公开(公告)号：US11642609B2

公开(公告)日：2023-05-09

申请号：US17048918

申请日：2018-12-31

申请人： ProPharma Group Europe B.V.

发明人： Trinath Pathapati ,  Pieter Johannes Den Boer ,  Dennis Nicholas Rütze

IPC分类号： B01D15/18

CPC分类号： B01D15/1828 ,  B01D15/1807 ,  B01D15/1842 ,  B01D15/1871 ,  B01D15/1885 ,  B01D2215/023

摘要： The present invention relates to a method for separating one or more components from a liquid feed mixture in an EBA-SMB operating mode without the need of pumps at the outlets of the EBA columns. The present invention also relates to a simulated moving bed separation device with expanded bed adsorption columns which can be used in the method according to the invention.

公开(公告)号：US08529757B2

公开(公告)日：2013-09-10

申请号：US12774319

申请日：2010-05-05

申请人： Anthony Go ,  Dana Lynn Pilliod ,  John R. Porter

发明人： Anthony Go ,  Dana Lynn Pilliod ,  John R. Porter

IPC分类号： B01D15/10 ,  C07C7/13

CPC分类号： C07C7/13 ,  B01D15/1807 ,  B01D15/1821 ,  B01D15/1828 ,  B01D15/1835 ,  B01D2215/023 ,  C07C7/12 ,  C10G25/08 ,  C07C15/08

摘要： A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process.

摘要翻译： 将产物从多组分进料流分离到吸附装置或系统的方法。 该装置或系统可包括移动床或模拟移动床吸附装置。 产物包含至少一种有机化合物，例如具有烷基取代基的芳基化合物。 在实施例中，用于将进料流供应到设备或系统的管道用多个等级的介质冲洗。 在实施方案中，该方法实现了吸附分离效率，吸附装置系统的容量和通过吸附过程可获得的产物的纯度中的一种或多种的改进。

公开(公告)号：US20070119783A1

公开(公告)日：2007-05-31

申请号：US11698111

申请日：2007-01-26

申请人： Couenne Nicolas ,  Wolff Luc

发明人： Couenne Nicolas ,  Wolff Luc

IPC分类号： B01D15/08

CPC分类号： C07C7/12 ,  B01D15/1828 ,  B01D15/185 ,  B01D2215/023 ,  C07C15/08 ,  C07C15/073

摘要： The method allows to minimize the solvent ratio and to maximize the capacity of the separation unit while keeping product specifications such as purity and yield constant. It has been verified that these two objectives cannot be reached simultaneously and it is recommended to operate with a minimum solvent ratio while guaranteeing a high capacity compatible with stable operation of the separation unit. These optimization objectives are reached while keeping good stability around the optimum point thus defined, by using a known operation control process such as the one described in patent EP-875,268 for example.

摘要翻译： 该方法允许最小化溶剂比并使分离单元的容量最大化，同时保持产品规格如纯度和产率恒定。 已经证实，这两个目标不能同时达到，建议以最小溶剂比操作，同时保证与分离单元的稳定运行兼容的高容量。 通过使用例如专利EP-875,268中所述的已知的操作控制过程，在如此限定的最佳点周围保持良好的稳定性的同时达到这些优化目标。

公开(公告)号：US07141172B2

公开(公告)日：2006-11-28

申请号：US10416826

申请日：2002-09-27

申请人： Nien-Hwa Linda Wang ,  Chim Yong Chin

发明人： Nien-Hwa Linda Wang ,  Chim Yong Chin

IPC分类号： B01D15/08

CPC分类号： B01D53/0446 ,  B01D15/1842 ,  B01D53/0454 ,  B01D53/08 ,  B01D2215/023 ,  B01D2257/90 ,  B01D2259/40005 ,  B01D2259/40086 ,  B01D2259/4067

摘要： Distributed valve simulated moving beds are described in which junctions located between successive columns interrupt the flow of process fluid between columns, and either transmit the process fluid through a zone bypass to a succeeding column within the same zone or, if the junction is located between zones, direct the process fluid to an input/output line that is dedicated to the particular zone that immediately follows the junction. At each step of the SMB's operation, the distribution of flows in each junction is modulated to accomplish movement of ports consistent with the SMB's design. Further described are simulated moving beds that contain one or more decoupled on-line regeneration zones. The regeneration zone is decoupled from the separation zones in the sense that it observes a step time (a “regeneration interval”) that is different than the step time observed by the separation zones of the SMB. Because the regeneration zone is “on-line,” the SMB need not be stopped to remove columns for regeneration. Because the regeneration zone is decoupled from the separation zones, the column can stay in the regeneration zone as long as needed to accomplish the regeneration, regardless of the step time observed by the SMB.

摘要翻译： 描述了分布式阀模拟移动床，其中位于连续柱之间的连接点中断了塔之间的过程流体的流动，并且将过程流体通过区域旁路传送到同一区域内的后续柱，或者如果结点位于区域之间 将工艺流体引导到专用于紧接在结点之后的特定区域的输入/输出线。 在SMB运营的每个步骤中，调整每个交叉点的流量分布，以实现与SMB设计一致的端口的移动。 进一步描述的是包含一个或多个解耦的在线再生区的模拟移动床。 在再现区域与分离区域分离的意义上，它观察到与SMB分离区观察到的步进时间不同的步骤时间（“再生间隔”）。 因为再生区域是“在线”，所以不需要停止SMB以除去再生区。 因为再生区域与分离区分离，所以只要需要完成再生，柱子就可以停留在再生区域中，而不管SMB观察到的步骤时间如何。

公开(公告)号：US06652755B2

公开(公告)日：2003-11-25

申请号：US10109671

申请日：2002-04-01

申请人： Hirokazu Ikeda

发明人： Hirokazu Ikeda

IPC分类号： B01D1500

CPC分类号： B01D15/1842 ,  B01D2215/023

摘要： A simulated moving bed separation system is provided, in which a fluid circulation flow path can be washed for a short time. This system is provided with a circulation flow path having two or more packed beds connected in series and endlessly to each other, with desorbing-charging inlet, extract draw-out port, feedstock introducing port and raffinate draw-out port arranged in this order in the direction of flow of a circulation liquid, which are allowed to intermittently shift in the direction while being kept in this order, and with packed bed-washing pipes, valves and pumps. A desorbing liquid is introduced through the desorbing liquid introducing port into the circulation flow path. An extract rich in a strongly adsorptive constituent to be separated is drawn out through the extract draw-out port. A feedstock containing strongly and weakly adsorptive constituents is introduced through the feedstock introducing port into the circulation flow path, and a raffinate rich in a weakly adsorptive constituent is drawn out through the raffinate draw-out port.

公开(公告)号：US20030010716A1

公开(公告)日：2003-01-16

申请号：US10003043

申请日：2001-11-15

申请人： Purdue Research Foundation

发明人： Phillip C. Wankat

IPC分类号： B01D011/00

CPC分类号： B01D15/1842 ,  B01D15/1864 ,  B01D15/265 ,  B01D15/34 ,  B01D15/361 ,  B01D2215/023

摘要： Systems and processes are provided that are useful for separating components from feed streams containing multiple components. Systems and processes of the present invention are based on simulated moving bed technology.

摘要翻译： 提供了可用于从包含多个组分的进料流中分离组分的系统和方法。 本发明的系统和方法基于模拟移动床技术。

公开(公告)号：US20020108905A1

公开(公告)日：2002-08-15

申请号：US10109671

申请日：2002-04-01

申请人： Daicel Chemical Industries, Ltd.

发明人： Hirokazu Ikeda

IPC分类号： B01D011/00

CPC分类号： B01D15/1842 ,  B01D2215/023

摘要： A simulated moving bed separation system is provided, in which a fluid circulation flow path can be washed for a short time. This system is provided with a circulation flow path having two or more packed beds connected in series and endlessly to each other, with desorbing-charging inlet, extract draw-out port, feedstock introducing port and raffinate draw-out port arranged in this order in the direction of flow of a circulation liquid, which are allowed to intermittently shift in the direction while being kept in this order, and with packed bed-washing pipes, valves and pumps. A desorbing liquid is introduced through the desorbing liquid introducing port into the circulation flow path. An extract rich in a strongly adsorptive constituent to be separated is drawn out through the extract draw-out port. A feedstock containing strongly and weakly adsorptive constituents is introduced through the feedstock introducing port into the circulation flow path, and a raffinate rich in a weakly adsorptive constituent is drawn out through the raffinate draw-out port.

公开(公告)号：US06331250B1

公开(公告)日：2001-12-18

申请号：US09308560

申请日：1999-05-20

申请人： Kikuzo Kaneko ,  Takayuki Masuda ,  Fumihiko Matsuda ,  Kohei Sato ,  Kouji Tanikawa

发明人： Kikuzo Kaneko ,  Takayuki Masuda ,  Fumihiko Matsuda ,  Kohei Sato ,  Kouji Tanikawa

IPC分类号： B01D1508

CPC分类号： B01D15/1828 ,  B01D15/361 ,  B01D2215/023

摘要： At least 2 different packings differing in the resolution of components contained in a starting fluid material such as a starting solution material and desired to be separated are used in a coexistent state to adjust the resolution of the components. The starting fluid material is flowed through the resultant packing bed to effect chromatographic separation, whereby high-purity fractions enriched with respective components can be obtained at high recoveries with a small amount of desorbent such as eluent. In a chromatographic separator, at least 2 packings comprising a first packing high in the resolution of a component having a medium affinity (affinity for packing) and a weak-affinity component and a second packing high in the resolution of a strong-affinity component and the medium-affinity component in a coexistent state are used as chromatographic packing in contact with a fluid containing the medium-affinity component to adjust the resolution of every two of at least 3 components, whereby at least 3 fractions can be obtained.

摘要翻译： 在起始溶液材料（例如起始溶液材料）中包含的期望分离的组分的分辨率不同的至少2种不同的填料以共存状态使用以调节组分的分辨率。 起始流体材料流过所得填料床以进行色谱分离，由此可以用少量解吸剂如洗脱液以高回收率获得富含各组分的高纯度馏分。 在色谱分离器中，包含至少2个包装，其具有高分辨率的具有中等亲和性（对包装的亲和性）和弱亲和性成分的成分的高度分离的第一包装，以及高亲和性成分分辨率的第二包装， 共存状态的中等亲和性成分用作与含有中等亲和力成分的流体接触的色谱填料，以调节至少3种成分中的每两种的分辨率，由此可以获得至少3个级分。

公开(公告)号：US20010008220A1

公开(公告)日：2001-07-19

申请号：US09799015

申请日：2001-03-06

申请人： Institut Francais du Petrole

发明人： Gilles Ferschneider ,  Jean-Christophe Viguie ,  Olivier Callebert ,  Frederic Hoffmann

IPC分类号： C02F001/26

CPC分类号： B01J8/0492 ,  B01D15/1842 ,  B01D53/0423 ,  B01D53/0446 ,  B01D2215/023 ,  B01D2257/7027 ,  B01D2259/402 ,  B01F5/0601 ,  B01F15/0264 ,  B01J8/0453 ,  C07C7/12 ,  C07C15/08

摘要： Device (DME) or panel for collecting, distributing, mixing or drawing off several fluids, at least one main fluid and at least two secondary fluids, that comprises at least: means for collecting a main fluid (3, 9), at least two injection and/or draw-off rails (6, 7) that allow the passage of secondary fluids, at least two mixing chambers (11a, 11b) that communicate with injection and/or draw-off rails (6, 7) with orifices or passages (6i, 7i), means (12, 4) for redistributing the fluid that is obtained from said mixing chambers, means (5a, 5b) for separating collecting and redistributing means and draw-off rails (6, 7) are arranged one above the other, and mixing chambers (11a, 11b) are arranged on both sides of the rails and symmetrically relative to the orifices that have an injection function.

摘要翻译： 用于收集，分配，混合或抽出多种流体的装置（DME）或面板，至少一个主流体和至少两个次级流体，至少包括：用于收集主流体（3,9）的装置，至少两个 允许次流体通过的至少两个混合室（11a，11b）的喷射和/或牵引轨道（6,7），所述至少两个混合室（11a，11b）与喷嘴和/或排出轨道（6,7） 通道（6i，7i），用于重新分配从所述混合室获得的流体的装置（12,4），用于分离收集和重新分配装置和抽出轨道（6,7）的装置（5a，5b） 并且混合室（11a，11b）相对于具有注射功能的孔对称地布置在轨道的两侧。

公开(公告)号：US06261458B1

公开(公告)日：2001-07-17

申请号：US09362906

申请日：1999-07-29

申请人： Olivier Callebert ,  Gérard Hotier

发明人： Olivier Callebert ,  Gérard Hotier

IPC分类号： B01D1508

CPC分类号： B01D53/0446 ,  B01D15/1842 ,  B01D53/0423 ,  B01D53/0454 ,  B01D2215/023 ,  B01D2259/40005 ,  B01J8/0453 ,  B01J8/0492 ,  B01J2219/1942

摘要： A system that makes it possible to merge at least four fluids with a column for separating a feedstock, for example, in a simulated moving bed, comprises at least one trunnion-mounted ball valve, whereby this valve comprises at least one means that makes it possible to circulate one or more fluids, this fluid is placed inside the valve to ensure communication between two zones of the column or between at least one of said zones and at least one point that is outside of the column, and several openings (OA, OB) that are placed to ensure the circulation of fluids according to the stages that are necessary to the separation process that is carried out in said column.

摘要翻译： 一种能够将至少四种流体与用于分离原料（例如在模拟移动床中）合并的系统包括至少一个耳轴安装的球阀，由此该阀包括至少一种使其形成的装置 可能使一种或多种流体循环，该流体被放置在阀内，以确保塔的两个区域之间或至少一个所述区域和至少一个位于塔外部的点之间的连通，以及若干开口（OA， OB），其被放置以确保根据在所述塔中进行的分离过程所必需的阶段的流体循环。