公开(公告)号：US20190183870A1

公开(公告)日：2019-06-20

申请号：US16066693

申请日：2017-01-04

申请人： The United States of America, as represented by Secretary, Dept. of Health and Human Services

发明人： James W. Hodge ,  Sofia R. Gameiro

IPC分类号： A61K31/4406 ,  A61K31/167 ,  A61P35/00 ,  A61K31/4166 ,  A61K31/58 ,  A61K39/00 ,  A61K39/235 ,  A61K39/275

CPC分类号： A61K31/4406 ,  A61K31/167 ,  A61K31/4166 ,  A61K31/58 ,  A61K39/001102 ,  A61K39/001152 ,  A61K39/001182 ,  A61K39/001194 ,  A61K39/235 ,  A61K39/275 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

摘要： A method of reducing cancer cell growth, a method of increasing sensitivity of cancer cells to CTL mediated killing, and a method of increasing sensitivity of cancer cells to NK mediated killing are provided. The methods comprise treating cancer cells with a combination of a HDAC inhibitor and immunotherapy.

公开(公告)号：US20190113517A1

公开(公告)日：2019-04-18

申请号：US16217540

申请日：2018-12-12

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Stephen M. Hewitt ,  Joon-Yong Chung

IPC分类号： G01N33/574 ,  G16H50/20 ,  G01N33/58

摘要： Compositions, methods and kits are described for identifying biomolecules (e.g., proteins and nucleic acids) expressed in a biological sample that are associated with the presence, development, or progression of a disease (such as cancer), or more generally determination of the etiology or risk factors associated with a disease. Sample types analyzed by the disclosed methods include but are not limited to archival tissue blocks that have been preserved in a fixative, tissue biopsy samples, tissue microarrays, and so forth. The methods disclosed herein correlate expression profiles of biomolecules with various disease types, and allow for the determination of relative survival rates; in some embodiments, the methods permit determination of survival rates for a subject with cancer. In other embodiments, the disclosure relates to methods for evaluating therapeutic regimes for the treatment, such as treatment of cancer.

公开(公告)号：US10227395B2

公开(公告)日：2019-03-12

申请号：US14181099

申请日：2014-02-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Zhaochun Chen ,  Stephen H. Leppla ,  Mahtab Moayeri ,  Suzanne U. Emerson ,  Robert H. Purcell

IPC分类号： C07K16/12 ,  A61K39/00

摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

公开(公告)号：US20180369358A1

公开(公告)日：2018-12-27

申请号：US16025624

申请日：2018-07-02

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services ,  The Government of the United States, as Represented by The Secretary of the Army

发明人： Alexander G. Pletnev ,  Joseph R. Putnak ,  Robert M. Chanock ,  Brian R. Murphy ,  Stephen S. Whitehead ,  Joseph E. Blaney

IPC分类号： A61K39/12 ,  C12Q1/6888 ,  C12N7/00 ,  C07K14/005 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24143 ,  C12N2770/24162 ,  C12Q1/6888 ,  Y02A50/386 ,  Y02A50/394

摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

公开(公告)号：US10143721B2

公开(公告)日：2018-12-04

申请号：US15114505

申请日：2015-01-13

申请人： THE POPULATION COUNCIL, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES

发明人： Barry R. O'Keefe ,  Melissa Robbiani ,  José A. Fernández Romero

IPC分类号： A01N37/18 ,  A61K38/00 ,  A61P31/18 ,  A61K38/16 ,  A61K9/06 ,  A61K45/06 ,  A61K31/717 ,  A61K31/731 ,  A61K33/04 ,  A61K33/30 ,  A61K33/34 ,  A61K36/04 ,  A61K47/12 ,  A61K47/14

摘要： Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified lectins. Also disclosed are methods for making and using the compositions.

公开(公告)号：US10081659B2

公开(公告)日：2018-09-25

申请号：US15092482

申请日：2016-04-06

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services ,  University of Florida Research Foundation, Inc.

发明人： John A. Chiorini ,  Sandra Wainer ,  Mavis Agbandje-McKenna ,  Sujata Halder

IPC分类号： A61K39/12 ,  C07K14/005 ,  A61K48/00

CPC分类号： C07K14/005 ,  A61K48/0008 ,  A61K48/0075 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2810/6027

摘要： A modified adeno-associated virus (AAV) capsid protein comprising at least one non-native amino acid that confers to the modified AAV particles new properties, such as increased transduction efficiency and reduced immunogenicity. These modified AAV proteins and particles are particularly useful for gene therapy and the treatment of various diseases and conditions.

公开(公告)号：US20180265936A1

公开(公告)日：2018-09-20

申请号：US15989924

申请日：2018-05-25

申请人： The United States of America as represented by the Secretary, Dept. of Health and Human Services

发明人： Bo Shu ,  Stephen Lindstrom ,  Kai-Hui Wu ,  LaShondra Berman ,  Shannon L. Emery ,  Christine Warnes ,  Catharine McCord

IPC分类号： C12Q1/70 ,  C07H21/00

CPC分类号： C12Q1/701 ,  C07H21/00 ,  C12Q2600/16

摘要： The present disclosure relates to compositions and methods for detecting presence of an influenza virus in a sample, such as a biological sample obtained from a subject or an environmental sample. In some embodiments, the compositions and methods can be used to quickly identify particular subtypes of influenza virus (such as seasonal or variant influenza subtype H3, influenza subtype H5, Eurasian influenza subtype H7, North American influenza subtype H7, and/or influenza subtype H9) present in a sample. Probes and primers are provided herein that permit the rapid detection and/or discrimination of influenza virus subtype nucleic acids in a sample. Devices (such as arrays) and kits for detection and/or discrimination of influenza virus subtype nucleic acids are also disclosed herein.

公开(公告)号：US09734573B2

公开(公告)日：2017-08-15

申请号：US14245011

申请日：2014-04-04

申请人： The United States of America, as respresented by the Secretary, Dept. of Health and Human Services ,  Siemens Healthcare GmbH

发明人： Bruce S. Spottiswoode ,  Xiaoguang Lu ,  Xiaoming Bi ,  Hui Xue ,  Christopher Glielmi ,  Peter Kellman ,  Andreas Greiser

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  G06T2207/10088 ,  G06T2207/30048

摘要： A computer-implemented method for determining magnetic field inversion time of a tissue species includes generating a T1-mapping image of a tissue of interest, the T1-mapping image comprising a plurality of T1 values within an expected range of T1 values for the tissue of interest. An image mask is created based on predetermined identification information about the tissue of interest. Next, an updated image mask is created based on a largest connected region in the image mask. The updated image mask is applied to the T1-mapping image to yield a masked image. Then, a mean relaxation time value is determined for the largest connected region. The mean relaxation time value is then used to determine a time point for nulling longitudinal magnetization.

公开(公告)号：US09678074B2

公开(公告)日：2017-06-13

申请号：US14388293

申请日：2013-03-14

申请人： The United States of America, as represented by THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES

发明人： Liudmila Prokunina ,  Thomas R. O'Brien ,  Brian Muchmore ,  Raymond P. Donnelly ,  Patricia A. Porter-Gill

IPC分类号： C07K14/555 ,  G01N33/569 ,  C07K16/24 ,  C12Q1/68 ,  C12Q1/70

CPC分类号： G01N33/56983 ,  C07K14/555 ,  C07K16/249 ,  C07K2317/76 ,  C12Q1/6883 ,  C12Q1/707 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/52

摘要： The invention is related to identification of an interferon-analog (IFNL4) protein and genetic association with spontaneous clearance of HCV infection and response to treatment for HCV infection.

公开(公告)号：US09512429B2

公开(公告)日：2016-12-06

申请号：US14886970

申请日：2015-10-19

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： John Milburn Jessup ,  Nikolay Korokhov

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  C12N15/63 ,  C12N15/113 ,  C12N15/86

CPC分类号： C12N15/113 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/32 ,  C12N2710/10032 ,  C12N2710/10043 ,  C12N2710/10045 ,  C12N2799/022 ,  C12N2799/028 ,  C12N2820/007 ,  C12N2830/008

摘要： The present description relates to an inhibitory RNA molecule, comprising an oligonucleotide that selectively knocks down expression a Nanog pseudogene expressed in many human cancers, a replicating viral vector capable of encoding such inhibitory RNA molecule, pharmaceutical compositions comprising said vector, and methods of treating cancer by administration of said pharmaceutical composition.

摘要翻译： 本说明书涉及抑制性RNA分子，其包含选择性敲低在许多人类癌症中表达的Nanog假基因表达的寡核苷酸，能够编码该抑制性RNA分子的复制型病毒载体，包含所述载体的药物组合物和治疗癌症的方法 通过施用所述药物组合物。