ,  B01J4/00 ,  G01N30/46 ,  G01N30/88 ,  B01D15/08

    CPC分类号： B01D15/1842 ,  B01D15/14 ,  B01D2215/023

    摘要： A simulated moving bed connected with a sample supply apparatus is constructed such that a sample liquid can be supplied continually to a simulated moving bed separation device without causing any problems due to a penetration of gas phase and admixture of the plurality of sample liquids. At this end, the sample supply apparatus is composed of a plurality of sample supply vessels each with a sample liquid passageway disposed thereto, a sample liquid-amount management vessel for storing a sample to be supplied from the sample supply vessels through the sample liquid passageways and the supplying sample liquid through the liquid-amount management vessel to the simulated moving bed chromatographic device. The apparatus also has a control for alternatingly opening and closing opening-closing devices in the sample supply vessels in response to liquid levels in the sample liquid-amount management vessel.

    摘要翻译： 与样品供给装置连接的模拟移动床被构造成使得可以将样品液体连续地供给到模拟移动床分离装置，而不会由于气相的渗透和多个样品液体的混合而引起任何问题。 此时，样本供给装置由多个样本供给容器构成，各样本供给容器具有设置有样本液体通道的样品供给容器，用于将从样品供给容器供给的样品通过样品液体通道存储的样品液量管理容器 并将样品液体通过液量管理容器提供给模拟移动床层析装置。 该装置还具有响应于样品液量管理容器中的液位而在样品供应容器中交替打开和关闭打开 - 关闭装置的控制。

    Versatile simulated moving bed systems
    94.
    发明申请
    Versatile simulated moving bed systems 失效
    多功能模拟移动床系统

    公开(公告)号：US20040129137A1

    公开(公告)日：2004-07-08

    申请号：US10416826

    申请日：2004-03-01

    发明人： Nien-Hwa Linda Chin ,  Chim Yong Chin

    IPC分类号： B01D053/12

    CPC分类号： B01D53/0446 ,  B01D15/1842 ,  B01D53/0454 ,  B01D53/08 ,  B01D2215/023 ,  B01D2257/90 ,  B01D2259/40005 ,  B01D2259/40086 ,  B01D2259/4067

    摘要： Distributed valve simulated moving beds are described in which junctions located between successive columns interrupt the flow of process fluid between columns, and either transmit the process fluid through a zone bypass to a succeeding column within the same zone or, if the junction is located between zones, direct the process fluid to an input/output line that is dedicated to the particular zone that immediately follows the junction. At each step of the SMB's operation, the distribution of flows in each junction is modulated to accomplish movement of ports consistent with the SMB's design. Further described are simulated moving beds that contain one or more decoupled on-line regeneration zones. The regeneration zone is decoupled from the separation zones in the sense that it observes a step time (a nullregeneration intervalnull) that is different than the step time observed by the separation zones of the SMB. Because the regeneration zone is nullon-line,null the SMB need not be stopped to remove columns for regeneration. Because the regeneration zone is decoupled from the separation zones, the column can stay in the regeneration zone as long as needed to accomplish the regeneration, regardless of the step time observed by the SMB.

    摘要翻译： 描述了分布式阀模拟移动床，其中位于连续柱之间的连接点中断了塔之间的过程流体的流动，并且将过程流体通过区域旁路传送到同一区域内的后续柱，或者如果结点位于区域之间 将工艺流体引导到专用于紧接在结点之后的特定区域的输入/输出线。 在SMB运营的每个步骤中，调整每个交叉点的流量分布，以实现与SMB设计一致的端口的移动。 进一步描述的是包含一个或多个解耦的在线再生区的模拟移动床。 在再现区域与分离区域分离的意义上，它观察到与SMB分离区观察到的步进时间不同的步骤时间（“再生间隔”）。 因为再生区域是“在线”，所以不需要停止SMB以除去再生区。 因为再生区域与分离区分离，所以只要需要完成再生，柱子就可以停留在再生区域中，而不管SMB观察到的步骤时间如何。

    High performance continuous reaction/separation process using a continuous liquid-solid contactor
    95.
    发明申请
    High performance continuous reaction/separation process using a continuous liquid-solid contactor 有权

    公开(公告)号：US20040063992A1

    公开(公告)日：2004-04-01

    申请号：US10412502

    申请日：2003-04-11

    发明人： Chen-Chou Chiang ,  David L. Fair

    IPC分类号： C07C069/74

    CPC分类号： C07C37/20 ,  B01D15/1857 ,  B01D15/1864 ,  B01D2215/023 ,  B01D2215/028 ,  C07C39/16

    摘要： A process for reaction and separation which comprises inputting a process material into at least one column of a plurality of columns wherein each column has at least one inlet for accepting flow from another column or group of columns, an external feed stream, an external eluent stream or a combination thereof, and each column has at least one outlet for connecting to another column, a group of columns, an external product stream or a combination thereof. Each column is independently operable in an up-flow or down-flow mode and connected independently to one of the group comprising another column, an external feed stream, an external eluent stream, an external product stream and combinations thereof.

    Method for the fractionation of molasses
    96.
    发明授权
    Method for the fractionation of molasses 失效
    糖蜜分馏方法

    公开(公告)号：US06649066B2

    公开(公告)日：2003-11-18

    申请号：US09736071

    申请日：2000-12-13

    申请人： Heikki Heikkila ,  Göran Hyöky ,  Jarmo Kuisma

    发明人： Heikki Heikkila ,  Göran Hyöky ,  Jarmo Kuisma

    IPC分类号： B01D1508

    CPC分类号： C13B35/06 ,  B01D15/1828 ,  B01D15/185 ,  B01D2215/023 ,  C13B20/148

    摘要： The invention relates to a method for the fractionation of molasses using a chromatographic simulated moving bed system in which the liquid flow is effected in a single direction in a system comprising at least two chromatographic partial packing material beds. In the method of the invention, the product or products are recovered during a multi-step sequence comprising the following phases: feeding phase of molasses, eluting phase and recycling phase. The liquid present in the partial packing material beds with their dry solids profile is recycled in the recycling phase in a loop comprising one, two or several partial packing material, beds.

    摘要翻译： 本发明涉及一种使用色谱模拟移动床系统对糖蜜进行分馏的方法，其中液体流在包括至少两个色谱部分包装材料床的系统中沿单一方向进行。 在本发明的方法中，产品或产品在包括以下阶段的多步骤序列期间回收：糖浆的进料阶段，洗脱阶段和循环阶段。 存在于部分包装材料床中的具有干燥固体分布的液体在回收阶段被循环，循环包括一个，两个或几个部分包装材料床。

    Process and device for separation with variable-length chromatographic zones
    99.
    发明申请
    Process and device for separation with variable-length chromatographic zones 有权
    用可变长度色谱区分离的方法和装置

    公开(公告)号：US20020174769A1

    公开(公告)日：2002-11-28

    申请号：US10105220

    申请日：2002-03-26

    发明人： Phillippe Adam ,  Roger Marc Nicoud ,  Michel Bailly ,  Olivier Ludemann-Hombourger

    IPC分类号： B01D053/02 ,  B01D053/14

    CPC分类号： B01D15/1828 ,  B01D2215/023

    摘要： A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection points and draw-off points are shifted by the same number of columns or column sections and advantageously by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection points and draw-off points of at least one column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable. Application to the separation particularly of stereoisomers for pharmaceutics.

    摘要翻译： 描述了在一组闭环色谱柱中分离混合物的至少一种组分的方法，其中该回路包含至少一个原料注入点，萃余液抽出点，洗脱液注入点和萃取液 离开点，其中在注入点和抽出点之间进行确定，反之亦然是确定色谱区，并且在给定时间段结束时，所有注入点和引出点为 通过相同数量的柱或柱部分移动，并且有利地通过相对于通过环路循环的主流体流的给定方向的一个柱或柱部分。 在此期间，至少一列或多列部分的不同注入点和抽出点的移位在不同时间进行，使得由所述不同点限定的区域的长度是可变的。 适用于特别是药物立体异构体的分离。

    Process and device for separation with variable-length chromatographic
    100.
    发明授权
    Process and device for separation with variable-length chromatographic 有权
    用可变长度色谱分离的方法和装置

    公开(公告)号：US06413419B1

    公开(公告)日：2002-07-02

    申请号：US09670349

    申请日：2000-09-27

    申请人： Phillippe Adam ,  Roger Marc Nicoud ,  Michel Bailly ,  Olivier Ludemann-Hombourger

    发明人： Phillippe Adam ,  Roger Marc Nicoud ,  Michel Bailly ,  Olivier Ludemann-Hombourger

    IPC分类号： B01D1508

    CPC分类号： B01D15/1842 ,  B01D2215/023

    摘要： A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection points and draw-off points are shifted by the same number of columns or column sections and advantageously by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection points and draw-off points of at least one column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable. The process is useful for the separation particularly of steroisomers for pharmaceuticals.

    摘要翻译： 描述了在一组闭环色谱柱中分离混合物的至少一种组分的方法，其中该回路包含至少一个原料注入点，萃余液抽出点，洗脱液注入点和萃取液 离开点，其中在注入点和抽出点之间进行确定，反之亦然是确定色谱区，并且在给定时间段结束时，所有注入点和引出点为 通过相同数量的柱或柱部分移动，并且有利地通过相对于通过环路循环的主流体流的给定方向的一个柱或柱部分。 在此期间，至少一列或多列部分的不同注入点和抽出点的移位在不同时间进行，使得由所述不同点限定的区域的长度是可变的。 该方法特别用于药物的立体异构体的分离是有用的。