公开(公告)号：US20230120975A1

公开(公告)日：2023-04-20

申请号：US17915676

申请日：2021-03-29

申请人： UNIVERSITE GRENOBLE ALPES ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Lara Marwa JOBEILI ,  Alexandre Gaston Mickaël LELLOUCH ,  Walid RACHIDI ,  Laurent Alexandre LANTIERI

IPC分类号： A61L24/00 ,  A61L24/10 ,  A61L27/38 ,  A61K35/33 ,  A61P17/02

摘要： A biomaterial including a resorbable porous matrix formed from a material including collagen, and exhibiting an inner volume and an outer surface. Advantageously, the biomaterial includes at least one type of living biological cells of a tissue, disposed in the inner volume and alternatively or complementarily on the surface of the porous matrix. The biomaterial forms a tissue substitute being close to a native tissue, in particular in terms of biological structure present in the tissue, and physiological functions.

公开(公告)号：US11631739B2

公开(公告)日：2023-04-18

申请号：US16681905

申请日：2019-11-13

申请人： Commissariat A L'Energie Atomique et aux Energies Alternatives

发明人： Fabrice Nemouchi ,  Antonio Lacerda Santos Neto ,  Francois Lefloch

IPC分类号： H01L29/08 ,  H01L21/28 ,  H01L21/324 ,  H01L21/8234 ,  H01L29/49

摘要： A method for producing a transistor includes producing on a substrate provided with a semiconductor surface layer in which an active area can be formed, a gate block arranged on the active area. Lateral protection areas are formed against lateral faces of the gate block. Source and drain regions based on a metal material-semiconductor material compound are formed on either side of the gate and in the continuation of a portion located facing the gate block. Insulating spacers are formed on either side of the gate resting on the regions based on a metal material-semiconductor material compound.

公开(公告)号：US11631646B2

公开(公告)日：2023-04-18

申请号：US17216828

申请日：2021-03-30

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Stefan Landis ,  Michaël May

IPC分类号： H01L23/00 ,  H01L21/768

摘要： A method for producing a plurality of chips each comprising an individualisation region, each chip comprising at least: a first and a second level of the electrical tracks, and an interconnections level comprising vias. The method includes producing on the dielectric layer covering the first level a mask having openings located in line with the electrical tracks and making the dielectric layer accessible. The method includes producing, in a region of the chip comprising the individualisation region, patterns conformed so that: first openings of the hard mask are not masked by the patterns, and second openings of the hard mask are masked by the patterns. The method includes producing via openings in the dielectric layer in line solely with the first openings. The method further includes filling in the via openings with an electrically conductive material, and producing the second level of the electrical tracks on the vias.

公开(公告)号：US20230115626A1

公开(公告)日：2023-04-13

申请号：US17938783

申请日：2022-10-07

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Jean-Philippe COLONNA ,  Jean BRUN ,  Sami OUKASSI

IPC分类号： H01M10/0585 ,  H01M10/0562 ,  H01M50/562

摘要： A battery includes, stacked successively above a first face of a support, in a stacking direction, at least a cathode including a lower face, an upper face and a side wall directed in the stacking direction from the lower face to the upper face, a solid electrolyte, an anode, the battery including a coating portion surrounding, and in contact with, all of the side wall of the cathode, without covering the upper face of the cathode.

公开(公告)号：US11618001B2

公开(公告)日：2023-04-04

申请号：US16463907

申请日：2017-11-30

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Nathalie Herlin ,  Florent Boismain ,  John Alper

IPC分类号： B01J19/12 ,  B01J13/02 ,  C01B32/05 ,  B22F9/30 ,  B22F1/17

摘要： A device for synthesising core-shell nanoparticles by laser pyrolysis is provided. The device includes a reactor having a first chamber for the synthesis of the core, provided with an inlet for a core precursor, a second chamber for the synthesis of the shell, provided with an inlet for a shell precursor, and at least one communication channel between the two chambers to transmit the cores of the nanoparticles intended to be formed from the first chamber towards the second chamber. The device also includes an optical device to illuminate each of the two chambers, the device comprising at least one laser capable of emitting a laser beam intended to interact with the precursors to form the core and the shell. The device further includes at least a shell precursor inlet channel, one end of which is in the form of a distribution chamber surrounding the communication channel between the two chambers of the reactor, said distribution chamber being further provided, on its inner periphery, with at least one opening leading inside said communication channel.

公开(公告)号：US11613753B2

公开(公告)日：2023-03-28

申请号：US16758104

申请日：2018-10-26

申请人： LES LABORATOIRES SERVIER ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE GRENOBLE ALPES ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Annie Andrieux ,  Marie-José Moutin ,  Christophe Bosc ,  Chrystelle Aillaud ,  Leticia Peris ,  Philippe Delagrange

IPC分类号： A61P25/28 ,  C12N15/113 ,  C12Q1/37

摘要： Using chemical proteomics with a potent unique irreversible inhibitor, inventors found that major brain tubulin carboxypeptidase (TCP) is a complex of vasohibin-1 (VASH1) with the Small Vasohibin-Binding Protein (SVBP). VASH1 and its homologue vasohibin-2 (VASH2), when complexed with SVBP, exhibit robust and specific Tyr/Phe carboxypeptidase activity on microtubules. Accordingly inventors are the first to identify the enzymatic activity of vasohibin and vasohibin/SVBP complex. Knock down of vasohibins or SVBP in cultured neurons results in a marked reduction of tyrosinated α-tubulin levels and onset of severe differentiation defects. Furthermore, knock down of vasohibins disrupts neuronal migration in developing mouse neocortex. These results establish vasohibin/SVBP complexes as TCP enzymes. Accordingly, the present invention relates methods and pharmaceutical compositions for treating tubulin carboxypeptidases (TCP) associated diseases such as neurological disorders and cardiovascular diseases with an inhibitor of activity or expression of Vasohibin or Vasohibin/SVBP complex.

公开(公告)号：US11613520B2

公开(公告)日：2023-03-28

申请号：US16751856

申请日：2020-01-24

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Lionel Picard ,  Laurent Bernard ,  Sandrine Lyonnard ,  Hakima Mendil

IPC分类号： C07C309/47 ,  C07C307/02 ,  H01M10/052 ,  H01M10/0566 ,  H01M10/056 ,  C07C311/48 ,  C09K19/32 ,  C09K19/40 ,  H01M10/054

摘要： The present invention relates to thermotropic ionic liquid crystal molecules of general formula (I) With E1 and E2, which may be identical or different, representing, independently of one another, a linear, saturated and unsubstituted C10 to C14 hydrocarbon-based radical, Ax− representing a sulfonate anion or a sulfonylimide anion of formula —SO2—N−—SO2CyF2y+1 with y being an integer ranging from 0 to 2 and Cx+ a sodium, lithium or potassium ion, most particularly advantageous for their conductivity performance qualities as an electrolyte in particular for lithium batteries.

公开(公告)号：US20230086994A1

公开(公告)日：2023-03-23

申请号：US17899095

申请日：2022-08-30

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Pierre-André MORTEMOUSQUE ,  Benoit BERTRAND ,  Baptiste JADOT ,  Tristan MEUNIER ,  Matias URDAMPILLETA ,  Maud VINET

IPC分类号： G05B19/4099 ,  H01L27/18 ,  H01L39/22 ,  H01L39/24 ,  G06N10/40

摘要： A semiconductor device includes a layer of a semiconductor material in which is formed an active zone; a plurality of first gates forming a plurality of lines substantially parallel to each other and covering in part the active zone; a plurality of second gates forming a plurality of columns; at least one third gate, designated measurement gate, extending along an axis substantially parallel to the lines of the plurality of lines and in a direction opposite to the lines of the plurality of lines with respect to the active zone, and a first electrode and a second electrode situated on either side of the plurality of measurement gates in the active zone.

公开(公告)号：US11601107B2

公开(公告)日：2023-03-07

申请号：US16956375

申请日：2018-12-21

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： Marie Gorisse ,  Alexandre Reinhardt ,  Lamine Benaissa ,  Jean-Sébastien Moulet

IPC分类号： H03H3/02 ,  H03H9/02 ,  H03H9/13 ,  H03H9/17

摘要： A method for producing an adjustable bulk acoustic wave resonator comprising a transducer stack (E1) and a tuning stack (E2). According to the invention, transducer stack (E1) includes two defined electrodes (4, 6) and piezoelectric material (2), and stack (E2) includes a layer of piezoelectric material (8) and two defined electrodes (10, 12). The method includes: a) production of the transducer stack; b) formation of an electrically insulating layer on an electrode (6) of the transducer stack; c) formation of a defined electrode (10) of the tuning stack on the electrically insulting layer such that it is aligned with the electrodes of the transducer stack; d) assembly, on the electrode (10), of a substrate of piezoelectric material; e) fracturing of the substrate of piezoelectric material; and f) formation of the other defined electrode (12) of the tuning stack, aligned with the defined electrode (10).

公开(公告)号：US11600962B2

公开(公告)日：2023-03-07

申请号：US16774131

申请日：2020-01-28

申请人： Commissariat a l'energie atomique et aux energies alternatives

发明人： Quentin Mermillod-Ansleme ,  Nicolas Aubert ,  Claude Chabrol ,  Mathieu Dupoy

IPC分类号： A61F7/00 ,  H01S3/16 ,  H01S3/04 ,  A61F7/12

摘要： A device for cooling locally, including a cooling member, a crystal having the capacity to cool via absorption of a near-infrared exciting light signal, an illuminating system intended to deliver an exciting light signal, the crystal having an elongate shape about a longitudinal axis between a near end and a far end and having a closed constant outside cross section and containing a central channel formed, from its far end, over at least some of its length, the cooling member including a rod embedded via a first end into the central channel of the crystal and including a protruding second end that forms a cooling finger.